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51.
目的:为临床外科寻找简便易行有效的预防腹腔术后粘连的新方法和药物:方法:用白及、黄芪等多味中药制成抗粘灵气雾剂,通过对60只家免盲肠部分切除制造实验动物模型,并对其创面进行活体药物喷涂。结果:抗粘灵气雾剂预防腹腔术后粘连效果良好,总有效率86.67%,与对照组比较,有非常显著差异(P〈0.01)。结论:抗粘灵气雾剂预防腹腔术后粘连有效,且方法简便易行,从而可为临床外科领域提供高效。价廉的木申抗粘连药物。 相似文献
52.
53.
The biology of Helicobacter pylori infection, a major risk factor for gastric adenocarcinoma. 总被引:1,自引:0,他引:1
Delia Pinto-Santini Nina R Salama 《Cancer epidemiology, biomarkers & prevention》2005,14(8):1853-1858
Helicobacter pylori infection of the human stomach is the most important risk factor for development of gastric cancer. Whereas persistent viral infection leads to a number of cancers, H. pylori was the first bacteria linked to a human cancer. The exact mechanisms that lead to cancer induction are not clear, but study of the bacterial factors important for colonization and the host responses to the infection are starting to yield important clues. 相似文献
54.
Justyna D. Kowalska Carlo Biekowski Luk Fleischhans Sergii Antoniak Agata Skrzat-Klapaczyska Magdalena Suchacz Nikolina Bogdanic Deniz Gokengin Cristiana Oprea Igor Karpov Kerstin Kase Raimonda Matulionyte Antonios Papadopoulos Nino Rukhadze Arjan Harxhi David Jilich Botond Lakatos Dalibor Sedlacek Gordana Dragovic Marta Vasylyev Antonia Verhaz Nina Yancheva Josip Begovac Andrzej Horban 《Viruses》2022,14(5)
55.
Nina Streefkerk Marianne J. Heins Jop C. Teepen Elizabeth A. M. Feijen Dorine Bresters Eline van Dulmen‐den Broeder Margriet van der Heiden‐van der Loo Marry M. van den Heuvel‐Eibrink Flora E. van Leeuwen Jacqueline J. Loonen Helena J. H. van der Pal Ccile M. Ronckers A. Birgitta Versluys Wim J. E. Tissing Joke C. Korevaar Leontien C. M. Kremer 《Pediatric blood & cancer》2019,66(8)
56.
Stefanie Wessely Marc Tappiser Nina Eisenburger Sven Feddern Andreas Gehlhar Anna Kilimann Lisa Klee Johannes Nießen Nikola Schmidt Gerhard A. Wiesmüller Annelene Kossow Barbara Grüne Christine Joisten 《Obesity facts》2022,15(4):570
IntroductionPublic health measures enacted to reduce COVID-19 transmission have affected individuals'' lifestyles, mental health, and psychological well-being. To date, little is known how stay-at-home orders have influenced the eating behaviors, weight development, and alcohol consumption of quarantined persons. The CoCo-Fakt cohort study analyzed these parameters and their association with psychological distress and coping strategies.MethodsAn online survey was conducted of all persons who tested positive for SARS-CoV-2 (infected persons [IP]) between December 12, 2020, and January 6, 2021, as well as their close contacts (contact persons [CP]) registered by the public health department of Cologne. 8,075 of 33,699 individuals were included in the analysis. In addition to demographic data, psychological distress, and coping strategies, information on changes in body weight, eating, and drinking behaviors was collected.ResultsIP lost 1.2 ± 4.4 kg during the quarantine period, and CP gained 1.6 ± 4.1 kg. The reasons given by IP for weight change were mainly loss of taste and feeling sick, whereas CP were more likely than IP to eat out of boredom. Higher psychological burden and lower coping strategies were associated with both weight gain and loss. Of the 30.8% of participants who changed their alcohol consumption during the quarantine period, CP in particular drank more alcohol (IP 15.2%; CP 47.7%). Significantly less alcohol was consumed by individuals with higher coping scores.ConclusionIn this short but psychologically stressful period of stay-at-home orders, changes in eating and drinking behavior as well as weight development are evident, mainly in high-risk contacts. To avoid possible long-term sequelae, health authorities should take these findings into account during the quarantine period; in particular, general practitioners should consider these findings during follow-up. 相似文献
57.
Simie Degefu M.D. April Gale O''Quinn M.D. H.Nina Dhurandhar M.D. 《Gynecologic oncology》1986,25(3):347-354
The vulva is one of the extramammary sites which has a potential for developing Paget's Disease with which an underlying sweat gland carcinoma or breast carcinoma is frequently associated. Urogenital malignancy may be a third contender. Such a case managed by the authors herein reported and a review of the literature about such lesions support this assumption. 相似文献
58.
Valter Poltojainen Janette Kemppainen Nina Keinnen Michaela Bode JuhaMatti Isokangas Hanne Kuitunen Juha Nikkinen Eila Sonkajrvi Vesa Korhonen Timo Tuovinen Matti Jrvel Niko Huotari Lauri Raitamaa Janne Kananen Tommi Korhonen Sami Tetri Outi Kuittinen Vesa Kiviniemi 《Human brain mapping》2022,43(13):4030
Primary central nervous system lymphoma (PCNSL) is an aggressive brain disease where lymphocytes invade along perivascular spaces of arteries and veins. The invasion markedly changes (peri)vascular structures but its effect on physiological brain pulsations has not been previously studied. Using physiological magnetic resonance encephalography (MREGBOLD) scanning, this study aims to quantify the extent to which (peri)vascular PCNSL involvement alters the stability of physiological brain pulsations mediated by cerebral vasculature. Clinical implications and relevance were explored. In this study, 21 PCNSL patients (median 67y; 38% females) and 30 healthy age‐matched controls (median 63y; 73% females) were scanned for MREGBOLD signal during 2018–2021. Motion effects were removed. Voxel‐by‐voxel Coefficient of Variation (CV) maps of MREGBOLD signal was calculated to examine the stability of physiological brain pulsations. Group‐level differences in CV were examined using nonparametric covariate‐adjusted tests. Subject‐level CV alterations were examined against control population Z‐score maps wherein clusters of increased CV values were detected. Spatial distributions of clusters and findings from routine clinical neuroimaging were compared [contrast‐enhanced, diffusion‐weighted, fluid‐attenuated inversion recovery (FLAIR) data]. Whole‐brain mean CV was linked to short‐term mortality with 100% sensitivity and 100% specificity, as all deceased patients revealed higher values (n = 5, median 0.055) than surviving patients (n = 16, median 0.028) (p < .0001). After adjusting for medication, head motion, and age, patients revealed higher CV values (group median 0.035) than healthy controls (group median 0.024) around arterial territories (p ≤ .001). Abnormal clusters (median 1.10 × 105mm3) extended spatially beyond FLAIR lesions (median 0.62 × 105mm3) with differences in volumes (p = .0055). 相似文献
59.
Mahmoud Omer Hessein Ali Nina Orlovskaya Amelia Ballesteros Vee San Cheong Kari Martyniak Fei Wei Boyce E. Collins Sergey N. Yarmolenko Jackson Asiatico Michael Kinzel Christopher Ngo Jagannathan Sankar Ashley Calder Timothy Gilbertson Teerin Meckmongkol Ranajay Ghosh Melanie Coathup 《Nutrients》2022,14(15)
The influence of diet on the development of osteoporosis is significant and not fully understood. This study investigated the effect of diets of varying lipid profiles and ω-3, ω-6 and ω-9 composition on the structural and mechanical properties of bone. The hypothesis studied was that a diet high in saturated fat would induce osteoporosis and produce an overall increased detrimental bony response when compared with a diet high in unsaturated ω-6, or ω-9. Male C57BL/6J mice were fed either a control diet, 50:50 mix (saturated:unsaturated) high in ω-9 (HFD50:50), a diet high in saturated fat (HSF) or a polyunsaturated fat diet high in ω-6 (PUFA) over an 8-week duration. Tibiae were retrieved and evaluated using DMA, 3-point-bending, histomorphometry, and microCT. Mice fed a HSF diet displayed key features characteristic of osteoporosis. The loss tangent was significantly increased in the HFD50:50 diet group compared with control (p = 0.016) and PUFA-fed animals (p = 0.049). HFD50:50-fed mice presented with an increased viscous component, longer tibiae, increased loss modulus (p = 0.009), and ultimate stress, smaller microcracks (p < 0.001), and increased trabecular width (p = 0.002) compared with control animals. A diet high in ω-9 resulted in an overall superior bone response and further analysis of its role in bone health is warranted. 相似文献