全文获取类型
收费全文 | 1759篇 |
免费 | 98篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 25篇 |
妇产科学 | 47篇 |
基础医学 | 260篇 |
口腔科学 | 31篇 |
临床医学 | 89篇 |
内科学 | 560篇 |
皮肤病学 | 38篇 |
神经病学 | 80篇 |
特种医学 | 36篇 |
外科学 | 250篇 |
综合类 | 3篇 |
一般理论 | 1篇 |
预防医学 | 59篇 |
眼科学 | 13篇 |
药学 | 64篇 |
肿瘤学 | 316篇 |
出版年
2024年 | 4篇 |
2023年 | 19篇 |
2022年 | 33篇 |
2021年 | 64篇 |
2020年 | 29篇 |
2019年 | 33篇 |
2018年 | 50篇 |
2017年 | 35篇 |
2016年 | 49篇 |
2015年 | 58篇 |
2014年 | 50篇 |
2013年 | 59篇 |
2012年 | 112篇 |
2011年 | 136篇 |
2010年 | 66篇 |
2009年 | 65篇 |
2008年 | 112篇 |
2007年 | 110篇 |
2006年 | 97篇 |
2005年 | 109篇 |
2004年 | 128篇 |
2003年 | 100篇 |
2002年 | 106篇 |
2001年 | 31篇 |
2000年 | 11篇 |
1999年 | 25篇 |
1998年 | 14篇 |
1997年 | 18篇 |
1996年 | 15篇 |
1995年 | 25篇 |
1994年 | 16篇 |
1993年 | 13篇 |
1992年 | 15篇 |
1991年 | 8篇 |
1990年 | 13篇 |
1989年 | 8篇 |
1988年 | 7篇 |
1987年 | 10篇 |
1986年 | 3篇 |
1985年 | 5篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 4篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1955年 | 1篇 |
1954年 | 1篇 |
排序方式: 共有1875条查询结果,搜索用时 218 毫秒
91.
Mitsuo Okada M.D. Masahide Arita Mitsuo Iida Tsuneyoshi Yao Toshihiro Sakurai Kiyomi Hoshiko Kazuhiro Maeda Yasuhiro Okada Kiyoto Sakamoto 《Journal of gastroenterology》1992,27(2):179-186
A randomized controlled study comparing once-a-day morning and once-a-day bedtime administration of 40 mg famotidine in treating
duodenal ulcers was carried out in 99 Japanese patients. Endoscopic examinations were performed at the baseline and repeated
at 3-week intervals until healing was confirmed. Eighty-two patients fulfilled the evaluation criteria (38 in the morning
group and 44 in the bedtime group). In 13 of these patients the antisecretory effects of these regimens were also assessed
by 24 h intragastric pH monitoring. The healing rates were 66% after 3 weeks and 95% after 6 weeks in the morning group, and
57% after 3 weeks and 80% after 6 weeks in the bedtime group. The differences were insignificant between the two groups, but
there was a higher healing rate tendency after 6 weeks in the morning group (0.05<P<0.10). Regarding pain subsidence, there
were no significant differences between the two groups. Both treatments were significantly superior to the controlgroup in
increasing 24 h intragastric pH. The morning regimen was significantly superior to the bedtime regimen in suppression of daytime
acidity. On the contrary, the bedtime regimen was significantly superior to the morning regimen in suppression of nocturnal
acidity. These findings suggest that suppression of nocturnal acidity is important but not essential to promote duodenal ulcer
healing and suppression of daytime acidity is equally important. Thus, once-a-day morning administration of 40 mg famotidine
seems to be at least as effective as once-a-day bedtime administration of 40 mg famotidine in treating duodenal ulcers. 相似文献
92.
Yoriko Nishizawa Masaki Fujimura Atsurou Tagami Miki Abo Chihiro Honjyo Masahide Yasui Shinji Nakao 《Nihon Kokyūki Gakkai zasshi》2005,43(4):241-246
We encountered two cases of pulmonary infection by Mycobacterium abscessus (M. abscessus). [Case 1] A 66-year-old man who had been treated for non-tuberculous mycobacterium in the past was admitted because of productive cough. His chest X-ray film showed cavitation and direct microscopy of sputum revealed positive acid-fast bacilli (AFB). He was given rifampicin (RFP), ethambutol (EB), and clarythromycin (CAM), and then his symptoms and radiographic findings improved. [Case 2] A 74-year-old man with multiple myeloma as an underlying disease was admitted because of a cavitation found on chest radiography and a positive result for AFB in his sputum. Standard antituberculous drug therapy with isoniazid (INH), RFP, EB, and pyradinamide (PZA) was initiated and then the chest radiographic findings improved. As M. abscessus was isolated two weeks after the induction of therapy, the therapeutic regimen was changed to another combination therapy consisting of EB, clarithromycin (CAM) and ciprofloxacin (CPFX), and then his symptoms and radiographic findings were further improved. In both cases, the bacilli found in their sputum were identified as M. abscessus by DNA hybridization. They were completely resistant to all anti-tuberculosis agents and many antibiotics with a high value of MIC. However, their symptoms, radiographic abnormalities and the results of sputum examination improved following chemotherapy. The results obtained by MIC measurement were inconsistent with the clinical outcomes. The measurement of the MIC value of antibiotics do not necessarily predict its therapeutic effect. 相似文献
93.
Abstract: It is well known that cytomegalovirus infection is often accompanied by hepatitis, but there have been few comparative studies with respect to clinical features of cytomegalovirus-associated hepatitis and other acute viral hepatitides. In the present study, clinical and pathological features of 11 acute sporadic cytomegalovirus hepatitis infections in previously healthy adults were compared with those of 45 acute sporadic viral hepatitis, including type A, type B and type C. As a result, the characteristics of cytomegalovirus hepatitis were a long-lasting fever, splenomegaly, atypical lymphocytosis, a mild transaminasemia, a low ratio of alanine aminotransferase level to lactate dehydrogenase level, and mild hepatic histopathological changes. 相似文献
94.
Naoko Takaoka Kenichi Tsujita Koichi Kaikita Seiji Hokimoto Michio Mizobe Masahide Nagano Eiji Horio Koji Sato Naoki Nakayama Hiromi Yoshimura Kenshi Yamanaga Naohiro Komura Sunao Kojima Shinji Tayama Sunao Nakamura Hisao Ogawa 《International journal of cardiology》2014
Background
Some plaques lead to ST-segment elevation myocardial infarction (STEMI), whereas others cause non-ST-segment elevation acute coronary syndrome (NSTEACS). We used angiography and intravascular ultrasound (IVUS) to investigate the difference of culprit lesion morphologies in ACS.Methods
Consecutive 158 ACS patients whose culprit lesions were imaged by preintervention IVUS were enrolled (STEMI = 81; NSTEACS = 77). IVUS and angiographic findings of the culprit lesions, and clinical characteristics were compared between the groups.Results
There were no significant differences in patients' characteristics except for lower rate of statin use in patients with STEMI (20% vs 44%, p = 0.001). Although angiographic complex culprit morphology (Ambrose classification) and thrombus were more common in STEMI than in NSTEACS (84% vs 62%, p = 0.002; 51% vs 5%, p < 0.0001, respectively), SYNTAX score was lower in STEMI (8.6 ± 5.4 vs 11.5 ± 7.1, p = 0.01). In patients with STEMI, culprit echogenicity was more hypoechoic (64% vs 40%, p = 0.01), and the incidence of plaque rupture, attenuation and “microcalcification” were significantly higher (56% vs 17%, p < 0.0001; 85% vs 69%, p = 0.01; 77% vs 61%, p = 0.04, respectively). Furthermore, the maximum area of ruptured cavity, echolucent zone and arc of microcalcification were significantly greater in STEMI compared with NSTEACS (1.80 ± 0.99 mm2 vs 1.13 ± 0.86 mm2, p = 0.006; 1.52 ± 0.74 mm2 vs 1.21 ± 0.81 mm2, p = 0.004; 99.9 ± 54.6° vs 77.4 ± 51.2°, p = 0.01, respectively). Quantitative IVUS analysis showed that vessel and plaque area were significantly larger at minimum lumen area site (16.6 ± 5.4 mm2 vs 14.2 ± 5.5 mm2, p = 0.003; 13.9 ± 5.1 mm2 vs 11.6 ± 5.2 mm2, p = 0.003, respectively).Conclusion
Morphological feature (outward vessel remodeling, plaque buildup and IVUS vulnerability of culprit lesions) might relate to clinical presentation in patients with ACS. 相似文献95.
Obara Hiromichi Morito Noriyuki Matsuno Naoto Yoshikawa Ryo Nakajo Tetsuya Gochi Mikako Otani Masahide Shonaka Tatsuya Furukawa Hiroyuki Hirano Toshihiko Enosawa Shin 《Journal of artificial organs》2020,23(1):62-69
Journal of Artificial Organs - Improvement of machine perfusion (MP) technologies is required to enhance organ quality for donor after cardiac death (DCD) grafts. Installing a dialyzer or a filter... 相似文献
96.
97.
Hideo Ohkita Akira Tsuchida Masahide Yamamoto James A. Moore Donald R. Gamble 《Macromolecular chemistry and physics.》1996,197(8):2493-2499
The photocleavage reaction of dimer model compounds of photosensitive polyimides having cyclobutane rings in the main chain was studied. Efficient photocleavage was observed for the dimer models (CBAM2, CBAM4, and CBPM2) which had an electron-donating aromatic substituent at the electron-accepting imide group. On the other hand, the cleavage quantum yield was nearly zero for a dimer (CBCM2) which had a cyclohexane substituent instead of the aromatic ring. Solvent polarity effects on the cleavage quantum yield revealed that these dimers gave the largest photocleavage efficiency in medium-polar solvents. The transient absorption band of the excited triplet of CBPM2 was effectively quenched by oxygen, whereas no oxygen quenching was observed for the cleavage quantum yield. This leads to the conclusion that the cyclobutane ring in the polyimide is photocleaved via the excited singlet intramolecular CT state. 相似文献
98.
99.
Tomoyuki Ishigo Toshiyuki Yano Satoshi Katano Ryo Takada Tomohiro Aigami Keita Nakano Fuki Kondo Hidemichi Kouzu Katsuhiko Ohori Hiromasa Nakata Masatoshi Nonoyama Manabu Kitagawa Tomoko Kimyo Masahide Fukudo Tetsuji Miura 《Internal medicine (Tokyo, Japan)》2022,61(2):167
Objective We recently reported a novel score for the detection of glomerular filtration rate (GFR) overestimation using a creatinine-based equation. We examined the utility of this score in patients with cardiovascular/renal diseases and diabetes mellitus. Methods We enrolled 1,425 patients (65±15 years old; 37% women) who were admitted to our hospital for the management of cardiovascular and renal diseases and their risk factors. Overestimation of the GFR (OE) was defined as a creatinine-based GFR (eGFRcre) ≥120% of the cystatin C-based estimated GFR. The OE score was calculated as the sum of the scores for the body weight, hemoglobin concentration, and blood urea nitrogen (BUN)/serum creatinine (Scr), totaling 1 point if the body weight was <63.0 kg in men or <42.0 kg in women, 1 point if the hemoglobin concentration was <12.4 g/dL in men or <11.0 g/dL in women, and 1 point if the BUN/Scr was >26.5. Results The proportion of patients with OE was 14.2%. The score predicted OE with a sensitivity of 70.8% and a specificity of 99.6%, and the sensitivity was increased in patients ≥75 years old (88.3%) and decreased in diabetics (58.6%). When patients were divided into subgroups by the total score, the frequencies of OE were 8% (59/754), 14% (72/502), 38% (58/151), and 72% (13/18) in patients with scores of 0, 1, 2, and 3, respectively. Conclusion The OE score is useful for detecting elderly cases of cardiovascular and renal diseases in which eGFRcre overestimates the GFR, although its utility is limited in diabetics. 相似文献
100.
Yasuo Kondo Tomoaki Suzuki Masahide Enomoto Noriyuki Takashima Takeshi Kinoshita 《Indian Journal of Thoracic and Cardiovascular Surgery》2022,38(2):134
PurposeThis study investigated the use of psoas muscle area index (PAI) as an indicator of mortality risk in relation to survival in elderly patients after isolated surgical aortic valve replacement (SAVR) for aortic valve stenosis (AS).MethodsBetween January 2005 and March 2015, 140 patients with AS, aged ≥ 70 years, and with preoperative abdominal computed tomography scans, underwent elective, primary, isolated SAVR. PAI showed the ratio of the psoas muscle cross-sectional area at the fourth lumbar vertebral level to body surface area, and PAI less than the gender-specific lowest 20th percentile we called “low PAI” for the purposes of this study. Patients were classified as low PAI (n = 29) or normal PAI (n = 111).ResultsThe mean age in the low-PAI group was significantly older than in the normal-PAI group (81.0 vs. 77.3 years; p = 0.001). The mean follow-up was 4.25 years. The low-PAI group had a lower survival rate than the normal-PAI group at 1 year (89.7 ± 5.7% vs. 96.3 ± 1.8%), at 3 years (71.6 ± 9.3% vs. 91.5 ± 2.7%), and overall (53.0 ± 13.4% vs. 76.0 ± 5.6%; p = 0.039). The prognostic factors of mortality included low PAI (hazard ratio 2.95; 95% confidence interval 1.084–8.079; p = 0.034).ConclusionsPAI was associated with reduced overall survival after isolated SAVR in elderly people. PAI measurement may help to predict patient risks. 相似文献