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排序方式: 共有632条查询结果,搜索用时 281 毫秒
51.
52.
Jonathan Ophir S. Kaisar Alam Brian S. Garra Faouzi Kallel Elisa E. Konofagou Thomas Krouskop Christopher R. B. Merritt Raffaella Righetti Remi Souchon Seshadri Srinivasan Tomy Varghese 《Journal of Medical Ultrasonics》2002,29(4):155-171
Elastography is a method that can ultimately generate several new kinds of images, called elastograms. As such, all the properties
of elastograms are different from the familiar properties of sonograms. While sonograms convey information related to the
local acoustic backscatter energy from tissue components, elastograms relate to its local strains, Young's moduli or Poisson's
ratios. In general, these elasticity parameters are not directly correlated with sonographic parameters, i.e. elastography
conveys new information about internal tissue structure and behavior under load that is not otherwise obtainable. In this
paper we summarize our work in the field of elastography over the past decade. We present some relevant background material
from the field of biomechanics. We then discuss the basic principles and limitations that are involved in the production of
elastograms of biological tissues. Results from biological tissues in vitro and in vivo are shown to demonstrate this point.
We conclude with some observations regarding the potential of elastography for medical diagnosis. 相似文献
53.
Abolhassani Hassan Landegren Nils Bastard Paul Materna Marie Modaresi Mohammadreza Du Likun Aranda-Guillén Maribel Sardh Fabian Zuo Fanglei Zhang Peng Marcotte Harold Marr Nico Khan Taushif Ata Manar Al-Ali Fatima Pescarmona Remi Belot Alexandre Béziat Vivien Zhang Qian Casanova Jean-Laurent Kämpe Olle Zhang Shen-Ying Hammarström Lennart Pan-Hammarström Qiang 《Journal of clinical immunology》2022,42(3):471-483
Journal of Clinical Immunology - Inborn errors of immunity (IEI) and autoantibodies to type I interferons (IFNs) underlie critical COVID-19 pneumonia in at least 15% of the patients, while the... 相似文献
54.
[Purpose] To investigate the effect of performing a draw-in maneuver (DI) on knee adduction moment (KAM) and hip and trunk muscle activities while walking. [Participants and Methods] We included 30 healthy young adults (21.5 ± 0.6 years, 16 males and 14 females) in this study. We measured the KAM and lever arm while participants walked with either a normal gait or a DI gait. We also performed surface electromyography (EMG) of the hip and trunk muscles (i.e., internal oblique abdominal muscle [IO], external oblique abdominal muscle [EO], multifidus muscle [MF], and gluteus medius muscle [GM]). [Results] The 1st peak of the KAM was significantly lower when walking with a DI gait compared to when walking with a normal gait. The integrated EMG activity of the IO, EO, and GM during the 1st half of the stance phase, and of the IO and EO during the 2nd half of the stance phase was significantly higher during the DI than during normal gait. [Conclusion] Compared with a normal gait, a DI gait leads to a decrease in the 1st peak of the KAM as a result of the shorter lever arm, and an increase in the muscular activity of the GM, IO, and EO.Key words: Draw-in maneuver, Knee adduction moment, Hip abduction muscle activity 相似文献
55.
Rossato LG Costa VM de Pinho PG Carvalho F de Lourdes Bastos M Remião F 《Archives of toxicology》2011,85(8):929-939
Synephrine is a natural compound, frequently added to ephedra-free dietary supplements for weight-loss, due to its effects
as a nonspecific adrenergic agonist. Though only p-synephrine has been documented in plants, the presence of m-synephrine has also been reported in weight-loss products. The use of synephrine in dietary supplements was accompanied by
reports of adverse effects, especially at the cardiovascular level. It is well known that the imbalance in cardiac glutathione
levels can increase the risk of cardiomyopathy. The present work aimed to study the role of organic cation-mediated transport
of m- and p-synephrine and the possibility that p- and m-synephrine induce intracellular changes in glutathione levels in calcium-tolerant freshly isolated cardiomyocytes from adult
rat. After a 3 h incubation with 1 mM p- or m-synephrine, the intracellular content of synephrine was measured by gas chromatography/ion trap-mass spectrometry (GC/IT-MS);
cell viability and intracellular glutathione levels were also determined. To evaluate the potential protective effects of
antioxidants against the adverse effects elicited by m-synephrine, cells were pre-incubated for 30 min with Tiron (100 μM) or N-acetyl-cysteine (NAC) (1 mM). To assess the influence
of α1-adrenoceptors activation in glutathione depletion, a study with prazosin (100 nM) was also performed. The results obtained
provide evidence that organic cation transporters OCT3 and OCT1 play a major role in m- and p-synephrine-mediated transport into the cardiomyocytes. The importance of these transporters seems similar for both isomers,
although p-synephrine enters more into the cardiomyocytes. Furthermore, only m-synephrine induced intracellular total glutathione (GSHt) and reduced glutathione (GSH) depletion. NAC and Tiron were able
to counteract the m-synephrine-induced GSH and GSHt decrease. On the other hand, the incubation with prazosin was not able to change m-synephrine-induced glutathione depletion showing that this effect is independent of α1-adrenoceptor stimulation. In conclusion, both positional isomers require OCT3 and OCT1-mediated transport to enter into the
cardiomyocytes; however, the hydroxyl group in the p-position favours the OCT-mediated transport into cardiomyocytes. Furthermore, the structural isomerization of synephrine influences its toxicological profile since only m-synephrine caused GSH depletion. 相似文献
56.
Samuel Cordey Roland Sahli Marie-Laurence MorazChristine Estrade Laurence Morandi Pascal Cherpillod Remi N. CharrelStefan Kunz Laurent Kaiser 《Journal of virological methods》2011,177(1):118-122
Lymphocytic choriomeningitis virus (LCMV) is a rare cause of central nervous system disease in humans. Screening by real-time RT-PCR assay is of interest in the case of aseptic meningitis of unknown etiology.A specific LCMV real-time RT-PCR assay, based on the detection of genomic sequences of the viral nucleoprotein (NP), was developed to assess the presence of LCMV in cerebrospinal fluids (CSF) sent for viral screening to a Swiss university hospital laboratory.A 10-fold dilution series assay using a plasmid containing the cDNA of the viral NP of the LCMV isolate Armstrong (Arm) 53b demonstrated the high sensitivity of the assay with a lowest detection limit of ≤50 copies per reaction. High sensitivity was confirmed by dilution series assays in a pool of human CSF using four different LCMV isolates (Arm53b, WE54, Traub and E350) with observed detection limits of ≤10 PFU/ml (Arm53b and WE54) and 1 PFU/ml (Traub and E350).Analysis of 130 CSF showed no cases of acute infection. The absence of positive cases was confirmed by a published PCR assay detecting all Old World arenaviruses.This study validates a specific and sensitive real-time RT-PCR assay for the diagnosis of LCMV infections. Results showed that LCMV infections are extremely rare in hospitalized patients western in Switzerland. 相似文献
57.
Mori H Sakai H Sanada M Shimamoto K Sasaki S Azuma R Higuchi T Harada H Niikura H Omine M Fujita K Takahashi N 《[Rinshō ketsueki] The Japanese journal of clinical hematology》2007,48(7):547-553
The type of leukemia was defined as HLA-DR(-) non-M3-AML, when HLA antigens were detected by flow cytometry at an incidence of < 20% of the blast population excluding M3-AML. Out of 109 patients with de novo acute myeloid leukemia, 8 patients had HLA-DR(-) non-AML-M3. According to the French-American-British criteria, 7 patients could be subdivided into 3 patients with M1, 4 patients with M2 and 1 patient with M4. The morphological features of bone marrow aspiration demonstrated no dysplasia and peroxidase stain positivity was noted in over 86% of the blast cells in all patients, the blast cells with fine granularity in 7 patients. The cytogenetic analysis revealed a normal karyotype. There was no expression marker of the blast antigens except CD13, CD14, CD33, CD34 and CD56. All of 7 patients who underwent induction therapy attained complete remission. Overall survival and disease-free survival showed no significant differences between the HLA-DR(-) non- M3-AML group and the HLA-DR(+) AML group. 相似文献
58.
De Lamballerie X Tolou H Durand JP Charrel RN 《Vector borne and zoonotic diseases (Larchmont, N.Y.)》2007,7(2):275-277
Toscana virus (TOSV) is a sandfly-borne phlebovirus causing meningitis and encephalitis during the summer period. A significant proportion of infection results in asymptomatic or pauci-symptomatic forms. Although seroprevalence studies had been conducted in Italy, Spain, Greece, and Cyprus, no data were available from France at the outset of this study. We present here results of seroprevalence studies conducted in volunteer blood donors and in patients presenting with central nervous system (CNS) infections. Twelve percent of sera from blood donors and 18.9% of sera from patients hospitalized for CNS infection contained immunoglobulin G (IgG) reacting against TOSV or TOSV-related phleboviruses. This study confirms that TOSV and possibly TOSV-related phleboviruses actively circulates in southeastern France and demonstrates that a significant proportion of healthy blood donors and patients with CNS infections have a history of TOSV or TOSV-related phlebovirus infection. 相似文献
59.
Lactate dehydrogenase is a prognostic indicator for prostate cancer patients with bone metastasis 总被引:1,自引:0,他引:1
Naruse K Yamada Y Aoki S Taki T Nakamura K Tobiume M Zennami K Katsuda R Sai S Nishio Y Inoue Y Noguchi H Hondai N 《Hinyokika kiyo. Acta urologica Japonica》2007,53(5):287-292
We analyzed clinical data to identify prognostic indicators in prostate cancer patients with bone metastasis. The subjects were 60 patients with bone metastasis out of 165 patients diagnosed with prostate cancer at our clinic over 6 years from January 1998 to December 2003. The age at the initial diagnosis was 61 to 91 (mean: 73.7 +/- 7.5) years old. The following items were considered to be possible prognostic indicators: T (type) classification, N (node) classification, Gleason score, prostate specific antigen (PSA) value before therapy, disease grade, alkaline phosphatase (ALP), lactate dehydrogenase (LDH), serum calcium (Ca), hemoglobin (Hgb), and platelet count (Plt). The 5-year overall survival rate was 45.7% in the 60 patients. Univariate analysis showed statistically significant differences in N (1), Gleason score 7 + 8/Gleason score 9 + 10, and LDH level (p = 0.0053, 0.0261, and 0.0049, respectively). Multivariate Cox proportional hazard analysis of these three items showed a statistically significant difference in LDH level and Gleason score 9 +/- 10 (p = 0.0167 and 0.0371). LDH was suggested to be an excellent prognostic indicator, because of its objectivity and convenience of measurement, in prostate cancer patients with bone metastasis. 相似文献