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141.
Objective. To evaluate the results of operative treatment of spinal fracture-dislocation without neumlogic deficits. Metods. Eighteen patients with spinal fracture-dislocation were neurologically intact at the time of injury, and all were treated operatively. The fracture sites were:8 cases in cervical spine, 3 cases in thoracic spine, and 7 cases in lumbar spine. Eight patients with cervical injuries had variant degrees of forward slide and kyphotic deformity. Of the 10 thoracic and lumbar fractures, one had lateral dislocation, 4 cases with kyphotic deformities, 5 cases withspinal canal compromise averaged 50% (ranging from 40% to 70% ).Results. The aveiage period of follow-up was 4.4 years with a range of 11 months to 13 years. All the patients returned to full-time work. No patient developed neurologic deterioration. Kyphotic deformity was corrected in the 4 cases, and no progressive kyphosis was noted. There was no operation-related complication. The averaged post-opera-five hospitalization time was 13 days. Conclusions. Despite the rare incidence of spinal fracture-dislocation without neurologic deficits, we suggested that kind of fracture be considered unstable fracture because of its potential risk of delayed neurologic deterioration and kyphotic deformity, and be treated operatively to restore the sagittal alignment and the stability of the spine. 相似文献
142.
目的:探讨妊娠早期人巨细胞病毒(HCMV)感染和妇女自然流产的关系。方法:采用ELISA和PCR分别为40例自然流产妇女和40例人工流产妇女和血清中人巨细胞病毒IgM抗体(HCMV-IgM)胎盘组织中人巨细胞病毒核酸(HCMV-DNA)进行检测。结果自然流产组妇女HCMV-IgM检出率为55%(22/40),人工流产组妇女为25%(10/40),自然流产组妇女胎盘组织HCMV-DNA检出率为10% 相似文献
143.
Journal of Digital Imaging - Although medical imaging is frequently used to diagnose diseases, in complex diagnostic situations, specialists typically need to look at different modalities of image... 相似文献
144.
人原发性肝细胞癌核基质蛋白的研究 总被引:6,自引:2,他引:4
目的比较正常肝与原发性肝细胞癌(HCC)核基质蛋白的异同,观察是否有HCC特异性核基质蛋白的存在。方法用双向电泳方法比较了3例正常肝和8例HCC核基质蛋白成分。结果正常肝和HCC的核基质蛋白组成极为相似,但在HCC中发现至少有4个HCC的特异性核基质蛋白。其中以分子量为62000、等电点为5.3的蛋白最具代表性,它存在于所研究的8例HCC中。其余3个HCC特异性蛋白亦存在于大多数HCC中。3例正常肝组织中未见有这4个HCC特异性核基质蛋白。结论HCC确实有HCC特异性核基质蛋白的存在,它的发现可能会为HCC的发生、发展、发病机理的研究提供一个新途径。 相似文献
145.
目的评价B超对肺癌急症的快速鉴别诊断价值。方法应用B超诊断肺癌急症35例,其中有中央型右上肺癌肿块压迫引起的上腔静脉综合征(SVC)5例,探查取胸骨右缘第2、3肋间;中大量心包积液伴亚急性心包填塞症10例,包括心肌与心包转移癌致急性出血性心包积液2例,探查取心前区及左腋前线第5、6肋间;恶性胸腔大量积液20例,探查位于两侧背部膈上。介入性治疗,B超定位穿刺抽液并腔内注入中药榄香烯乳,配合临床化疗药物、输血等综合治疗。结果在4周内急症得到暂时缓解者占82.8%,稳定占8.5%,无效占8.5%。结论简便、可重复性的超声诊断及时、可靠,并可提供疗效参考依据,证实榄香烯乳对控制急性心肌心包出血有特效,起乳剂微栓止血作用。对部分包裹性胸腔积液无效。B超对SVC诊断有一定局限性。 相似文献
146.
LEVIER DAVID G.; MCCAY J. ANN; STERN MALVIN L.; HARRIS LOUIS S.; PAGE DENNIS; BROWN RONNETTA D.; MUSGROVE DEBORAH L.; BUTTERWORTH LEON F.; WHITE KIMBER L. JR.; MUNSON ALBERT E. 《Toxicological sciences》1994,22(4):525-542
This study was undertaken to investigate a number of immuneparameters which may be compromised with exposure to morphinesulfate. Mice were implanted subcutaneously with 8-, 25-, or75-mg morphine sulfate pellets. Placebo pellets of identicalmakeup to the 75-mg morphine pellet (without morphine of course)were used as a control. Twenty-four hours after implantationof a 75-mg morphine pellet, blood levels reached a peak of 1610ng/ml. Corticosterone increased in parallel with morphine andreached a peak level of 966 ng/ml 24 hr after implantation.The dose response of morphine to increase corticosterone, however,was fiat. The weight of the lymphoid organs, spleen and thymus,and the liver were significantly reduced in the morphine-treatedgroups. Morphine treatment was associated with an increase inserum albumin, SGPT, BUN, and alkaline phosphatase indicativeof hepatic damage. In contrast to increased serum proteins,the C3 component of complement was reduced in a dose-dependentmanner. Leukocyte number in the peripheral blood was significantlyreduced, while erythro-cyte number and hematocrit were bothincreased. The number of B cells and T cells was decreased inmorphine-treated animals. However, the percentage of T cellsrelative to B cells was increased. The primary IgM antibodyresponse to the T-depen-dent antigen, sheep red blood cells,was decreased. Natural killer cell activity was reduced in responseto morphine, as was the phagocytic capacity of Kupffer cells.Host-resistance models of Listeria monocytogenes or Streptococcuspneumoniae showed an increased resistance following administrationof morphine. This increased host resistance, however, was notdue to an increase in antimicrobial action of sera obtainedfrom mice treated with morphine. The majority of morphine'seffects on the immune system exhibited a flat dose response,suggesting that these effects may be mediated secondarily throughcorticosterone. 相似文献
147.
GOLDEY ELLEN S.; O'CALLAGHAN JAMES P.; STANTON MARK E.; BARONE STAN JR.; CROFTON KEVIN M. 《Toxicological sciences》1994,23(3):447-464
Testing procedures for identification of potential developmentalneurotoxicants were evaluated using two prototypical developmentalneurotoxicants, methylazoxymethanol (MAM) and methylmercury(MeHg). Evaluation of offspring of LongEvans rats incorporatedassessments of developmental toxicity, neurochemistry, histology,and behavior, with most testing being completed near weaning.A number of endpoints in the testing strategy were sensitiveto the effects of prenatal exposure to MAM [30 mg/kg on GestationDay (GD) 15]: (1) MAM caused reduced neonatal body weights butdid not effect viability or postnatal survivorship; (2) measurementof total and regional brain weight and histological analysisshowed that a number of regions, the cortex and hippocampusin particular, were affected by MAM exposure; (3) an assay forglial fibrillary acidic protein (GFAP) showed that the concentrationof this protein was significantly increased in the cortex andhippocampus of treated offspring; (4) a T-maze delayed-alternationprocedure indicated that MAM-treated pups were slower in theacquisition phase of the task relative to control pups; (5)motor activity testing revealed hyperactivity in treated offspringthat persisted into adulthood; and (6) acoustic startle proceduresrevealed reduced startle amplitudes in preweanlings. Few endpointswere significantly affected by prenatal MeHg exposure (1, 2,or 4 mg/kg on GD 615). High fetal and neonatal mortalityand lower neonatal body weights were detected at the highestdose of MeHg. Although minimal effects of MeHg may reflect arelative insensitivity of the test species and/or the test methods,the combined results from both chemicals suggest that some proceduresnot currently required in the developmental neurotoxicity guidelinemay be useful in hazard identification, and further evaluationwith other chemicals, species, strains, and/or exposure paradigmsmay be warranted. 相似文献
148.
Absorption, Metabolism, and Excretion of N,N-Diethyl-m-toluamide Following Dermal Application to Human Volunteers 总被引:1,自引:0,他引:1
SELIM SAMI; HARTNAGEL RALPH E. JR.; OSIMITZ THOMAS G.; GABRIEL KARL L.; SCHOENIG GERALD P. 《Toxicological sciences》1995,25(1):95-100
The absorption, metabolism, and excretion of N,N-diethyl-m-toluamide(DEET) in male human volunteers following dermal applicationof |14C|DEET was studied. DEET was applied to two groups ofsix volunteers either as the undiluted technical grade materialor as a 15% solution in ethanol. The material was applied overa 4 x 6-cm area on the volar surface of the forearm and wasleft in contact with the skin for 8 hr, then rinsed off theskin. Application sites also were tape stripped at 1, 23, and45 hr after rinsing. Serial blood samples and all urine andfeces were collected for 5 days after application. Aliquotsof these materials were analyzed for total radioactivity inorder to define absorption and excretion patterns. Urine samplesalso were analyzed by HPLC to characterize the metabolic profileand/or to identify metabolites. Absorption of DEET as evidencedby plasma radioactivity occurred within 2 hr after dose application.Elimination of radioactivity from plasma was rapid and quantifiablelevels of radioactivity were observed in plasma for only 4 hrafter the end of the 8-hr exposure period. Urine was the principalroute of excretion of radioactivity and accounted for an averageof 5.61 and 8.33/ of the applied dose in the undiluted DEETand 15/ DEET in ethanol groups, respectively. Excretion of radioactivityin the feces was less than 0.08/ of the applied dose in bothgroups. DEET did not accumulate in the superficial layers ofthe skin as evidenced by low amounts of radioactivity in thetape strippings. The major fraction of the applied radioactivitywas recovered in the skin rinses. Absorbed DEET was completelymetabolized and six major metabolites were observed in urine.Two major urinary metabolites tenta tively were identified.Based upon the percentage of applied dose recovered in the excreta,dermal absorption of DEET ranged from 3 to 8% with a mean of5.6/ in the volunteers applied undiluted technical grade DEET.The corresponding values for the volunteers applied 15/ DEETin ethanol were 4 to 14/ and 8.4/, respectively. 相似文献
149.
研究了田七洋参冲剂对小鼠抗应激能力,免疫功能和心血管系统的作用以及对大鼠血液系统的作用。结果表明,田七洋参冲剂可显著提高小鼠应激能力,明显增强小鼠的免疫功能,增强其抗心律失常能力,并能降低大鼠血液中红细胞的聚集度。 相似文献
150.
目的:探讨顺铂作用于卵巢癌细胞的作用机理。方法:通过电镜、光镜、流式细胞仪等方法观察顺铂诱导人亲代和耐药卵巢癌细胞COC1 、COC1/DDP凋亡,进行细胞周期分析及计算凋亡率。结果:顺铂引起细胞S期增多、S期细胞凋亡,COC1 、COC1/DDP细胞凋亡率不同。结论:顺铂药理机制之一是诱导细胞凋亡,耐药与凋亡减少有关。 相似文献