全文获取类型
收费全文 | 347篇 |
免费 | 25篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 24篇 |
妇产科学 | 7篇 |
基础医学 | 31篇 |
口腔科学 | 9篇 |
临床医学 | 17篇 |
内科学 | 53篇 |
皮肤病学 | 12篇 |
神经病学 | 67篇 |
特种医学 | 7篇 |
外科学 | 67篇 |
综合类 | 6篇 |
一般理论 | 3篇 |
预防医学 | 15篇 |
眼科学 | 7篇 |
药学 | 25篇 |
中国医学 | 4篇 |
肿瘤学 | 10篇 |
出版年
2024年 | 2篇 |
2023年 | 3篇 |
2022年 | 8篇 |
2021年 | 10篇 |
2020年 | 8篇 |
2019年 | 9篇 |
2018年 | 15篇 |
2017年 | 12篇 |
2016年 | 15篇 |
2015年 | 8篇 |
2014年 | 11篇 |
2013年 | 12篇 |
2012年 | 28篇 |
2011年 | 32篇 |
2010年 | 22篇 |
2009年 | 14篇 |
2008年 | 23篇 |
2007年 | 19篇 |
2006年 | 17篇 |
2005年 | 14篇 |
2004年 | 13篇 |
2003年 | 11篇 |
2002年 | 5篇 |
2001年 | 8篇 |
2000年 | 9篇 |
1999年 | 5篇 |
1998年 | 4篇 |
1997年 | 1篇 |
1996年 | 3篇 |
1995年 | 1篇 |
1993年 | 1篇 |
1992年 | 5篇 |
1991年 | 2篇 |
1990年 | 3篇 |
1989年 | 6篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1984年 | 1篇 |
1982年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1970年 | 1篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1965年 | 1篇 |
1947年 | 1篇 |
排序方式: 共有374条查询结果,搜索用时 15 毫秒
11.
Phenotypic comparison of two Scottish families with mutations in different genes causing autosomal dominant nocturnal frontal lobe epilepsy 总被引:3,自引:0,他引:3
McLellan A Phillips HA Rittey C Kirkpatrick M Mulley JC Goudie D Stephenson JB Tolmie J Scheffer IE Berkovic SF Zuberi SM 《Epilepsia》2003,44(4):613-617
PURPOSE: Mutations in genes coding for the alpha 4 and beta 2 subunits of the neuronal nicotinic acetylcholine receptor receptor (CHRN) are known to cause autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). Here we examined the phenotypes in two families, from the same ethnic and geographic backgrounds, with ADNFLE as a result of mutations in these two different subunits of CHRN. METHODS: All affected family members underwent a detailed clinical evaluation and review of available EEG, neuroimaging, and videotapes of seizures. The molecular study of family D is reported here; family S has a previously reported mutation in the beta 2 subunit of CHRN. RESULTS: A total of 16 individuals with ADNFLE were identified in the two families. In both families, seizure semiology, age at seizure onset, and the natural history of the seizure disorder was similar. Intrafamilial variation in terms of severity of epilepsy syndrome was present in both families. A significant number of individuals from each family had a history of psychological problems. The molecular study of family D revealed a Ser248Phe mutation in the alpha 4 subunit of CHRN. CONCLUSIONS: The epilepsy phenotype is not distinguishable in the two families who have ADNFLE as a result of mutations in genes coding for different CHRN subunits. This is likely to be due to the similar functional consequences of each mutation on the CHRN receptor. 相似文献
12.
13.
14.
Horrocks IA Nechay A Stephenson JB Zuberi SM 《Archives of disease in childhood》2005,90(12):1283-1287
Aims: To describe a large series of children with anoxic-epileptic seizures (AES)—that is, epileptic seizures induced by syncopes. Methods: Retrospective case-note review in a tertiary paediatric neurology unit. For all 27 children seen with a definite diagnosis of AES between 1972 and 2002, a review of clinical histories, videotapes, and EEG/ECG studies was undertaken. Main outcome measures were: age of onset, frequency and type of syncopes; age of onset and frequency of AES; type and duration of induced epileptic seizures; effect of treatment of syncopal and epileptic components. Results: Median age of onset of syncopes was 8 months (range 0.2–120), frequency 2 in total to 40/day, median total ~200. Syncopes were predominantly reflex asystolic (RAS), prolonged expiratory apnoea (cyanotic breath-holding spells), or of mixed or uncertain origin; there was one each of ear piercing and hair grooming vasovagal syncope and one of compulsive Valsalva. Median age of onset of AES was 17 months (range 7–120), frequency from total 1 to 3/day, median total 3. The epileptic component was almost always bilateral clonic; three had additional epilepsy, one each with complex partial seizures, myoclonic absences, and febrile seizures plus. Median duration of epileptic component was 5 minutes (range 0.5–40, mean 11). Cardiac pacing prevented RAS in two patients: most other anti-syncope therapies were ineffective. Diazepam terminated the epileptic component in 6/8. Valproate or carbamazepine abolished AES in 5/7 without influencing syncope frequency. Conclusions: Although uncommon compared with simple syncopes, syncope triggered epileptic seizures (AES) are an important treatable basis of status epilepticus. 相似文献
15.
The movement disorders of Coffin-Lowry syndrome 总被引:2,自引:0,他引:2
Stephenson JB Hoffman MC Russell AJ Falconer J Beach RC Tolmie JL McWilliam RC Zuberi SM 《Brain & development》2005,27(2):108-113
Coffin-Lowry syndrome (CLS) is an X-linked semi-dominant condition with learning difficulties and dysmorphism caused by mutations in the gene RSK2. Originally, epilepsy was reported as a feature. We and others have since described predominantly sound-startle induced drop attacks that have been labelled 'cataplexy', abnormal startle response and hyperekplexia. We sought to clarify why there should be controversy over the type of paroxysmal events. Review of the literature and our patients confirmed that each centre had studied only a small numbers of individuals (mean = 2). The type of movement disorder varied both with age and between individuals. One individual might have more than one movement disorder. One of our adult patients had several types of movement disorder and epilepsy that merged seamlessly: there was true cataplexy triggered by telling a joke, something close to cataplexy ('cataplexy') triggered by sound-startle, a predominantly hypertonic reaction varying from hyperekplexia to a more prolonged tonic reaction resembling startle epilepsy, and true unprovoked epileptic seizures. In the large database of the Coffin-Lowry Syndrome Foundation family support group, 34 of 170 (20%) individuals with CLS and known age had 'drop attacks' and an additional 9 (5%) of these had additional epileptic seizures. The onset of such events was usually after age 5 years, prevalence peaking at 15-20 years (27%). Many became wheelchair bound as a result. This unique combination of more than one non-epileptic movement disorder and epilepsy deserves further semiological and genetic study both for the patients with CLS and for the wider implications. 相似文献
16.
Macleod S Mallik A Tolmie JL Stephenson JB O'Regan ME Zuberi SM 《Brain & development》2005,27(2):118-124
Chromosome imbalances are associated with epilepsy but electro-clinical phenotypes are lacking for all but the best-known syndromes. Scanty information is contained in older case reports published in genetics journals that describe children with severe patterns of malformation and dysmorphism. From a larger series of children with chromosome abnormalities and epilepsy, we identified 10 patients with associated dysmorphism without malformation. Electro-clinical features are described for each patient. We found that these patients are at greater risk of delayed diagnosis, particularly when there are no learning difficulties at the onset of epilepsy, as in ring chromosome 20 syndrome. Chromosome studies should be ordered on all children with learning difficulties and epilepsy, and on children with atypical non-lesional epilepsy, even in the absence of learning difficulties or dysmorphism. 相似文献
17.
Although global and national strategies to promote a human rights-based approach to HIV/AIDS have been in place for many years, these strategies appear to have had little impact at the local level, where human rights violations are commonplace. In this article, Peris Jones and Farhana Zuberi summarize findings from a recently completed research project, the Tswelopele study, in South Africa. The study documented human rights violations in three areas: privacy and disclosure; informed consent and HIV testing; and access to health-care services. The article describes these violations and explores why discrimination still occurs at the local level. The authors conclude that remedial action is required, targeting the persons and institutions that shape attitudes and beliefs, including churches, workplaces, schools, and the media; and that this action needs to be complemented by wider public education, activism at hospitals and in the courts and, more generally, fulfillment of socio-economic rights. 相似文献
18.
19.
20.