全文获取类型
收费全文 | 5157篇 |
免费 | 515篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 198篇 |
妇产科学 | 90篇 |
基础医学 | 756篇 |
口腔科学 | 134篇 |
临床医学 | 461篇 |
内科学 | 857篇 |
皮肤病学 | 62篇 |
神经病学 | 385篇 |
特种医学 | 325篇 |
外科学 | 848篇 |
综合类 | 162篇 |
一般理论 | 31篇 |
预防医学 | 382篇 |
眼科学 | 92篇 |
药学 | 533篇 |
中国医学 | 10篇 |
肿瘤学 | 348篇 |
出版年
2022年 | 34篇 |
2021年 | 78篇 |
2020年 | 46篇 |
2019年 | 73篇 |
2018年 | 92篇 |
2017年 | 53篇 |
2016年 | 80篇 |
2015年 | 95篇 |
2014年 | 125篇 |
2013年 | 192篇 |
2012年 | 231篇 |
2011年 | 218篇 |
2010年 | 164篇 |
2009年 | 152篇 |
2008年 | 189篇 |
2007年 | 201篇 |
2006年 | 238篇 |
2005年 | 219篇 |
2004年 | 214篇 |
2003年 | 188篇 |
2002年 | 183篇 |
2001年 | 190篇 |
2000年 | 196篇 |
1999年 | 170篇 |
1998年 | 100篇 |
1997年 | 101篇 |
1996年 | 90篇 |
1995年 | 84篇 |
1994年 | 76篇 |
1993年 | 79篇 |
1992年 | 126篇 |
1991年 | 118篇 |
1990年 | 101篇 |
1989年 | 95篇 |
1988年 | 107篇 |
1987年 | 75篇 |
1986年 | 78篇 |
1985年 | 75篇 |
1984年 | 51篇 |
1983年 | 52篇 |
1982年 | 38篇 |
1981年 | 33篇 |
1980年 | 38篇 |
1979年 | 58篇 |
1978年 | 44篇 |
1977年 | 52篇 |
1976年 | 47篇 |
1975年 | 36篇 |
1974年 | 32篇 |
1973年 | 43篇 |
排序方式: 共有5687条查询结果,搜索用时 15 毫秒
31.
β-Lactoglobulin was isolated from infant formulae that were ultra high temperature (UHT) -treated, sterilized or spray-dried. The effect of the isolated β-lactoglobulin on SfaII-fimbriae-mediated adhesion of Escherichia coli to human ileostomy glycoproteins was studied in vitro. β-Lactoglobulin isolated from sterilized formulae was found to perform significantly less well than preparations from spray-dried formulae (p = 0:05). Great heterogeneity was observed in the adhesion inhibitory capacity of β-lactoglobulin isolated from UHT-treated formulae. Therefore, no significant difference was observed between UHT-treated and sterilized formulae or spray-dried formulae (p < 0:10). It can be hypothesized that β-lactoglobulin from spray-dried and some UHT-treated infant formulae may affect the colonization of mucous membranes by E. coli strains causing neonatal septicaemia and meningitis. 相似文献
32.
Uroscopy in the 21st century: high-field NMR spectroscopy 总被引:1,自引:1,他引:0
Neild GH; Foxall PJ; Lindon JC; Holmes EC; Nicholson JK 《Nephrology, dialysis, transplantation》1997,12(3):404-417
From the experiments described, it can be seen that there are different
research approaches that can be taken and these are summarized in Table 1.
Whereas much scientific research is principally hypothesis led, there
remains, nevertheless, an important place for exploratory research. High
resolution NMR can measure, directly and simultaneously, a wide range of
endogenous metabolites in biological fluids and has the unique capability
of providing structural information on the metabolites detected. It has
proved to be a powerful research tool with which to study inherited
metabolic diseases, renal disease, drug metabolism, and toxicity, and can
be used to monitor the effects of drug therapy. For instance, by using a
library of experimental toxins one can map the metabolic profile of
site-specific nephron injury. With this approach in man one could
eventually take an unknown disease such as Balkan nephropathy and predict
the initial site of tubular injury, the mode of injury and therefore the
kind of toxin capable of producing that injury. NMR spectroscopic
techniques are still advancing rapidly, with ever increasing sensitivity
and sophistication of NMR pulse sequences to enhance structural elucidation
in complex mixtures. Given the advances in directly coupled HPLC-NMR and
even HPLC-NMR-mass spectroscopy it is likely that these technologies in
conjunction with pattern recognition will make major contribution to our
understanding of renal processes and provide new diagnostic insights in the
21st century.
相似文献
33.
34.
35.
36.
S Jenkins B Arroll S Hawken R Nicholson 《The British journal of general practice》1997,47(415):107-108
An essential mode of contact between general practitioners (GPs) and hospital staff is the referral letter. This must be clear and concise with sufficient information to aid the GP, the consultant and the patient. In order to ensure this, a proposal was made for the use of a structured or standardized referral letter: a form letter. This report shows that form letters were shorter than typed letters. Form letters were also proven to contain more information than nonform letters. 相似文献
37.
M L Nicholson P S Veitch P K Donnelly A J Flower P R Bell 《Transplantation proceedings》1990,22(4):1811-1812
38.
Intrapericardial teratoma. Ultrasonic and pathological features 总被引:1,自引:0,他引:1
39.
Biochemical characterisation of para-aminophenol-induced nephrotoxic lesions in the F344 rat 总被引:5,自引:0,他引:5
Kevin P. R. Gartland Frank W. Bonner John A. Timbrell Jeremy K. Nicholson 《Archives of toxicology》1989,63(2):97-106
The acute biochemical effects of the nephrotoxin p-aminophenol (PAP) were studied in detail using a combination of conventional bioanalytical and 1H-NMR spectroscopic methods. Dosing PAP (25–100 mg/kg) to male F344 rats resulted in a dose-related proximal nephropathy with consequent elevations in urinary enzymes, glucose, and urine total protein as shown by conventional methodology. 1H-NMR spectroscopy at 400 MHz of urine from PAP-treated rats also revealed a characteristic glycosuria, with concomitant amino aciduria. The increased excretion of these compounds indicates functional defects in the proximal tubule and reduced solute reabsorption efficiency. In addition, 1H-NMR urinalysis and conventional enzymatic analysis showed a dose-related lactic aciduria. Other changes detected by 1H-NMR included a dose-related reduction in the excretion of citrate (confirmed by a conventional biochemical method) and an increase in the excretion of acetate. The degree of abnormalities shown by 1H-NMR urinalysis agreed well with histopathological observations and conventional biochemical indices of nephrotoxicity. 1H-NMR urinalysis therefore serves to highlight changes in the excretion of low MW urine components not routinely studied by conventional biochemical analysis.Abbreviations ALP
alkaline phosphatase
- APAP
paracetamol
- BUN
blood urea nitrogen
- GFR
glomerular filtration rate
- GOT
glutamate oxaloacetate transaminase
- LAP
leucine aminopeptidase
- LDH
lactate dehydrogenase
- MW
molecular weight
- NAG
N-acetyl--D-glucosaminidase
- PAP
p-aminophenol
- ppm
parts per million
- TMAO
trimethylamine N-oxide
- UFR
urine flow rate 相似文献
40.
Hydrolysis of peptides within lumen of small intestine 总被引:2,自引:0,他引:2