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排序方式: 共有336条查询结果,搜索用时 15 毫秒
61.
Ce Tan Yutaka Sasagawa Ken-ichi Kamo Takehiro Kukitsu Sayaka Noda Kazuma Ishikawa Natsumi Yamauchi Takashi Saikawa Takanori Noro Hajime Nakamura Fumihiko Takahashi Fumihiro Sata Mitsuhiro Tada Yasuo Kokai 《Environmental health and preventive medicine》2016,21(6):470-479
Objectives
To prevent the onset of lifestyle-related diseases associated with metabolic syndrome (MetS) in Japan, research into the development of a useful screening method is strongly desired. We developed a new screening questionnaire (JAMRISC) utilizing a logistic regression model and evaluated its ability to predict the development of MetS, type 2 diabetes and other lifestyle-related diseases in Japanese populace.Methods
JAMRISC questionnaire was sent to 1,850 individuals in Rumoi, a small city in Hokkaido. We received a total of 1,054 valid responses. To maximize the target individuals accurately diagnosed with MetS, logistic regression analysis was used to generate a unique metabolic syndrome score calculation formula as taking into consideration the clinical relevance of each question item as individual coefficients.Results
The results of our comparative research utilizing both JAMRISC and Finnish Diabetes Risk Score (FINDRISC) questionnaires revealed the usefulness of JAMRISC for its ability to detect risks for MetS, pre-MetS, diabetes, and pre-diabetes. Study of disease risk detection via JAMRISC questionnaire targeting the 4283 residents of Rumoi indicated a high detection rate for pre-MetS (98.8 %), MetS (94.2 %), pre-diabetes (85.1 %) and type 2 diabetes (94.9 %). In addition, JAMRISC was useful not only as a MetS risk score test, but also as a screening tool for diagnosing insulin resistance.Conclusions
JAMRISC questionnaire is a useful instrument for the detection of early risk of not only MetS and type 2 diabetes but also insulin resistance.62.
63.
Lelli KM Noro B Mann RS 《Proceedings of the National Academy of Sciences of the United States of America》2011,108(52):21122-21127
Homeotic selector (Hox) proteins often bind DNA cooperatively with cofactors such as Extradenticle (Exd) and Homothorax (Hth) to achieve functional specificity in vivo. Previous studies identified the Hox YPWM motif as an important Exd interaction motif. Using a comparative approach, we characterize the contribution of this and additional conserved sequence motifs to the regulation of specific target genes for three Drosophila Hox proteins. We find that Sex combs reduced (Scr) uses a simple interaction mechanism, where a single tryptophan-containing motif is necessary for Exd-dependent DNA-binding and in vivo functions. Abdominal-A (AbdA) is more complex, using multiple conserved motifs in a context-dependent manner. Lastly, Ultrabithorax (Ubx) is the most flexible, in that it uses multiple conserved motifs that function in parallel to regulate target genes in vivo. We propose that using different binding mechanisms with the same cofactor may be one strategy to achieve functional specificity in vivo. 相似文献
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65.
Etiology of Syncope and Unexplained Falls in Elderly Adults with Dementia: Syncope and Dementia (SYD) Study
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Andrea Ungar MD PhD Chiara Mussi MD PhD Alice Ceccofiglio MD Giuseppe Bellelli MD PhD Franco Nicosia MD Mario Bo MD Daniela Riccio MD Anna Maria Martone MD Livia Guadagno MD Gabriele Noro MD Giulia Ghidoni MD Martina Rafanelli MD Niccolò Marchionni MD Pasquale Abete MD PhD 《Journal of the American Geriatrics Society》2016,64(8):1567-1573
66.
Mizokami F Koide Y Noro T Furuta K 《The American journal of geriatric pharmacotherapy》2012,10(2):123-128
BackgroundElderly persons are exposed to polypharmacy because of multiple chronic conditions. Many risk factors for polypharmacy have been identified including age, race/ethnicity, sex, educational achievement level, health status, and number of chronic diseases. However, drugs prescribed for individual diseases have not been analyzed.ObjectiveThe objective of this study was to analyze each common disease in the elderly with respect to prescribed drugs and polypharmacy.MethodsA 1-year (January through December 2009) cross-sectional study was performed in which all drugs given to hospitalized elderly patients (age, >65 years) were investigated. Common diseases of the elderly were separated into disease groups including hypertension, hyperlipidemia, gastric ulcer, previous stroke, reflux esophagitis, diabetes mellitus, malignancy, osteoporosis, angina pectoris, congestive heart failure, chronic obstructive pulmonary disease, dementia, and depression.ResultsAmong 1768 elderly patients, the mean (range) age of study patients was 78 (65 to 100) years. The mean (SD) number of diseases was 7.7 (3.4), and the number of drugs overall was 4.9 (3.6). The number of drugs and prevalence of polypharmacy were hypertension, 5.2 (3.9 [51%]); hyperlipidemia, 5.6 (3.8 [58%]); gastric ulcer, 5.4 (3.8 [53%]); previous stroke, 5.8 (3.2 [61%]); reflux esophagitis, 5.6 (3.8 [40%]), diabetes mellitus, 5.6 (3.1 [54%]); malignancy, 4.1 (3.1 [37%]); osteoporosis, 5.4 (3.4 [45%]); angina pectoris, 5.7 (3.6 [42%]); congestive heart failure, 6.1 (4.0 [60%]); chronic obstructive pulmonary disease, 5.0 (3.5 [53%]); dementia, 5.1 (3.2 [52%]); and depression, 7.0 (4.2 [73%]).ConclusionsWhen assessing the risk of polypharmacy, physicians should carefully consider the type of any chronic disease. Elderly patients with multiple diseases may be subjected to further polypharmacy. 相似文献
67.
Daiki Abukawa Yusaku Tazawa Tomoyo Noro Michiko Nakagawa Kazuie Iinuma Kohachiro Sugiyama Alexander S. Knisely 《Pediatric and developmental pathology》2001,4(3):304-309
A 12-year-old Japanese boy had chronic elevation and fluctuation of serum transaminase levels since infancy, with no signs
or symptoms of liver failure. Usual infections or metabolic disorders were eliminated from consideration. No coagulopathy
or abnormality in plasma concentrations of clotting factors was found. Light microscopy of liver biopsy specimens obtained
at ages 2, 5, and 7 years showed slight hepatocyte disarray and minimal mononuclear-leukocyte lobular inflammation, with eosinophilic
inclusion bodies in the cytoplasm of hepatocytes throughout the lobule. These bodies stained with the periodic acid-Schiff
(PAS) technique; the PAS-positive material was partly diastase digestible and on immunostaining marked for fibrinogen but
not for α1-antitrypsin. On transmission electron microscopy, the bodies were represented by finely granular material contained within
membranes and were interpreted as tentatively endoplasmic reticulum. Fibrinogen storage may be manifest as minimal hepatitis
without coagulopathy.
Received August 12, 1999; accepted June 27, 2000. 相似文献
68.
Glaucoma is a neurodegenerative disease of the eye,and it presents with visual field defects accompanied by progressive degeneration of the optic nerve and retinal ganglion cells(RGCs).It is one of the major causes of blindness worldwide and affects 1 in 20 people over the age of 40.Glaucoma is caused by multiple factors,but it is usually associated with elevated intraocular pressure(IOP).Extensive studies have been carried out to discover therapeutic targets and to develop new drugs to treat ocular hypertension using experimental models of rodents(rats and mice)and non-human primates(e.g.,cynomologus,rhesus,or marmoset monkeys). 相似文献
69.