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Yoann Perreux Marie Alexandre Chaix Anna Kamp François-Pierre Mongeon Magali Pham Loïc Boussel Roland Henaine Annie Dore Blandine Mondésert Sylvie Di-Filippo Paul Khairy Francis Bessiere 《Congenital heart disease》2020,15(6):473-482
Sudden cardiac death and heart failure are well known long-term complications after atrial switch for D-transposition of the great arteries (D-TGA).
Right systemic ventricular dysfunction is common and myocardial ischemia has
been implicated as a putative mechanism for sudden death, with coronary anomalies prevalent in 30% of cases. We sought to assess an association between
adverse events and coronary anomalies in patients with D-TGA and atrial switch
surgery. An observational study was conducted in 3 tertiary centers (Montreal
Heart Institute, Canada, Nationwide Children’s hospital, Chicago, USA and Hopital cardiologique Louis Pradel de Lyon, France). Adults with D-TGA and atrial
switch surgery qualified for inclusion if they had a major adverse cardiovascular
event (MACE), i.e., ventricular arrhythmia, sudden cardiac death, heart failure,
cardiac transplantation, or cardiovascular death. The prevalence of coronary
anomalies was compared to historical controls. Forty-five patients were included.
Twenty-one (46.7%) patients experienced a ventricular arrhythmia and 35
(77.8%) suffered from symptomatic heart failure and/or severe right ventricular
dysfunction. Twelve patients (26.7%) had congenitally abnormal coronary
arteries. There was no difference in the prevalence of coronary anomalies between
the cohort with a MACE and a pooled population of 647 historical controls with
D-TGA (28.7%, p = 0.89). In conclusion, the prevalence of congenital coronary
anomalies is not higher in patients with D-TGA and atrial switch surgery who had
adverse cardiovascular events. It could be hypothesized that ischemic complications in this patient population are more likely to be related to a supply-demand
mismatch of the distal microvasculature rather than proximal coronary anomalies. 相似文献
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Aquatic bird bornavirus 1 (ABBV-1) is associated with chronic meningoencephalitis and ganglioneuritis. Although waterfowl species act as the natural host of ABBV-1, the virus has been sporadically isolated from other avian species, showing the potential for a broad host range. To evaluate the host restriction of ABBV-1, and its potential to infect commercial poultry species, we assessed the ability of ABBV-1 to replicate in cells and embryos of different avian species. ABBV-1 replication was measured using multi- and single-step growth curves in primary embryo fibroblasts of chicken, duck, and goose. Embryonated chicken and duck eggs were infected through either the yolk sac or chorioallantoic cavity, and virus replication was assessed by immunohistochemistry and RT-qPCR in embryonic tissues harvested at two time points after infection. Multi-step growth curves showed that ABBV-1 replicated and spread in goose and duck embryo fibroblasts, establishing a population of persistently infected cells, while it was unable to do so in chicken fibroblasts. Single-step growth curves showed that cells from all three species could be infected; however, persistence was only established in goose and duck fibroblasts. In ovo inoculation yielded no detectable viral replication or lesion in tissues. Data indicate that although chicken, duck, and goose embryo fibroblasts can be infected with ABBV-1, a persistent infection is more easily established in duck and goose cells. Therefore, ABBV-1 may be able to infect chickens in vivo, albeit inefficiently. Additionally, our data indicate that an in ovo model is inadequate to investigating ABBV-1 host restriction and pathogenesis. 相似文献
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Emmanouil Angelakis Sophie Edouard Marie-Alix Lafranchi Thao Pham Pierre Lafforgue Didier Raoult 《Journal of clinical microbiology》2014,52(4):1064-1067
Osteoarticular infection is an uncommon presentation of Q fever. Positron emission tomography (PET) scanning is a valuable tool for the diagnosis of Coxiella burnetii graft prosthesis infection and endocarditis. Our objective was to test a series of culture-negative osteoarticular samples using molecular assays for Coxiella burnetii. We tested for C. burnetii by molecular assays targeting the IS1111 and the IS30A spacer regions, using culture-negative osteoarticular samples obtained in our laboratory between January 2011and December 2012. We examine a total of 1,410 osteoarticular samples, and we observed two cases of arthritis and subacromial bursitis caused by C. burnetii. The infections were localized using PET scanning, and the diagnosis was confirmed through serology. For one, a C. burnetii strain with a multispacer sequence type 8 genotype was isolated from synovial fluid culture. Q fever articular infections could be undiagnosed because of the long evolution of articular attack, and patients with high antibody titers against C. burnetii should be tested using PET scanning to localize the site of infection. 相似文献
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