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11.
HIROSHI TANAKA SHINOBU WAGA YOSHIKI KAKIZAKI KAZUHIKO SUGIMOTO KAZUO NOMURA MASARU YOKOYAMA 《Pediatrics international》1997,39(1):64-68
The patient was a 7-year-old girl with early onset urticarial cutaneous lesions and was later complicated with aseptic meningitis. Her skin lesions occurred in the infantile period and were diagnosed as urticaria, but did not disappear with antihistamines and were recurrent and persistent. In addition, she had experienced an episode of headache about once a month since 1991, when she was 4 years old, and was diagnosed as aseptic meningitis. All studies including skin biopsy for urticarial vasculitis (UV) and systemic lupus erythematosus (SLE) were negative except for the data from non-specific inflammations. A systemic corticosteroid therapy dramatically reduced her symptoms. An unusual clinical course for this patient is described. It might suggest that this case is a presentation of the disease entity of UV, chronic urticaria and possibly SLE. To our knowledge, a similar case has not been previously reported. 相似文献
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HIROSHI TANAKA SHINOBU WAGA YOSHIKI KAKIZAKI TAKASHI TATEYAMA MAKOTO KODA MASARU YOKOYAMA 《Pediatrics international》1997,39(6):698-700
An 11-year-old boy with glomerulonephritis developed acute renal failure 4 days after beginning piperacillin (PIPC) treatment. Renal biopsy revealed acute tubulointerstitial nephritis (ATIN) with marked eosinophils. A lymphocyte stimulation test (LST) for PIPC demonstrated an extremely high LST index of 626%. The serum levels of immunoglobulin E and eosinophil cationic protein also showed a significant increase at 9021 IU/mL and greater than 150 μg/L, respectively. These observations suggest that a hypersensitivity reaction might play a role in the pathogenesis of ATIN. This is the first report to describe PIPC-induced ATIN in a child. 相似文献
13.
NORIHIKO TSUCHIYA SHIGERU SATOH SHINTARO NARITA NAOTAKE SHIMODA SHINOBU MATSUURA CHIKARA OHYAMA KAZUNARI SATO TETSURO KATO HIROSHI OHTANI ATSUSHI KOMATSUDA TOMONORI HABUCHI 《International journal of urology》2005,12(10):912-916
Deep venous thrombosis (DVT) possibly occurs in the perioperative period, and induces serious complications such as a pulmonary embolism. On the other hand, allograft renal vein thrombosis leads to a high incidence of graft loss. We experienced a case in which a serious DVT occurred prior to renal transplantation; however, a successful renal transplantation in the right iliac fossa was performed after 2 years of anticoagulant therapy. It is suggested that the external iliac vein even after suffering from DVT can be anastomosed to an allograft vein successfully, when enough blood fl ow or a lower venous pressure is confirmed. However, one should be aware of the risk factors and the adequate management of thrombosis in renal transplantation because of the serious complications of DVT and the poor prognosis of allograft vein thrombosis. 相似文献
14.
HARADA MINE; YOSHIDA TAKASHI; FUNADA HISASHI; KODO HIDEKI; MORI TAKAO; ISHINO CHIZUKO; MATSUE KOSEI; SHIOBARA SHINTARO; OHTAKE SHIGEKI; ODAKA KAZUAKI; TESHIMA HIROFUMI; KONDO KUNIO; NAKAO SHINJI; UEDA MIKIO; NAKAMURA SHINOBU; HATTORI KEN-ICHI 《Japanese journal of clinical oncology》1982,12(3):301-314
Twelve patients with acute leukemia (7 with nonlymphoblasticleukemia and 5 with lymphoblastic leukemia) were treated withhigh-dose cyclophosphamide and 1,000 rad total body irradiationfollowed by allogeneic bone marrow transplantation from theirHLA-identical sibling donors. Of eight patients given transplantsat relapse, only one patient has become a long-term survivor;he is alive in disease-free complete remission (CR) 4 yr afterthe transplantation. A cure is probable in this patient. Offour patients given transplants during remission, two have survivedin unmaintained CR for almost 1 yr or more. Recurrent leukemiawas observed in two patients whose disease was resistant toconventional therapy at the time of transplantation. Major causesof treatment failure were interstitial pneumonia, hepatic failuredue to veno-occlusive disease, severe infection and relapse.Transplantation-related complications were more frequent andserious in patients who received transplants at relapse thanin those receiving them during remission. The incidence of graft-versus-hostdisease was relatively high but the disease was neither primarynor leading cause of death. These preliminary but relativelyencouraging data suggest that transplantation during remissionmay reduce posttransplant morbidity and mortality. This approachwill contribute to producing long-term survival or cure in patientswith adult acute leukemia if a suitable donor is available. 相似文献
15.
JUNZO IIDA MD SHINOBU SAKIYAMA HIDEMI IWASAKA MB FUMIO HIRAO MD KENICHI HASHINO MD YOKO KAWABATA GENRO IKAWA MD 《Psychiatry and clinical neurosciences》1996,50(4):185-189
Twenty-three patients with Tourette's disorder (13 with obsessive-compulsive symptoms [OCS] and 10 without) were comparatively investigated. In contrast to OCS-free Tourette's disorder patients, those with OCS were found to be characterized by (i) a higher incidence of volatile temper, (ii) a higher incidence of compulsive tics, (iii) a higher incidence of perinatal disorders and brain wave abnormalities, (iv) a higher severity as rated using the Seventy Scale, and (v) a higher prevalence of complications, especially of developmental disorders. Of the subjects with OCS-accompanied Tourette's disorder, approximately half had developed OCS by the onset of tics. These findings suggest the likelihood that OCS-accompanied Tourette's disorder is more strongly associated with organic cerebral disorders, independently of sites of tic disorders, than is OCS-free Tourette's disorder. 相似文献
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KENICHI HASHINO MD JUNZO IIDA MD HIDEMI IWASAKA MD NAOTO ITO SHINOBU SAKIYAMA KATSUKI KITERA HIROFUMI MATSUMOTO HIROKAZU TSUJIMOTO GENRO IKAWA MD TOSHIFUMI KISHIMOTO MD 《Psychiatry and clinical neurosciences》1997,51(2):57-65
Abstract Cognitive development in seventy-one mentally retarded children (19 autistic, 52 non-autistic; aged 7–19 years) from a school for handicapped children was studied, using Ohta's scale for evaluating cognitive development level based on language comprehension (Ohta's stage), and other developmental scales. Behavior problems were also examined. The present study reports on the utility of Ohta's stage in non-autistic children, and the relationship between cognitive development level and behavior problems in mentally retarded children. In non-autistic children, there were temporal correlations between Ohta's stage and other development scales (a standard developmental test, speech development, symbolic play development, imitation development), suggesting that in non-autistic children as well, Ohta's stage may serve well as a scale for cognitive development, and reflect symbolic representational functioning. In non-autistic children, most behavior problems in feeding, elimination and sleeping, hyperkinesis, hypokinesis, stereotyped behaviors, self-injurious behavior and licking were closely associated with cognitive development level, and were more often noted in children of lower cognitive development level rather than only in the severely mentally retarded children. Some behavior problems may often occur in the sensorimotor period and hardly occur in the symbolic representational period. 相似文献
17.
TRH兴奋试验在生长激素缺乏症患儿中的意义 总被引:5,自引:1,他引:5
探讨GHD患儿下丘脑-垂体-甲状腺轴功能的改变。方法诊断为生长激素缺乏症患儿22例,根据GHRH兴奋试验结果分为两组:Ⅰ组为垂体性GHD(5例,GH峰值<15μg/L;Ⅱ组为下丘脑性GHD(17例,GH峰值≥15μg/L),用GH治疗前进行TRH兴奋试验。结果两组患儿TSH、PRL对TRH刺激反应均低于正常对照组,且以Ⅰ组为著。互组与Ⅱ组垂体TSH储备或分泌功能低下发生率分别为40%和294%。Ⅰ组患儿PRL峰值与GHRH兴奋试验时GH峰值显著正相关(r=0.8648,P<0.05);Ⅱ组两者呈负相关(r=-0.2576),但相关无显著性。结论GHD患儿下丘脑-垂体-甲状腺轴功能存在一定程度的异常。此外,ThH兴奋试验时PRL(90min)峰值及ThH(30min)峰值对GHD患儿病变部位(下丘脑或垂体)的鉴别可能有潜在的参考价植。 相似文献
18.
MASATO HOMMA KITARO OKA HITOSHI KOBAYASHI TOMOYUKI NIITSUMA SHINOBU YAMAMOTO HISAO ITOH NORIYUKI TAKAHASHI 《The Journal of pharmacy and pharmacology》1993,45(9):844-846
Abstract— Saiboku-To, a mixture of ten different herbal extracts, has been used in Japan and Czechoslovakia for corticosteroid-dependent severe asthma to reduce the maintenance doses of corticosteroid. Magnolol has been considered to be an active component of Saiboku-To as an inhibitor of 11β-hydroxysteroid dehydrogenase and T-lymphocyte proliferation resulting in corticosteroid-sparing. To investigate the relationship between magnolol and the clinical effects of Saiboku-To, urinary magnolol excretion was compared in responders and non-responders under long-term Saiboku-To treatment. The clinical outcome of the Saiboku-To treatment was evaluated in nine asthmatic patients at 52 weeks after the onset of the treatment, using individual fluctuation of asthmatic points obtained from the patients' diary cards. Three patients whose clinical conditions were improved by the treatment were termed responders and six others were termed non-responders. The difference in the amounts of the total magnolol excreted were not significant; however, free (or non-conjugated) amounts of magnolol excreted in the responders were 7 times those in the non-responders (P < 0·05). These results suggest that the magnolol might be responsible for the therapeutic effect of Saiboku-To, indicating practical bioavailability in the responders. 相似文献
19.
Summary.— In 2168 infants, 17 cases of strawberry mark were followed from the earliest neonatal stage. Three angiomata began as telangiectatic lesions surrounded by a pale halo; red puncta then appeared on the dilated vessels. They coalesced and became papular, and red plaques were formed. Three angiomata began as a pale patch; telangiectasia then appeared on this patch. One angioma, first seen as a bruise-like macule. transformed into a nodular lesion. One angioma began as a simple and uniform erythema and subsequently became nodular. Two infants already showed early haemangiomata at our first examination. In 5 infants, on whom no abnormality was found within the first week of life, a strawberry mark was found later. Two pale patches in the neonatal stage remained abortive angiomata. The haemangiomatous component developed in the majority of cases between the third and fifth weeks of life. 相似文献
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