全文获取类型
收费全文 | 6198篇 |
免费 | 301篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 99篇 |
儿科学 | 409篇 |
妇产科学 | 73篇 |
基础医学 | 581篇 |
口腔科学 | 101篇 |
临床医学 | 420篇 |
内科学 | 1389篇 |
皮肤病学 | 178篇 |
神经病学 | 358篇 |
特种医学 | 194篇 |
外科学 | 1049篇 |
综合类 | 130篇 |
一般理论 | 3篇 |
预防医学 | 272篇 |
眼科学 | 305篇 |
药学 | 457篇 |
中国医学 | 18篇 |
肿瘤学 | 479篇 |
出版年
2023年 | 49篇 |
2022年 | 80篇 |
2021年 | 226篇 |
2020年 | 106篇 |
2019年 | 139篇 |
2018年 | 182篇 |
2017年 | 127篇 |
2016年 | 134篇 |
2015年 | 160篇 |
2014年 | 232篇 |
2013年 | 275篇 |
2012年 | 440篇 |
2011年 | 457篇 |
2010年 | 273篇 |
2009年 | 188篇 |
2008年 | 335篇 |
2007年 | 348篇 |
2006年 | 342篇 |
2005年 | 329篇 |
2004年 | 281篇 |
2003年 | 232篇 |
2002年 | 218篇 |
2001年 | 96篇 |
2000年 | 70篇 |
1999年 | 81篇 |
1998年 | 51篇 |
1997年 | 43篇 |
1996年 | 41篇 |
1995年 | 39篇 |
1994年 | 25篇 |
1993年 | 27篇 |
1992年 | 87篇 |
1991年 | 63篇 |
1990年 | 49篇 |
1989年 | 62篇 |
1988年 | 49篇 |
1987年 | 43篇 |
1986年 | 52篇 |
1985年 | 41篇 |
1984年 | 34篇 |
1983年 | 21篇 |
1981年 | 21篇 |
1979年 | 33篇 |
1977年 | 20篇 |
1976年 | 33篇 |
1975年 | 23篇 |
1972年 | 21篇 |
1971年 | 23篇 |
1970年 | 28篇 |
1969年 | 27篇 |
排序方式: 共有6515条查询结果,搜索用时 56 毫秒
11.
12.
An unusual case of heteropagus twinning. 总被引:1,自引:0,他引:1
S K Biswas A N Gangopadhyay B D Bhatia D Bandopadhyay S Khanna 《Journal of pediatric surgery》1992,27(1):96-97
A 3-day-old boy baby presented with a cystic umbilical swelling covered mostly by skin and partly by amnion. On the surface, an early embryo-like structure was attached (facial features and limb buds). The deeper aspect of it was composed of large cystic and tubular structures and solid organs resembling liver and spleen. It was labeled as acardiac amorphous parasitic twin, the first of its kind to be reported. 相似文献
13.
Chandralekha Tampi Prashant Mullerpatan Rajiv Shah Palepu Jagannath Arthur Zimmermann 《Pancreatology》2006,6(3):248-253
Microcystic adenoma or serous cystadenoma is an uncommon tumor and accounts for 1-2% of the exocrine neoplasms of the pancreas. Usually unifocal, they present as single, large, well-demarcated multiloculated cystic tumors, ranging in size from 1 to 25 cm. Multifocal variants or diffuse serous cystadenomas are extremely rare. We present 2 cases of which 1 is a diffuse variant affecting the body, tail and part of the neck of the pancreas. In both the patients the tumors were detected incidentally. We highlight on the diffuse variant in view of its rarity and present a review of literature. In this case the entire body and tail of the pancreas was spongy replaced by multicystic lobules and hyalinized fibrocollagenous stroma. The cysts were lined by low cuboidal glycogen containing bland cells. Such a unique presentation wherein the entire body and tail of the pancreas is replaced with multiple cysts is a diffuse presentation of microcystic adenoma and a search through literature revealed only 7 such cases among the 15 cases with multifocal presentation reported. 相似文献
14.
The effect of increasing haemoglobin by erythropoietin therapy on exercise capacity was investigated in 11 regular haemodialysis patients, previously transfusion dependent. Exercise work load increased from a median of 100 W (95% confidence limit, 25-135) to 120 (45-180; p < 0.05) following erythropoietin, and the duration of the exercise test from 13 (3.5-20) to 15.5 min (4-22; p < 0.05). Resting blood lactate concentration decreased from 0.8 (0.6-1.6) to 0.3 mmol/l (0.3-0.4), p < 0.05, following treatment with erythropoietin, as did blood lactate concentration at maximal exertion from 2.0 (1.0-4.1) to 1.8 mmol/l (0.5-2.8; p < 0.05). In association with the increase in haemoglobin from a median of 6 (5.1-6.8) to 11.1 g/dl (11-11.9) following erythropoietin therapy, patients were able to achieve greater exercise capacity both in terms of maximum work load and duration of exercise in association with a reduced resting arterial lactate and a similar exercise-induced lactate production. This suggests that treatment had improved muscle function in terms of lactate production and/or utilisation. This was probably due to the increase in tissue oxygen delivery, as there was an increase in the median arterial oxygen content from 79 (65-85) to 150 ml O2 (144-157) following erythropoietin treatment. 相似文献
15.
Dengue is a mosquito-borne viral disease caused by four antigenically distinct serotypes of dengue viruses (DENVs). This disease, which is prevalent in over a hundred tropical and sub-tropical countries of the world, represents a significant global public health problem. A tetravalent dengue vaccine capable of protecting against all four DENV serotypes has been elusive so far. Current efforts are focused on producing a tetravalent vaccine by mixing four monovalent vaccine components. In this work, we have utilized a discrete carboxy-terminal region of the major DENV envelope (E) protein, known as domain III (EDIII), which mediates virus entry into target cells and contains multiple serotype-specific neutralizing epitopes, to create a chimeric tetravalent antigen. This antigen derived by in-frame fusion of the EDIII-encoding sequences of the four DENV serotypes was expressed using a replication-defective recombinant human adenovirus type 5 (rAdV5) vaccine vector. This rAdV5 vector induced cell-mediated immune responses and virus-neutralizing antibodies specific to each of the four DENVs in mice. Interestingly, anti-AdV5 antibodies did not suppress the induction of DENV-specific neutralizing antibodies. We observed that anti-AdV5 antibodies in the sera of immunized mice could promote uptake of a rAdV5-derived reporter vector into U937 cells, suggesting that pre-existing immunity to AdV5 may in fact facilitate the uptake of rAdV5 vectored vaccines into antigen presenting cells. This work presents an alternative approach to developing a single component tetravalent vaccine that bypasses the complexities inherent in the currently adopted four-in-one physical mixture approach. 相似文献
16.
Gautham Kulamarva Mark Wilbourn Rajiv Anand Constantinos Mourouzis Anne V Spedding Peter A Brennan 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2007,104(2):240-242
Chordoma is a rare tumor, arising from notochord remnants, which usually occurs in the axial skeleton and rarely metastasizes. Although there have been 3 previous reports of metastatic disease to the facial bones from sacrococcygeal chordoma, this is the first to describe spread to the mandible from a vertebral primary chordoma. 相似文献
17.
18.
Rajiv Jalan Rebecca Gooday Ronan E. O'Carroll Doris N. Redhead Robert A. Elton Peter C. Hayes 《Journal of hepatology》1995,23(6)
Background/Aims: This study was designed to assess changes in: (a) neuropsychological tests, measures of memory, quality of life and scores for anxiety and depression; (b) liver function tests; and (c) the relationship between these following transjugular intrahepatic portosystemic stent-shunt.Methods: Twenty-nine patients undergoing transjugular intrahepatic portosystemic stent-shunt for recurrent variceal haemorrhage, 12 matched patients with cirrhosis and variceal haemorrhage manage with variceal band ligation and 16 normal controls were studied. Patients in any of the groups who were clinically encephalopathic were excluded from the study. Serial changes in the conventional liver function tests and Indocyanine green clearance, and psychometric function (Hospital Anxiety Depression Scale, Rivermead Behavioral Memory Test, Quality of Life and the memory and reaction sub-tests of the Cambridge Automated Neuropsychological Test Assessment Battery) were measured prior to and 1, 3, 9 and 15 months following transjugular intrahepatic portosystemic stent-shunt.Results: Over a mean follow up of 9.1 months in the transjugular intrahepatic portosystemic stent-shunt group (range 3–28), one patient (3%) developed clinically detectable encephalopathy. Sixty-seven percent of patients with cirrhosis showed evidence of subclinical encephalopathy as compared with the control population. Significant deterioration occurred in the reaction sub-tests of the Cambridge Automated neuropsychological Test Assessment Battery in patients, both in the transjugular intrahepatic portosystemic stent-shunt group and the controls with cirrhosis, during follow up. Transjugular intrahepatic portosystemic stent-shunt was followed by significant deterioration in levels of anxiety and psychological component of the quality of life. The Rivermead Behavioural Memory Test and the memory sub-test of the Cambridge Automated Neurpsychological Test Assessment Battery did, however, improve significantly at 1 and 15 months after transjugular intrahepatic portosystemic stent-shunt, respectively. Serum alanine aminotransferase, bilirubin and indocyanine green clearance deteriorated significantly following transjugular intrahepatic portosystemic stent-shunt (p<0.001, p<0.001 and p<0.0001, respectively). Significant correlation was observed between changes in the indocyanine green clearance and changes in the complex and simple reaction time subtests of the Cambridge Automated Neuropsychological Test Assessment Battery (r=0.6 and r=0.66, respectively).Conclusions: The results of this study showed that about 67% of patients with cirrhosis were subclinically encephalopathic and that temporary deterioration occurred in the Cambridge Automated Neuropsychological Test Assessment Battery during follow up, both in patients having transjugular intrahepatic portosystemic stent-shunt and in the controls with cirrhosis. These parallel the changes in the liver function tests and indocyanine green clearance. Temporary deterioration was also observed in the Quality of Life and Hospital Anxiety Depression Scale in the transjugular intrahepatic portosystemic stent-shunt group, although the measures of memory improved. Further studies should address the biochemical mechanisms of these changes and the role of prophylactic measures. 相似文献
19.
20.