全文获取类型
收费全文 | 2220篇 |
免费 | 171篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 41篇 |
妇产科学 | 33篇 |
基础医学 | 277篇 |
口腔科学 | 29篇 |
临床医学 | 324篇 |
内科学 | 395篇 |
皮肤病学 | 52篇 |
神经病学 | 271篇 |
特种医学 | 48篇 |
外科学 | 309篇 |
综合类 | 105篇 |
一般理论 | 2篇 |
预防医学 | 187篇 |
眼科学 | 18篇 |
药学 | 179篇 |
中国医学 | 1篇 |
肿瘤学 | 116篇 |
出版年
2022年 | 39篇 |
2021年 | 68篇 |
2020年 | 31篇 |
2019年 | 75篇 |
2018年 | 94篇 |
2017年 | 46篇 |
2016年 | 62篇 |
2015年 | 63篇 |
2014年 | 111篇 |
2013年 | 129篇 |
2012年 | 133篇 |
2011年 | 112篇 |
2010年 | 88篇 |
2009年 | 76篇 |
2008年 | 90篇 |
2007年 | 73篇 |
2006年 | 79篇 |
2005年 | 66篇 |
2004年 | 59篇 |
2003年 | 50篇 |
2002年 | 56篇 |
2001年 | 33篇 |
2000年 | 31篇 |
1999年 | 44篇 |
1998年 | 21篇 |
1997年 | 20篇 |
1996年 | 17篇 |
1994年 | 15篇 |
1992年 | 25篇 |
1991年 | 22篇 |
1990年 | 30篇 |
1989年 | 43篇 |
1988年 | 34篇 |
1987年 | 26篇 |
1986年 | 23篇 |
1985年 | 25篇 |
1984年 | 25篇 |
1983年 | 19篇 |
1982年 | 31篇 |
1981年 | 13篇 |
1980年 | 21篇 |
1979年 | 14篇 |
1977年 | 16篇 |
1975年 | 12篇 |
1974年 | 18篇 |
1973年 | 20篇 |
1972年 | 17篇 |
1971年 | 15篇 |
1969年 | 13篇 |
1927年 | 15篇 |
排序方式: 共有2396条查询结果,搜索用时 15 毫秒
41.
42.
Aim The increased utilization of smartphones within the clinical environment together with connected applications (apps) provides opportunity for doctors, including coloproctologists, to integrate such technology into clinical practice. However, the reliability of unregulated medical apps has recently been called into question. Here, we review contemporary medical apps specifically themed towards colorectal diseases and assess levels of medical professional involvement in their design and content. Method The most popular smartphone app stores (iPhone, Android, Blackberry, Nokia, Windows and Samsung) were searched for colorectal disease themed apps, using the disease terms colorectal cancer, Crohn’s disease, ulcerative colitis, diverticulitis, haemorrhoids, anal fissure, bowel incontinence and irritable bowel syndrome. Results A total of 68 individual colorectal themed apps were identified, amongst which there were five duplicates. Only 29% of colorectal apps had had customer satisfaction ratings and 32% had named medical professional involvement in their development or content. Conclusion The benefits of apps are offset by lack of colorectal specification. There is little medical professional involvement in their design. Increased regulation is required to improve accountability of app content. 相似文献
43.
Ushma S. Neill 《The Journal of clinical investigation》2014,124(6):2291-2292
44.
45.
Purpose
Non-invasive measurements of arterial stiffness including the augmentation index (AIx) and central blood pressure (BP) have been used to assess the cardiovascular health of patients with obstructive sleep apnoea (OSA), a well-established independent risk factor of cardiovascular disease. Continuous positive airway pressure (CPAP) can significantly reduce the AIx, but no studies have analysed the effect of auto-adjusting PAP (APAP) or studied morbidly obese patients with severe OSA at higher risk of cardiovascular disease. In this randomised, single-blinded crossover pilot trial, we aimed to compare the efficacy of CPAP with APAP (ResMed S8 Autoset II) in improving peripheral BP, central BP and the AIx, using SphygmoCor technology. 相似文献46.
47.
Ushma S. Neill 《The Journal of clinical investigation》2014,124(11):4671-4672
48.
49.
Greene CM Miller SD Carroll T McLean C O'Mahony M Lawless MW O'Neill SJ Taggart CC McElvaney NG 《Journal of inherited metabolic disease》2008,31(1):21-34
Summary Alpha-1 antitrypsin (A1AT) is a serine anti-protease produced chiefly by the liver. A1AT deficiency is a genetic disorder
characterized by serum levels of less than 11 μmol/L and is associated with liver and lung manifestations. The liver disease,
which occurs in up to 15% of A1AT-deficient individuals, is a result of toxic gain-of-function mutations in the A1AT gene,
which cause the A1AT protein to fold aberrantly and accumulate in the endoplasmic reticulum of hepatocytes. The lung disease
is associated with loss-of-function, specifically decreased anti-protease protection on the airway epithelial surface. The
so-called ‘Z’ mutation in A1AT deficiency encodes a glutamic acid-to-lysine substitution at position 342 in A1AT and is the
most common A1AT allele associated with disease. Here we review the current understanding of the molecular pathogenesis of
A1AT deficiency and the best clinical management protocols.
Competing interests: None declared
References to electronic databases: Alpha 1-antitrypsin deficiency: +107400.
C.M. Greene and S.D.W. Miller contributed equally to the work. 相似文献
50.