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141.
142.
R. Alan Aitkena Michael C. Bibby John A. Double Roger M. Phillips Shiv Kumar Sharma 《Archiv der Pharmazie》1996,329(11):489-497
A range of 17 derivatives of flavone-8-acetic acid (FAA) with a 6-methyl substituent have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro, this essentially disappears in vivo, possibly due to degradation before the compounds can reach the tumour site. 相似文献
143.
John F. Teare Roger W. Peterson Karen Authier Linda Schroeder Daniel L. Daly 《Child & youth care forum》1998,27(2):125-138
The purpose of this study was to examine the correlates of post-shelter maternal family satisfaction in a group of youth who
were reunified with their families following a shelter stay. Findings indicated that higher ratings of family satisfaction
were related to greater maternal problem solving skill and less family conflict. 相似文献
144.
Yu L. Liu Stephen J. Riederer Phillip J. Rossman Roger C. Grim Josef P. Debbins Richard L. Ehman 《Magnetic resonance in medicine》1993,30(4):507-511
A technique is described that provides improved reproducibility of breath-holding for MR image acquisition by monitoring the superior-inferior (S/I) position of the diaphragm. The method incorporates detection of the level of inspiration using an MR signal, rapid display to the patient of diaphragm position to enable breath-hold adjustment, and triggering of image data acquisition once appropriate position is attained. The response time of the system is short, approximately 10 ms. Studies in six volunteers using this method demonstrate a considerable decrease in the S/I range of diaphragm position over 10 consecutive periods of suspended respiration. The mean range is 1.3 mm with the system, while it is 8.3 mm without using it is expected that this method will be of assistance in many abdominal and cardiothoracic studies that use breath-hold techniques. 相似文献
145.
146.
Fine Structural Alterations of Bovine Peripheral Pulmonary Arteries in Hypoxia-Induced Hypertension 下载免费PDF全文
Cellular alterations of the distal bovine pulmonary arteries in hypoxia-induced pulmonary hypertension were studied. These lesions were related to pulmonary hemodynamic changes and contrasted to the cellular response observed in hyperkinetic pulmonary and systemic hypertension as well as other forms of vascular injury. Medial thickening and mild adventitial proliferation with an absence of intimal proliferative lesions related to a progressive increase in mean pulmonary arterial pressure and pulmonary vascular resistance were observed. Smooth muscle and endothelial cells exhibited distinct degenerative alterations in response to the maintained hypertensive state resulting from the lowered alveolar oxygen tension. 相似文献
147.
148.
Summary Cell cultures (GTS) of epithelioid nature derived from the skin of a green sea turtle,Chelonia mydas, were treated with colchicine at a final concentration of 0.5 g/ml for 16 h. Mitotic cells were harvested by brief treatment with trypsin-Versene, subjected to hypotonic solution (1% sodium citrate) and fixed in (13) acetic acid: methanol. Giemsa stained preparations were photographed on High Contrast Copy film under phase contrast optics using a bluegreen filter. The result was significant enhancement of the microchromosome portion of the complement morphologically characteristic of reptilian metaphase chromosomes. By this method it was determined that the GTS cell line retains the female diploid number of the Chelonia species. 相似文献
149.
Karoly Jakab Brook Damon Françoise Marga Octavian Doaga Vladimir Mironov Ioan Kosztin Roger Markwald Gabor Forgacs 《Developmental dynamics》2008,237(9):2438-2449
The Differential Adhesion Hypothesis (DAH) posits that differences in adhesion provide the driving force for morphogenetic processes. A manifestation of differential adhesion is tissue liquidity and a measure for it is tissue surface tension. In terms of this property, DAH correctly predicts global developmental tissue patterns. However, it provides little information on how these patterns arise from the movement and shape changes of cells. We provide strong qualitative and quantitative support for tissue liquidity both in true developmental context and in vitro assays. We follow the movement and characteristic shape changes of individual cells in the course of specific tissue rearrangements leading to liquid-like configurations. Finally, we relate the measurable tissue-liquid properties to molecular entities, whose direct determination under realistic three-dimensional culture conditions is not possible. Our findings confirm the usefulness of tissue liquidity and provide the scientific underpinning for a novel tissue engineering technology. Developmental Dynamics 237:2438-2449, 2008. (c) 2008 Wiley-Liss, Inc. 相似文献
150.
The specific impedance of cardiac tissue cannot be measured directly. Instead, the investigator obtains voltage and current
measurements and places them into a model of the tissue's structure to infer the impedances of elements of the model. If the
model fails to describe major aspects of the real tissue, the results may be worthless, although possibly self-consistent.
In the literature of impedance measurement in cardiac tissue, only rarely is the model explicitly described; more commonly,
the tissue model is adopted implicitly when equations giving the impedance in terms of voltage and current measurements are
adopted. This paper examines the series of models that have been used in specific impedance measurements of cardiac tissue
and shows how the same or similar measurements can accurately describe tissue impedivity or can lead to significant errors
when inadequate models such as isotropic and anisotropic monodomains (although a part of work of historical merit) are used. 相似文献