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61.
Arijit Biswas Vytautas Ivaskevicius Anne Thomas Michael Varvenne Brigitte Brand Hannelore Rott Iris Haussels Heiko Ruehl Ute Scholz Robert Klamroth Johannes Oldenburg 《Annals of hematology》2014,93(10):1665-1676
Mild FXIII deficiency is an under-diagnosed disorder because the carriers of this deficiency are often asymptomatic and reveal a phenotype only under special circumstances like surgery or induced trauma. Mutational reports from this type of deficiency have been rare. In this study, we present the phenotypic and genotypic data of nine patients showing mild FXIII-A deficiency caused by eight novel heterozygous missense mutations (Pro166Leu, Arg171Gln, His342Tyr, Gln415Arg, Leu529Pro, Gln601Lys, Arg703Gln and Arg715Gly) in the F13A1 gene. None of these variants were seen in 200 healthy controls. In silico structural analysis of the local wild-type protein structures (activated and non-activated) from X-ray crystallographic models downloaded from the protein databank identified potential structural/functional effects for the identified mutations. The missense mutations in the core domain are suggested to be directly influencing the catalytic triad. Mutations on other domains might influence other critical factors such as activation peptide cleavage or the barrel domain integrity. In vitro expression and subsequent biochemical studies in the future will be able to confirm the pathophysiological mechanisms proposed for the mutations in this article. 相似文献
62.
Yousra H. AL JAZAIRY Hassan Suliman HALAWANY Nawaf AL HUSSAINAN Nassr AL MAFLEHI Nimmi Biju ABRAHAM Vimal JACOB 《Industrial health》2014,52(4):324-333
A disparity exists in the educational qualifications of dental assistants working in
various public and private institutions in Riyadh, Saudi Arabia. The aim of this study was
to assess the influence of professional and personal characteristics on job satisfaction
among dental assistants. A cross-sectional survey was performed among dental assistants
using a 24-item self-administered questionnaire. Multinomial logistic regression was used
to assess the relationship between overall job satisfaction and other variables. The
overall response rate was 72.1%. Factor analysis suggested that five underlying factors
were related to job satisfaction. The mean score for overall job satisfaction was 3.86
(satisfied) out of 5. Among the work environment factors, the highest mean score, 4.26
(satisfied), was obtained for quality of service, and the lowest mean score, 2.78
(neutral), was obtained for the perception of income. The income and general prospects of
the profession was significantly associated with overall job satisfaction. This study
suggests that for dental assistants, professional and personal life, quality of service,
perception of income and prestige and self-respect are important factors for job
satisfaction. Despite differences in professional formation standards, in general, the
study participants were considerably satisfied with their jobs. 相似文献
63.
Stewart Landers Elizabeth F. Closson Catherine E. Oldenburg Richard Holcomb Shannon Spurlock Matthew J. Mimiaga 《American journal of public health》2014,104(11):e100-e102
We examined data derived from a needs assessment of the personal and social characteristics and HIV risk behavior of street-based male sex workers, in Providence, Rhode Island, who engage in transactional sexual intercourse with other men. Substance use, injected drugs, needle sharing, and psychosocial distress were highly prevalent among the sample. History of physical, sexual, and emotional abuse was associated with increased risk of condomless anal sexual intercourse with paying male clients.In the United States, studies show that male sex workers (MSWs) engage in sexual and drug-using risk behaviors that put themselves and their partners at risk for HIV acquisition. Male sex workers have a significantly higher HIV prevalence (7.3% vs 1.1%) and incidence (4.7% vs 0.9%) than do men who have sex with men but who do not engage in transactional sexual intercourse.1–6 Street-based MSWs have been shown to have the highest rates of HIV risk behavior both with clients and nontransactional partners.5,7 Several psychosocial factors, including sexual abuse, homelessness, and substance use (particularly injecting), are known to heighten sexual risk behavior among street-based MSWs.8–13Given the clandestine nature of sex work, there are limited surveillance data on MSWs in the United States. Project Weber (http://www.projectweber.org), a nonprofit health service organization serving MSWs in Providence, Rhode Island, estimates that there are between 300 and 500 street-based MSWs in the city. Collected by Project Weber as part of a needs assessment of street-based MSWs in Providence, the data reported here detail the personal and social characteristics and HIV risk behavior among this group. 相似文献
64.
Iman Amy Betawi Sinaria Kamil Abdel Jabbar Mohammad. A. AL Jabery Haidar Ibrahim Zaza Muhannad Al-Shboul 《Early child development and care》2014,184(12):1992-2003
This study examined fathers' perceptions regarding their home-based activities (HBA) and the influence of fathers' demographic characteristics on their perceptions and practices at home. A total of 396 fathers completed a survey questionnaire describing their demographic information, perceptions and their practices regarding their involvement in HBA. Results indicated that fathers have moderate level of practice concerning their HBA, yet they have low perception of their actual practice at HBA. In addition, there was a statistical significance in HBA due to fathers' age, educational level and specialisation which had an influence on their perceptions as well. Recommendations and implications of future research were discussed. 相似文献
65.
Danielle Carpenter Carmen Taype Jon Goulding Mike Levin Brian Eley Suzanne Anderson Marie-Anne Shaw John AL Armour 《BMC medical genetics》2014,15(1):1-8
Background
22q11.2 deletion syndrome (22q11.2DS) is a common microdeletion syndrome, which occurs in approximately 1:4000 births. Familial autosomal dominant recurrence of the syndrome is detected in about 8-28% of the cases. Aim of this study is to evaluate the intergenerational and intrafamilial phenotypic variability in a cohort of familial cases carrying a 22q11.2 deletion.Methods
Thirty-two 22q11.2DS subjects among 26 families were enrolled.Results
Second generation subjects showed a significantly higher number of features than their transmitting parents (212 vs 129, P?=?0.0015). Congenital heart defect, calcium-phosphorus metabolism abnormalities, developmental and speech delay were more represented in the second generation (P?<?0.05). Ocular disorders were more frequent in the parent group. No significant difference was observed for the other clinical variables. Intrafamilial phenotypic heterogeneity was identified in the pedigrees. In 23/32 families, a higher number of features were found in individuals from the second generation and a more severe phenotype was observed in almost all of them, indicating the worsening of the phenotype over generations. Both genetic and epigenetic mechanisms may be involved in the phenotypic variability.Conclusions
Second generation subjects showed a more complex phenotype in comparison to those from the first generation. Both ascertainment bias related to patient selection or to the low rate of reproductive fitness of adults with a more severe phenotype, and several not well defined molecular mechanism, could explain intergenerational and intrafamilial phenotypic variability in this syndrome. 相似文献66.
67.
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69.
Yingting Cao Quan Huynh Nitin Kapoor Panniyammakal Jeemon Gabrielli Thais de Mello Brian Oldenburg Kavumpurathu Raman Thankappan Thirunavukkarasu Sathish 《Nutrients》2022,14(3)
The association between dietary patterns and cardiometabolic risk factors is not well understood among adults in India, particularly among those at high risk for diabetes. For this study, we analyzed the data of 1007 participants (age 30–60 years) from baseline and year one and two follow-ups from the Kerala Diabetes Prevention Program using multi-level mixed effects modelling. Dietary intake was measured using a quantitative food frequency questionnaire, and dietary patterns were identified using principal component analysis. Two dietary patterns were identified: a “snack-fruit” pattern (highly loaded with fats and oils, snacks, and fruits) and a “rice-meat-refined wheat” pattern (highly loaded with meat, rice, and refined wheat). The “snack-fruit” pattern was associated with increased triglycerides (mg/dL) (β = 6.76, 95% CI 2.63–10.89), while the “rice-meat-refined wheat” pattern was associated with elevated Hb1Ac (percentage) (β = 0.04, 95% CI 0.01, 0.07) and central obesity (OR 1.16, 95% CI 1.01, 1.34). These findings may help inform designing dietary interventions for the prevention of diabetes and improving cardiometabolic risk factors in high-diabetes-risk individuals in the Indian setting. 相似文献
70.
AL Naik A Savlania A Gupta P Rastogi A Singh 《Annals of the Royal College of Surgeons of England》2021,103(3):e94
Behçet’s disease is a rare disease characterised by recurrent oral ulcers, with systemic manifestations including genital ulcers, ocular disease, skin lesions, gastrointestinal disease, neurologic disease, vascular disease and arthritis. Most clinical manifestations of Behçet’s disease are believed to be due to vasculitis. The heterogeneous clinical spectrum is influenced by sex, ethnicity and country of residence. Vascular manifestation in the form of isolated large brachial artery aneurysm is rare in children. Treatment involves aneurysmorrhaphy to avoid rupture or ischaemic sequelae in addition to lifelong medical management to control vasculitis. 相似文献