全文获取类型
收费全文 | 10710篇 |
免费 | 670篇 |
国内免费 | 68篇 |
专业分类
耳鼻咽喉 | 72篇 |
儿科学 | 278篇 |
妇产科学 | 193篇 |
基础医学 | 1318篇 |
口腔科学 | 205篇 |
临床医学 | 890篇 |
内科学 | 2501篇 |
皮肤病学 | 184篇 |
神经病学 | 1098篇 |
特种医学 | 417篇 |
外科学 | 1588篇 |
综合类 | 30篇 |
一般理论 | 1篇 |
预防医学 | 839篇 |
眼科学 | 347篇 |
药学 | 801篇 |
中国医学 | 14篇 |
肿瘤学 | 672篇 |
出版年
2023年 | 80篇 |
2022年 | 194篇 |
2021年 | 326篇 |
2020年 | 166篇 |
2019年 | 258篇 |
2018年 | 310篇 |
2017年 | 232篇 |
2016年 | 247篇 |
2015年 | 280篇 |
2014年 | 365篇 |
2013年 | 441篇 |
2012年 | 693篇 |
2011年 | 687篇 |
2010年 | 393篇 |
2009年 | 359篇 |
2008年 | 618篇 |
2007年 | 608篇 |
2006年 | 630篇 |
2005年 | 634篇 |
2004年 | 626篇 |
2003年 | 550篇 |
2002年 | 496篇 |
2001年 | 244篇 |
2000年 | 211篇 |
1999年 | 190篇 |
1998年 | 121篇 |
1997年 | 84篇 |
1996年 | 106篇 |
1995年 | 61篇 |
1994年 | 69篇 |
1993年 | 36篇 |
1992年 | 101篇 |
1991年 | 86篇 |
1990年 | 79篇 |
1989年 | 98篇 |
1988年 | 102篇 |
1987年 | 69篇 |
1986年 | 67篇 |
1985年 | 62篇 |
1984年 | 60篇 |
1983年 | 36篇 |
1982年 | 22篇 |
1979年 | 29篇 |
1978年 | 31篇 |
1976年 | 24篇 |
1975年 | 23篇 |
1974年 | 24篇 |
1973年 | 35篇 |
1972年 | 19篇 |
1968年 | 21篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
Vianello F Olszak IT Poznansky MC 《Journal of molecular medicine (Berlin, Germany)》2005,83(10):752-763
Chemotaxis or active movement of leukocytes toward a stimulus has been shown to occur in response to chemokinetic agents including members of the recently identified superfamily of proteins called chemokines. Leukocyte chemotaxis is thought to play a central role in a wide range of physiological and pathological processes including the homing of immune cells to lymph nodes and the accumulation of these cells at sites of tissue injury and pathogen or antigen challenge. We have recently identified a novel biological mechanism, which we term fugetaxis (fugere, to flee from; taxis, movement) or chemorepulsion, which describes the active movement of leukocytes away from chemokinetic agents including the chemokine, stromal cell derived factor-1, and the HIV-1 envelope protein, gp120. In this article, we review the evidence that supports the observation that leukocyte fugetaxis occurs in vitro and in vivo and suggestions that this novel mechanism can be exploited to modulate the immune response. We propose that leukocyte fugetaxis plays a critical role in both physiological and pathological processes in which leukocytes are either excluded or actively repelled from specific sites in vivo including thymic emigration, the establishment of immune privileged sites and immune evasion by viruses and cancer. We believe that current data support the thesis that a greater understanding of leukocyte fugetaxis will lead to the development of novel therapeutic approaches for a wide range of human diseases. 相似文献
102.
Zoledronic acid-related angiogenesis modifications and survival in advanced breast cancer patients. 总被引:5,自引:0,他引:5
Bruno Vincenzi Daniele Santini Giordano Dicuonzo Fabrizio Battistoni Michele Gavasci Annalisa La Cesa Claudia Grilli Vladimir Virzì Simona Gasparro Laura Rocci Giuseppe Tonini 《Journal of interferon & cytokine research》2005,25(3):144-151
The proven antiangiogenic activity of zoledronic acid, a third-generation bisphosphonate widely used in bone metastatic cancer patients, led us to investigate if the vascular endothelial growth factor (VEGF)-related zoledronic acid modifications are correlated with survival advantages in advanced breast cancer patients. Forty-two consecutive breast cancer patients with scintigraphic and radiographic evidence of bone metastases were treated with a single infusion of 4 mg zoledronic acid before anticancer chemotherapy. The patients were prospectively evaluated for circulating levels of VEGF and interferon-gamma (IFN-gamma) just before and at 1, 2, 7, and 21 days after zoledronic acid infusion. Afterward, clinical outcome was prospectively monitored. The basal serum VEGF median levels were significantly decreased at each time point, but the major reduction was recorded 21 days after the infusion. In particular, 25 patients of 42 (59.5%) experienced a reduction of at least 25% in the VEGF circulating levels. In contrast, no statistically significant modifications of the IFN-gamma serum levels were recorded. We stratified patients on the basis of this VEGF reduction 21 days after the infusion. No differences in patient features were recorded between those with or without the VEGF reduction. The analysis of survival showed that patients with a reduction in the VEGF circulating levels had a longer time to first skeletal-related event (p = 0.0002), time to bone progression disease (p = 0.0024), and time to performance status worsening (p = 0.0352) than those without the VEGF reduction. No statistically significant differences were recorded in terms of overall survival and time to visceral progression. This study confirms that zoledronic acid could have an in vivo antiangiogenic property and that the VEGF modifications may represent a surrogate marker able to predict time to first skeletal-related event, time to bone progression disease, and time to worsening of performance status. 相似文献
103.
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders 总被引:14,自引:1,他引:14
Benoit Viollet Marc Foretz Bruno Guigas Sandrine Horman Renaud Dentin Luc Bertrand Louis Hue Fabrizio Andreelli 《The Journal of physiology》2006,574(1):41-53
It is now becoming evident that the liver has an important role in the control of whole body metabolism of energy nutrients. In this review, we focus on recent findings showing that AMP-activated protein kinase (AMPK) plays a major role in the control of hepatic metabolism. AMPK integrates nutritional and hormonal signals to promote energy balance by switching on catabolic pathways and switching off ATP-consuming pathways, both by short-term effects on phosphorylation of regulatory proteins and by long-term effects on gene expression. Activation of AMPK in the liver leads to the stimulation of fatty acid oxidation and inhibition of lipogenesis, glucose production and protein synthesis. Medical interest in the AMPK system has recently increased with the demonstration that AMPK could mediate some of the effects of the fat cell-derived adiponectin and the antidiabetic drugs metformin and thiazolidinediones. These findings reinforce the idea that pharmacological activation of AMPK may provide, through signalling and metabolic and gene expression effects, a new strategy for the management of metabolic hepatic disorders linked to type 2 diabetes and obesity. 相似文献
104.
Annalisa Rubino Laura Mantelli Sandra Amerini Fabrizio Ledda 《Naunyn-Schmiedeberg's archives of pharmacology》1990,342(5):520-522
Summary Transmural stimulation of non-adrenergic, non-cholinergic sensory nerves in guinea-pig atria, isolated from reserpine-pretreated animals, in the presence of atropine and the beta-adrenoceptor-blocking drug CGP 20712A, induced a positive inotropic effect. Adenosine (0.1–10 M) concentration-dependently reduced the cardic response to transmural nerve stimulation, without modifying the response to exogenous calcitonin gene-related peptide; the inhibitory effect of adenosine was antagonized by 1 M 8-phenyltheophylline. Moreover, the cardiac response to field stimulation was enhanced by 8-phenyltheophylline (0.1, 1 M) and by adenosine deaminase (1 g/ml), but was reduced by dipyridamole (1 M). These findings indicate the presence of inhibitory adenosine receptors on cardiac sensory nerves and suggest a modulatory effect of endogenous adenosine on cardiac non-adrenergic, non-cholinergic neurotransmission.Send offprint requests to A. Rubino at the above address 相似文献
105.
Gian Marco Moneta Claudia Bracaglia Ivan Caiello Chiara Farroni Denise Pires Marafon Raffella Carlomagno Linda Hiraki Marina Vivarelli Alessandra Gianviti Simone Carbogno Walter Ferlin Cristina de Min Earl Silverman Rita Carsetti Fabrizio De Benedetti Emiliano Marasco 《European journal of immunology》2023,53(7):2250319
106.
Valentina Mazzotta Alessandro Cozzi Lepri Francesca Colavita Silvia Rosati Eleonora Lalle Claudia Cimaglia Jessica Paulicelli Ilaria Mastrorosa Serena Vita Lavinia Fabeni Alessandra Vergori Gaetano Maffongelli Fabrizio Carletti Simone Lanini Emanuela Caraffa Eugenia Milozzi Raffaella Libertone Pierluca Piselli Enrico Girardi AnnaRosa Garbuglia Francesco Vaia Fabrizio Maggi Emanuele Nicastri Andrea Antinori INMI COVID- Outpatient Treatment Study Group 《Journal of medical virology》2023,95(1):e28186
107.
Battista P Palmirotta R Vitullo P Veri M Colalongo C Rigoli L Fedele F Caruso R Inferrera C Romano F Marianicostantini R Frati L Cama A 《International journal of oncology》1997,10(1):65-70
Microsatellite replication errors (RERs), consisting in random tumour-associated allele contractions or expansions, represent a frequent genetic alteration in gastric cancer and appear to be associated with important clinicopathologic parameters. To verify the role of microsatellite instability in the initial phases of gastric carcinogenesis, we analysed the status of II microsatellites in paired microdissected samples of tumour and unaffected mucosa from 30 cases of early gastric carcinoma. Fifteen tumours (50%) demonstrated RERs: these included 7 cases with RERs at one locus and 8 cases with RERs at 2 or more loci. Cases with 2 or more RERs were more frequent among intramucosal tumours, compared to tumours with submucosal spread (43% vs. 12%) and among tumours staged T1NOMx, compared to tumours staged T1N1Mx (35% vs. 0%). RER-positive microsatellite typings were statistically more frequent among tumours with intramucosal extension, lower stage (T1NOMx) and excavated growth pattern (macroscopic type III), compared to tumours with submucosal extension, higher stage (T1N1Mx) and elevated, flat or depressed growth patterns (macroscopic types IIa-IIb-IIc respectively). The above findings indicate that microsatellite instability occurs early in the progression of sporadic gastric cancer and tends to be associated with good prognostic indicators. 相似文献
108.
109.
Crossed aphasia. An update 总被引:2,自引:0,他引:2
Luciano Mastronardi Luigi Ferrante Alberto Maleci Fabrizio Puzzilli Pierpaolo Lunardi Giuseppe Schettini 《Neurosurgical review》1994,17(4):299-304
The aim of this article is to present an update of a rare but interesting problem: crossed aphasia. This term indicates the presence of aphasia after unilateral cerebral lesion of the hemisphere ipsilateral to the patient's dominant hand. We report two cases, review the most relevant literature, and analyze clinical, neuroanatomical, and neurophysiological aspects, taking in consideration the various interpretations proposed to explain this unusual language disorder. 相似文献
110.