全文获取类型
收费全文 | 394篇 |
免费 | 38篇 |
国内免费 | 13篇 |
专业分类
儿科学 | 29篇 |
妇产科学 | 3篇 |
基础医学 | 49篇 |
口腔科学 | 4篇 |
临床医学 | 40篇 |
内科学 | 74篇 |
皮肤病学 | 7篇 |
神经病学 | 56篇 |
特种医学 | 85篇 |
外科学 | 22篇 |
综合类 | 10篇 |
一般理论 | 1篇 |
预防医学 | 13篇 |
眼科学 | 1篇 |
药学 | 26篇 |
肿瘤学 | 25篇 |
出版年
2023年 | 2篇 |
2022年 | 3篇 |
2021年 | 9篇 |
2020年 | 2篇 |
2018年 | 6篇 |
2017年 | 3篇 |
2016年 | 8篇 |
2015年 | 8篇 |
2014年 | 11篇 |
2013年 | 14篇 |
2012年 | 5篇 |
2011年 | 5篇 |
2010年 | 8篇 |
2009年 | 13篇 |
2008年 | 11篇 |
2007年 | 16篇 |
2006年 | 6篇 |
2005年 | 9篇 |
2004年 | 8篇 |
2003年 | 8篇 |
2002年 | 6篇 |
2001年 | 6篇 |
2000年 | 13篇 |
1999年 | 17篇 |
1998年 | 24篇 |
1997年 | 24篇 |
1996年 | 25篇 |
1995年 | 25篇 |
1994年 | 14篇 |
1993年 | 9篇 |
1992年 | 8篇 |
1991年 | 5篇 |
1990年 | 5篇 |
1989年 | 12篇 |
1988年 | 11篇 |
1987年 | 12篇 |
1986年 | 14篇 |
1985年 | 13篇 |
1984年 | 3篇 |
1983年 | 7篇 |
1982年 | 4篇 |
1981年 | 6篇 |
1980年 | 5篇 |
1979年 | 4篇 |
1978年 | 3篇 |
1976年 | 7篇 |
1975年 | 2篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1965年 | 1篇 |
排序方式: 共有445条查询结果,搜索用时 15 毫秒
101.
Blood cells participate in the fibrinolytic response to tissue-type plasminogen activator 总被引:1,自引:0,他引:1
Exercise and venous occlusion stimulate fibrinolysis. In addition to increased concentrations of tissue-type plasminogen activator (tPA) and increased plasmin-mediated fibrinolysis in plasma, these stimuli produce additional cellular-phase activity in blood that is of the same magnitude as the plasma response. To determine whether tPA alone, rather than other consequences of these stimuli, is responsible for the cellular response, the in vitro effects of tPA on whole blood, plasma, and calculated cellular-phase (whole blood minus plasma) activities were determined by solid-phase radiofibrin assay on venous blood from ten normal subjects (seven men, three women). At tPA concentrations encompassing physiological and therapeutic levels (5 to 100 ng/mL; 0.7 to 14 IU/mL), increments in whole blood were consistently in excess of those in companion plasma and represented increased cellular-phase activity equivalent in magnitude to the well-known increase in plasma activity. Fibrinolytic activity produced by 10 to 20 ng tPA/mL (1.4 to 2.8 IU/mL) was consistently detected in whole blood and plasma by 60 minutes, with higher concentrations (100 ng or 14 IU tPA/mL) detectable after a five-minute assay in all subjects. Thus, tPA alone, without invoking fibrinolytic factors extraneous to blood or other effects of exercise or venous occlusion, accounts for both cellular and plasma responses to these stimuli. The considerable cellular response, the mechanism of which remains to be elucidated, may constitute a determinant of individual therapeutic responsiveness to tPA. 相似文献
102.
HK Ulatowska G Streit Olness MW Keebler KE Goins 《International journal of speech-language pathology》2013,15(1):3-14
This investigation explores the discourse devices associated with high-quality personal narratives. The study examined normative characteristics of 11 high-quality personal narratives of a frightening experience identified (from a larger set of 72 narratives) for their effectiveness in engaging the audience. Lay ratings and an ethnographic interview with seven of the excellent storytellers further characterized the stories and validated their selection. Narratives of both African Americans and Caucasians were represented, and were similar in nature. The excellent narratives were longer, conveyed more fearful topics, and were more dramatic than average narratives. Drama was achieved through direct speech, prosodic shifts, voice changes, inclusion of multiple characters, repetition, and syntactic and semantic parallelism. Illustrative narrative excerpts are provided. This study illustrates the potential in pairing holistic and analytical approaches to narrative analysis. 相似文献
103.
Lydian Veldhuis Mirjam K Struijk Willemieke Kroeze Anke Oenema Carry M Renders Anneke MW Bulk-Bunschoten Remy A HiraSing Hein Raat 《BMC public health》2009,9(1):177
Background
The prevalence of overweight and obesity in children has at least doubled in the past 25 years with a major impact on health. In 2005 a prevention protocol was developed applicable within Youth Health Care. This study aims to assess the effects of this protocol on prevalence of overweight and health behaviour among children. 相似文献104.
GL Ray KE Baidoo KJ Wong M Williams K Garmestani MW Brechbiel DE Milenic 《British journal of pharmacology》2009,157(8):1541-1548
Background and purpose:
The studies described here are the first to evaluate the in vitro and in vivo properties of 111In-CHX-A″-panitumumab for radioimmunotherapy (α- and β--emitters) and radioimmunoimaging (single photon emission computed tomography and positron emission tomography).Experimental approach:
Twenty-seven human carcinoma cell lines were analysed for expression of epidermal growth factor receptors by flow cytometry. Panitumumab was conjugated with CHX-A″-DTPA (diethylenetriamine-pentaacetic acid) and radiolabelled with 111In. Immunoreactivity of the CHX-A″-DTPA-panitumumab and 111In-CHX-A″-DTPA-panitumumab was evaluated by radioimmunoassays. Tumour targeting was determined in vivo by direct quantitation of tumour and normal tissues and by γ-scintigraphy.Key results:
For 26 of 27 human tumour cell lines, 95% of the cells expressed epidermal growth factor receptors over a range of intensity. Immunoreactivity of panitumumab was retained after modification with CHX-A″-DTPA. Radiolabelling of the immunoconjugate with 111In was efficient with a specific activity of 19.5 ± 8.9 mCi·mg−1 obtained. Immunoreactivity and specificity of binding of the 111In-panitumumab was shown with A431 cells. Tumour targeting by 111In-panitumumab was demonstrated in athymic mice bearing A431, HT-29, LS-174T, SHAW or SKOV-3 s.c. xenografts with little uptake observed in normal tissues. The 111In-panitumumab was also evaluated in non-tumour-bearing mice. Pharmacokinetic studies compared the plasma retention time of the 111In-panitumumab in both non-tumour-bearing and A431 tumour-bearing mice. Tumour targeting was also visualized by γ-scintigraphy.Conclusions and implications:
Panitumumab can be efficiently radiolabelled with 111In with high labelling yields. Based on the efficiency in tumour targeting and low normal tissue uptake, panitumumab may be an effective targeting component for radioimmunodiagnostic and radioimmunotherapeutic applications. 相似文献105.
Wessels MW, Willems PJ. Genetic factors in non‐syndromic congenital heart malformations. The genetic defect in most patients with non‐syndromic congenital heart malformations (CHM) is unknown, although more than 40 different genes have already been implicated. Only a minority of CHM seems to be due to monogenetic mutations, and the majority occurs sporadically. The multifactorial inheritance hypothesis of common diseases suggesting that the cumulative effect of multiple genetic and environmental risk factors leads to disease, might also apply for CHM. We review here the monogenic disease genes with high‐penetrance mutations, susceptibility genes with reduced‐penetrance mutations, and somatic mutations implicated in non‐syndromic CHM. 相似文献
106.
JC Ingram MW Woolridge RJ Greenwood L McGrath 《Acta paediatrica (Oslo, Norway : 1992)》1999,88(5):493-499
Previous attempts to show a quantitative relationship between maternal hormone levels and early milk output have used small sample sizes and simple correlations. Women of mixed parity and similar socio-economic status and education were recruited to a study using multivariate analysis to look for these associations. Hormone levels (oestradiol, progesterone, prolactin and thyrotropin (TSH)) were determined for 91 mothers at four time points (ante- and postnatally) from finger-prick blood spots by fluoro-immunoassay. Milk output at 1 and 4 weeks was determined from 24-h test weighings. Parity was found to be the most significant factor affecting breast milk volume at 1 wk postpartum (multiparous women delivered 142 ml more milk in 24 h than primiparous women). Total time spent feeding had a strong association with breast milk volume, with increasing time having a negative effect. Multiple regression analysis, controlling for parity and time spent feeding, showed a positive association of milk output at 1 wk with antenatal progesterone and antenatal prolactin levels. At 4 wk, higher postpartum oestradiol levels had a negative association and antenatal progesterone levels a positive association with milk output. This study demonstrates that there are quantitative associations between antenatal maternal hormone levels and breast milk output in the early postnatal period. 相似文献
107.
Conjugated linoleic acid and the control of cancer and obesity 总被引:3,自引:0,他引:3
The effects of conjugated linoleic acid (CLA) in animals are reviewed. In
most of the CLA preparations that have been investigated to date for
biological activity, two CLA isomers are present in about equal
concentrations: cis-9,trans-11 CLA, and trans-10,cis-12 CLA. The occurrence
of these isomers in foods and their production by rumen microorganisms are
discussed. Potential mechanisms of action as regards the effects of CLA on
cancer and body composition are reviewed, including recent evidence that
body composition changes are produced by the trans-10,cis-12 CLA isomer.
Evidence is presented indicating that CLA may modulate cellular response to
tumor necrosis factor-alpha (TNF- alpha). The mechanistic implications of
this finding are considered.
相似文献
108.
N Warnasuriya MA Downham A Skelton MW Turner JF Soothill 《Archives of disease in childhood》1980,55(11):876-878
36 parents of infants who had died suddenly did not differ in frequency of atopic symptoms, immediate skin tests, IgE, IgE antibody, immunoglobulin G, A, and M, or yeast opsonisation, from 36 matched controls, although atopy was common (about half had atopy in both groups. 相似文献
109.
Fifty-one children with a bacteriologically proven urinary tract infection had both an intravenous urogram (IVU) and a micturating cystogram. The IVU was normal in 35. Only 6 of these children showed reflux in the cystogram, affecting 7 of the 70 ureters at risk. Since reflux on its own does not cause renal damage, which occurs only with super-added infection, detection of reflux is not important providing the urine is kept sterile. We suggest that cystography be deferred providing the IVU is normal until recurrent infections occur while under hospital care, and, with this policy this unpleasant and sometimes hazardous investigation could be avoided in many children with a single urinary tract infection. 相似文献
110.
R Krempien MW Muenter PE Huber S Nill H Friess C Timke B Didinger P Buechler S Heeger KK Herfarth A Abdollahi MW Buchler J Debus 《BMC cancer》2005,5(1):1-11