全文获取类型
收费全文 | 323154篇 |
免费 | 10940篇 |
国内免费 | 781篇 |
专业分类
耳鼻咽喉 | 2505篇 |
儿科学 | 10398篇 |
妇产科学 | 5701篇 |
基础医学 | 36503篇 |
口腔科学 | 4945篇 |
临床医学 | 26547篇 |
内科学 | 62709篇 |
皮肤病学 | 3523篇 |
神经病学 | 30684篇 |
特种医学 | 14862篇 |
外国民族医学 | 6篇 |
外科学 | 50879篇 |
综合类 | 4230篇 |
现状与发展 | 2篇 |
一般理论 | 139篇 |
预防医学 | 28565篇 |
眼科学 | 5841篇 |
药学 | 19665篇 |
2篇 | |
中国医学 | 871篇 |
肿瘤学 | 26298篇 |
出版年
2023年 | 818篇 |
2022年 | 1240篇 |
2021年 | 2829篇 |
2020年 | 1961篇 |
2019年 | 2830篇 |
2018年 | 24873篇 |
2017年 | 19653篇 |
2016年 | 22062篇 |
2015年 | 4377篇 |
2014年 | 5783篇 |
2013年 | 7524篇 |
2012年 | 17226篇 |
2011年 | 31503篇 |
2010年 | 24586篇 |
2009年 | 17193篇 |
2008年 | 29004篇 |
2007年 | 31836篇 |
2006年 | 10790篇 |
2005年 | 12628篇 |
2004年 | 13223篇 |
2003年 | 13626篇 |
2002年 | 11239篇 |
2001年 | 1738篇 |
2000年 | 1508篇 |
1999年 | 1754篇 |
1998年 | 2331篇 |
1997年 | 1866篇 |
1996年 | 1518篇 |
1995年 | 1396篇 |
1994年 | 1245篇 |
1993年 | 1182篇 |
1992年 | 810篇 |
1991年 | 867篇 |
1990年 | 739篇 |
1989年 | 675篇 |
1988年 | 618篇 |
1987年 | 617篇 |
1986年 | 540篇 |
1985年 | 577篇 |
1984年 | 658篇 |
1983年 | 588篇 |
1982年 | 792篇 |
1981年 | 708篇 |
1980年 | 650篇 |
1979年 | 366篇 |
1978年 | 392篇 |
1977年 | 413篇 |
1976年 | 354篇 |
1975年 | 301篇 |
1974年 | 267篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Michael Krause Agns Rouleau Holger Stark Peter Luger Monique Garbarg Jean-Charles Schwartz Walter Schunack 《Archiv der Pharmazie》1996,329(4):209-215
The therapeutic value of histamine H3-receptor ligands is under current investigation. On the basis of recently described diaryl imine prodrugs of the histamine H3-receptor agonist (R)-α-methyl-histamine ( 1 ) a series of new azomethine prodrugs containing five- and six-membered heterocycles were synthesized and tested for their in vitro hydrolysis rates and in vitro activity after oral application. It was found that electron-deficient six-membered heterocycles drastically destabilized the imine double bond so that these prodrugs decomposed unsuitably fast. On the contrary, prodrugs containing five-membered heterocycles appeared to be highly effective for the CNS delivery of 1 , and a remarkable correlation between chemical structure and pharmacokinetic profile was observed. Particularly (R)-4-fluoro-2-[[N-[1-(1H-imidazol-4-yl)-2-propyl]imino](1H-pyrrol-2-yl)methyl]phenol ( 8c ), the 2-furanyl analogue 8d , and its 3-furanyl isomer 8e proved to be equipotent to the most potent of recently described halogenated diaryl imine prodrugs of 1. However, in contrast to any other azomethine prodrug, 8c exhibited an incomparably long lasting delivery of 1 in the CNS and can thus be regarded as a ‘retard’ prodrug. Assuming that a therapeutic indication of histamine H3-receptor agonists will soon be established, these highly potent heteroarylphenyl azomethine prodrugs, which already serve as valuable pharmacological tools, may also become potential drugs in clinical use. 相似文献
992.
Angiotensin-converting enzyme (ACE) gene polymorphism in type II diabetic patients with increased albumin excretion rate 总被引:1,自引:0,他引:1
Sianna Panagiotopoulos Trudy Jeanne Smith G. Peter Aldred Elizabeth Jane Baker Carolyn Jane Jacklin George Jerums 《Journal of diabetes and its complications》1995,9(4):272-276
Approximately one in three patients with diabetes is at risk of developing kidney disease, despite current methods of treatment. It has long been suspected that diabetic kidney disease has a genetic basis, but this has been difficult to prove. Polymorphisms of the angiotensin-converting enzyme (ACE) gene have been shown to be related to the occurrence of nephropathy in type I diabetic patients. This study showed that there was no association in the ACE genotype frequency and increased albumin excretion rate in type II diabetic patients. 相似文献
993.
In a recent paper, we showed that the number of endoneurial microvessels per square millimeter and the average luminal area and size distribution of these microvessels are not significantly different in sural nerves of patients with diabetes mellitus as compared to control subjects. Mural area, especially the component due to basement membrane reduplication and cellular debris, was unequivocally increased in diabetes mellitus. Because these latter changes are associated with a decrease in periendothelial cell area, we hypothesized that cellular degeneration, especially of pericytes, may account for basement membrane reduplication and increased frequency of cellular debris. In the present study, we showed that endoneurial microvessels undergo a statistically significant increase in basement membrane area, mural area, and frequency of cellular debris in diabetics without polyneuropathy and an even greater increase in diabetics with polyneuropathy. We also found that duration of diabetes mellitus was significantly associated with area occupied by reduplicated basement membrane and cellular debris, but not with mural and periendothelial area. None of the examined measurements was associated with age. Since the microvessel abnormalities we describe are already present before the development of polyneuropathy and increase with severity of polyneuropathy, it is likely that they reflect functional derangements of pericytes and microvessel function which precede and might be implicated in fiber degeneration. 相似文献
994.
Jerrold L. Boxerman Peter A. Bandettini Kenneth K. Kwong John R. Baker Timothy L. Davis Bruce R. Rosen Robert M. Weisskoff 《Magnetic resonance in medicine》1995,34(1):4-10
Understanding the relationship between fMRI signal changes and activated cortex is paramount to successful mapping of neuronal activity. To this end, the relative extravascular and intravascular contribution to fMRI signal change from capillaries (localized), venules (less localized) and macrovessels (remote, draining veins) must be determined. In this work, the authors assessed both the extravascular and intravascular contribution to blood oxygenation level-dependent gradient echo signal change at 1.5 T by using a Monte Carlo model for susceptibility-based contrast in conjunction with a physiological model for neuronal activation-induced changes in oxygenation and vascular volume fraction. The authors compared our Model results with experimental fMRI signal changes with and without velocity sensitization via bipolar gradients to null the intravascular signal. The model and experimental results are in agreement and suggest that the intravascular spins account for the majority of fMRI signal change on T2*-weighted images at 1.5 T. 相似文献
995.
Jeff A. Stanley Dick J. Drost Peter C. Williamson R. Terry Thompson 《Magnetic resonance in medicine》1995,34(1):17-24
In vivo 1H MR spectra of the prefrontal cortex acquired with the stimulated echo acquisition mode (STEAM) TE = 20 ms sequence were quantified to determine relative levels of cerebral metabolites. A priori knowledge of spectra from individual metabolites in aqueous solution was incorporated into a frequency domain quantification technique. The accuracy and precision of modeling these metabolites were investigated with simulated spectra of varying signal-to-noise ratios (SNRs) and relative metabolite levels. The efficacy of modeling in vivo data was tested by quantifying 10 repeated measures of two consecutively acquired in vivo spectra (an 8?cm3 volume of interest (VOI) and a 4?cm3 VOI positioned within the 8?cm3 VOI) on the same normal subject. The differences in levels of glutamate (Glu), phosphocreatine plus creatine (PCr+Cr) and choline-containing compounds (Cho1 between spectra from the 8? and 4?cm3 VOIs corresponded with the expected differences observed in the proportions of gray matter within the VOIs (estimated from 1H images). Correcting for the T1 and T2 relaxation, the estimated concentrations of N-acetylaspartate, PCr+Cr, Cho1, Glu, and glutamine were consistent with previous in vivo and in vitro reports. 相似文献
996.
Prof Dr. Siegfried E. Miederer MD Peter Grübel MD 《Digestive diseases and sciences》1996,41(5):944-949
The effect of pH onH. pylori urease activity in its ecological niche was studied in gastric antral biopsy specimens. Specimens were incubated in 10 mmol/liter urea solutions at pH range 3.3–8.2. Activity of urease was studied by measuring production of ammonia and change in pH of the solutions. Urease activity was reduced at pH 8.2 (1424 ± 218 µmol/liter) but decreasing initial pH to neutral and acidic values resulted in significant maximal 6.5-fold increase in ammonia production (9491 ± 1073 µmol/liter,P<0.0005), which considerably raised the pH of the test solutions. Peak urease activity was between pH 5.0 and 7.0. In contrast to specimens incubated initially at pH 8.0, reincubation of washed specimens from solutions with initial pH 7.0 showed eightfold decreased urease activity. It is concluded that urease activity is markedly pH dependent with pH optima below the physiological mucosal surface pH. Furthermore, availability of urease is limited. Thus, an impaired gastric mucosal integrity allowing back diffusion of hydrogen ions may release urease activity, which might further weaken the mucus barrier and damage the gastric epithelium.This study was supported by the Deutsche Forschungsgemeinschaft (Mi 190/3). 相似文献
997.
998.
Dermatitis in bulb growers 总被引:2,自引:0,他引:2
Derk P. Bruynzeel Edith M. de Boer Elly J. Brouwer Frederik A. de Wolff Peter de Haan 《Contact dermatitis》1993,29(1):11-15
A damaged skin forms a health hazard in flower-bulb growers as it enables higher permeation rates For pesticides than normal skin. Therefore, an investigation was performed into the skin condition of 103 bulb growers and 49 controls. Contact dermatitis of the hands was of the same order (11 and 10%) in both groups. However, minor signs of dermatitis were seen more often in bulb growers (30 versus 8%, p <0.05). Most growers had contact with narcissus sap during the investigation. This irritant sap, as well as many other skin contacts with irritants such as hyacinth dust and pesticides, seemed to be responsible for many skin complaints. Contact serialization was suspected in 19 growers and 3 controls. Patch tests showed that contact sensitization existed to pesticides in probably 10, and to flower-bulb extracts in 4 growers. Reactions to propachlor were not regarded as very reliable as the test concentration seemed to be marginally irritant. There were only a few allergic reactions to narcissus (3) and tulip (2) and none to hyacinth. This investigation showed that minor irritant contact dermatitis was frequent in bulb growers, and indicated that contact sensitization to pesticides and bulbs seemed to be a less frequent but important cause of dermatitis. 相似文献
999.
The anisotropy of the water diffusion tensor inside brain causes contrast in diffusion images, which depends on the relative orientation of the diffusion gradients and the subject. Because the trace of a tensor is invariant upon rotation, measurement of this trace can reduce the orientation effect. A family of imaging pulse sequences is presented in which the signal intensity is weighted by the trace of the diffusion tensor in a single scan. The methods are demonstrated for chicken gizzard in several orientations with respect to the gradient frame of reference, and for ischemic injury in cat brain after middle cerebral artery occlusion. The sensitivity of the techniques to the presence of background gradients is measured and discussed in detail. As a result, pulse sequences are suggested that provide reliable diffusion constants in both homogeneous and inhomogeneous magnetic fields. The efficiency of the techniques for clinical application is also evaluated. 相似文献
1000.
BALB/c mice are susceptible to a high-dose infection of the protozoan Leishmania major, which induces a parasite-specific antibody, Th2-like response, exclusive of a significant and protective cell-mediated Th1 component. We have shown, in contrast, that infection with a low number of parasites induces cell-mediated immunity exclusive of antibody production, and results in resistance to substantial subsequent high-dose infection. Low-dose exposure thus constitutes effective vaccination. In the present study, we analyze lymphokine production by parasite-specific T cells from these low-dose exposed, resistant mice and from normal, susceptible mice following high-dose infection. Two findings stand out. First, the parasite-specific T cells in mice rendered resistant appear not to be in an activated, effector state at the time of parasite challenge, as assessed by lack of lymphokine production on short-term stimulation with parasite antigens, but to be rather in a memory state. Second, the ratio of parasite antigen-dependent production of interferon-γ to that of interleukin-4 by spleen cells of low-dose exposed and normal mice upon high-dose challenge takes a dramatically different course. This ratio is similar in both groups of mice shortly after challenge, but increases dramatically in the resistant and declines dramatically in the control mice over a period of weeks, such that these ratios differ by about 60-fold 12 weeks after the high-dose challenge. In addition, we show that a similar state of resistance occurs following low-dose infection with a more virulent strain of L. major. In toto, our observations suggest that resistance may be generally achievable by low-dose exposure and may be associated with a memory state which, when activated by parasite challenge, results in the evolution of the response over weeks such that the protective, Th1 component becomes ever more dominant over the Th2 component. 相似文献