全文获取类型
收费全文 | 1898522篇 |
免费 | 139631篇 |
国内免费 | 4807篇 |
专业分类
耳鼻咽喉 | 26879篇 |
儿科学 | 63574篇 |
妇产科学 | 51268篇 |
基础医学 | 276696篇 |
口腔科学 | 51459篇 |
临床医学 | 169535篇 |
内科学 | 372714篇 |
皮肤病学 | 42051篇 |
神经病学 | 143202篇 |
特种医学 | 73956篇 |
外国民族医学 | 724篇 |
外科学 | 286450篇 |
综合类 | 43257篇 |
现状与发展 | 10篇 |
一般理论 | 525篇 |
预防医学 | 140747篇 |
眼科学 | 42786篇 |
药学 | 142856篇 |
26篇 | |
中国医学 | 6040篇 |
肿瘤学 | 108205篇 |
出版年
2019年 | 15020篇 |
2018年 | 21210篇 |
2017年 | 16151篇 |
2016年 | 17730篇 |
2015年 | 20420篇 |
2014年 | 28069篇 |
2013年 | 41775篇 |
2012年 | 56742篇 |
2011年 | 59595篇 |
2010年 | 35688篇 |
2009年 | 33612篇 |
2008年 | 55653篇 |
2007年 | 59339篇 |
2006年 | 59786篇 |
2005年 | 57372篇 |
2004年 | 55822篇 |
2003年 | 53783篇 |
2002年 | 52377篇 |
2001年 | 92973篇 |
2000年 | 95611篇 |
1999年 | 80549篇 |
1998年 | 21752篇 |
1997年 | 19321篇 |
1996年 | 19827篇 |
1995年 | 18779篇 |
1994年 | 17670篇 |
1993年 | 16275篇 |
1992年 | 62890篇 |
1991年 | 61708篇 |
1990年 | 60053篇 |
1989年 | 57918篇 |
1988年 | 53107篇 |
1987年 | 51952篇 |
1986年 | 48642篇 |
1985年 | 46335篇 |
1984年 | 34531篇 |
1983年 | 29063篇 |
1982年 | 16594篇 |
1981年 | 14997篇 |
1979年 | 30915篇 |
1978年 | 21571篇 |
1977年 | 18231篇 |
1976年 | 17210篇 |
1975年 | 18686篇 |
1974年 | 21822篇 |
1973年 | 20931篇 |
1972年 | 19438篇 |
1971年 | 17833篇 |
1970年 | 16956篇 |
1969年 | 15412篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
131.
OBJECTIVE: To study the effect of high-frequency (100 Hz) repetitive conditioning electrical stimulation (CES, 10 min) on human somatosensory evoked potentials (SEPs) to evaluate if short-term cortical plasticity could be induced. METHODS: Painful electrical stimulations were applied to thumb (D1) and little finger (D5) fingertips, respectively. The 124-channel EEG was recorded from 10 healthy male volunteers. Peak stages around 34, 45, 212, 331 ms were analyzed with focal maximum amplitude (FA) and area magnitude (AM) of scalp field potential, topography, and equivalent current dipole source localisation, comparing before and after two-level CES (high- vs. low-level) applied to the He-Gu acupoint. RESULTS: After a high-level CES, the positive FA and AM of the current efflux showed a significant increase at the early phase 34 ms, and significantly decreased at 45 ms in D1 SEPs. The negative FA and AM of the current influx were significantly increased at late phase 350 ms of the D5 SEPs. Only 36 ms, the z-axis position of dipole was significantly changed from (x: -15.9 mm, y: 29.6 mm, z: 43.9 mm) to (x: -12.9 mm, y: 29.4mm, z: 51.5mm) for the D5 SEPs. CONCLUSIONS: The high-level CES significantly attenuated the subsequent cortical activation (45 ms peak for D1 stimulation). Both low- and high-level CES significantly enhanced the late activities (226, 350 ms) in D5 stimulation. This may be explained by pain sensation change at the level of subcortical cingulate cortex induced by the site-dependent post-effect of CES. SIGNIFICANCE: This study showed cortical plasticity induced by conditioning somatosensory stimulation. 相似文献
132.
Asawanonda P. Chingchai A. Torranin P. 《世界核心医学期刊文摘》2006,2(3):25-25
目的:确定UVB靶向光疗治疗局限性银屑病是否安全有效及是否存在量效关系。设计:随机、对评估者设盲对照研究。机构:泰国曼谷大学医院皮肤病门诊。患者:14例稳定性局限性斑块型银屑病患者。干预:依据预定的最小红斑量(M EDs),随机给予患者不同通量的UVB靶向光线治疗,3次/周。在4 相似文献
133.
Willemijn A K M Windt Atsua Tahara Alex C A Kluppel Dick de Zeeuw Robert H Henning Richard P E van Dokkum 《Journal of the renin-angiotensin-aldosterone system》2006,7(4):217-224
INTRODUCTION: Vasopressin, mainly through the V1a-receptor, is thought to be a major player in the maintenance of hyperfiltration. Its inhibition could therefore lead to a decrease in progression of chronic renal failure. To this end, the effect of the vasopressin V1a-receptor-selective antagonist, YM218, was studied on proteinuria and focal glomerulosclerosis in early and late intervention after 5/6 nephrectomy in rats, and compared with an angiotensin-converting enzyme inhibitor (ACE-I). MATERIALS AND METHODS: After 5/6 nephrectomy, early intervention was performed between week 2 and 10 thereafter with the V1a-receptor-selective antagonist (VRA, 10 mg/kg/day, n=10), enalapril (ACE-I, 10 mg/kg/day, n=9), or vehicle (n=8). Late intervention was performed in another group between week 6 and 12 with VRA (10 mg/kg/day, n=7), lisinopril (ACE-I, 5 mg/kg/day, n=7), or vehicle (n=7). RESULTS: In early intervention, proteinuria and focal glomerulosclerosis were significantly decreased by VRA compared to vehicle (44+7% and 59+8% respectively). ACE-I significantly decreased proteinuria (67+7%) and a trend towards a decrease in focal glomerulosclerosis was observed (30+18%). In late intervention, VRA did not decrease proteinuria and focal glomerulosclerosis compared to vehicle (21+20% and 0%, respectively), ACE-I significantly lowered proteinuria (92+2%) and a focal glomerulosclerosis (69+1%) lowering trend was observed. CONCLUSION: These results indicate that VRA may protect against early progression of renal injury after 5/6 nephrectomy, whereas its effectiveness seems limited in established renal damage. 相似文献
134.
135.
136.
137.
138.
H Ishihara M Bjeljac D Straumann Y Kaku P Roth Y Yonekawa 《Minimally invasive neurosurgery》2006,49(3):168-172
OBJECTIVE: A safe entry zone to tegmental lesions was identified based on intraoperative electrophysiological findings, the compound muscle action potentials (CMAP) from the extraocular muscles, and anatomic considerations. This entry zone is bordered caudally by the intramesencephalic path of the trochlear, laterally by the spinothalamic tract, and rostrally by the caudal margin of the brachium of the superior colliculus. METHODS: Four intrinsic midbrain lesions were operated upon via the safe entry zone using the infratentorial paramedian supracerebellar approach. All lesions involved the tegmentum and included an anaplastic astrocytoma, a metastatic brain tumor, a radiation necrosis, and a cavernous angioma. CMAP were bilaterally monitored from the inferior recti (for oculomotor function) and superior oblique (for trochlear nerve function) muscles. RESULTS: In three of four cases, CMAP related to the oculomotor nerve were obtained upon stimulation at the cavity wall after removal of the tumor. Stimulation at the surface of the quadrigeminal plate, however, did not cause any CMAP response. Using this monitoring as an indicator, the lesions were totally removed. CONCLUSIONS: In the surgery of tegmental lesions, CMAP monitoring from extraocular muscles is particularly helpful to prevent damage to crucial neural structures during removal of intrinsic lesions, but less so to select the site of the medullary incision. The approach via the lateral part of the colliculi is considered to be a safe route to approach the tegmental lesions. 相似文献
139.
140.