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51.
M. Saeedi K. Morteza-Semnani M. R. Mahdavi F. Rahimi 《Indian journal of pharmaceutical sciences》2008,70(3):403-406
The antimicrobial activity of the methanol extracts of the dried flowering aerial parts of Stachys byzantina, S. inflata, S. lavandulifolia and S. laxa (Labiatae) were studied using the disc diffusion method and determination of minimum inhibitory concentration (MIC) values against Staphylococcus aureus, Streptococcus sanguis, Escherichia coli, Pseudomonas aeroginosa, Klebsiella pneumoniae, Aspergilus niger and Candida albicans. The extracts of plants exhibited concentration-dependent antibacterial activity against the bacteria tested. The extracts were more active against Gram-positive microorganisms. The extracts, however, did not show any antifungal activity. 相似文献
52.
Mohammad Nasser Hashemian Mehrdad Shamshiri Firoozeh Rahimi Mohammad Taher Rajabi Seyed All Tabatabaee Mohammad Reza Salari 《国际眼科杂志》2008,8(8):1530-1532
我们报道成功治疗波氏假阿利什菌引发的真菌性角膜炎1例,患者只留有很小的角膜瘢痕。一位71岁女性患者,有疼痛、红肿和异物感病史,来到我们第三眼科中心就诊。最初角膜刮片显示有真菌成分,2d后真菌培养为阳性,5d后显示生长物为波氏假阿利什菌。患者仅用药物疗法取得临床治愈,留下微小的角膜瘢痕,最终视力为3/10。 相似文献
53.
Chronic subdural hematoma (CSDH) is particularly common in the older patient. Chronic subdural hematoma can present with atypical, and sometimes unusual, manifestations. It has an insidious onset and can, at times, be very difficult to diagnose. The most frequent presenting symptoms are headache, changes in mental status, and hemiparesis. Chronic subdural hematoma might also present as a transient ischemic attack. Here we report a case of CSDH that presented with intermittent aphasia and no other neurological deficit. Chronic subdural hematoma usually begins with a hemorrhage into the subdural space, which then becomes encapsulated by a membrane with abundant abnormal vessels in the outer portion of the membrane. Chronic subdural hematoma is a distinct and interesting clinical entity with diverse and insidious onset. A high index of suspicions is needed to make the early diagnosis and to start appropriate treatment to avoid morbidity and mortality. 相似文献
54.
BACKGROUND: It is common to find older patients who have received thyroid hormone replacement for years without clear-cut documentation of hypothyroidism. The diagnosis of hypothyroidism in older patients presents a difficult problem. OBJECTIVE: We sought to determine the prevalence of hypothyroidism and the sensitivity of clinical determinants for hypothyroidism during withdrawal of thyroid hormone therapy (vital signs, weight, MMSE, and depression scale) in a nursing home population. METHODS: We studied a cohort of patients in two nursing centers in southeast Georgia. Those receiving thyroid hormone without documented hypothyroidism had complete a physical examination and serum TSH, MMSE,depression scale assessment at baseline and 3 and 6 weeks after discontinuation of thyroid therapy. Weights and vital signs were monitored throughout the study. The hypothyroid state was defined by an attending physician by clear documentation of elevated TSH > 10 microIU/mL and clinical manifestation of hypothyroidism. RESULTS: Thirteen of 129 patients were receiving thyroid supplement; seven had documented hypothyroidism. Five of the six without documented hypothyroidism completed the study. Three of those five were found to be hypothyroid (TSH: 69.4-110.4 microIU/mL at 6 weeks of thyroid therapy). Among the clinical determinants, only weight correlated with elevated TSH and hypothyroidal state. At 6 weeks, the other two patients had borderline elevation of TSH, and one patient normalized at 4 months. Both had negative antimicrosomal antibodies and were considered euthyroid. CONCLUSIONS: The prevalence of true hypothyroidism ranged from 6.2% to 7.8%. We identified unnecessary therapy in two of 13 patients. Increased weight was the most sensitive indicator of evolving hypothyroidism. 相似文献
55.
A A Ghazi D Mofid F Rahimi H Marandi H Nasri S Afghah 《Archives of disease in childhood》1994,71(4):358-359
A 14 year old boy is presented who was admitted to the psychiatric ward because of delirium. He also had gynaecomastia, facial oedema, striae, and hypertension. He was finally proved to have a mixed oestrogen and cortisol producing adrenal tumour which was removed surgically with complete improvement and no relapse. 相似文献
56.
Vascular dysfunction of venous bypass conduits is mediated by reactive oxygen species in diabetes: role of endothelin-1 总被引:2,自引:0,他引:2
Ergul A Johansen JS Strømhaug C Harris AK Hutchinson J Tawfik A Rahimi A Rhim E Wells B Caldwell RW Anstadt MP 《The Journal of pharmacology and experimental therapeutics》2005,313(1):70-77
Diabetes is associated with increased risk for complications following coronary bypass grafting (CABG) surgery. Augmented superoxide (*O2*) production plays an important role in diabetic complications by causing vascular dysfunction. The potent vasoconstrictor endothelin-1 (ET-1) is also elevated in diabetes and following CABG; however, the effect of ET-1 on *O2* generation and/or vascular dysfunction in bypass conduits remain unknown. Accordingly, this study investigated basal and ET-1-stimulated *O2* production in bypass conduits and determined the effect of *O2* on conduit reactivity. Saphenous vein specimens were obtained from nondiabetic (n = 24) and diabetic (n = 24) patients undergoing CABG. Dihydroethidium staining and NAD(P)H oxidase activity assays (5380 +/- 940 versus 16,362 +/- 2550 relative light units/microg) demonstrated increased basal *O2* levels in the diabetes group (p < 0.05). Plasma ET-1 levels were associated with elevated basal *O2* levels, and treatment of conduits with exogenous ET-1 further increased *O2* production and augmented vasoconstriction. Furthermore, vascular relaxation was impaired in the diabetic group (75 versus 40%), which was restored by *O2* scavenger superoxide dismutase. These findings suggest that ET-1 causes bypass conduits dysfunction via stimulation of *O2* production in diabetes. Novel therapies that attenuate *O2* generation in bypass conduits may improve acute and late outcome of CABG in diabetic patients. 相似文献
57.
Halliday GM Song YJ Lepar G Brooks WS Kwok JB Kersaitis C Gregory G Shepherd CE Rahimi F Schofield PR Kril JJ 《Annals of neurology》2005,57(1):139-143
Presenilin-1 (PS-1) mutations can cause Pick's disease without evidence of Alzheimer's disease (AD). We describe a family with a PS-1 M146L mutation and both Pick bodies and AD. Sarkosyl-insoluble hyperphosphorylated tau showed three bands consistent with AD, although dephosphorylation showed primarily three-repeat isoforms. M146L mutant PS-1 may predispose to both Pick's disease and AD by affecting multiple intracellular pathways involving tau phosphorylation and amyloid metabolism. 相似文献
58.
Comparison of necrosis in human ovarian tissue after conventional slow freezing or vitrification and transplantation in ovariectomized SCID mice 总被引:8,自引:0,他引:8
Rahimi G Isachenko E Isachenko V Sauer H Wartenberg M Tawadros S Hescheler J Mallmann P Nawroth F 《Reproductive biomedicine online》2004,9(2):187-193
This paper examines and compares necrosis in human ovarian tissue after conventional slow freezing or vitrification and ensuing xenotranplantation. Slow cryoconserved or vitrified ovarian tissue samples and fresh controls from nine patients were subcutaneously transplanted into SCID mice. The tissue samples were explanted after 6 weeks and the necrotic areas were examined by staining with Lucifer yellow SV. The size of the necrotic areas in parallel cultivated ovarian tissue samples was compared, as was necrosis in cultivated prostate tumour spheroids where the emergence of necrosis and its pathophysiological correlation have been described. Examinations showed no significant rise in the proportion of necrotic areas after slow cryoconservation/transplantation and in the controls (transplanted fresh tissue, not transplanted fresh tissue, long-term culture). The proportion of necrotic areas in the tumour spheroids was significantly higher than in the ovarian tissue. Vitrification could, after these results, be presented as an alternative to conventional slow cryoconservation. 相似文献
59.
Baldwin WM Armstrong LP Samaniego-Picota M Rahimi S Zachary AA Kasper EK Conte JV Hruban RH Rodriguez ER 《Human immunology》2004,65(11):1273-1280
Polyclonal antithymocyte globulin preparations contain antibodies with reactivity to endothelial cells. Therefore, we investigated whether treatment with this reagent caused complement deposition in human cardiac transplants. Frozen tissue was available from endomyocardial biopsies of 75 patients, who were transplanted between April 1995 and April 2000. Nine of these patients were converted from cyclosporin A (CsA) to horse antithymocyte globulin (ATGAM) in the first month after transplantation. All of the biopsies were stained by immunofluorescence for C4d as evidence of activation of the classical pathway of complement. In addition, biopsies from patients treated with ATGAM and control patients were stained for deposition of horse immunoglobulin (Ig)G. All nine patients who received ATGAM had deposition of horse IgG and C4d. Two color stains demonstrated that the horse IgG colocalized with the C4d staining. No staining for horse IgG or C4d was evident in biopsies obtained before ATGAM treatment. Likewise, no staining for horse IgG was detected in seven control patients who had C4d staining. Most patients treated with ATGAM had no histologic evidence of rejection, but did have myocyte damage and macrophage infiltration. Thus prophylactic treatment with ATGAM is associated with the deposition of horse IgG and activation of complement in the transplant. 相似文献
60.