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101.
The Asia–Pacific Working Party on Non‐alcoholic Fatty Liver Disease guidelines 2017—Part 2: Management and special groups
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Shiv Chitturi Vincent Wai‐Sun Wong Wah‐Kheong Chan Grace Lai‐Hung Wong Simon Kin‐Hung Wong Jose Sollano Yen‐Hsuan Ni Chun‐Jen Liu Yu‐Cheng Lin Laurentius Adrianto Lesmana Seung Up Kim Etsuko Hashimoto Masahide Hamaguchi Khean‐Lee Goh Jiangao Fan Ajay Duseja Yock Young Dan Yogesh Chawla Geoff Farrell Henry Lik‐Yuen Chan 《Journal of gastroenterology and hepatology》2018,33(1):86-98
102.
Jun Tanabe Masakazu Yasumaru Masahiko Tsujimoto Hideki Iijima Satoshi Hiyama Akira Nishio Yoshiaki Sasayama Naoki Kawai Masahide Oshita Takashi Abe Sunao Kawano 《Clinical journal of gastroenterology》2013,6(6):442-446
A 25-year-old Japanese female was referred to our clinic for the investigation of moderate iron-deficiency anemia and epigastralgia. Endoscopic examination showed diffuse mucosal nodules in the gastric body resembling nodular gastritis, but this pattern was not observed in the antrum. Histology of the gastric biopsies taken from the gastric body showed mild atrophic mucosa with chronic active inflammation. Some of the biopsy specimens showed deposition of patchy, band-like subepithelial collagen. Four years later, the patient showed no clinical symptoms and signs. A follow-up endoscopic examination showed similar findings, which mimicked pseudopolyposis or a cobblestone-like appearance. The biopsy specimens from the depressed mucosa between the nodules revealed a thickened subepithelial collagen band with no improvement, which led to a diagnosis of collagenous gastritis. Treatment with oral administration of proton-pump inhibitors and histamine-2-receptor antagonists had proved ineffective. To make a correct diagnosis of collagenous gastritis, we should determine the characteristic endoscopic findings and take biopsies from the depressed mucosa between the nodules. 相似文献
103.
Hideo Ohkita Akira Tsuchida Masahide Yamamoto James A. Moore Donald R. Gamble 《Macromolecular chemistry and physics.》1996,197(8):2493-2499
The photocleavage reaction of dimer model compounds of photosensitive polyimides having cyclobutane rings in the main chain was studied. Efficient photocleavage was observed for the dimer models (CBAM2, CBAM4, and CBPM2) which had an electron-donating aromatic substituent at the electron-accepting imide group. On the other hand, the cleavage quantum yield was nearly zero for a dimer (CBCM2) which had a cyclohexane substituent instead of the aromatic ring. Solvent polarity effects on the cleavage quantum yield revealed that these dimers gave the largest photocleavage efficiency in medium-polar solvents. The transient absorption band of the excited triplet of CBPM2 was effectively quenched by oxygen, whereas no oxygen quenching was observed for the cleavage quantum yield. This leads to the conclusion that the cyclobutane ring in the polyimide is photocleaved via the excited singlet intramolecular CT state. 相似文献
104.
105.
Yasuo Kondo Tomoaki Suzuki Masahide Enomoto Noriyuki Takashima Takeshi Kinoshita 《Indian Journal of Thoracic and Cardiovascular Surgery》2022,38(2):134
PurposeThis study investigated the use of psoas muscle area index (PAI) as an indicator of mortality risk in relation to survival in elderly patients after isolated surgical aortic valve replacement (SAVR) for aortic valve stenosis (AS).MethodsBetween January 2005 and March 2015, 140 patients with AS, aged ≥ 70 years, and with preoperative abdominal computed tomography scans, underwent elective, primary, isolated SAVR. PAI showed the ratio of the psoas muscle cross-sectional area at the fourth lumbar vertebral level to body surface area, and PAI less than the gender-specific lowest 20th percentile we called “low PAI” for the purposes of this study. Patients were classified as low PAI (n = 29) or normal PAI (n = 111).ResultsThe mean age in the low-PAI group was significantly older than in the normal-PAI group (81.0 vs. 77.3 years; p = 0.001). The mean follow-up was 4.25 years. The low-PAI group had a lower survival rate than the normal-PAI group at 1 year (89.7 ± 5.7% vs. 96.3 ± 1.8%), at 3 years (71.6 ± 9.3% vs. 91.5 ± 2.7%), and overall (53.0 ± 13.4% vs. 76.0 ± 5.6%; p = 0.039). The prognostic factors of mortality included low PAI (hazard ratio 2.95; 95% confidence interval 1.084–8.079; p = 0.034).ConclusionsPAI was associated with reduced overall survival after isolated SAVR in elderly people. PAI measurement may help to predict patient risks. 相似文献
106.
Tomoyuki Ishigo Toshiyuki Yano Satoshi Katano Ryo Takada Tomohiro Aigami Keita Nakano Fuki Kondo Hidemichi Kouzu Katsuhiko Ohori Hiromasa Nakata Masatoshi Nonoyama Manabu Kitagawa Tomoko Kimyo Masahide Fukudo Tetsuji Miura 《Internal medicine (Tokyo, Japan)》2022,61(2):167
Objective We recently reported a novel score for the detection of glomerular filtration rate (GFR) overestimation using a creatinine-based equation. We examined the utility of this score in patients with cardiovascular/renal diseases and diabetes mellitus. Methods We enrolled 1,425 patients (65±15 years old; 37% women) who were admitted to our hospital for the management of cardiovascular and renal diseases and their risk factors. Overestimation of the GFR (OE) was defined as a creatinine-based GFR (eGFRcre) ≥120% of the cystatin C-based estimated GFR. The OE score was calculated as the sum of the scores for the body weight, hemoglobin concentration, and blood urea nitrogen (BUN)/serum creatinine (Scr), totaling 1 point if the body weight was <63.0 kg in men or <42.0 kg in women, 1 point if the hemoglobin concentration was <12.4 g/dL in men or <11.0 g/dL in women, and 1 point if the BUN/Scr was >26.5. Results The proportion of patients with OE was 14.2%. The score predicted OE with a sensitivity of 70.8% and a specificity of 99.6%, and the sensitivity was increased in patients ≥75 years old (88.3%) and decreased in diabetics (58.6%). When patients were divided into subgroups by the total score, the frequencies of OE were 8% (59/754), 14% (72/502), 38% (58/151), and 72% (13/18) in patients with scores of 0, 1, 2, and 3, respectively. Conclusion The OE score is useful for detecting elderly cases of cardiovascular and renal diseases in which eGFRcre overestimates the GFR, although its utility is limited in diabetics. 相似文献
107.
108.
Asuka Iwanaga Tokiharu Sato Kazushi Sugihara Atsushi Hirao Nobuyuki Takakura Hiroshi Okamoto Masahide Asano Katsuji Yoshioka 《Neuroscience letters》2007
We previously identified c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 (JSAP1, also known as JNK-interacting protein 3) as a scaffolding factor for JNK intracellular signaling pathways. Targeted gene-disruption studies have shown that JSAP1-null mice are unable to breathe and die shortly after birth. Although neural defects might be responsible for their death, there has been no convincing evidence for this. Here we first generated genetically engineered mice carrying a loxP-flanked (floxed) jsap1 gene. To evaluate the validity of this deletion as a jsap1 conditional knockout (KO), we created mice in which the same exon was deleted in all cell lineages, and compared their phenotypes with those of the jsap1 conventional KO mice reported previously. The two KO lines showed indistinguishable phenotypes, i.e., neonatal death and morphological defects in the telencephalon, indicating that the conditional deletion was a true null mutation. We then introduced the floxed jsap1 deletion mutant specifically into the neural lineage, and found that the jsap1 conditional KO mice showed essentially the same phenotypes as the JSAP1-null mice. These results strongly suggest that the neonatal death of jsap1-deficient mice is caused by defects in the nervous system. 相似文献
109.
Distinct Recurrence Pattern and Outcome of Adenocarcinoma of the Gastric Cardia in Comparison with Carcinoma of Other Regions of the Stomach 总被引:4,自引:0,他引:4
Saito H Fukumoto Y Osaki T Fukuda K Tatebe S Tsujitani S Ikeguchi M 《World journal of surgery》2006,30(10):1864-1869
Background Carcinoma arising in the cardioesophageal junction is a distinct clinical entity compared with tumors located in other regions
of the stomach. The prognosis for adenocarcinoma of the upper stomach is considered to be relatively poorer than carcinomas
of the more distal stomach. We have therefore investigated patients with carcinoma of the gastric cardia in order to evaluate
the underlying cause of this poor prognosis.
Materials and Methods Clinicopathologic features and postoperative prognosis of 101 patients with carcinoma of the cardia were evaluated and compared
with findings on 1884 patients with tumors in other regions of the stomach.
Results Tumors of the cardia had a mean size of 6.8 cm, which was significantly larger than the mean size of 5.9 cm for tumors found
in the middle- and lower third of the stomach. The incidence of serosal invasion, lymph node metastasis, and lymphatic and
blood vessel invasion was higher in association with adenocarcinoma of the cardia than with adenocarcinoma in remaining parts
of the stomach. In the analysis of patients who had undergone curative resection, the 5-year survival rates were 61.6, 79.1,
and 82.6% in patients with carcinoma of the cardia, upper one-third, and remaining middle- and lower one-third of the stomach,
respectively, and the differences were statistically significant. Multivariate analysis indicated that adenocarcinoma of the
gastric cardia is an independent prognostic factor. With regard to the site of recurrence, both lymph node and hematogenous
recurrence were observed more frequently in the cardia than in the remaining parts of the stomach.
Conclusions Our data indicate that the prognosis of patients with adenocarcinoma of the gastric cardia is extremely poor. To improve their
prognosis, new treatments in addition to gastrectomy with extensive lymph node dissection are needed. 相似文献
110.