全文获取类型
收费全文 | 1624篇 |
免费 | 74篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 38篇 |
妇产科学 | 24篇 |
基础医学 | 253篇 |
口腔科学 | 64篇 |
临床医学 | 159篇 |
内科学 | 471篇 |
皮肤病学 | 29篇 |
神经病学 | 101篇 |
特种医学 | 31篇 |
外科学 | 217篇 |
综合类 | 10篇 |
预防医学 | 89篇 |
眼科学 | 18篇 |
药学 | 67篇 |
中国医学 | 2篇 |
肿瘤学 | 125篇 |
出版年
2023年 | 7篇 |
2022年 | 15篇 |
2021年 | 31篇 |
2020年 | 24篇 |
2019年 | 22篇 |
2018年 | 37篇 |
2017年 | 23篇 |
2016年 | 40篇 |
2015年 | 33篇 |
2014年 | 65篇 |
2013年 | 63篇 |
2012年 | 98篇 |
2011年 | 113篇 |
2010年 | 43篇 |
2009年 | 50篇 |
2008年 | 79篇 |
2007年 | 89篇 |
2006年 | 90篇 |
2005年 | 68篇 |
2004年 | 65篇 |
2003年 | 68篇 |
2002年 | 59篇 |
2001年 | 58篇 |
2000年 | 53篇 |
1999年 | 40篇 |
1998年 | 18篇 |
1997年 | 22篇 |
1996年 | 19篇 |
1995年 | 13篇 |
1994年 | 11篇 |
1993年 | 10篇 |
1992年 | 42篇 |
1991年 | 24篇 |
1990年 | 21篇 |
1989年 | 16篇 |
1988年 | 27篇 |
1987年 | 21篇 |
1986年 | 17篇 |
1985年 | 20篇 |
1984年 | 14篇 |
1983年 | 8篇 |
1981年 | 4篇 |
1979年 | 6篇 |
1977年 | 8篇 |
1976年 | 7篇 |
1974年 | 5篇 |
1973年 | 5篇 |
1972年 | 7篇 |
1967年 | 4篇 |
1966年 | 5篇 |
排序方式: 共有1707条查询结果,搜索用时 31 毫秒
61.
I Sagara B Fofana J Gaudart B Sidibe A Togo S Toure K Sanogo D Dembele A Dicko R Giorgi OK Doumbo AA Djimde 《The American journal of tropical medicine and hygiene》2012,87(1):50-56
Artemisinin-based combination therapies (ACTs) are the first-line treatment of uncomplicated malaria. The public health benefit and safety of repeated administration of a given ACT are poorly studied. We conducted a randomized trial comparing artemether-lumefantrine, artesunate plus amodiaquine (AS+AQ) and artesunate plus sulfadoxine-pyrimethamine (AS+SP) in patients 6 months of age and older with uncomplicated malaria in Mali from July 2005 to July 2007. The patient received the same initial treatment of each subsequent uncomplicated malaria episode except for treatment failures where quinine was used. Overall, 780 patients were included. Patients in the AS+AQ and AS+SP arms had significantly less risk of having malaria episodes; risk ratio (RR) = 0.84 (P = 0.002) and RR = 0.80 (P = 0.001), respectively. The treatment efficacy was similar and above 95% in all arms. Although all drugs were highly efficacious and well tolerated, AS+AQ and AS+SP were associated with less episodes of malaria. 相似文献
62.
Ambroise Wonkam Jean Jacques N. Noubiap François Djomou Karen Fieggen Richard Njock Geneviève Bengono Toure 《European journal of medical genetics》2013,56(1):20-25
BackgroundSevere hearing loss is a global problem affecting particularly developing countries. There is scarcity of recent published data on the epidemiology of childhood deafness in sub-Saharan Africa.ObjectiveTo determine the etiological profile of severe childhood deafness in Cameroon.MethodsProspective cross-sectional study of patients with a severe hearing loss that started before the age of 15 years. Detailed family and medical history was obtained; careful clinical, otological and audiological examinations were performed.ResultsA total of 582 patients with a severe hearing loss were examined. Prelingual deafness accounted for 75.1% (n = 437), with a mean age at medical diagnosis of 3.3 ± 1.2 years. This late presentation may be explained by limited parental awareness of signs raising suspicion of hearing loss, poor access to health care and the absence of neonatal screening for hearing loss in Cameroon. Identified genetic causes accounted for 14.8% (n = 86), putative environmental causes for 52.6% (n = 306) and unknown causes for 32.6% (n = 190). Amongst Genetic causes, the syndromic hearing loss accounted for 13.1% (n = 12) of cases, the rest being non syndromic (n = 74). Consanguineous families accounted for 5.7% (n = 33) of the whole sample, and 15.1% (n = 13) of genetic cases. No union between deaf parents was observed.ConclusionThese data highlight the possible predominance of putative environmental causes of childhood deafness in Cameroon, and emphasize the need for improved policies for prevention of infectious diseases and for neonatal hearing screening. However, further molecular analyses and targeted CT scan investigations are required to more accurately gauge the contribution of genetics etiologies. 相似文献
63.
Eduardo D. E. Papa Izo Helber Manes R. Ehrlichmann Claudia Maria Rodrigues Alves Marcia Makdisse Livia N. Matos Jairo Lins Borges Renato D. Lopes Edson Stefanini Antonio Carlos Carvalho 《Clinics (S?o Paulo, Brazil)》2013,68(12):1481-1487
OBJECTIVES:
To correlate the importance of the ankle-brachial index in terms of cardiovascular morbimortality and the extent of coronary arterial disease amongst elderly patients without clinical manifestations of lower limb peripheral arterial disease.METHODS:
We analyzed prospective data from 100 patients over 65 years of age with coronary arterial disease, as confirmed by coronary angiography, and with over 70% stenosis of at least one sub-epicardial coronary artery. We measured the ankle-brachial index immediately after coronary angiography, and a value of <0.9 was used to diagnose peripheral arterial disease.RESULTS:
The patients'' average age was 77.4 years. The most prevalent risk factor was hypertension (96%), and the median late follow-up appointment was 28.9 months. The ankle-brachial index was <0.9 in 47% of the patients, and a low index was more prevalent in patients with multiarterial coronary disease compared to patients with uniarterial disease in the same group. Using a bivariate analysis, only an ankle-brachial index of <0.9 was a strong predictive factor for cardiovascular events, thereby increasing all-cause deaths and fatal and non-fatal acute myocardial infarctions two- to three-fold.CONCLUSION:
In elderly patients with documented coronary disease, a low ankle-brachial index (<0.9) was associated with the severity and extent of coronary arterial disease, and in late follow-up appointments, a low index was correlated with an increase in the occurrence of major cardiovascular events. 相似文献64.
Papa G Baratta R Calì V Degano C Iurato MP Licciardello C Maiorana R Finocchiaro C 《Acta diabetologica》2012,49(5):387-393
In clinical practice, basal insulin dosage (BID) for the treatment for type 2 diabetes given as slow-acting analogues or NPH insulin varies widely when adjusted for body weight (UI/kg). In this study, we investigated the interrelationship between BID and anthropometric, laboratory and clinical parameters. A total of 681 type 2 diabetic patients, treated with bedtime insulin in association with other antidiabetic drugs (preprandial insulin and/or oral agents), were studied. Anthropometric, clinical and biochemical parameters, as well as micro- and macrovascular complications, were evaluated. Non-alcoholic fatty liver disease (NAFLD) was assessed by liver ultrasound. BID was titrated to achieve a fasting blood glucose target of ≤6.7?mmol/L (120?mg/dL). In the multivariate analysis, BID was significantly associated with waist circumference (p?=?0.04) and the insulin treatment duration (p?=?0.004) as the type of insulin treatment ("basal-bolus" regimen vs. basal insulin only, p?0.0001), the use of lipid-lowering drugs (p?=?0.0003) and insulin sensitizers (p?=?0.005). Several glycometabolic parameters were strongly associated with BID (HbA1c p?=?0.01, FPG p?0.0001, HDL p?=?0.02, triglycerides p?=?0.03). Moreover, the presence of severe NAFLD resulted in a higher BID (p?=?0.03). We concluded that when starting and titrating the basal insulin in type 2 diabetes, certain anthropometric, laboratory and clinical factors can be useful to find optimal BID more quickly and appropriately. 相似文献
65.
66.
David Goitein Alex Zendel Gal Westrich Douglas Zippel Moshe Papa Moshe Rubin 《Obesity surgery》2013,23(2):222-225
Background
Laparoscopic sleeve gastrectomy (LSG) is an accepted bariatric procedure. Swallow studies (SS) after LSG are not uniform and display different patterns with regard to contrast passage through the gastric sleeve. The impact of immediate postoperative contrast transit time on weight loss has not been studied. The influence of immediate fluid tolerance on weight loss after LSG is herein reported.Methods
Ninety-nine patients after LSG were included. There were 67 females, mean age 41 (range 17–67), mean BMI 44.4 (range 37–75). A routine SS was performed on postoperative day (POD) 1. Pattern of contrast transit was noted. Patients were followed-up in our bariatric clinic.Results
Percent excess weight loss was significantly lower in the patients with rapid contrast passage (Group 1, n?=?50) than those with delayed passage (Group 2, n?=?49). Group 1 achieved 62, 58, and 53 % at 1, 2, and 3 years, respectively, while Group 2 attained 69, 74, and 75 % at the same time points (p?=?0.05, 0.001, and 0.04, respectively). Group 1 patients displayed a negative weight loss trend after 1 year whereas Group 2 patients plateaued after 2 years.Conclusions
Tolerance of fluid intake after LSG is crucial for patient recovery and discharge. Distinct radiologic appearance on POD 1 helps predict this behavior. Mid-term weight loss after LSG appears to be dependent on immediate postoperative contrast transit time, whereas patients with slow contrast passage tend to lose more weight. Long-term follow-up will reveal whether this finding will hold true. 相似文献67.
68.
Carlos Eduardo Bezerra Moura Naisandra Bezerra Silva Juliana Carvalho Sa Geraldo Barroso Cavalcanti Junior Silvia Regina Batistuzzo de Medeiros Hugo Alexandre Oliveira Rocha Paula Carvalho Papa Clodomiro Alves Jr 《Artificial organs》2016,40(5):497-504
To evaluate the effect of topography in nanoscale, titanium surfaces were bombarded by argon ions (a chemically inert gas), in an atmosphere of plasma. The effects of surface parameters on morphology, adhesion, proliferation, and MC3T3‐E1 preosteoblasts differentiation were analyzed. Nontreated (smooth) surfaces were used as a control. The levels of average roughness (Ra) observed in bombarded and smooth titanium surfaces were of 95 and 14 nm, respectively. The wettability increased on treated surfaces. The number of attached cells (30 and 60 min) was significantly higher on the bombarded surface. The cell proliferation after 3 and 7 days was also significantly higher on the ion‐bombarded surface. In addition, the ALP activity and expression of osteocalcin were higher in cells grown on the treated surface. The results showed that bombardment with argon ions increased the roughness and the wettability of the Ti surface, promoting a significant increase in the adhesion, proliferation, and differentiation of preosteoblasts. 相似文献
69.
70.
V. Papa B. Romanin R. Bergamaschi D. M. Cordelli R. Costa L. Badiali De Giorgi 《Ultrastructural pathology》2016,40(2):83-85
Juvenile dermatomyositis (JDM), an autoimmune idiopathic myositis, is characterized by rash and proximal muscle weakness. Immunohistopathology typically shows perivascular inflammatory infiltrate with predominance of CD4+ T lymphocytes, perifascicular atrophy, and upregulation of major histocompatibility complex class I. JDM has been attributed to a humoral-driven muscle microangiopathy probably implicating the type I interferon pathway. Tubulo-reticular inclusions present in endothelial cell of muscle are biomarkers of interferon exposure, and so may be an indirect data of this myopathy especially in the absence of rash and inflammatory infiltrate. We report on three patients in which electron microscopy solves the differential diagnosis among infantile myositis showing peculiar inclusions. 相似文献