A ZnO@ABS/TPU/CaSiO3 3D skeleton and its adsorption/photocatalysis properties for dye contaminant removal

Both adsorption and photocatalysis are considered to be effective methods for removing organic contaminants from dye wastewater. In this study, the construction of 3D skeletons based on the nanoparticles ZnO and ABS/TPU/calcium silicate (CaSiO₃) (shortened as ATC) were fabricated via fused deposition molding (FDM) technology. Characterization by scanning electron microscopy (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) depicted that ZnO nanospheres had been successfully grown on the 3D skeleton surface with an enlarged specific surface area. As the results of the RhB adsorption and photocatalytic degradation experiments showed, the removal ratio of RhB onto the ZnO-ATC skeleton was as high as 97.94% and the synergistic effect of adsorption and photocatalysis greatly shortened the RhB degradation time under ultraviolet light irradiation. The nanocomposites synthesized in this study showed a significant removal ability for organic pollutants, and could effectively overcome the limitation of the secondary removal of photocatalysts.

Enhanced synergistic effect of photocatalytic and adsorption was realized through the system constructed of ZnO nanoparticle loaded 3D skeleton.     

Thiolated poly(aspartic acid)-functionalized two-dimensional MoS2, chitosan and bismuth film as a sensor platform for cadmium ion detection

In this work, a sensitive electrochemical platform for determination of cadmium ions (Cd²⁺) is obtained using thiolated poly(aspartic acid) (TPA)-functionalized MoS₂ as a sensor platform by differential pulse anodic stripping voltammetry (DPASV). The performance of the TPA–MoS₂-modified sensor is systemically studied. It demonstrates that the TPA–MoS₂ nanocomposite modified sensor exhibits superior analytical performance for Cd²⁺ over a linear range from 0.5 μg L⁻¹ to 50 μg L⁻¹, with a detection limit of 0.17 μg L⁻¹. Chitosan is able to form a continuous coating film on the surface of the GC electrode. The good sensing performance of the TPA–MoS₂-modified sensor may be attributed to the following factors: the large surface area of MoS₂ (603 m² g⁻¹), and the abundant thiol groups of TPA. Thus, the TPA–MoS₂-modified sensor proves to be a reliable and environmentally friendly tool for the effective monitoring of Cd²⁺ existing in aquacultural environments.

In this work, a sensitive electrochemical platform for determination of cadmium ions (Cd²⁺) is obtained using thiolated poly(aspartic acid) (TPA)-functionalized MoS₂ as a sensor platform by differential pulse anodic stripping voltammetry (DPASV).     

Synthesis of stable-isotope-labeled N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide and N-(3-dimethylaminopropyl)-N′-ethylurea

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide (EDC) is a carbodiimide coupling reagent commonly used for the preparation of amides from carboxylic acids and amines. Because of initial concerns regarding the genotoxicity of EDC and its use in GMP syntheses at Bristol Myers Squibb, the quantitation of residual EDC and its by-product N-(3-dimethylaminopropyl)-N′-ethylurea (EDU) by liquid chromatography–mass spectrometry (LCMS) impurity analysis was required. These analyses required the use of stable-isotope-labeled EDC and EDU to serve as internal standards. To meet this need, stable-isotope-labeled EDC 9 and EDU 10 were prepared from [1,2-¹³C₂] ethylene glycol and [¹³C,¹⁵N] potassium cyanide in overall yields of 6% and 8%, respectively.     

不同剂量右美托咪定对老年糖尿病足截趾患者全身麻醉苏醒期的影响

目的对比分析不同剂量右美托咪定对老年糖尿病足截趾患者全身麻醉苏醒期的影响。方法选取2017年4月至2018年8月北京市丰台区南苑医院收治的102例拟行截趾术治疗的老年糖尿病足患者作为研究对象,并按照随机数表法将其随机分为低剂量组(51例)和高剂量组(51例),其中低剂量组患者于全身麻醉时静脉缓慢泵注0. 4μg/kg的盐酸右美托咪定注射液,高剂量组患者于全身麻醉时静脉缓慢泵注0. 8μg/kg的盐酸右美托咪定注射液,对比观察两组患者诱导麻醉前、拔管时、拔管后5 min、拔管后10 min的平均动脉压(MAP)、心率(HR)、血氧饱和度(SpO_2),以及苏醒时间及拔管时间。结果诱导麻醉前、拔管时、拔管后5 min、拔管后10 min,两组患者MAP、HR及SpO_2对比,P均0.05,差异无统计学意义;低剂量组患者的苏醒时间为(14. 02±5. 87) min、拔管时间为(16. 55±5. 26) min,明显低于高剂量组患者的苏醒时间(18. 16±6.29) min、拔管时间(22. 73±6.84) min,两组对比,P均0.05,差异具有统计学意义。结论老年糖尿病足患者在截趾术中应用低剂量右美托咪定辅助麻醉,可有效缩短患者苏醒时间及拔管时间,维持患者苏醒期的血流动力学稳定性,安全性较高,具有临床推广价值。