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81.
Rapid communication: pure robot-assisted laparoscopic ureteral reimplantation for ureteral stricture disease: case report 总被引:1,自引:0,他引:1
Yohannes P Chiou RK Pelinkovic D 《Journal of endourology / Endourological Society》2003,17(10):891-893
BACKGROUND AND PURPOSE: The role of the da Vinci robot is slowly being defined in minimally invasive urologic surgery. We report its use in the management of ureteral stricture disease. CASE REPORT: A 42-year-old man with recurrent kidney stone disease was found to have a left distal-ureteral stricture. After failure of endoscopic treatment, a robot-assisted laparoscopic ureteral reimplantation was performed. The total operative time was 210 minutes. The estimated blood loss was <50 mL. There were no intraoperative or postoperative complications. Total analgesic use was 30 mg of morphine. The hospital stay was 5 days. CONCLUSION: Pure robot-assisted laparoscopic ureteral reimplantation is a safe and feasible approach to the management of ureteral stricture disease. 相似文献
82.
Miyaoka T Yasukawa R Tsubouchi K Miura S Shimizu Y Sukegawa T Maeda T Mizuno S Kameda A Uegaki J Inagaki T Horiguchi J 《International clinical psychopharmacology》2003,18(3):175-177
Nocturnal eating/drinking disorder (NE/DS) is a rare syndrome that includes disorders of both eating and sleeping. It is characterized by awakening in the middle of the night, getting out of bed, and consuming large quantities of food quickly and uncontrollably, then returning to sleep. This may occur several times during the night. Some patients are fully conscious during their nocturnal eating, while some report total amnesia. The aetiology of NE/DS is still unclear, and there is no satisfactory treatment. Four patients with NE/DS are described. Treatment with a selective seroronin reuptake inhibitor (SSRI) was effective in controlling their episodes of nocturnal eating. To our knowledge, this is the first published case report of successful treatment with SSRIs in NE/DS. 相似文献
83.
Suppressed complement activation in human decay accelerating factor transgenic porcine liver cross-circulated with nonhuman primates 总被引:1,自引:0,他引:1
Matsushita T Ikai I Nishitai R Katsura N Yamanokuchi S Matsuo K Sugimoto S Shiotani T Takahashi R Terajima H Yamaoka Y 《Transplantation》2003,75(11):1807-1812
BACKGROUND: We developed an extracorporeal liver perfusion (ECLP) system as a liver-assist device. In this study, we evaluated the safety of the ECLP using human decay accelerating factor (hDAF) transgenic porcine livers in healthy baboons. METHODS: Livers were isolated from five hDAF transgenic pigs and five nontransgenic pigs for the ECLP. Ten cross-circulations between the ECLP and healthy baboons were performed without immunosuppressive agents. Cross-circulation was discontinued in any of the following circumstances: elevated hepatic arterial (>200 mm Hg) or portal (>60 mm Hg) perfusion pressure, massive exudate from the graft liver, mild macroscopic hemolysis, thrombocytopenia, or 24-hr well-conditioned cross-circulation. RESULTS: The cross-circulations with nontransgenic porcine livers were discontinued at 4.4+/-1.2 hr (mean+/-standard deviation) because of high perfusion pressure (n=2) or hemolysis (n=3). Three cross-circulations with hDAF transgenic porcine livers were performed for 24 hr; the other two cross-circulations were discontinued at 13 and 17 hr because of massive exudate and thrombocytopenia, respectively. The duration was 20.4+/-5.1 hr. Deposition of membrane attack complex in the hDAF transgenic porcine liver was less than that in the nontransgenic liver, although immunoglobulin-M deposition was comparable. The porcine livers showed no apparent interlobular bleeding or lobular necrosis. All porcine livers maintained bile production during the cross-circulation. No baboons showed any serious complications after the cross-circulation. CONCLUSION: The hDAF transgenic porcine liver reduced complement activation in xenoperfusion with healthy nonhuman primate blood and led to extended duration of cross-circulation. 相似文献
84.
Sato K Takenokishin M Anzai S Sato R Tatewaki M Takahashi M 《Gan to kagaku ryoho. Cancer & chemotherapy》2003,30(Z1):149-152
The home drip infusion is a stressful procedure for both patients and families under HPN at home. Effective and reliable guidance for drip infusion management should be provided while patients are still at the hospital to realize reliable home care. We revised the HPN Guidance Manual and report the process in this article. We revised the manual according to the principles that "the guidance is subdivided into 3 steps so that the contents of the guidance can be adjusted for individual patients", that "a lot of photos and illustrations for frequently used 2 models are placed" and that "a video is prepared to make the most of the impact motion pictures can give". We want to use the manual in future clinical practices. 相似文献
85.
Reissig D Rassoul F Salvetter J Wagner O Richter V 《European journal of nutrition》2003,42(4):224-227
Summary.Background: With respect
to linoleic acid both beneficial
and proatherogenic effects
have been described. However, the
effect on expression of cell adhesion
molecules on human coronary
artery endothelial cells (HCAEC) is
not yet established. The aim of the
experiments was to evaluate the influence
of linoleic acid in comparison
with palmitic acid regarding
the cytokine-induced expression of
endothelial leukocyte adhesion
molecules (intercellular cell adhesion
molecule-1 ICAM-1, vascular
cell adhesion molecule-1 VCAM-1,
E-selectin).Methods: HCAEC were
cultured in microvascular endothelial
cell growth medium. In the experiments,
the cells were preincubated
with linoleic acid and
palmitic acid, respectively
(10 µmol/l, 2 days) or under control
conditions, after which interleukin-
1 (IL-1, 10 ng/ml in the test
medium) was added for 1 day. The
monoclonal antibodies used were
fluorescein isothiocyanate (FITC)-
labeled anti-ICAM-1, FITC-labeled
anti-VCAM-1, and FITC-labeled
anti-E-selectin. Expression was analyzed
by flow cytofluorimetry.
Next, to examine the effects of fatty
acids on adhesion of monocytes to
endothelial cells, adhesion experiments
with the monocytic U 937
cell line were performed.Results and conclusions: IL-1 increased
ICAM-1,VCAM-1, and E-selectin
expression compared to controls.
Incubation with IL-1 together
with linoleic acid reduced the expression
of ICAM-1 and VCAM-1
in contrast to palmitic acid. Furthermore,
in the presence of
linoleic acid a tendency of diminished
adhesion of monocytes is
seen.The results indicate that a reduced
expression of cell adhesion
molecules may be relevant to the
antiatherogenic effects of linoleic
acid. This is in contrast to the properties
of palmitic acid. 相似文献
86.
Tomoda A Nomura K Shiraishi S Hamada A Ohmura T Hosoya M Miike T Sawaishi Y Kimura H Takashima H Tohda Y Mori K Kato Z Fukushima A Nishio H Nezu A Nihei K 《Brain & development》2003,25(7):514-517
Ten patients with SSPE were surveyed during the last 4 years from the viewpoint of clinical safety for use of ribavirin therapy. Although effectiveness varied among cases, they were all treated safely with intraventricular ribavirin. This study suggests that treatment is safe and well-tolerated. 相似文献
87.
Ichiki M Gohara R Rikimaru T Kitajima T Fujiki R Shimada A Aizawa H 《Chemotherapy》2003,49(4):200-205
This phase II study was conducted to investigate the efficacy and safety of irinotecan (CPT-11) and ifosfamide as second-line chemotherapy for relapsed small cell lung cancer (SCLC). Eligibility criteria included histologically or cytologically confirmed SCLC, prior chemotherapy including platinum + etoposide, and measurable or evaluable disease. CPT-11 (80 mg/m(2)) was administered intravenously on days 1, 8 and 15, while ifosfamide (1.5 g/m(2)) was given on days 1 through 3 every 4 weeks. Thirty-four patients (29 men) with a median age of 69 years (range 42-77) and a median Eastern Cooperative Oncology Group (ECOG) performance status of 1 (range 0-2) were enrolled. The response rate was 52.9% (95% confidence interval: 29.8-64.9%) with 2 complete responses and 16 partial responses. Our analyses of prognostic factors showed risk factors assessed before receiving second-line chemotherapy, which were the number of metastatic sites, performance status and the type of relapse. WHO grade 3-4 neutropenia was recorded in 52.9% of the patients, grade 3 diarrhea in 5.9%. The combination of CPT-11 and ifosfamide demonstrated clinical efficacy in relapsed SCLC with a favorable toxicity profile, particularly for performance status 0-1 and sensitive cases with only one metastatic site. 相似文献
88.
89.
Aberrant methylation of p16INK4a in anatomic and gender-specific subtypes of sporadic colorectal cancer. 总被引:16,自引:0,他引:16
J K Wiencke S Zheng A Lafuente M J Lafuente C Grudzen M R Wrensch R Miike A Ballesta M Trias 《Cancer epidemiology, biomarkers & prevention》1999,8(6):501-506
Colorectal cancer (CRC) occurring in the proximal colon and among women may represent a distinct subtype of the disease. In the present study of 120 sporadic CRCs, we used methylation-specific PCR to test whether methylation of the CpG island in the 5' region of the p16INK4a tumor suppressor gene was associated with anatomical location, gender, or other clinicopathological characteristics. Overall, 18.3% of the tumors had detectable p16INK4a methylation. A marked preponderance of methylated tumors occurred within the proximal colon; cancers occurring proximal to the sigmoid colon were 13.1 times more likely to contain methylated p16INK4a compared with distal tumors. In addition, female patients were 8.8 times more likely than males to have methylation-positive cancers, and p16INK4a methylation was also associated with poorly differentiated tumors. The localization of tumors with p16INK4a methylation within the proximal colon and among female patients specifically adds to a growing database of molecular alterations that define important subtypes of sporadic CRC. The potentially reversible nature of CpG methylation may provide novel therapeutic opportunities for this increasing subtype of the disease, which, due to anatomical location, presents a great challenge for early detection. 相似文献
90.
Previous studies suggest an association between calcium consumption and glioma risk. In the present study, we compare consumption of calcium and other dairy components and foods (cholesterol, fat, protein, calories, milk, and cheese) of 337 astrocytic glioma case patients with 450 controls from the San Francisco Bay Area Adult Glioma Study, 1991-1995. We use unconditional logistic regression models to estimate odds ratios (ORs) by gender controlling for age, education, and income. A statistically significant inverse association [p (trend) = 0.05] was observed for dietary calcium intake for women only [OR = 0.49, 95% confidence interval (CI) = 0.24-1.03 for highest vs. lowest quartile of consumption]. In addition, we observed elevated ORs for highest vs. lowest quartiles of cholesterol intake among women and men (OR = 2.07, 95% CI = 1.00-4.28 and OR = 1.75, 95% CI = 0.92-3.31, respectively). Calcium may exert a protective effect through its known roles in apoptosis, DNA repair, and inhibition of parathyroid hormone production. Recent evidence suggests that parathyroid hormone may influence growth and dedifferentiation of astrocytoma cells. Finally, circulating estradiol might directly stimulate intestinal absorption of calcium and may therefore explain why the inverse association of calcium intake and glioma is confined to women. 相似文献