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61.
Gontrand Lopez-Nava Miguel Angel Rubio Susana Prados Gabriela Pastor Mar Rodriguez Cruz Ena Companioni Andres Lopez 《Obesity surgery》2011,21(1):5-9
Background
The BioEnterics® Intragastric Balloon (BIB®) is a well-established device for temporary treatment in morbidly obese patients. The aim of this study is the evaluation, in a population of 714 consecutive outpatient setting cases, BIB® results in terms of weight loss and comorbidity change.Methods
BIB® was positioned in all cases after diagnostic endoscopy. The device was inflated under direct endoscopic vision with saline solution (600–700 ml) and methylene blue (10 ml). Intubation was carried out in patients with body mass index (BMI)?>?40 kg/m2 affected by sleep apnea or chronic obstructive pulmonary disease. After 6 months, balloon removal was carried out, and patients were discharged with drug therapy and 1,000 kcal diet. More than 100 patients underwent a second consecutive balloon positioning. One month from the removal of the first BIB, patients were given a second BIB. Patients were followed up weekly. Mortality, complications and their treatment, postplacement symptoms, comorbidities, BMI, percentage of excess BMI loss (%EBL), and percentage of excess weight loss (%EWL) were considered. Data are expressed as mean?±?standard deviation.Results
From June 1, 2005, to May 31, 2007, 714 patients underwent BIB® placement (143 males/571 females; mean age, 38.4?±?16.1; mean BMI, 37.6?±?5.7 kg/m2; mean EW, 56.3?±?27.1 kg). After 6 months, mean BMI was 31.1?±?7.2, mean %EWL was 41.6?±?21.8, mean BMI loss was 6.5?±?12.7, and mean %EBL was 44.5?±?22.6. Of 714 patients, 112 underwent a second BIB placement. At the time of the second balloon placement, mean BMI was 32.9?±?6.7 kg/m2; range was 31–51. After the second balloon removal, mean BMI was 30.3?±?7.2.Conclusions
BIB® treatment is a safe and effective procedure for weight reduction, without mortality and with very low morbidity rates even in nonhospitalized patients. A second balloon can also be positioned without difficulties, achieving good results after 12 months of treatment.62.
Bujons Tur A Errando Smet C Prados Saavedra M Báez C Arañó Bertrán P Gutiérrez Ruiz C Villavicencio Mavrich H 《Actas urologicas espa?olas》2007,31(1):43-48
The Remeex system it's a sling with regulable tension created for the surgical correction of the female urinary incontinente. The system contains a varitensor central part of the protesis that regulates the tension of the uretra. The screwdriver that acts against the varitensor to the modify the tension under the uretra in the postop inmediately or time after also. We present a clinic case of a patient with diagnostic of urinary stress incontinence and the surgical treatment with advantages against others kind of systems used for incontinence treatment at this time. 相似文献
63.
Antoni Sicras‐Mainar PhD Soledad Velasco‐Velasco MPh Ruth Navarro‐Artieda MD Alba Aguado Jodar MD Oleguer Plana‐Ripoll MD Eduardo Hermosilla‐Pérez MD Bonaventura Bolibar‐Ribas PhD Alejandra Prados‐Torres PhD Concepción Violan‐Fors PhD 《Journal of evaluation in clinical practice》2013,19(2):267-276
Objective The study aims to obtain the mean relative weights (MRWs) of the cost of care through the retrospective application of the adjusted clinical groups (ACGs) in several primary health care (PHC) centres in Catalonia (Spain) in routine clinical practice. Methods This is a retrospective study based on computerized medical records. All patients attended by 13 PHC teams in 2008 were included. The principle measurements were: demographic variables (age and sex), dependent variables (number of diagnoses and total costs), and case‐mix or co‐morbidity variables (International Classification of Primary Care). The costs model for each patient was established by differentiating the fix costs from the variable costs. In the bivariate analysis, the Student's t, analysis of variance, chi‐squared, Pearson's linear correlation and Mann–Whitney–Wilcoxon tests were used. In order to compare the MRW of the present study with those of the United States (US), the concordance [intraclass correlation coefficient (ICC) and concordance correlation coefficient (CCC)] and the correlation (coefficient of determination: R2) were measured. Results The total number of patients studied was 227 235, and the frequentation was 5.9 visits/habitant/year) and with a mean diagnoses number of 4.5 (3.2). The distribution of costs was €148.7 million, of which 29.1% were fixed costs. The mean total cost per patient/year was €654.2 (851.7), which was considered to be the reference MRW. Relationship between study‐MRW and US‐MRW: ICC was 0.40 [confidential interval (CI) 95%: 0.21–0.60] and the CCC was 0.42 (CI 95%: 0.35–0.49). The correlation between the US MRW and the MRW of the present study can be seen; the adjusted R2 value is 0.691. The explanatory power of the ACG classification was 36.9% for the total costs. The R2 of the total cost without considering outliers was 56.9%. Conclusions The methodology has been shown appropriate for promoting the calculation of the MRW for each category of the classification. The results provide a possible practical application in PHC clinical management. 相似文献
64.
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66.
Jordi Castellsague Susana Perez‐Gutthann Brian Calingaert Christine Bui Cristina Varas‐Lorenzo Alejandro Arana Alexandra Prados‐Torres Beatriz Poblador‐Plou Francisca Gonzalez‐Rubio Maria Giner‐Soriano Albert Roso‐Llorach Marie Linder Anna Citarella Oliver Scholle Tilo Blenk Edeltraut Garbe 《Pharmacoepidemiology and drug safety》2017,26(6):615-624
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69.
J A Marchal C Melguizo J Prados A E Aránega J A Gómez J Campos M A Gallo A Espinosa N Arena A Aránega 《Japanese journal of cancer research》2000,91(9):934-940
The in vitro study of mechanisms involved in drug-induced maturation has made it possible to use differentiation-based therapy in clinical practice. The goal of this new therapy is the development of specific agents to induce cancer cells to stop proliferating and express characteristics of normal cells. Recently, by structural modifications of 5-fluorouracil (5-FU), we synthesized a new pyrimidine acyclonucleoside-like compound, 1-?[3-(3-chloro-2-hydroxypropoxy)-1-methoxy]propyl?-5-fluorouracil (QF-3602), which showed in rhabdomyosarcoma cells a low toxicity and time-dependent growth inhibition. In this work, we compared the degree of myogenic differentiation of RD rhabdomyosarcoma (RMS) cells after treatment with QF-3602 and 5-FU. Scanning and transmission electron microscopy (SEM and TEM) and immunocytochemical analyses showed that QF-3602 induced the appearance of myofilaments along the myotube-like giant RD cells, an increase in fibronectin and a decrease in vimentin expression. In contrast, only minor changes were observed with 5-FU. Moreover, polymerase chain reaction (PCR) analyses showed that QF-3602 did not induce overexpression of the mdr 1 gene, a resistance mechanism that frequently appears in classical cytotoxic therapy in these tumors. Compounds obtained by structural modifications of 5-FU may be useful in differentiation therapy as a new approach to the treatment of RMS. 相似文献
70.
Juan Antonio Marchal Consolación Melguizo Jose Prados Amelia Eva Aránega Jose Antonio Gómez Joaquin Campos Miguel Angel Gallo Antonio Espinosa Nicolo Arena Antonia Aránega 《Cancer science》2000,91(9):934-940
The in vitro study of mechanisms involved in drug-induced maturation has made it possible to use differentiation-based therapy in clinical practice. The goal of this new therapy is the development of specific agents to induce cancer cells to stop proliferating and express characteristics of normal cells. Recently, by structural modifications of 5-fluorouracil (5-FU), we synthesized a new pyrimidine acyclonucleoside-like compound, 1-{[3-(3-chloro-2-hydroxypropoxy)-1-methoxy]propyl}-5-fluorouracil (QF-3602), which showed in rhabdomyosarcoma cells a low toxicity and time-dependent growth inhibition. In this work, we compared the degree of myogenic differentiation of RD rhabdomyosarcoma (RMS) cells after treatment with QF-3602 and 5-FU. Scanning and transmission electron microscopy (SEM and TEM) and immunocytochemical analyses showed that QF-3602 induced the appearance of myofilaments along the myotube-like giant RD cells, an increase in fibronectin and a decrease in vimentin expression. In contrast, only minor changes were observed with 5-FU. Moreover, polymerase chain reaction (PCR) analyses showed that QF-3602 did not induce overexpression of the mdr 1 gene, a resistance mechanism that frequently appears in classical cytotoxic therapy in these tumors. Compounds obtained by structural modifications of 5-FU may be useful in differentiation therapy as a new approach to the treatment of RMS. 相似文献