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61.
Fernando Arias de la Vega Miguel Angel Domínguez Domínguez Ana Manterola Burgaleta Ruth Vera García Maria Eugenia Echeverría Zabalza Eugenio Oria Mundin Enrique Martínez López Pilar Romero Rojano Elena Villafranca Iture 《Clinical & translational oncology》2005,7(2):60-65
INTRODUCTION: This study aims to asses the effectiveness and toxicity of boost radiotherapy concomitant and concurrent cisplatin for patients with locally advanced head and neck cancer (LAHNC). MATERIAL AND METHODS: There were 30 patients included in a prospective, phase II single-institution trial and of whom, 29 were at AJCC stage IV and 1 at stage III. Treatment consisted of radiotherapy acceleration fractionation with concomitant boost, 72 Gy, and 2 cycles of concomitant cisplatin (20 mg/m2/day continuous infusion; days 1-5 and 29-33). Amifostine, (i.v. 200 mg/m2) was administered to 26 prior to the first fraction of radiotherapy. Endpoints of the study were quality-of-life (QL), overall survival, and local control of disease. RESULTS: Complete response (CR) was achieved in 23 patients (77%), 2 patients had partial response (PR) (7%), 4 had no response (13%), and 1 was not evaluated for response. The 2-year overall survival and loco-regional control were 60% and 56%, respectively. Main toxicity was grade 3 or 4 mucositis in 93% of the patients. QL scores (questionnaire QLQC30; version 3.0) and the HN cancer module QLQ-HN35) showed a worsening in areas related to the treatment e.g. dry mouth, problems stretching the mouth, and sticky saliva. CONCLUSIONS: this combination modality is active, but toxic, in the treatment for LAHNC. Concomitant boost radiotherapy is probably, not the best radiotherapy schema for combining with chemotherapy in LAHNC. 相似文献
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Carlos Camps Herrero Pilar Bayo Zaera Rafael Sirera Pérez Eva Sancho Salvador Ana Blasco Cordellat María José Safont Aguilera 《Clinical & translational oncology》2005,7(3):122-126
INTRODUCTION: Presence of circulating DNA in the serum of patients with cancer makes detection of tumour-specific genetic alterations feasible. OBJECTIVE: To study serum DNA concentration in patients diagnosed as having advanced Non-Small Cell Lung Cancer (NSCLC) and to evaluate its relationship with age, histology, stage, response, time-to-progression (TTP), and survival. METHODS: Serum DNA from 78 patients was purified and spectrophotometrically quantified. RESULTS: No significant correlations were found between serum DNA concentration and age, histology, response and survival. There was a significant correlation with respect to stage (IIIB = 408.75 ng/ml; IV = 478.74 ng/ml; p = 0.02). When patients were grouped according to DNA concentration, significant correlation with TTP was found; establishing a cut-off point at 500 ng/ml ([DNA] < 500 ng/ml TTP = 7.25 months, 95%CI: 3.5-5.25; [DNA ] > or = 500 ng/ml TTP = 4.25 months, 95%CI: 2-6.5; p = 0.05). CONCLUSIONS: Using the present method, DNA concentration quantification appears to be simple, but with certain deficiencies due to inter-sample variability and low specificity. This is because total DNA concentration is measured without distinguishing as to whether it is tumour-related. We suggest that there is a correlation between DNA concentration and prognosis which enables an analysis of the natural history of the disease. 相似文献
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Esther Navarro-Escobar Pilar Baca Matilde Ruiz-Linares Maria Teresa Arias-Moliz Mercedes Perez-Heredia Carmen Maria Ferrer-Luque 《Acta odontologica Scandinavica》2014,72(8):819-824
Objective. The aim of this study was to compare the efficacy of different dentine adhesives in delaying the coronal bacterial leakage of Enterococcus faecalis in filled root canals. Materials and methods. Ninety-five lower incisors of patients >65 years of age were instrumented using the ProTaper® system and were irrigated with 1 mL of 2.5% sodium hypochlorite (NaOCl) alternated with 1 mL 17% EDTA between each file change. Final irrigation was performed with 5 mL of 17% EDTA and then flushed with 5 mL of distilled water. The teeth were randomly divided into five experimental groups (n = 15/group) and one of the following dentine adhesives was applied: (1) AdheSE®; (2) Excite® DSC; (3) Clearfil? Protect Bond; (4) One Coat 7.0; or (5) Control group without adhesive. After filling the root canals, the samples were mounted on a double chamber device to evaluate the bacterial filtration of E. faecalis during a period of 240 days. The results underwent non-parametric Kaplan-Meier survival analysis and comparisons among groups were done using the Log-Rank test. Results. At 240 days, E. faecalis was detected in samples of all groups in the lower chamber. The highest survival value was obtained by One Coat 7.0, giving statistically significant differences from the other groups, whereas Clearfil? Protect Bond, AdheSE® and Excite® DSC showed similar behaviours, likewise similar to the Control group. Conclusions. One Coat 7.0 adhesive system provides the longest survival value to delay E. faecalis coronal leakage in filled root canals. 相似文献
67.
Natalia Curto-García Julio García-Suárez Marta Callejas Chavarria Juan José Gil Fernández Yolanda Martín Guerrero Elena Magro Mazo Shelly Marcellini Antonio Luis Miguel Juárez Isabel Gutierrez Juan José Arranz Irene Montalvo Carmen Elvira Pilar Domínguez María Teresa Díaz Carmen Burgaleta 《Supportive care in cancer》2016,24(1):93-101
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María Pérez-Crespo José Manuel Ramos-Rincón María Pilar Albares-Tendero Isabel Betlloch-Mas 《Journal of immigrant and minority health / Center for Minority Public Health》2016,18(1):16-20
Over the past 10 years Spain has become an important immigrant receiver country as the proximity with Africa and the cultural facilities with Latino-American countries have made of Spain a very attractive place to settle down for immigrants. From 1st January 2007 to 31st December 2007, all the pediatric patients visits (0–14 years old) seen in the units of the Dermatology Section of the University General Hospital of Alicante (Spain) were prospectively recorded. During the study period 3,108 visits were recorded. Of these, 447 (14.3 %) were generated by immigrant children, 243 (54.3 %) being episodes requested by 167 Latin American patients. Latin children consulted mainly in the outpatient clinic, like Spanish children. The most frequent type of dermatoses in these patients was eczema/atopic dermatitis. Infectious dermatitis showed no differences between them and Spaniards, but scabies was six times more frequent in the formers. 相似文献
70.
Pedro Christian Aravena Stephania Pilar Sandoval Felipe Eduardo Pizarro María Isabel Simpson Nicolás Castro-Adams Guillaume Serandour Cristian Rosas 《Journal of oral and maxillofacial surgery》2021,79(3):575-584
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