全文获取类型
收费全文 | 1336935篇 |
免费 | 100004篇 |
国内免费 | 4421篇 |
专业分类
耳鼻咽喉 | 16803篇 |
儿科学 | 43595篇 |
妇产科学 | 36377篇 |
基础医学 | 198004篇 |
口腔科学 | 35920篇 |
临床医学 | 129696篇 |
内科学 | 258274篇 |
皮肤病学 | 26390篇 |
神经病学 | 111990篇 |
特种医学 | 48204篇 |
外国民族医学 | 369篇 |
外科学 | 184096篇 |
综合类 | 29041篇 |
现状与发展 | 1篇 |
一般理论 | 460篇 |
预防医学 | 114489篇 |
眼科学 | 29021篇 |
药学 | 99024篇 |
7篇 | |
中国医学 | 3271篇 |
肿瘤学 | 76328篇 |
出版年
2021年 | 10966篇 |
2019年 | 11685篇 |
2018年 | 16352篇 |
2017年 | 12318篇 |
2016年 | 13276篇 |
2015年 | 15246篇 |
2014年 | 20883篇 |
2013年 | 32114篇 |
2012年 | 44337篇 |
2011年 | 47002篇 |
2010年 | 27141篇 |
2009年 | 24992篇 |
2008年 | 42795篇 |
2007年 | 45141篇 |
2006年 | 45248篇 |
2005年 | 43675篇 |
2004年 | 41625篇 |
2003年 | 39553篇 |
2002年 | 38342篇 |
2001年 | 60868篇 |
2000年 | 62555篇 |
1999年 | 52310篇 |
1998年 | 14607篇 |
1997年 | 13301篇 |
1996年 | 13133篇 |
1995年 | 12474篇 |
1994年 | 11657篇 |
1993年 | 10934篇 |
1992年 | 41589篇 |
1991年 | 40771篇 |
1990年 | 39462篇 |
1989年 | 37352篇 |
1988年 | 34596篇 |
1987年 | 33698篇 |
1986年 | 32161篇 |
1985年 | 30644篇 |
1984年 | 23034篇 |
1983年 | 19589篇 |
1982年 | 11752篇 |
1979年 | 20804篇 |
1978年 | 14814篇 |
1977年 | 12064篇 |
1976年 | 11876篇 |
1975年 | 12110篇 |
1974年 | 14800篇 |
1973年 | 14472篇 |
1972年 | 13356篇 |
1971年 | 12418篇 |
1970年 | 11485篇 |
1969年 | 10410篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
81.
D. Sforza G. Iaria L. Petagna A. Parente A. Anselmo F. Sergi S. Marzio F. Corrado S. Telli T.M. Manzia G. Tisone 《Transplantation proceedings》2019,51(1):140-142
Background
One daily dose of tacrolimus (QDT) improves adherence in kidney transplant (KT) recipients. A switch from twice-daily tacrolimus (BDT) to QDT showed similar efficacy and safety.Methods
The aim of our study was to demonstrate the long-term efficacy and safety of switching from BDT to QDT in KT recipients. Preliminary results have already been published. Forty-one patients (34 men and 7 women), mean age at KT of 43.9 ± 12.7 years, underwent a 1:1 dose switch from BDT to QDT; the mean time from KT to switch was 36.6 ± 16.1 months. In our study population, 4 patients received a living donor KT and 2 received a second allograft.Results
The mean follow-up was 86.8 ± 13 months from the switch and 126.2 ± 22.3 months from KT. Graft and patient survival rates were 90.2% and 95.1%, respectively. All patients maintained stable renal function during follow-up. During the first 3 months after the switch we observed a significant decrease in tacrolimus blood level (P = .0001). No significant differences were observed regarding tacrolimus dose before and after QDT introduction (P = not significant [NS]). Fourteen patients who stopped steroids under BDT treatment and 16 patients who stopped steroids after the switch are currently steroid-free.Conclusion
Our study showed safety and efficacy in switching from BDT to QDT. After early (<1 year) dose adjustment, tacrolimus blood levels remained stable throughout follow-up. Moreover, QDT represented a valid alternative for patients showing steroid side effects. 相似文献82.
L. Picard 《中国脑血管病杂志》2006,3(7):289-291
1 Short historical background of interventional neuroradiology
Even if a number of us were among the pioneers of Interventional Neuroradiology, this specialty has now reached its period of maturity. Schematically, the era of the pioneers began forty years ago and lasted about 15 years, between 1960 and 1975. During that period, on the initiative of Fedor Serbinenko (Russia) and Ren6 Djindjian (France), "intracerebral navigation " using small balloons, which became gradually "detachable", has been invented. At the same time, we discovered how to use these balloons to occlude intracranial vascular lesions, inaccessible or hardly accessible to traditional open skull neurosurgery, for example, carotid cavernous fistulas. Very rapidly, a lot of different embolic particles were successively tested, ranging at first from pieces of muscle, to small glass or silastic beads, gelfoam and dura mater pieces... During this period, parallel progress of hyperselective catheterization and consequently of microangiography allowed to establish new classifications of main vascular pathologies (distinction between brain arteriovenous malformations and dural fistulas ... ). These new classifications allowed a better understanding of physiopathology. This first period was thus primarily devoted to development of very precise diagnosis and techniques of hyperselective endovascular occlusion. 相似文献
83.
Lars J Vatten Tom I L Nilsen P?l R Romundstad Wenche B Dr?yvold Jostein Holmen 《European journal of cardiovascular prevention and rehabilitation》2006,13(6):909-915
OBJECTIVE: To investigate whether cardiovascular mortality related to obesity could be modified by physical activity. DESIGN: Mortality follow-up. SETTING: Population study. PARTICIPANTS: Participants in a health survey: 34 868 women and 32 872 men free from known cardiovascular disease or diabetes at baseline. MAIN OUTCOME MEASURES: Total cardiovascular mortality. MAIN RESULTS: During 16 years of follow-up, 3026 women and 3526 men had died from cardiovascular causes. In middle age, obesity [body mass index (BMI) of 30 or higher] was associated with increased risk of cardiovascular death, but the association weakened with age. After 70, there was no association between BMI and cardiovascular death. At all ages, a lower level of physical activity was associated with a higher cardiovascular mortality. In women with high physical activity, indicated by at least 30 min of moderate to vigorous activity more than once a week, cardiovascular mortality was only slightly higher in the obese compared to lean women (adjusted relative risk, 1.27; 95% confidence interval, 0.80-2.00). In men with high physical activity, cardiovascular mortality was, however, significantly higher among the obese (relative risk, 1.62; 95% confidence interval, 1.09-2.40). In both genders cardiovascular mortality was substantially higher in obese people who reported no regular physical activity compared to obese people with a high level of physical activity. CONCLUSION: In obese women, being highly active may, to a large extent, compensate for the risk-increasing effect of being obese, whereas in obese men who engage in a high level of physical activity, the risk of cardiovascular death may be higher than in lean and equally active men. 相似文献
84.
Bernard–Soulier syndrome (BSS) is a rare autosomal recessively inherited bleeding disorder. Pregnancy in patients with BSS is characterized by ante‐, intra‐, or postpartum haemorrhage, which may be delayed and severe. There is no consensus in the management of BSS in pregnancy and so far only 16 pregnancies in nine patients have been described. We report a further three pregnancies in two women with the syndrome. We also outline our management of pregnant patients with BSS. 相似文献
85.
G Steinitz M C Martín N Gazit-Yaari M L Quesada J de la Nuez R Casillas U Malik Z B Begin 《Applied radiation and isotopes》2006,64(4):520-524
Multi-day signals, generally with duration of 2-10 days, are a prominent temporal variation type of radon (Rn) in geogas in the unsaturated zone. Rare multi-day Rn signals have been found which are characterized by: (a) a declining limb lasting up to 10 days which conforms to the radioactive decay of Rn, (b) recurs at the same location and (c) is recorded in diverse situations-volcanic and seismogenic. It suggested that a Rn blob is injected at a lower level on a steady upward flow of geogas whereby the rise and final fall of the signal are attributed to the edges of the blob while the central Rn-decay segment records the passing of the decaying blob itself. Rn-decay signals are a small subset of multi-day Rn signals which are considered as highly irregular and unusable for the understanding of geophysical processes. In difference, it is concluded that multi-day Rn signals are probably proxies of subtle geodynamic processes at upper crustal levels and are therefore significant for studying such processes. 相似文献
86.
D B Irving J L Cook H B Menz 《Journal of Science and Medicine in Sport》2006,9(1-2):11-22; discussion 23-4
87.
H. Wessling C. L. Simosono M. Escosa-Bagé P. de las Heras-Echeverría 《Acta neurochirurgica》2006,148(6):673-675
Summary We present a case of blindness and Anton’s syndrome in a psychiatric patient with late diagnosis of a giant frontal meningioma.
The criteria for advanced diagnostic imaging in the psychiatric population are discussed. We conclude that MR or CT scan is
indicated in psychiatric in-patients who fail to improve with standard psychiatric treatment. This strategy should be submitted
to a cost-benefit analysis. 相似文献
88.
89.
90.