Risk factors for development of dehydration in children aged under five who have acute watery diarrhoea: a case-control study

Objective: To identify risk factors for development of dehydration in under five year olds with acute watery diarrhoea.Design: Hospital based unmatched case-control study.Setting: Diarrhoea Treatment Unit, Government Medical College Hospital, Nagpur, India.Participants: The study included 387 cases of diarrhoea having severe or moderate dehydration and 387 controls suffering from diarrhoea with mild or no dehydration.Risk factors: The study included infancy, female sex, religion, residing in urban slums or rural area, under nutrition, cessation of breast feeding during diarrhoeal episode, fluid intake decreased/stopped during diarrhoea, ORS not received, home available fluids (HAF) not received, both ORS and HAF not received, non-washing of hands by mother before preparation of food, after defaecation, after disposal of faeces, history of measles in the previous six months, frequency of stools >8/d, frequency of vomiting more than twice per day and temperature more than 99°F, as risk factors for development of dehydration.Statistical analysis: Univariate analysis included OR, 95% CI for OR and Chi-square test. Multivariate analysis was carried out by unconditional multiple logistic regression (MLR).Results: This study identified the significance of infancy, religion, severe undernutrition, non-washing of hands by mother before preparation of food, frequency of stool >8/d, frequency of vomiting >2/d, history of measles in previous six months, withdrawal of breast feeding during diarrhoea, withdrawal of fluids during diarrhoea and not giving ORS, HAF or both during diarrhoea, in the outcome of development of moderate or severe dehydration.Conclusions: Timely intervention in the preventable risk factors included in this study may prevent the development of moderate or severe dehydration in the children suffering form acute watery diarrhoea.     

The influence of coccidiosis resistant, susceptible and unselected sires on progeny mortality after infection with Eimeria tenella

After four generations of selection for resistance to E. tenella, resistant, unselected and susceptible, sires were mated to dams of an unselected population. Mortality from coccidiosis in their progeny following inoculation of every chick with 50,000 sporulated oocysts was only 3.7% in progeny of resistant sires, compared with 20% in progeny of unselected sires and 25% in chicks from sires of a susceptible strain.     

Delayed hypersensitivity reaction in patients with metastatic testicular teratoblastoma

In 41 patients with testicular teratoblastoma the cell-mediated immunity was studied by delayed hypersensitivity skin testing. Skin tests for DNCB, PPD, polysaccharide fractions of teratoblastoma and normal human embryonal antigens were made. The DNCB response is shown to correlate with the process spread and patients' survival.     

The effect of hemosorption on the intensity of spontaneous chemiluminescence of the blood

1 day after intensive irradiation of cancer patients chemiluminescent (CL) signal of blood sera is considerably enhanced. Hemoperfusion (HP) decreases it by 62%, with the following slight increase in CL intensity. 42-47% increase in electrokinetic erythrocyte potential registered in patients after HP, as well as a certain decrease in blood viscosity may be considered as an indirect explanation of the mechanism of triboluminescence of human blood during HP.     

Relation of spontaneous chemiluminescence, electrochemiluminescence and resistance of blood serum in patients with cancer of the proximal part of the stomach and esophagus

The levels of spontaneous chemoluminescence of serum in patients with cancer of the proximal part of the stomach and the esophagus were found to be 2-6 times the age-connected norm. The said concentrations decreased by half following radiation treatment, to rise by 75% after surgery. At later periods after surgery, chemoluminescence levels dropped almost to normal unless complications developed. However, in patients with gastroesophageal cancer, the level of spontaneous chemoluminescence remained high over a long period of time. Variation patterns were identical, with an amplitude being significantly lower. Changes in blood serum resistance were insignificant. Scale factor K varied in the range of 6-66. In cases of purulent complications, spontaneous chemoluminescence levels showed a sharp rise, the values of K exceeding 75. This pattern made it easier to differentiate between inflammatory lesions and neoplasia.     

The role of ifosfamide and cyclophosphamide in the multi-modality treatment after surgery for cure for small-cell bronchial carcinomas (SCLC)

For the optimisation of the therapy for small cell bronchial carcinomas (SCLC), surgery is used to eliminate the primary tumor and its regional lymph nodes and chemo- and radiotherapy for the general treatment of micrometastasis. After patho-histological examination of the operation specimen, randomization for two arms is performed for a standard chemotherapy (CAV) or a sequential chemotherapy using three different drug combinations. Thereafter all disease-free patients receive prophylactic cranial irradiation (PCI). Preliminary evaluations in December 1987, of 112 patients from 19 cooperating departments show that the survival rate projected for 2 yr of 43 patients at stage pT1-3 N0 M0 is 76%, of 43 patients at stage pT1-3 N1 M0 it is 63% and of 26 patients at stage pT1-3 N2 M0 it is 38%.     

Breast neoplasms: duplex sonographic imaging as an adjunct in diagnosis

Sonographic breast imaging has been useful in the differentiation of cystic from solid masses. It has also been helpful in the characterization of palpable breast masses in the absence of corresponding abnormalities. The authors undertook a prospective study that incorporated pulsed Doppler analysis into sonographic real-time imaging of solid breast masses. Thirty-eight patients were examined. In 12 of the patients there were positive Doppler signals, while in 26 patients there were no Doppler signals. The 12 patients showing positive Doppler signals proved to have infiltrating ductal carcinoma, while the 26 patients with negative Doppler signals proved to have benign breast disorders. Pulsed Doppler analysis as a supplement to sonographic real-time imaging shows promise for the identification of breast carcinoma.