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Samia Salah Hala Salah Talaat Noussa Ragab El Basha Huda Marzouk Samah Abd Elhamid Eman Shafik Shafie 《The Egyptian Rheumatologist》2018,40(2):107-110
Aim of the work
To compare the D-dimer status in children with familial Mediterranean fever (FMF) during, and in between acute attacks.Patients and methods
The study included 50 children with FMF classified into group I (15 patients during acute attack) and group II (35 patients during attack free period) as well as and 20 matched controls. D-dimer was determined in all study population. Pattern and type of FMF gene mutation were reported from patients’ files.Results
The mean age of the patients was 8.7 ± 2.8 years, disease duration 4.4 ± 2.5 years and they were 28 males:22 females (1.3:1). In group I, the erythrocyte sedimentation rate (48.5 ± 28.6 mm/1st h) and aspartate transaminase (28.5 ± 5 U/L) were significantly increased compared to group II (26.6 ± 14.7 mm/1st h and 25.7 ± 2.7 U/L; p = 0.012 and p = 0.014 respectively). Positive D-dimer was significantly reported in 72% of FMF patients compared with 35% of control (p = 0.006). There was significant difference between frequency of positive D-dimer in group I (86.7%) and group II (65.7%) compared to (35%) in control (p = 0.005 and p = 0.048, respectively), without a significant difference in D-dimer frequency between group I and group II patients (p = 0.18). Fever and abdominal pain were significantly more frequent in patients with positive (100% and 97.2%) compared to negative D-dimer (78.6% and 71.4%) (p = 0.02). No significant association was found between positive D-dimer and specific types of MEFV gene mutation.Conclusion
D-dimer was significantly positive in FMF patients compared to control. These results raise the possibility of thrombosis in FMF patients regardless the presence or absence of acute attack. 相似文献105.
Riyaz U. Saif Hilal Ahmad Dar Sozia Mohammad Sofi Mushtaq Saif Andrabi Gul Javid Showkat Ali Zargar 《Indian journal of gastroenterology》2018,37(5):424-429
Background
Hepatorenal syndrome (HRS) occurs in decompensated liver disease and carries high mortality. Vasoconstrictors are the drug of choice. Terlipressin is widely used and is expensive. In this study, we compared noradrenaline and terlipressin in the management of type 1 HRS.Methods
Sixty consecutive patients with type 1 HRS were managed with noradrenaline (Group A, n?=?30) or terlipressin (Group B, n?=?30) with albumin in a randomized controlled trial at a tertiary center.Results
Reversal of type 1 HRS was achieved in 16 (53%) patients in group A and 17 (57%) in group B. There was statistically insignificant difference between the two groups in decreasing serum creatinine and increasing urine output (p?>?0.05). On univariate analysis, Child-Turcotte-Pugh (CTP) score, serum sodium, serum urea, serum albumin, prothrombin time, International normalized ratio (INR), serum alanine aminotransferase (ALT), ascitic fluid protein, and history of bleeding were associated with response to treatment (noradrenaline/terlipressin). However, on multivariate analysis, only baseline CTP score, serum urea, serum albumin, and prothrombin time were independent predictors of response. All patients who responded were discharged alive with no mortality within 30 days.Conclusions
There is no difference in outcome of patients with type 1 HRS treated with noradrenaline or terlipressin. Thus, noradrenaline, which is cheaper, can be used instead of terlipressin (Clinical Trials Registry-India [CTRI] No. CTRI/2011/09/002032).106.
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A. L.-Hassan Nasser Hamada EL-Naggar Haitham El-Bery Islam Basha Ahmed Abdelmoneim 《RSC advances》2019,9(19):10937
Correction for ‘Utilizing FBR to produce olefins from CO reduction using Fe–Mn nanoparticles on reduced graphene oxide catalysts and comparing the performance with SBR’ by AL-Hassan Nasser et al., RSC Adv., 2018, 8, 42415–42423.The authors regret that the original author list was incorrect. The correct author list is as shown above.The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers. 相似文献
108.
Sébastien Roujol Tamer A. Basha Sebastian Weing?rtner Mehmet Ak?akaya Sophie Berg Warren J. Manning Reza Nezafat 《Journal of cardiovascular magnetic resonance》2015,17(1)
Background
To evaluate and quantify the impact of a novel image-based motion correction technique in myocardial T2 mapping in terms of measurement reproducibility and spatial variability.Methods
Twelve healthy adult subjects were imaged using breath-hold (BH), free breathing (FB), and free breathing with respiratory navigator gating (FB + NAV) myocardial T2 mapping sequences. Fifty patients referred for clinical CMR were imaged using the FB + NAV sequence. All sequences used a T2 prepared (T2prep) steady-state free precession acquisition. In-plane myocardial motion was corrected using an adaptive registration of varying contrast-weighted images for improved tissue characterization (ARCTIC). DICE similarity coefficient (DSC) and myocardial boundary errors (MBE) were measured to quantify the motion estimation accuracy in healthy subjects. T2 mapping reproducibility and spatial variability were evaluated in healthy subjects using 5 repetitions of the FB + NAV sequence with either 4 or 20 T2prep echo times (TE). Subjective T2 map quality was assessed in patients by an experienced reader using a 4-point scale (1-non diagnostic, 4-excellent).Results
ARCTIC led to increased DSC in BH data (0.85 ± 0.08 vs. 0.90 ± 0.02, p = 0.007), FB data (0.78 ± 0.13 vs. 0.90 ± 0.21, p < 0.001), and FB + NAV data (0.86 ± 0.05 vs. 0.90 ± 0.02, p = 0.002), and reduced MBE in BH data (0.90 ± 0.40 vs. 0.64 ± 0.19 mm, p = 0.005), FB data (1.21 ± 0.65 vs. 0.63 ± 0.10 mm, p < 0.001), and FB + NAV data (0.81 ± 0.21 vs. 0.63 ± 0.08 mm, p < 0.001). Improved reproducibility (4TE: 5.3 ± 2.5 ms vs. 4.0 ± 1.5 ms, p = 0.016; 20TE: 3.9 ± 2.3 ms vs. 2.2 ± 0.5 ms, p = 0.002), reduced spatial variability (4TE: 12.8 ± 3.5 ms vs. 10.3 ± 2.5 ms, p < 0.001; 20TE: 9.7 ± 3.5 ms vs. 7.5 ± 1.4 ms) and improved subjective score of T2 map quality (3.43 ± 0.79 vs. 3.69 ± 0.55, p < 0.001) were obtained using ARCTIC.Conclusions
The ARCTIC technique substantially reduces spatial mis-alignment among T2-weighted images and improves the reproducibility and spatial variability of in-vivo T2 mapping. 相似文献109.
Poor memory B cell generation contributes to non-protective responses to DTaP vaccine antigens in otitis-prone children
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We recently identified a cohort of children with recurrent episodes of acute otitis media (AOM) who fail to generate protective antibody titres to otopathogens and several vaccine antigens. In this study we determined the antibody levels against DTaP vaccine antigens, diphtheria toxoid (DT), tetanus toxoid (TT) and acellular pertussis toxoid (PT) in sera from 15 stringently defined otitis-prone (sOP) children and 20 non-otitis-prone (NOP) children. We found significantly lower concentrations of immunoglobulin (Ig)G antibodies against vaccine antigens in the serum of sOP children compared to age-matched NOP children. To elucidate immunological cellular responses to the vaccines in these children, we investigated memory B cell responses to DTaP vaccination. We used fluorescently conjugated vaccine antigens to label antigen receptors on the surface of memory B cells and examined the frequency of antigen-specific CD19+ CD27+ memory B cells in the peripheral blood. sOP children showed a significantly lower percentage of antigen-specific CD19+ CD27+ memory B cells than NOP children. We also found a linear correlation between the frequencies of memory B cells and circulating IgG titres for DT, TT and PT proteins. To our knowledge, this is the first study to show significant differences in memory B cell responses to DTaP vaccine antigens and their correlation with the circulating antibodies in young children with recurrent AOM. 相似文献
110.
Max Liebo Joshua Newman Anjali Joshi Brian D Lowes Yael Peled-Potashnik Haseeb Ilias Basha Ronald Zolty John Y. Um Edwin McGee Alain Heroux Eugenia Raichlin 《Journal of cardiac failure》2019,25(4):249-256