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11.
Aloe vera affects changes induced in pulmonary tissue of mice caused by cigarette smoke inhalation 下载免费PDF全文
This study was undertaken to determine the influence of Aloe vera (AV) on changes induced in pulmonary tissue of cigarette smoke (CS) inhaling mice. CS inhalation for 4 weeks caused pulmonary damage as evident by histoarchitectural alterations and enhanced serum and tissue lactate dehydrogenase (LDH) activities. CS inhalation also led to increased mucin production as revealed by mucicarmine and Alcian Blue‐Periodic Acid Schiff (AB‐PAS) staining. Studies on bronchoalveolar lavage fluid (balf) of CS exposed animals revealed structural changes in phospholipids and increase in surface tension when compared with control counterparts. These changes were accompanied by enhanced nitric oxide (NO) levels, citrulline levels, peroxidative damage, and differential modulation of antioxidant defense system. AV administration (seven weeks, 500 mg/kg b.w. daily) to CS inhaling mice led to modulation of CS induced pulmonary changes as revealed by lesser degree of histoarchitectural alterations, lesser mucin production, decreased NO levels, citrulline levels, peroxidative damage, and serum LDH activity. AV treatment to CS inhaling mice was associated with varying response to antioxidant defense system, however balf of CS + AV treated animals did not exhibit appreciable changes when compared with that of CS exposed animals. These observations suggest that AV has the potential to modulate CS induced changes in the pulmonary tissue which could have implications in management of CS associated pulmonary diseases, however, further investigations are required to explore its complete mechanism of action. © 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 999–1013, 2015. 相似文献
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Prompt serum copper and zinc in addition to vitamin B12 levels should be measured in patients suffering from refractory anemia with neurological symptoms. A timely copper supplementation can help revert the hematological and possibly the neurological manifestations. 相似文献
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Rich-Garg Neha Danve Abhijeet Choi Dongseok Vakil-Gilani Kiana Akkoc Nurullah Azevedo Valderillo Russell Anthony Sharma Aman Cush John Curtis Jeffery R. Deodhar Atul 《Clinical rheumatology》2021,40(3):949-954
Clinical Rheumatology - This study aims to assess rheumatologists’ perceptions, utilization patterns, and attitudes towards the modified New York (mNY) criteria for ankylosing spondylitis... 相似文献
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Neha Reddy Beulah Elsa Anusha Bellapu Vasista Sharma Stephy Chacko Subeesh Viswam 《International journal of clinical pharmacy》2020,42(2):721-727
International Journal of Clinical Pharmacy - Background Signal generation through data mining algorithms is an innovative and emerging field in pharmacovigilance. Early detection of safety signals... 相似文献
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Soumadri Samanta Sunil Kumar V. R. Battula Arpna Jaryal Neha Sardana Kamalakannan Kailasam 《RSC advances》2020,10(50):29633
Metal-free organic polymer photocatalysts have attracted dramatic attention in the field of visible light-induced hydrogen evolution reaction (HER). Herein, we showed a polymeric O-linked heptazine polymer (OLHP) decorated with S, N co-doped graphene quantum dots (S,N-GQDs) as a photosensitizer to generate hydrogen upon quantum dot sensitization. Both of these heptazine-based systems show effective photosensitization with strong π–π interactions and enhanced photocatalytic H2 generation (24 times) as metal-free systems. Electrochemical impedance and optical measurements show effective charge transfer kinetics with decreased charge recombination, which is responsible for the enhanced photocatalytic activity. As a result, a significant high apparent quantum yield (AQY) with highest value of 10.2% was obtained for our photocatalyst OLHP/S,N-GQD10.A polymeric O-linked heptazine polymer (OLHP) decorated with S, N co-doped graphene quantum dots (S,N-GQDs) as a photosensitizer to utilize visible light (λ > 420 nm) for hydrogen generation. 相似文献
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Suman Srivastava Neha Thakur Ashutosh Singh Poonam Shukla Vipin Kumar Maikhuri Neha Garg Ashok Prasad Rampal Pandey 《RSC advances》2019,9(51):29856
A new fluorescent sensor 5 based on a fused imidazopyridine scaffold has been designed and synthesized via cascade cyclization. The reaction features the formation of three different C–N bonds in sequence. Imidazopyridine based fluorescent probe 5 exhibits highly sensitive and selective fluorescent sensing for Fe3+(‘turn-on’) and Hg2+(‘turn-off’). The excellent selectivity of imidazopyridine for Fe3+/Hg2+ was not hampered in the presence of any of the competing cations. The limit of detection (LOD) of 5 toward Fe3+ and Hg2+ has been estimated to be 4.0 ppb and 1.0 ppb, respectively, with a good linear relationship (R2 = 0.99). Notably, 5 selectively detects Fe3+/Hg2+ through fluorescence enhancement signalling both in vitro and in HeLa cells.A new fluorescent sensor 5 having fused imidazopyridine scaffold has been synthesized via cascade cyclization. It exhibits highly sensitive and selective detection of Fe3+ (‘turn-on’) and Hg2+ (‘turn-off’) in vitro and in HeLa cells. 相似文献
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Andrea Franceschini Roger Meier Alain Casanova Saskia Kreibich Neha Daga Daniel Andritschke Sabrina Dilling Pauli R?m? Mario Emmenlauer Andreas Kaufmann Raquel Conde-álvarez Shyan Huey Low Lucas Pelkmans Ari Helenius Wolf-Dietrich Hardt Christoph Dehio Christian von Mering 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(12):4548-4553