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991.
Luis Llorente Md Yvonne Richaud-Patin Bs Jacques Couderc PhD Donato Alarcon-Segovia Md Rodrigo Ruiz-Soto Md Natasha Alcocer-Castillejos Md Jorge Alcocer-Varela Md Julio Granados Md Susana Bahena Bs Pierre Galanaud Md Dominique Emilie Md Phd 《Arthritis \u0026amp; Rheumatology》1997,40(8):1429-1435
Objective. To evaluate interleukin-10 (IL-10) production in relatives of patients with systemic lupus erythematosus (SLE). Methods. Production of IL-10 was evaluated in 13 families in which several members had SLE. The constitutive IL-10 production in SLE patients (n = 16) was compared with that in healthy members of these multiplex families (n = 70), in 30 SLE patients who had no relatives with SLE, and in 46 healthy unrelated controls. Results. The level of IL-10 production did not differ between SLE patients who were members and those who were not members of multiplex families (mean ± SEM 4,384 ± 908 pg/ml and 4,709 ± 560 pg/ml, respectively), but was higher in both groups than in healthy unrelated controls (515 ± 88 pg/ml). The healthy members of the multiplex families constitutively produced large amounts of IL-10 (3,080 ± 311 pg/ml; P < 0.001 compared with healthy unrelated controls). This high IL-10 production was independent of age and sex, and was similar in first- and second-degree relatives of SLE patients. The IL-10 was produced both by monocytes and by a subpopulation of B lymphocytes in SLE patients and in their relatives. Conclusion. The dysregulation of IL-10 production previously identified in SLE patients is also present in healthy members of families with several cases of SLE, and it may contribute to the immunologic abnormalities affecting relatives of SLE patients. 相似文献
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BackgroundAdequate sleep in hospitalised children is important for a variety of physiological and psychological processes associated with growth, development, and recovery from illness and injury. Hospitalisation often prioritises clinical care activities at the expense of age-appropriate sleep. Nurses and the wider healthcare team contribute to this paradox. However, through conscious practice and partnering with mothers, nurses are able to enact change and promote sleep.ObjectivesTo adopt, adapt or contextualise existing guidelines to develop an evidence-based practice guideline to promote sleep-friendly ward environments and routines facilitated by nurses, and in partnership with mothers.MethodA six-step methodology for guideline adaptation was followed, as recommended by the South African Guidelines Excellence project: (1) existing guidelines and protocols were identified and (2) appraised using the AGREE II instrument; (3) an evidence base was developed; (4) recommendations were modified, (5) assigned levels of evidence and grades of recommendation; and (6) end user guidance was developed. Expert consultation was sought throughout.ResultsExisting relevant guidance comprised 61 adult-centric recommendations. Modification of the evidence base led to six composited recommendations that facilitate sleep in hospitalised children: (1) prioritising patient safety; (2) collaborating with the mother or caregiver to promote sleep; (3) coordinating ward routine and (4) environment to improve sleep; (5) work with clinical and non-clinical staff; and (6) performing basic sleep assessments. Practice recommendations were aligned to the South African regulatory framework for nursing.ConclusionHospitalisation is a time of physiological and psychological dysregulation for children, which is amplified by poor sleep in a hospital. Nurses have the opportunity to promote sleep during hospitalisation by implementing this African-centric guideline in partnership with mothers. 相似文献
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Peter H. O'Donnell MD Hendrick Tobias Arkenau MD Srikala S. Sridhar MD Michael Ong MD Alexandra Drakaki MD PhD Alexander I. Spira MD PhD Jingsong Zhang MD Michael S. Gordon MD Arnold N. Degboe MD PhD Ashok K. Gupta MD PhD Pralay Mukhopadhyay PhD Wenmei Huang PhD Shaad E. Abdullah MD Natasha Angra PharmD Lorin K. Roskos PhD Xiang Guo PhD Terence Friedlander MD 《Cancer》2020,126(2):432-443
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Janice Natasha Ng Kathryn Anne G. Cembrano Rungsima Wanitphakdeedecha Woraphong Manuskiatti 《Journal of Cosmetic Dermatology》2020,19(8):1826-1827
The rapidly increasing number of COVID‐19‐infected patients and evidence of human‐to‐human transmission even within the asymptomatic incubation period prompted the attention of the entire world. The field of dermatology and procedural dermatology is not exempt from this global issue. We cannot deny the fact that this situation will have a lasting impact on the health‐seeking behaviors of our patients. It is necessary for dermatologists and dermatologic surgeons to be aware of the potential risks and precautions when re‐emerging their practices after COVID‐19. 相似文献
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James E. Siegler Steven R. Mess Heidi Sucharew Scott E. Kasner Tapan Mehta Niraj Arora Amy K. Starosciak Felipe De Los Rios La Rosa Natasha R Barnhill Akshitkumar M. Mistry Kishan Patel Salman Assad Amjad Tarboosh Katarina Dakay Jeff Wagner Alicia Bennett Bharathi Jagadeesan Christopher Streib Stewart A. Weber Rohan Chitale John J. Volpi Stephan A. Mayer Shadi Yaghi Mahesh V. Jayaraman Pooja Khatri Eva A. Mistry 《Journal of neuroimaging》2020,30(2):219-226
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