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131.
HIV,highly active antiretroviral therapy and the heart: a cellular to epidemiological review 下载免费PDF全文
CT Lambert PB Sandesara B Hirsh LJ Shaw W Lewis AA Quyyumi RF Schinazi WS Post L Sperling 《HIV medicine》2016,17(6):411-424
The advent of potent highly active antiretroviral therapy (HAART) for persons infected with HIV‐1 has led to a “new” chronic disease with complications including cardiovascular disease (CVD). CVD is a significant cause of morbidity and mortality in persons with HIV infection. In addition to traditional risk factors such as smoking, hypertension, insulin resistance and dyslipidaemia, infection with HIV is an independent risk factor for CVD. This review summarizes: (1) the vascular and nonvascular cardiac manifestations of HIV infection; (2) cardiometabolic effects of HAART; (3) atherosclerotic cardiovascular disease (ASCVD) risk assessment, prevention and treatment in persons with HIV‐1 infection. 相似文献
132.
Marcia MG Gowdak Mateus C Laterza Maria Urbana PB Rondon Ivani C Trombetta Alexandre C Pereira José Eduardo Krieger Carlos Eduardo Negrão 《Lipids in health and disease》2010,9(1):55
Background
Forearm blood flow responses during mental stress are greater in individuals homozygous for the Glu27 allele. A high-fat meal is associated with impaired endothelium-dependent dilatation. We investigated the impact of high-fat ingestion on the muscle vasodilatory responses during mental stress in individuals with the Glu27 allele and those with the Gln27 allele of the β2-adrenoceptor gene. 相似文献133.
高效毛细管电泳法测定川芎注射液中川芎嗪含量 总被引:3,自引:0,他引:3
目的建立测定川芎注射液中川芎嗪含量的高效毛细管电泳法.方法以15mmol/L磷酸盐缓冲液(pH=7.6)为电泳电解液,电压30kV(运行电流为25~30μA,检测波长280nm,内标为氨茶碱.结果川芎嗪迁移时间为2.70min,氨茶碱迁移时间为3.10min.川芎嗪含量在5.83~93.33μgm*l-1时,浓度与峰面积比呈良好线性关系,r=0.9999,日内、日间变异系数均<2%.结论该方法简便,灵敏,特异性和重现性良好,具有较强的实用价值. 相似文献
134.
Bijay Pattnaik Sryma PB Mansi Verma Sanjeev Kumar Saurabh Mittal Sudheer Arava Pavan Tiwari Vijay Hadda Anant Mohan Randeep Guleria Karan Madan 《Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders》2022,38(4)
Background:Cardiac sarcoidosis (CS) is an underdiagnosed and life-threatening condition. Histopathological diagnosis is difficult due to the risks and variable diagnostic yield of endomyocardial biopsy.Objectives:To study the clinical profile and compare the diagnostic criteria of CS in a cohort of sarcoidosis.Methods:A retrospective review of the Sarcoidosis database (375 patients) was performed to identify patients with CS. Demographic and clinical details were retrieved. We applied the available diagnostic criteria for the diagnosis of CS: The World Association of Sarcoidosis and Other Granulomatous Diseases (WASOG), Heart Rhythm Society (HRS), and Japanese Ministry of Health and Welfare (JMHW) criteria.Results:Out of the 375 patients, 15 (4%) were identified with CS. The median age was 41 years, and 53% were female. The most common symptoms were breathlessness, palpitation, and fatigue in 80%, 53.3%, and 46.6% of patients, respectively. Tuberculin positivity (≥ 10mm induration) was seen in 26.6%. 80% and 53.3% of the patients had abnormal ECG and 2D echocardiography findings, respectively. Six patients had a history of Ventricular tachycardia (40%). LV Ejection fraction was reduced in 12 subjects (80%). Cardiac-MRI showed late gadolinium enhancement in 53.3%. A definitive histopathological diagnosis for sarcoidosis was established in 86.6% (13/15) patients. Of the 15, all satisfied JMHW criteria and WASOG criteria (12 (80%) at least probable category, 3 (20%) possible CS), and 13 (86.6%) met HRS criteria for a diagnosis of CS.Conclusion:In a cohort of 375 patients with sarcoidosis in a tuberculosis endemic setting, 4% were diagnosed with cardiac sarcoidosis. Histopathological diagnosis may be obtained by sampling from extracardiac sites. JMHW and WASOG criteria perform equally well in TB endemic settings. 相似文献
135.
Photochemical inactivation of viruses and bacteria in platelet concentrates by use of a novel psoralen and long-wavelength ultraviolet light 总被引:15,自引:0,他引:15
L Lin ; DN Cook ; GP Wiesehahn ; R Alfonso ; B Behrman ; GD Cimino ; L Corten ; PB Damonte ; R Dikeman ; K Dupuis ; YM Fang ; CV Hanson ; JE Hearst ; CY Lin ; HF Londe ; K Metchette ; AT Nerio ; JT Pu ; AA Reames ; M Rheinschmidt ; J Tessman ; ST Isaacs ; S Wollowitz ; L Corash 《Transfusion》1997,37(4):423-435
BACKGROUND: A photochemical treatment process has been developed for the inactivation of viruses and bacteria in platelet concentrates. This process is based on the photochemical reaction of a novel psoralen, S- 59, with nucleic acids upon illumination with long-wavelength ultraviolet light (UVA, 320–400 nm). STUDY DESIGN AND METHODS: High levels of pathogens were added to single-donor platelet concentrates containing 3 to 5 × 10(11) platelets in 300 mL of 35-percent autologous plasma and 65-percent platelet additive solution. After treatment with S-59 (150 microM) and UVA (0-3 J/cm2), the infectivity of each pathogen was measured with established biologic assays. In vitro platelet function after photochemical treatment was evaluated during 7 days of storage by using a panel of 14 assays. The in vivo recovery and life span of photochemically treated platelets were evaluated after 24 hours of storage in a primate transfusion model. RESULTS: The following levels of pathogen inactivation were achieved:>10(6.7) plaque-forming units (PFU) per mL of cell-free human immunodeficiency virus (HIV),>10(6.6) PFU per mL of cell-associated HIV,>10(6.8) infectious dose (ID50) per mL of duck hepatitis B virus (a model for hepatitis B virus),>10(6.5) PFU per mL of bovine viral diarrhea virus (a model for hepatitis C virus),>10(6.6) colony-forming units of Staphylococcus epidermidis, and>10(5.6) colony-forming units of Klebsiella pneumoniae. Expression of integrated HIV was inhibited by 0.1 microM S- 59 and 1 J per cm2 of UVA. In vitro and in vivo platelet function were adequately maintained after antiviral and antibacterial treatment. CONCLUSION: Photochemical treatment of platelet concentrates offers the potential for reducing transfusion-related viral and bacterial diseases. 相似文献
136.
137.
HER2 challenge contest: a detailed assessment of automated HER2 scoring algorithms in whole slide images of breast cancer tissues 下载免费PDF全文
Talha Qaiser Chaitanya Reddy PB Sai D Munugoti Vamsi Tallam Tomi Pitkäaho Taina Lehtimäki Thomas Naughton Matt Berseth Aníbal Pedraza Ramakrishnan Mukundan Matthew Smith Abhir Bhalerao Erik Rodner Marcel Simon Joachim Denzler Chao‐Hui Huang Gloria Bueno David Snead Ian O Ellis Mohammad Ilyas Nasir Rajpoot 《Histopathology》2018,72(2):227-238
Aims
Evaluating expression of the human epidermal growth factor receptor 2 (HER2) by visual examination of immunohistochemistry (IHC) on invasive breast cancer (BCa) is a key part of the diagnostic assessment of BCa due to its recognized importance as a predictive and prognostic marker in clinical practice. However, visual scoring of HER2 is subjective, and consequently prone to interobserver variability. Given the prognostic and therapeutic implications of HER2 scoring, a more objective method is required. In this paper, we report on a recent automated HER2 scoring contest, held in conjunction with the annual PathSoc meeting held in Nottingham in June 2016, aimed at systematically comparing and advancing the state‐of‐the‐art artificial intelligence (AI)‐based automated methods for HER2 scoring.Methods and results
The contest data set comprised digitized whole slide images (WSI) of sections from 86 cases of invasive breast carcinoma stained with both haematoxylin and eosin (H&E) and IHC for HER2. The contesting algorithms predicted scores of the IHC slides automatically for an unseen subset of the data set and the predicted scores were compared with the ‘ground truth’ (a consensus score from at least two experts). We also report on a simple ‘Man versus Machine’ contest for the scoring of HER2 and show that the automated methods could beat the pathology experts on this contest data set.Conclusions
This paper presents a benchmark for comparing the performance of automated algorithms for scoring of HER2. It also demonstrates the enormous potential of automated algorithms in assisting the pathologist with objective IHC scoring. 相似文献138.
139.
Oral Diseases (2012) 19 , 18–36 Objective: Solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients are at risk of several diseases, principally attributable to immunosuppression. This global overview of SOT/HSCT‐associated orofacial diseases is aimed at providing a practical instrument for the oral healthcare management of SOT/HSCT recipients. Methods: Literature search was made through MEDLINE. The associations between orofacial diseases and SOT/HSCT were assessed using observational studies and case series and were classified into ‘association’, ‘no association’, and ‘unclear association’. Results: Lip/oral cancers, drug‐induced gingival overgrowth (DIGO), infections, including hairy leukoplakia and, less frequently, post‐transplantation lymphoproliferative disorders (PTLDs) and oral lichenoid lesions of graft‐versus‐host disease (GVHD), were associated with SOT. Lip/oral cancers, GVHD, mucositis, DIGO, infections and, less frequently, PTLDs were associated with HSCT. Associations of orofacial granulomatosis‐like lesions and oral mucosa‐associated lymphoid tissue‐type lymphoma with SOT, and of pyogenic granuloma and hairy leukoplakia with HSCT were unclear. Periodontal disease and dental caries were not associated with SOT/HSCT. For none of the local treatments was there a strong evidence of effectiveness. Conclusions: Solid organ transplant/HSCT recipients are at risk of orofacial diseases. Adequate management of these patients alleviates local symptoms responsible for impaired eating, helps prevent systemic and lethal complications, and helps where dental healthcare has been neglected. 相似文献
140.
E Stage ER Mathiesen PB Emmersen G Greisen P Damm 《Acta paediatrica (Oslo, Norway : 1992)》2010,99(7):997-999
Aim: As a result of increased neonatal morbidity, the infants of diabetic mothers have routinely been admitted to a neonatal special care unit (NSCU). We therefore investigated whether the offer of rooming‐in diabetic mothers and their newborn infants has an effect on neonatal morbidity. Methods: The records of an old cohort of 103 infants routinely admitted to the NSCU, and a new cohort (N = 102), offered rooming‐in were assessed for neonatal morbidity. Results: Eighty‐four (82%) of the new cohort infants followed their mothers to the maternity ward; whereas 19 (18%) were transferred to the NSCU chiefly because of prematurity. Ten infants were later transferred to the NSCU for minor problems. Neonatal morbidity and neonatal hypoglycaemia were significantly less common in the new cohort than in the old cohort [27 (26%) vs. 55 (54%), p < 0.001 and 42 (41%) vs. 64 (63%), p = 0.0027 respectively]. Maternal HbA1c in late pregnancy was significantly lower in the new cohort, but the only independent predictors of neonatal morbidity were belonging to the old cohort and preterm delivery. Conclusion: Neonatal care with rooming‐in mothers with type 1 diabetes and their newborn infants seems safe and is associated with reduced neonatal morbidity, when compared with routine separation of infants from their mothers. 相似文献