全文获取类型
收费全文 | 5324篇 |
免费 | 438篇 |
国内免费 | 34篇 |
专业分类
耳鼻咽喉 | 57篇 |
儿科学 | 155篇 |
妇产科学 | 86篇 |
基础医学 | 752篇 |
口腔科学 | 164篇 |
临床医学 | 704篇 |
内科学 | 1003篇 |
皮肤病学 | 34篇 |
神经病学 | 382篇 |
特种医学 | 245篇 |
外科学 | 610篇 |
综合类 | 134篇 |
一般理论 | 3篇 |
预防医学 | 586篇 |
眼科学 | 104篇 |
药学 | 568篇 |
中国医学 | 4篇 |
肿瘤学 | 205篇 |
出版年
2022年 | 58篇 |
2021年 | 89篇 |
2020年 | 67篇 |
2019年 | 84篇 |
2018年 | 91篇 |
2017年 | 71篇 |
2016年 | 74篇 |
2015年 | 92篇 |
2014年 | 119篇 |
2013年 | 205篇 |
2012年 | 249篇 |
2011年 | 246篇 |
2010年 | 150篇 |
2009年 | 134篇 |
2008年 | 208篇 |
2007年 | 279篇 |
2006年 | 218篇 |
2005年 | 229篇 |
2004年 | 210篇 |
2003年 | 207篇 |
2002年 | 213篇 |
2001年 | 205篇 |
2000年 | 213篇 |
1999年 | 155篇 |
1998年 | 84篇 |
1997年 | 69篇 |
1996年 | 85篇 |
1995年 | 57篇 |
1994年 | 59篇 |
1993年 | 46篇 |
1992年 | 122篇 |
1991年 | 123篇 |
1990年 | 114篇 |
1989年 | 111篇 |
1988年 | 115篇 |
1987年 | 103篇 |
1986年 | 81篇 |
1985年 | 71篇 |
1984年 | 44篇 |
1983年 | 41篇 |
1982年 | 30篇 |
1981年 | 42篇 |
1980年 | 33篇 |
1979年 | 46篇 |
1978年 | 37篇 |
1977年 | 48篇 |
1976年 | 38篇 |
1973年 | 36篇 |
1972年 | 39篇 |
1968年 | 26篇 |
排序方式: 共有5796条查询结果,搜索用时 15 毫秒
21.
Antimicrobial resistance in Branhamella catarrhalis 总被引:1,自引:0,他引:1
T V Riley 《The Journal of antimicrobial chemotherapy》1988,21(2):147-150
22.
Role of plasminogen-activator inhibitor type 1 in the pathogenesis and outcome of the hemolytic uremic syndrome. 总被引:5,自引:0,他引:5
BACKGROUND. Deposition of fibrin in glomeruli and renal failure are characteristic features of the hemolytic uremic syndrome. An inhibitor of glomerular fibrinolysis has been detected in plasma from children with this disorder. In this study, we define the inhibitor and show that its plasma level is correlated with the outcome of the disease. METHODS AND RESULTS. Plasminogen-activator inhibitor type 1 (PAI-1) in plasma was measured with an assay employing a specific monoclonal antibody in 40 consecutive children hospitalized with the hemolytic uremic syndrome: 12 who recovered adequate renal function (serum creatinine, less than or equal to 2.0 mg per deciliter [177 mumol per liter]) without dialysis, 23 who recovered adequate renal function after peritoneal dialysis, and 5 who did not recover adequate renal function after undergoing dialysis. At presentation, plasma PAI-1 levels were higher in the patients with the hemolytic uremic syndrome than in nine children with other forms of acute renal failure. That the inhibitor was PAI-1 was indicated by the fact that it was a potent inhibitor of tissue plasminogen activator, was acid-resistant, and was not inhibited by denaturation (all unique traits of PAI-1) and that it was neutralized by an antibody specific for PAI-1. Multivariate discriminant-function analysis revealed that the duration of elevated PAI-1 activity was strongly correlated with the outcome of the disease (P less than 0.001). Peritoneal dialysis reduced plasma PAI-1 levels dramatically. CONCLUSIONS. Our studies suggest that PAI-1 is the circulating inhibitor of fibrinolysis in the hemolytic uremic syndrome. Normalization of plasma PAI-1 levels (e.g., by peritoneal dialysis) is correlated with improvement in renal function. However, the possibility that increased plasma levels of PAI-1 are either causes or effects of the hemolytic uremic syndrome is not unequivocally established by these studies. 相似文献
23.
H Corriveau F Guarna E Dutil E Riley A B Arsenault G Drouin 《Scandinavian journal of rehabilitation medicine》1988,20(1):5-11
A protocol of evaluation of the hemiplegic patient based on the Bobath approach to treatment is presented. Six parameters are evaluated: sensorium, muscle tone, reflex activity, active movement, postural reactions and pain. The first and last of these are included because of their possible effects on the motor recovery process of the hemiplegic patient. The other four are directly borrowed from the Bobath modality of treatment. For each of these parameters, the procedures are given for its evaluation along with its respective rating scales. These scales are of an ordinal nature ranging from 0 to 3. It is suggested that this new evaluation protocol is fully compatible with the therapeutic modality developed by Bobath and as well is adequate to quantify patient progress in the principle aspects treated by this well used rehabilitation approach. 相似文献
24.
Anderson RA; Evans LW; Irvine DS; McIntyre MA; Groome NP; Riley SC 《Human reproduction (Oxford, England)》1998,13(12):3319-3325
Follistatin is a binding protein for the activin and inhibin family of
hormones, regulating their biological activity. In the male reproductive
tract, the interaction of these factors is likely to be involved in the
regulation of the proliferation of several cell types. We have investigated
the presence of follistatin and activin A in seminal plasma using specific
immunoassays and have localized follistatin and activin/inhibin subunits in
the adult human testis, prostate and seminal vesicle to establish their
likely sources. High concentrations of immunoreactive follistatin were
present in seminal plasma in normal men (mean 97.9 ng/ml; 1.43 ng/ml in
peripheral plasma) and were similar in men with oligo/azoospermia and
following vasectomy. Follistatin immunoreactivity was localized to both
Leydig and Sertoli cells of the testis, and to epithelial cells of the
prostate gland and seminal vesicle, which are likely to be the predominant
sources of the hormone in seminal plasma. Activin A was also present in
seminal plasma in normal men but was undetectable following vasectomy, thus
deriving from the testis. Consistent with this finding, the betaA-subunit
was immunolocalized in Sertoli and Leydig cells but was not present in
seminal vesicle or prostate gland. The functional significance of the high
concentrations of follistatin secreted into seminal plasma by the prostate
gland and/or seminal vesicle is uncertain, but they may regulate the
biological activity of testis-derived activin A and inhibin B.
相似文献
25.
Gerard A. Riley 《Journal of developmental and physical disabilities》1998,10(2):153-165
The use of stimulus modifications in teaching involves altering the materials of a task in order to simplify its execution. Though their use in teaching stimulus discriminations to people with developmental disabilities has been extensively investigated, less attention has been given to their utilization in teaching response topography. This paper offers some general guidelines about their use for this purpose. In relation to their design, it is suggested that the aim should be to reduce the demands made by task components, to eliminate components, and/or to increase the attentional value of the discriminating features of the response topography. In relation to their application, guidelines are suggested about when they should be employed in conjunction with response prompts; when they should be used, either alone or in conjunction with response prompts, in preference to response prompts alone; whether one or a series of modifications is required; and at what point during teaching should probe trials on the unmodified task be introduced. 相似文献
26.
27.
Measurement of dissociation 总被引:1,自引:0,他引:1
K C Riley 《The Journal of nervous and mental disease》1988,176(7):449-450
Dissociation, a failure to integrate thoughts, feelings, and actions into consciousness, has been hypothesized to be the mechanism by which classical "hysterical" phenomena (e.g., trance states, conversion symptoms, multiple personality) are produced. With the exception of a recent article by Bernstein and Putnam (J Nerv Ment Dis 174:727-735, 1986), no standardized techniques are available to study or quantify this construct. A scale, the Questionnaire of Experiences of Dissociation, has been developed and extensively tested in the general population. The QED demonstrates good reliability and validity and is offered as an alternate assessment technique for the study of dissociation. 相似文献
28.
Controversy surrounding the term "globus hystericus" points up the historical dichotomy between organic disease and conversion disorder that has hampered the understanding of this syndrome. Regardless of its sometimes incapacitating nature, there is little information in the literature regarding the treatment of globus when an organic cause cannot be established. Regarding the syndrome as psychosomatic in nature, rather than merely hysterical, we suggest the need for an integrated treatment approach. A case study is utilized to illustrate a model for psychiatric management of the globus syndrome. In this model, pharmacologic and psychotherapeutic interventions are integrated into a comprehensive, biopsychosocial treatment plan. Each aspect of the model is reviewed and discussed. 相似文献
29.
Dr. Peter J. Silk Christopher M. Riley Charles J. Wiesner 《Archives of environmental contamination and toxicology》1988,17(5):631-636
A method is described for the colorimetric determination of fenitrothion spray deposit on conifer foliage. The technique is suitable for rapid deposit determination in the field using a portable mini-spectrophotometer. The detection limit is approximately 0.5 g fenitrothion/g foliage, although this could be improved. The technique is used in conjunction with gas chromatography to examine the evaporation and absorption dynamics of fenitrothion deposits on balsam fir foliage. 相似文献
30.
Chiara Riley Jack P. London John A. Burmeister 《Journal of oral pathology & medicine》1992,21(3):124-127
Two hundred HIV-positive subjects were surveyed to determine their periodontal health status. Particular attention was given to the occurrence of a severe and rapidly progressing form of periodontal disease designated "HIV-associated periodontitis", which has been reported as being unique to AIDS patients. Among the subjects comprising the cohort, 85 subjects had good gingival health, 59 subjects exhibited gingivitis, 49 cases of adult periodontitis were observed, 5 subjects presented with advance adult periodontitis, and 2 cases of necrotizing ulcerative periodontitis (NUP) were found within the group. The periodontitis of the patients in this survey did not have unique or pathognomonic characteristics which could set their periodontal disease apart from the periodontal disease seen in HIV negative population. 相似文献