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排序方式: 共有632条查询结果,搜索用时 103 毫秒
561.
BM Junghans PhD SG Crewther PhD DP Crewther PhD B Pirie 《Clinical & experimental ophthalmology》1997,25(4):103-105
Purpose: Although it is generally thought that lymphatics do not exist in the choroid, there is mounting evidence that lymphatic-like structures do exist in primates and fowl. Methods/Results: Our comparison of the ultrastructure of chick and rabbit outer choroid indicates that major differences exist in the non-vascular areas of the choroid: notably, the chick has large lymphatic sinusoids, whereas the rabbit only has a system of large vacuoles contained within the processes of individual fibroblasts. Conclusions: These results raise questions regarding the similarities or otherwise between species of the management of retinal metabolites, excess tissue fluid and choroidal homeostasis, especially during conditions of overload. 相似文献
562.
Ramella-Virieux SG; Steghens JP; Barbieux A; Zech P; Pozet N; Hadj-Aissa A 《Nephrology, dialysis, transplantation》1997,12(3):449-455
BACKGROUND: Extracellular types (high-Na) of cold-storage solution (CSS)
have been shown to be more effective in preserving kidneys than
intracellular CSS (high-K). On the other hand, calcium entry blockers (CEB)
have been demonstrated to improve graft function when administered after
and/or prior to transplantation. The ischaemia reperfusion syndrome
involves, in part, an alteration in intracellular calcium metabolism that
induces an increase in renal vascular resistances (RVR) and other cellular
dysfunction, and high-K CSS per se are vasoconstrictive. Since CEB act via
a modification in intracellular calcium metabolism on vascular smooth
muscle, glomerular, and tubular cells, we evaluated the actual benefit on
CEB on kidneys preserved in Belzer's CSS (K-UW) and a high-Na version of
Belzer's CSS (Na-UW). METHOD: The isolated perfused rat kidney (IPK) was
used, first as a vascular bed to test the effects of CSS on RVR, and the
influence of nifedipine. Second, the recovery function of the IPK was
assessed by GFR and tubular Na reabsorption, after 24 h preservation in
K-UW and Na- UW, with or without nifedipine. Results were compared with a
control group in which renal function was measured without prior
cold-storage. RESULTS: K-UW but not Na-UW induced an increase in RVR when
flushed into the kidney. This vasoconstriction is prevented by nifedipine.
K-UW CSS was more deleterious to renal function than Na-UW. Addition of
nifedipine to the flush, the CSS for 24 h, and to the normothermic
reperfusate further improved recovery function of the IPK cold stored in
Na-UW but not in K-UW, without any modification of RVR. CONCLUSION:
Nifedipine may be of potential effect in attenuating ischaemic injury by a
mechanism which does not involve its vasodilatory properties.
相似文献
563.
Erik K. Insko Thomas J. Connick Mitchell D. Schnall Susan G. Orel 《Magnetic resonance in medicine》1997,37(5):778-784
An RF multicoil array for high resolution imaging of the breast is presented. The RF multicoil is incorporated into a dedicated breast imaging apparatus that holds either breast in gentle compression during imaging. Simulations and imaging experiments demonstrate the high sensitivity and RF homogeneity of the multicoil array. Direct comparisons are made between the multicoil and a surface coil. In vivo images are presented to demonstrate the homogeneity of the RF field of the multicoil over the entire breast. An in vivo image of both high temporal and spatial resolution is shown, which demonstrates the sensitivity of the RF multicoil array that may be achieved in a practical imaging experiment. 相似文献
564.
Mueller PR; Saini S; Simeone JF; Silverman SG; Morris E; Hahn PF; Forman BH; McLoud TC; Shepard JO; Ferrucci JT Jr 《Radiology》1988,169(1):1-4
Twenty-six pleural biopsies were performed on 23 patients over a 3-year period. Twenty-three biopsies were performed guided with ultrasound; one, with computed tomography; and two, with fluoroscopy. Indications for an image-guided pleural biopsy were (a) pleural masses or thickening that were either not seen on chest radiographs or seen only on one view and (b) small or loculated pleural effusions of unknown cause with no mass seen. If only pleural fluid was present, reverse bevel needles were used for biopsy (n = 15). If a discrete pleural mass or thickening was seen with cross-sectional imaging, standard (16-20 gauge) biopsy needles were used (n = 11). In the 23 patients, biopsy results were true positive in ten (nine with malignancy, one with tuberculous pleurisy), true negative in ten (confirmed either at subsequent thoracotomy or clinical follow-up), and false negative in three. Complications were few, with a significant pneumothorax occurring in two patients (8.7%). Image-guided biopsy of small pleural lesions and small pleural effusions can be performed by the radiologist who understands the special needles and techniques involved. 相似文献
565.
566.
567.
Repopulation of marrow after transplantation: MR imaging with pathologic correlation 总被引:3,自引:0,他引:3
Sixty-seven magnetic resonance (MR) studies of the lumbar spine were performed in 15 patients with bone marrow transplants, and the appearance of marrow regeneration on MR images was correlated with results of bone marrow biopsy and pathologic examination. After transplantation, T1-weighted MR images of vertebral marrow showed a characteristic band pattern consisting of a peripheral zone of intermediate signal intensity and a central zone of bright signal intensity. Reciprocal changes were identified on short inversion time inversion recovery images. At histologic examination the central zone corresponded to fatty marrow; the peripheral zone corresponded to a zone of regenerating hematopoietic cells. Posttransplantation T1 and T2 relaxation times of the entire vertebral marrow were calculated from the spin-echo images; no statistically significant trends in relaxation times were noted. Knowledge of the normal MR pattern of marrow regeneration after transplantation may be useful in screening for residual marrow disease, determining marrow engraftment, and differentiating marrow repopulation with normal versus malignant cells. 相似文献
568.
BACKGROUND: The possible effects of long-term plasma donation remain unknown, but it is important to investigate them so that donor safety is ensured. The purpose of this study was to determine if long-term plasma donation alters plasma proteins or lymphocyte phenotypes. STUDY DESIGN AND METHODS: Two groups of long-term plasma donors, source plasma donors (n = 20) and Rh immune globulin plasma donors (n = 26), were compared with whole blood donors (n = 29) and nondonor controls (n = 30). Blood samples were obtained prior to donation. Serum protein, albumin, globulin, and immunoglobulin levels were determined. In an assay using whole blood, lymphocyte phenotypes were characterized with a panel of single- and dual-labeled monoclonal antibodies and subsequent analysis by flow cytometry. RESULTS: As compared to the nondonor controls and/or whole blood donors, the mean values for serum protein, globulin, and IgG levels were lower in both plasma donor groups, with a significant negative correlation between donation frequency and serum protein values for the source plasma donors. Albumin levels were within normal ranges for both groups of plasma donors. No significant differences existed among the donor groups in total white cell counts, the percentage or absolute number of lymphocytes, T (CD3) cells, or helper T (CD4) cells. However, there were increased percentages of B (CD19) cells and decreased percentages of suppressor T (CD8+/CD11b+) cells and natural killer cells in both groups of plasma donors as compared to nondonor controls. CONCLUSION: Many plasma donors have low levels of serum protein, globulin, and IgG. In addition, they have increased percentages of B cells and decreased percentages of suppressor T and natural killer cells. The clinical significance of these findings warrants further investigation. 相似文献
569.
A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43) 总被引:2,自引:0,他引:2
Eckman CB; Mehta ND; Crook R; Perez-tur J; Prihar G; Pfeiffer E; Graff- Radford N; Hinder P; Yager D; Zenk B; Refolo LM; Prada CM; Younkin SG; Hutton M; Hardy J 《Human molecular genetics》1997,6(12):2087-2089
We report a novel mutation in the amyloid precursor protein gene (APP
I716V) which probably leads to familial early onset Alzheimer's disease
with an onset age in the mid 50s. Cells transfected with cDNAs bearing this
mutation produce more A beta 1-42(43) than those transfected with wild-type
APP and this effect is additive with that of the previously reported APP
V717I mutation thus providing a novel approach for further increasing A
beta 1-42(43) in model systems.
相似文献
570.
A pilot study of the human chorionic gonadotrophin test for ovarian hyperandrogenism 总被引:1,自引:4,他引:1
A controlled clinical study was designed to investigate the value of human
chorionic gonadotrophin (HCG) challenge as a test for functional ovarian
hyperandrogenism. Dexamethasone administration was followed by 5000 IU HCG
and blood samples for steroid hormone assay were obtained 0, 8, 16, and 24
h thereafter. Study subjects were normal women (n = 13); women with
functional ovarian hyperandrogenism, defined by androgen excess,
amenorrhoea and an increased 17-hydroxyprogesterone response to nafarelin
(n = 6); and normal men (n = 4). The responses of 17-hydroxyprogesterone,
androstenedione and testosterone to HCG in women with functional ovarian
hyperandrogenism were significantly greater than in normal women. However,
the 17-hydroxyprogesterone response to HCG in functional ovarian
hyperandrogenism was significantly lower after HCG than after nafarelin.
The oestradiol response was also significantly lower after HCG than
nafarelin, although oestradiol concentration more than doubled in normal
women as well as in women with functional ovarian hyperandrogenism. The
responses to HCG confirm that functional ovarian hyperandrogenism
abnormalities are luteinizing hormone (LH)-dependent. Therefore, the 17-
hydroxyprogesterone response to HCG could represent a useful test for the
diagnosis of ovarian hyperandrogenism. The lower 17- hydroxyprogesterone
response to HCG than to nafarelin in functional ovarian hyperandrogenism
suggests that a follicle-stimulating hormone (FSH)-responsive factor
modulates thecal 17-hydroxyprogesterone secretion. The oestradiol response
to HCG is consistent with HCG directly stimulating the oestradiol secretion
by thecal cells.
相似文献