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Laura Evangelista Anna Rita Cervino Riccardo Sanco Michele Bignotto Tania Saibene Silvia Michieletto Cristina Ghiotto Fernando Bozza Marta Paiusco Giorgio Saladini 《Breast cancer research and treatment》2014,146(2):331-340
The aim of the present study was to assess the feasibility of a portable gamma camera (PGC) for guiding surgical treatment in locally advanced breast cancer (LABC) after neoadjuvant therapy (NT). Since January 2012, a PGC (Sentinella 102, ONCOVISION) has been available in our center. We planned to perform a feasibility monocentric prospective study involving 15–20 patients with LABC for assessing the diagnostic performance of this PGC after NT (Breast Cancer Surgery-S102). Before the surgical treatment and at the end of NT an injection of 99mTc-Sestamibi (100–150 MBq) was made. Conventional scintimmamography (SMM) and Sentinella 102 images were obtained from 18 patients. 10 (55.5 %) patients showed a focal uptake of tracer in the breast or lymph nodes before or after the surgical excision (on histological specimen), while 8 did not. The histological specimen concluded for a complete response to NT in 4 (22.2 %) patients and for a partial or no response to treatment in the remnant 14 subjects. The specificity and false-negative rate of the Sentinella 102 compared to SMM were 100 % for both and 38 % vs. 60 %, respectively. The global diagnostic accuracy of Sentinella 102 was: 66.7 % (95 % confidence interval: 44.88–88.44 %). The present feasibility study shows how a new nuclear imaging device can be useful in the operating theatre for guiding a radical surgery approach in patients with LABC after NT. 相似文献
93.
Laura Amodeo Lorys Castelli Paolo Leombruni Daniela Cipriani Alessia Biancofiore Riccardo Torta 《Supportive care in cancer》2012,20(2):375-384
Objectives
This study aimed to compare the tolerability and efficacy of two different titrations of paroxetine (slow and standard) in a population of cancer patients with depression. 相似文献94.
Riccardo V. D'Elia Kate Harrison Petra C. Oyston Roman A. Lukaszewski Graeme C. Clark 《Clinical and Vaccine Immunology : CVI》2013,20(3):319-327
Inflammation is the body''s first line of defense against infection or injury, responding to challenges by activating innate and adaptive responses. Microbes have evolved a diverse range of strategies to avoid triggering inflammatory responses. However, some pathogens, such as the influenza virus and the Gram-negative bacterium Francisella tularensis, do trigger life-threatening “cytokine storms” in the host which can result in significant pathology and ultimately death. For these diseases, it has been proposed that downregulating inflammatory immune responses may improve outcome. We review some of the current candidates for treatment of cytokine storms which may prove useful in the clinic in the future and compare them to more traditional therapeutic candidates that target the pathogen rather than the host response. 相似文献
95.
Gabriele Riccardi Olga Vaccaro Giuseppina Costabile Angela A. Rivellese 《Current cardiology reports》2016,18(7):66
The role for lifestyle modifications to correct dyslipidemia(s) is reviewed. Dietary composition is crucial. Replacing saturated fat with MUFA or n-6 PUFA lowers plasma low-density lipoproteins (LDL) cholesterol and ameliorates the LDL/HDL ratio. Replacing saturated fat with carbohydrates has diverging effects due to the heterogeneity of carbohydrate foods. Diets rich in refined carbohydrates increase fasting and postprandial triglycerides, whereas the consumption of fiber-rich, low GI foods lowers LDL cholesterol with no detrimental effects on triglycerides. The role of polyphenols is debated: available evidence suggests a lowering effect of polyphenol-rich foods on postprandial triglycerides. As for functional foods, health claims on a cholesterol lowering effect of psyllium, beta-glucans and phytosterols are accepted by regulatory agencies. The importance of alcohol intake, weight reduction, and physical activity is discussed. In conclusion, there is evidence that lifestyle affects plasma lipid. A multifactorial approach including multiple changes with additive effects is the best option. This may also ensure feasibility and durability. The traditional Mediterranean way of life can represent a useful model. 相似文献
96.
Francesco Scolari Elisa Delbarba Domenico Santoro Loreto Gesualdo Antonello Pani Nadia Dallera Laila-Yasmin Mani Marisa Santostefano Sandro Feriozzi Marco Quaglia Giuliano Boscutti Angelo Ferrantelli Carmelita Marcantoni Patrizia Passerini Riccardo Magistroni Federico Alberici Gian Marco Ghiggeri Claudio Ponticelli Pietro Ravani for the RI-CYCLO Investigators 《Journal of the American Society of Nephrology : JASN》2021,32(4):972
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S. Roperto V. Russo L. Leonardi M. Martano F. Corrado M. G. Riccardi F. Roperto 《Transboundary and Emerging Diseases》2016,63(6):628-634
Bovine papillomavirus type 13 (BPV‐13), a novel Deltapapillomavirus, has been found associated with urothelial tumours of the urinary bladder of cattle grazing on lands infested with bracken fern. BPV‐13 was detected in 28 of 39 urothelial tumours. Diagnosis was based on sequencing of L1 and E5 amplicons from tumour samples. The nucleotide sequences generated from these amplicons showed a 100% homology with the sequences of BPV‐13 L1 and E5 DNA found in Brazil from a fibropapilloma of the ear in a cow and from equine sarcoids in two horses. GenBank accession number of our representative BPV‐13 sequences is JQ798171.1 . Furthermore, mRNA encoding BPV‐13 E5 oncoprotein was also documented, and its expression was also shown by immunohistochemistry and immunofluorescence in the basal and suprabasal urothelial tumour cells. In twenty‐three tumours, BPV‐13 was simultaneously found with BPV‐2, a Deltapapillomavirus genus, species 4. The latter virus was detected by amplifying and sequencing a 154‐bp‐sized DNA fragment of BPV‐2 E5. In addition, BPV‐13 by itself was seen to be expressed in five BPV‐2‐negative urothelial tumours. This study shows that BPV‐13 is present in urothelial tumour cells thus sharing biological properties with BPV‐1 and BPV‐2. Although further studies are needed, BPV‐13 appears to be another worldwide infectious agent responsible for a distressing disease causing severe economic losses in cattle industry. 相似文献
100.
Red grape (Vitis vinifera L.) flavonoids down‐regulate collagen type III expression after UV‐A in primary human dermal blood endothelial cells
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Serena Di Francesco Monica Savio Nora Bloise Giovanni Borroni Lucia Anna Stivala Riccardo G. Borroni 《Experimental dermatology》2018,27(9):973-980
Red grape (Vitis vinifera L.) flavonoids including flavan‐3‐ols (eg, catechin and epicatechin), flavonols (eg, quercetin) and anthocyanins (eg, malvidin) exert anti‐inflammatory and antioxidant activities. In the skin they also have a photoprotective action, and their effects have been extensively investigated in keratinocytes, melanocytes and fibroblasts. Despite their known effects also on blood vasculature, little is known on their activities on human dermal blood endothelial cells (HDBECs), which are critically involved in skin homeostasis as well as in the pathogenesis of neoplastic and inflammatory skin diseases. We sought to study the biological effects of selected red grape flavonoids in preventing the consequences of ultraviolet (UV)‐A irradiation in vitro. Our results show that red grape flavonoids prevent UV‐A‐induced sICAM‐1 release in HDBECs, suggesting that this cell type could represent an additional target of the anti‐inflammatory activity of flavonoids. In addition, flavonoids effectively inhibited UV‐A‐induced synthesis of collagen type III at both RNA and protein level, indicating that dermal blood microvasculature could be actively involved in ECM remodelling as a consequence of skin photo‐ageing, and that this can be prevented by red grape flavonoids. 相似文献