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M A Rubio I Torres-Aleman J R Calle J A Cabranes A V Schally A L Charro 《The Journal of clinical endocrinology and metabolism》1987,65(2):368-369
The effect of a potent agonistic analog of LHRH, D-Trp6-LHRH, on hyperprolactinemia induced by sulpiride was studied in normal men. Six men received sulpiride (100 mg, twice daily, orally) for 44 days. D-Trp6-LHRH was given sc during the last 2 weeks of sulpiride administration; the dose was 500 micrograms on the first day and 100 micrograms daily for the subsequent 14 days. All men had high serum PRL levels before D-Trp6-LHRH administration (mean +/- SEM, 56 +/- 9 ng/mL), which decreased significantly after the first dose of the analog (45 +/- 5 ng/mL; P = 0.031) and also after 15 days of analog administration (41 +/- 6 ng/mL; P = 0.016). These data demonstrate that administration of LHRH agonist can inhibit the hyperprolactinemic effect of sulpiride, suggesting a direct action of the analog on the pituitary gland to modulate PRL secretion. 相似文献
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14.
S Dexeus R Rubio G Bassols D Jakob J Ojeda R Labastida 《European journal of gynaecological oncology》1992,13(2):167-176
We present a review of the relationship between Human Papillomavirus (HPV), Precancer and Epidermoid Cancer of the uterine cervix, Co-factors that contribute in cervical carcinogenesis and the mechanism through which Papillomaviruses transform normal cells into neoplastic cells by inducing an overproduction of the encoded proteins. We also offer final remarks and conclusions on this pathology that increases its incidence every year. 相似文献
15.
Ofelia Dolores Hernández Ángel José Gutiérrez Dailos González‐Weller Gonzalo Lozano Enrique García Melón Carmen Rubio Arturo Hardisson 《Environmental toxicology》2010,25(3):227-233
This document shows the results obtained from a study on the concentration of toxic heavy metals in the internal tissue and exoskeleton of sea urchins, collected from their natural habitat. The levels of lead and cadmium were measured by Graphite Furnace Atomic Absorption Spectrometry. The mean concentrations of lead and cadmium in the internal tissue were 304.04 and 260.54 μg/kg respectively, whereas in the shell they were 185.02 and 142.48 μg/kg. We also performed a statistical analysis of the differences in the distribution of metals between their exoskeleton and their internal content, a correlation study of the metal content in internal tissue and shell and sampling areas, and a correlation study between the metal content and sample size. Since the sea urchin Diadema antillarum presents a wide range of variation in metal content, this study suggests that this species is an excellent bioindicator of heavy metal contamination. © 2009 Wiley Periodicals, Inc. Environ Toxicol, 2010. 相似文献
16.
Histologic Classification of Endoscopically Removed Flat Colorectal Polyps: A Multicentric Study 总被引:1,自引:0,他引:1
A total of 594 flat colorectal polyps, removed at endoscopy, were histologically classified into non-neoplastic (n=49) and neoplastic (n=545) polyps. Non-neoplastic polyps were subdivided into metaplastic (n=45) and hyperplastic (n=4), whereas neoplastic polyps were subdivided into adenomas (n=481), intramucosal carcinomas (n=28) and invasive adenocarcinomas (n=36). Several adenoma phenotypes were discerned: tubular (n=375), serrated (n=59), villous (n=39), mixed (n=7) and fenestrated (n=1). Intramucosal carcinomas were subdivided into tubular (n=26) and serrated (n=2), and invasive adenocarcinomas into tubular (n=32), serrated (n=3) and fenestrated (n=1). The microscopic characteristics of each histologic phenotype described in this communication are defined and illustrated. 相似文献
17.
The presence of a resident T lymphocyte population in the meninges of normal SJL/J mice has been detected by the use of the T cell-specific mitogen concanavalin A. Optimal conditions for [3H]thymidine incorporation were studied. An antigen-specific meningeal T cell proliferative response in SJL/J mice, primed by intracerebral inoculation of Theiler's murine encephalomyelitis virus, was also detected. This response indicated that leptomeningeal mononuclear cell infiltrations are involved in the immune response that triggers the demyelinating disease. 相似文献
18.
Musculo-fibrous anomaly in Barrett's mucosa with dysplasia 总被引:1,自引:0,他引:1
We investigated the histological alterations occurring in the muscularis mucosae, the lamina propria mucosae, and the submucosa in areas adjacent to invasive adenocarcinoma in 32 resected esophagi with Barrett's mucosa. In 26 of the 32 specimens, we observed a thickening of the muscularis mucosae, with overgrowth of the muscle fibers into the lamina propria mucosae. In other areas, collagen-rich fibrotic tissue replaced the muscularis mucosae, the lamina propria mucosae, and even the submucosa. In 31 of the 32 specimens, we noted cystic dilatations of the esophageal glands. Normal esophageal glands and cystically dilated glands with dysplastic lining were often surrounded, compressed, and deformed by the fibrotic tissue. The compression of the glandular outlets by the collagen-rich tissue or by proliferating dysplastic cells appeared to be the two main factors in the histogenesis of these cysts. This may result in difficulty in differentiating, in biopsy specimens, between normal and dysplastic esophageal glands "trapped" in the collagen-rich fibrotic tissue and true invasive adenocarcinoma in the Barrett's mucosa. 相似文献
19.
C. A. Rubio M.D. M. Sveander L.T. A. Duvander L.T. 《Diseases of the colon and rectum》1989,32(1):26-29
The effect of acute and chronic stress on the colonic mucosa of the rat was investigated at various time intervals, ranging from one day to eight weeks. The amount of DNA synthesized by the mucosa was used as a marker of time-related events. A total of 75 Sprague-Dawley rats were investigated. Acute stress was considered for rats briefly plunged (psychic stimulus) or swimming for two hours (physical stimulus). Chronic stress was determined when rats were briefly plunged or swam for two hours for periods ranging from one to eight weeks. "Sham-transported" rats were used as controls. DNA in the descending colon decreased significantly in rats swimming for two weeks, but increased (even for plunged rats) at four and eight weeks. In the ascending colon, a substantial increase in DNA content was found in rats plunged or swimming for eight weeks. The descending colon appears to be quantitatively more affected by various stressors than the ascending colon. It is apparent that, in control rats, the mucosa of the descending colon differs from the ascending colon. Fluctuations in the colonic DNA synthesis throughout the experiment suggest that this phenomenon may be connected to compensatory mechanisms toward cell adaptation to stress conditions. The model may prove of value in studies of the therapeutic abrogation of the fluctuations of the DNA replication of the colonic mucosa during the acute and chronic phases of a given stress. 相似文献
20.
Adenosine and active hyperemia in dog skeletal muscle 总被引:5,自引:0,他引:5