卟啉化合物的研究:取代四苯基卟啉与5-氟脲嘧啶共价相连化合物的合成及其抗癌活性

合成了3个取代四苯基卟啉与5-氟脲嘧啶以共价相连的化合物。通过用它们加光照对小鼠移植瘤生长的抑制作用、对小鼠癌细胞的杀伤效果及对小鼠耳指数的测定,初步结果显示,化合物1,2,3对癌细胞都有光敏毒杀效应,但1远较2和3显著。     

布地奈德都保短期加大剂量吸入治疗急性发作期儿童哮喘52例疗效观察

目的：观察哮喘急性发作期短期加大布地奈德都保用量与短期加用口服或静注糖皮质激素作疗效比较。方法：两组病例均应用常规剂量布地奈德都保,治疗组52例在急性发作期短期加用口服或静脉糖皮质激作比较。结果：两组病例的治疗总有效率均达100％,治疗半年后及治疗1年后的肺功能FEV1,FEF50％（呼气50％FVC时的流速）、PET经统计学处理无明显差异（P＞0．05）。结论：哮喘急性发作期短期加大布地奈德都保用量与短期加用口服或静注糖皮质激素可以取得相同效果。     

兔体内静脉输注乙酰普鲁卡因胺的药动学—药效学结合模型分析

用药动学-约效学结合模型,对ⅳ乙酰普鲁卡因胺(NAPA)后,进行了药代动力学和药效动力学分析。兔体内NAPA ⅳ后与静脉推注后的药动学参数基本一致;但效应按QT_c延长作为指标,其药效动力学的个别参数有显著性差异。输注后,NAPA的E_max,K_eo,S和EC₅₀分别为120±13.2ms,0.0182±0.007min^-1,2.26±0.93和6.31±0.71μg/ml;推注后,分别为53.6±2.5ms,0.061±0.017min^-1,2.19±0.39和6.21±1.74μg/ml。     

雷酚内酯的结构修正

雷公藤别名黄藤,系卫矛科植物雷公藤(Tripterygium wilfordii Hook.f.)。其根有舒筋活血,祛风湿,消肿止痛的功效,多用于类风湿关节炎的治疗。根皮中含有生物碱、甙、萜以及其它成分,其中多种二萜内酯成分有抗肿瘤活性和免疫     

苄普地尔与山莨菪碱合用对心肌缺血再灌注损伤的保护作用

卡普地尔与山莨菪碱合用对结扎大鼠冠脉左室支造成心肌缺血再灌注损伤的保护作用。两药同时合用可降低缺血再灌性心律失常发生率;明显提高复灌后心肌超氧物歧化酶活性及显著减轻心肌超微结构损伤。表明两药合用有协同作用,较单用苄普地尔或山莨菪碱疗效好。     

Analysis of SNP profiles in patients with major depressive disorder

The present study focused on 91 single-nucleotide polymorphisms (SNPs) in 21 candidate genes to find associations with major depressive disorder (MDD). In total, 160 healthy controls and 177 patients with MDD were studied. We applied arrayed primer extension (APEX) based genotyping technology followed by association and haplotype analysis. SNPs in CCKAR, DRD1, DRD2, and HTR2C genes showed nominally significant associations with MDD. None of these associations remained significant after adjustment for multiple testing. Haplotype analysis revealed CCKAR haplotypes to be associated with MDD (global p=0.004). More precisely, we found the GAGT haplotype to be associated with increased risk for MDD (OR 7.42, 95% CI 2.13-25.85, p=0.002). This haplotype effect remained significant after Bonferroni correction (p=0.04 after Bonferroni's adjustment). Altogether we were able to find some nominal associations, but due to small sample size these results should be taken as exploratory. However, the effect of GAGT haplotype on the CCKAR gene may be considered as increasing the risk for MDD.     

阿司匹林与埃索美拉唑合用较氯吡格雷减少高危患者再次溃疡出血的发生

问题：在有阿司匹林诱发溃疡出血史的患者中，用氯毗格雷预防溃疡出血复发，是否不次于小剂量阿司匹林加埃索美拉唑？[编者按]     

The hereditary pancreatitis gene maps to long arm of chromosome 7

Hereditary pancreatitis (HP) is an autosomal dominant disorder with incomplete penetrance characterized by recurring episodes of severe abdominal pain often presenting in childhood. Although this disorder has only been recently described, about 100 families have been documented worldwide. The pathophysiology of this disorder is unknown. Here, a large French family of 147 individuals (47 of whom were affected) from a four-generation kindred with HP has been examined and a genome segregation analysis of highly informative microsatellite markers has been performed. Linkage has been found between HP and six chromosome 7q markers. Maximal two point lod scores between HP and D7S 640, D7S 495, D7S 684, D7S 661, D7S 676 and D7S 688 were 4.00 (theta = 0.143), 5.85 (theta = 0.143), 4.91 (theta = 0.156), 8.58 (theta = 0.077), 8.28 (theta = 0.060), 4.40 (theta = 0.169), respectively. Multipoint linkage data combined with recombinant haplotype analysis indicated that the most likely order is: D7S 640-D7S 495-D7S 684-D7S 661-D7S 676-D7S 688, with the HP gene situated in the underlined region. As in all families reported in the literature, the clinical presentation of the disease is identical to the presentation of sporadic cases, one could expect that the knowledge of the HP gene could be a clue to pancreatitis in general. Based on its map position, this is the first step towards the positional cloning of the Hereditary Pancreatitis Gene (HPG).      

Anatomical study of five prenataly diagnosed sternopagus twins

Summary Among conjoined twins (1 out 50000 births), thoracopagus occurs most frequently and is generally lethal. Our anatomical study of five sets of sternopagus twins (3 female, 2 male) was performed to determine the ability of prenatal sonography to detect these anomalies. Autopsy in four cases revealed identical malformations: common sternum, single malformed heart, joined hepatic parenchyma, and a common small bowel leading to a cystic dilatation situated on the ileal segment at the end of the superior mesenteric artery. The diagnosis of conjoined twins was made in all cases by prenatal sonography at the mean time of 24.6 gestation weeks (range 19–34). The malformations detected by prenatal sonography were a single cardiac mass (all cases), joined hepatic parenchymas (3 cases), and an ileal cystic dilatation (1 case). Pregnancy was terminated in four cases. In one case cesarean delivery was performed, and the infants died 48 hours later. Prenatal sonography currently seems to be the best examination for diagnosis of sternopagus twins and the detection of lethal malformations thus allowing interruption of pregnancy.

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Etude anatomique de cinq jumeaux conjoints sternopages de diagnostic anté-natal

Résumé Les jumeaux conjoints représentent 1 pour 50000 naissances, les thoracopages sont les plus fréquents et présentent le plus souvent des malformations léthales. Une étude anatomique des malformations rencontrées chez les jumeaux conjoints sternopages a été effectuée dans le but d'évaluer l'intérêt de l'échographie anté-natale pour le diagnostic de ces malformations. Nous avons étudié anatomiquement cinq jumeaux conjoints (3 féminins, 2 masculins). Un examen nécropsique a été réalisé quatre fois, montrant dans tous les cas les mêmes malformations: sternum commun, coeur unique malformatif, union des parenchymes hépatiques, grèle commun aboutissant à une poche kystique située sur le segment iléal de l'intestin grèle, à la terminaison de l'artère mésentérique supérieure. Le diagnostic de jumeaux conjoints avait dans tous les cas été porté en anté-natal par les échographies, à un terme moyen de 26,6 semaines d'aménorrhée (extrèmes 21–26). Les malformations retrouvées par les échographies étaient: dans tous les cas une masse cardiaque unique, trois fois une union des parenchymes hépatiques, une fois une poche kystique du grèle. Le diagnostic avait conduit quatre fois à une interruption médicale précoce de la grossesse. Dans un cas une césarienne avait été pratiquée, les enfants étaient morts 48 heures après. L'échographie anté-natale nous semble actuellement le meilleur examen pour faire le diagnostic de jumeaux conjoints et rechercher des malformations léthales conduisant à une interruption de la grossesse.