全文获取类型
收费全文 | 2580304篇 |
免费 | 197799篇 |
国内免费 | 4207篇 |
专业分类
耳鼻咽喉 | 36587篇 |
儿科学 | 85934篇 |
妇产科学 | 74292篇 |
基础医学 | 371313篇 |
口腔科学 | 75386篇 |
临床医学 | 226305篇 |
内科学 | 500113篇 |
皮肤病学 | 54891篇 |
神经病学 | 205946篇 |
特种医学 | 101574篇 |
外国民族医学 | 794篇 |
外科学 | 393314篇 |
综合类 | 60263篇 |
现状与发展 | 4篇 |
一般理论 | 834篇 |
预防医学 | 198221篇 |
眼科学 | 60146篇 |
药学 | 195530篇 |
5篇 | |
中国医学 | 4799篇 |
肿瘤学 | 136059篇 |
出版年
2018年 | 24273篇 |
2015年 | 24304篇 |
2014年 | 33502篇 |
2013年 | 51159篇 |
2012年 | 69737篇 |
2011年 | 74179篇 |
2010年 | 43681篇 |
2009年 | 41530篇 |
2008年 | 71159篇 |
2007年 | 75978篇 |
2006年 | 77174篇 |
2005年 | 75309篇 |
2004年 | 73438篇 |
2003年 | 70599篇 |
2002年 | 69386篇 |
2001年 | 116250篇 |
2000年 | 119798篇 |
1999年 | 101814篇 |
1998年 | 28745篇 |
1997年 | 25930篇 |
1996年 | 26042篇 |
1995年 | 25046篇 |
1994年 | 23597篇 |
1993年 | 22174篇 |
1992年 | 83811篇 |
1991年 | 81968篇 |
1990年 | 80606篇 |
1989年 | 78037篇 |
1988年 | 72640篇 |
1987年 | 71665篇 |
1986年 | 68229篇 |
1985年 | 65591篇 |
1984年 | 49244篇 |
1983年 | 42813篇 |
1982年 | 25277篇 |
1981年 | 22480篇 |
1980年 | 21196篇 |
1979年 | 47196篇 |
1978年 | 33057篇 |
1977年 | 28141篇 |
1976年 | 26624篇 |
1975年 | 28548篇 |
1974年 | 34399篇 |
1973年 | 33198篇 |
1972年 | 31062篇 |
1971年 | 29028篇 |
1970年 | 26909篇 |
1969年 | 25427篇 |
1968年 | 23560篇 |
1967年 | 21127篇 |
排序方式: 共有10000条查询结果,搜索用时 9 毫秒
21.
N. V. Bashmakova G. N. Chistiakova I. A. Gazieva Y. M. Trapeznikova D. O. Mazurov 《Gynecological endocrinology》2015,31(10):31-33
AbstractThis study was undertaken to compare the concentrations of pro- and anti-angiogenic growth factors, nitric oxide (NO) stable metabolites in maternal serum and embryonic left ventricular (LV) isovolumic relaxation time (IRT, ms) during the first trimester in two groups of women: with pregnancy conceived by assisted reproductive technologies (ART, n?=?39) and normally conceived (control group, n?=?68) pregnancy. The concentration of vasoconstrictor endothelin 1 was 45.5 times more in ART than in control group. On the contrary, the concentrations of NO stable metabolites in ART were 1.9 times less than in control women. The assessment of angiogenic suppressors in ART women demonstrates the decrease in s-endoglin concentration was 1.6 times and in soluble receptor to vascular endothelial growth factor concentration was 2.0 times in comparison with control group. There was a significant increase in LV IRT in ART embryos in comparison to control ones. These data suggest significant changes in pro- anti-angiogenic factors balance and increase in vascular impedance in ART-conceived embryos. 相似文献
22.
Arjenne H.M. Gussenhoven Amika S. Singh S. Theo Goverts Marten van Til Johannes R. Anema Sophia E. Kramer 《International journal of audiology》2015,54(8):507-517
Objective: A multidisciplinary vocational rehabilitation programme, the Vocational Enablement Protocol (VEP) was developed to address the specific needs of employees with hearing difficulties. In the current study we evaluated the process of implementing the VEP in audiologic care among employees with hearing impairment. Design: In conjunction with a randomized controlled trial, we collected and analysed data on seven process parameters: recruitment, reach, fidelity, dose delivered, dose received and implemented, satisfaction, and perceived benefit. Study sample: Sixty-six employees with hearing impairment participated in the VEP. The multidisciplinary team providing the VEP comprised six professionals. Results: The professionals performed the VEP according to the protocol. Of the recommendations delivered by the professionals, 31% were perceived as implemented by the employees. Compliance rate was highest for hearing-aid uptake (51%). Both employees and professionals were highly satisfied with the VEP. Participants rated good perceived benefit from it. Conclusions: Our results indicate that the VEP could be a useful treatment for employees with hearing difficulties from a process evaluation perspective. Implementation research in the audiological setting should be encouraged in order to further provide insight into parameters facilitating or hindering successful implementation of an intervention and to improve its quality and efficacy. 相似文献
23.
Irmak Karaca Suzan Güven Yılmaz Melis Palamar Halil Ateş 《Ocular immunology and inflammation》2020,28(6):947-951
ABSTRACT
Purpose
To investigate the effect of 1% tropicamide on anterior chamber aqueous flare (ACAF) measurements acquired with laser flare meter in patients with pseudoexfoliation. 相似文献24.
Christopher R. LaFever 《Death Studies》2020,44(12):819-822
25.
Jeroen M. van de Pol Jurjen G. Geljon Svetlana V. Belitser Geert W.J. Frederix Anke M. Hövels Marcel L. Bouvy 《Research in social & administrative pharmacy》2019,15(1):70-76
Introduction
The nature of community pharmacy is changing, shifting from the preparation and distribution of medicines to the provision of cognitive pharmaceutical services (CPS); however, often the provision of traditional services leaves little time for innovative services. This study investigated the time community pharmacists spend on the tasks and activities of daily practice and to what extent they are able to implement CPS-related services in daily practice.Methods
Self-reporting work sampling was used to register the activities of community pharmacists. A smartphone application, designed specifically for this purpose, alerted participants to register their current activity five times per working day for 6 weeks. Participants also completed an online survey about baseline characteristics.Results
Ninety-one Dutch community pharmacists provided work-sampling data (7848 registered activities). Overall, 51.5% of their time was spent on professional activities, 35.4% on semi-professional activities, and 13.1% on non-professional activities. The proportion of time devoted to CPS decreased during the workweek, whereas the time spent on traditional task increased.Discussion and conclusion
This study shows it is feasible to collect work-sampling data using smartphone technology. Community pharmacists spent almost half of their time on semi-professional and non-professional activities, activities that could be delegated to other staff members. In practice, the transition to CPS is hampered by competing traditional tasks, which prevents community pharmacists from profiling themselves as pharmaceutical experts in daily practice. 相似文献26.
Amy Y. Zhang Christopher Burant Alex Z. Fu Gerald Strauss Donald R. Bodner Lee Ponsky 《Journal of psychosocial oncology》2020,38(2):210-227
AbstractPurpose: We examined underlying psychosocial processes of a behavioral treatment for urinary incontinence (UI) of prostate cancer survivors.Design: Secondary analysis of data collected from a clinical trial.Sample: Two hundred forty-four prostate cancer survivors who participated in a clinical trial of behavioral intervention to UI as intervention or control subjects.Methods: The participants had a 3-month behavioral intervention or usual care and were followed up for an additional 3?months. They were assessed at baseline, 3, and 6?months. Latent growth curve models were performed to examine trajectories of each study variable and relationships among the variables.Findings: Increasing self-efficacy and social support were significantly and independently associated with more reduction of urinary leakage frequency over time.Implications for psychosocial oncology: Providing problem-solving skills and social support, including peer support, are essential for empowering patients to reduce UI. 相似文献
27.
28.
29.
NAFDM, the National Action Forum for Diabetes Mellitus, is an umbrella organisation for the leading diabetes organisations in Germany. Since its foundation at the end of 2004, NAFDM has brought together the activities of these organisations, which up to now were frequently working independently of each other, under a single ‘roof’. Supported by a central coordination unit, three project groups work successfully on the topics scientific research and healthcare research, patient care and prevention. Activities and results are shared and thus integrated into the network. The working groups are supported by NAFDM’s medical and health-policy steering groups. Apart from a number of successful events, two key publications have meanwhile come out: one on the status of prevention and one analysing the healthcare situation for diabetics in Germany. All people interested in diabetology are invited to join in and work with the NAFDM. 相似文献
30.
Hepatic gene downregulation following acute and subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 总被引:1,自引:0,他引:1
Bladimir J Ovando Chad M Vezina Barbara P McGarrigle James R Olson 《Toxicological sciences》2006,94(2):428-438
Chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been shown to lead to the development of hepatotoxicity and carcinogenicity in the liver of female rats. In this study, we investigated hepatic gene downregulation in response to acute and subchronic TCDD exposure. We identified 61 probes which exhibited a downregulation of twofold or greater following subchronic (13 weeks) exposure to TCDD. Comparative analysis of the hepatic expression of these 61 probes was conducted with rats subchronically exposed to PeCDF, PCB126, PCB153, and a mixture of PCB126 and PCB153. PCB153 produced little or no alteration in these probes, while the binary mixture mimicked most closely the downregulation observed with TCDD. To discern if the repression of genes within this probe set occur as a primary response to TCDD exposure, we analyzed the early responsiveness of 11 genes at 6, 24, and 72 h following a single exposure to TCDD. We observed early repression of the 11 genes within this early time course, indicating that the repression of this subset of genes occurs as a primary response to TCDD exposure and not as a secondary response to 13 weeks of subchronic treatment. In addition, the gender, species, and AhR dependence of these responses were also investigated. Gender- and species-dependent repression was observed within this subset of genes. Furthermore, utilizing AhR knockout mice, we were able to determine the AhR-dependent downregulation of seven of 11 genes. Together these results assist efforts to understand the multitude of effects imposed by TCDD and AhR ligands on gene expression. 相似文献