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71.
Hashimoto Naoto Tominaga Naoki Wakagi Manabu Ishikawa-Takano Yuko 《Journal of natural medicines》2020,74(1):252-256
Journal of Natural Medicines - The lycopene content of tomatoes is important because of its effects on vital physiological functions such as improvement of glucose tolerance and non-alcoholic fatty... 相似文献
72.
Go Miyano Keiichi Morita Masakatsu Kaneshiro Hiromu Miyake Mariko Koyama Hiroshi Nouso Masaya Yamoto Reiji Nakano Yasuhiko Tanaka Tomizo Nishiguchi Takakazu Kawamura Koji Fukumoto Naoto Urushihara 《African Journal of Paediatric Surgery》2015,12(1):86-88
We describe herein a case of unilateral pulmonary agenesis (PA) with oesophageal atresia (EA)/tracheoesophageal fistula (TEF) that was diagnosed prenatally and repaired by esophagoesophagostomy with stable postoperative course. The patient was born at 34 weeks gestation, after ultrasonography at 22 weeks gestation showed possible right-sided diaphragmatic eventration or PA and EA was subsequently suspected due to hydramnios. The initial X-ray showed mediastinal shift to the right, and coil up sign of the nasogastric tube, without intracardiac anomaly. Immediately after the diagnosis of EA/TEF and unilateral PA on day 0, the patient was intubated in the operating room, and a gastrostomy tube was placed. After pulmonary status stabilized, at 4 days old, EA/TEF was repaired through a thoracotomy in the right 4th intercostal space. The right main bronchus was noted to continue into the distal oesophagus; this fistula was ligated and divided, and a single-layer esophagoesophagostomy was performed under mild tension with one vertebral gap. The neonate was maintained on mechanical ventilation and gradually weaned to extubation at 7 days old. The postoperative course was uneventful, with the exception of prolonged jaundice that emerged at 3 months old. Laparoscopic cholangiography at that time excluded biliary atresia, and jaundice resolved spontaneously. The patient has not shown any respiratory symptoms or feeding difficulties as of the 12-month follow-up. 相似文献
73.
Polygenic expression of teratozoospermia and normal fertility in B10.MOL‐TEN1 mouse strain 下载免费PDF全文
Keitaro Hirawatari Naoto Hanzawa Maki Kuwahara Hiroaki Aoyama Ikuo Miura Shigeharu Wakana Hideo Gotoh 《Congenital anomalies》2015,55(2):92-98
Subfertility and infertility are two major reproductive health problems in human and domestic animals. The contribution of the genotype to these conditions is poorly understood. To examine the genetic basis of male subfertility, we analyzed its relationship to sperm morphology in B10.MOL‐TEN1 mice, which shows high‐frequencies (about 50%) of morphologically abnormal sperm. Drastic histological changes were also found in the testis of the B10.MOL‐TEN1. Segregation analysis showed that the abnormal sperm phenotype in B10.MOL‐TEN1 was inherited and was predictably controlled by at least three loci. We also found that male fertility of this strain was normal. These findings indicate a complicated relationship between sperm morphology and male subfertility. 相似文献
74.
Inflammatory pseudotumor of the liver diagnosed by needle liver biopsy under ultrasonographic tomography guidance 总被引:7,自引:0,他引:7
Nakama T Hayashi K Komada N Ochiai T Hori T Shioiri S Tsubouchi H 《Journal of gastroenterology》2000,35(8):641-645
Inflammatory pseudotumor of the liver is a rare benign lesion, but exploratory laparotomy and a hepatectomy are often performed
unnecessarily after various misdiagnoses, including liver abscess, hepatocellular carcinoma, metastatic liver tumor, and cholangiocarcinoma.
We present a case of hepatic inflammatory pseudotumor in a 17-year-old man in whom diagnosis was confirmed by liver needle
biopsy under ultrasonographic tomography (UST) guidance. He had complained of fever and right hypochondralgia 2 months after
being operated for appendicitis. He was admitted to our hospital because of the persistence of these symptoms and the presence
of a hepatic mass lesion detected by UST. He had hepatomegaly, with tenderness; leukocytosis and elevated erythrocyte sedimentation
rate and C-reactive protein level were noted. UST showed a hypoechoic mass in the liver and pre-contrast computerized tomography
(CT) revealed a low-density area with an ill defined margin, which was barely enhanced by the contrast medium. On the basis
of the patient's clinical symptoms and the laboratory data and imaging studies, the presence of a liver abscess was suspected
and antibiotics were administered. One month after the initiation of the antibiotic therapy, UST demonstrated that the portal
vein had dilated serpiginously and penetrated into the mass. As the heterogeneous appearance displayed by post-enhanced CT
indicated the need for a differential diagnosis of the hepatic mass lesion to rule out hepatocellular carcinoma, percutaneous
needle biopsy was performed, under UST guidance. Histopathological examination demonstrated marked infiltration of plasma
cells and fibrosis, findings which were consistent with those of hepatic inflammatory pseudotumor. There was a spontaneous
reduction of the hepatic pseudotumor without continuous antibiotics and this reduction was documented on follow-up UST and
CT.
Received: June 30, 1999 / Accepted: December 17, 1999 相似文献
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77.
Tatsujiro Oka Toshiyuki Itoi Naoto Terada Hiroki Nakanishi Ryo Taguchi Kenji Hamaoka 《Circulation journal》2008,72(8):1359-1366
BACKGROUND: The effects of chronic hypoxia on cardiac membrane fatty acids and on lipid peroxidation were examined, as well as the effect of l-carnitine (LCAR), which suppresses lipid peroxidation, on this process. METHODS AND RESULTS: Four-week-old Sprague-Dawley rats were exposed to 10% oxygen for 14 days ("Hypoxia"), and then to 100% oxygen for 12 h (O2). LCAR (200 mg/kg) was administered by intraperitoneal injection daily for 2 weeks. Fatty acid composition, malondialdehyde (MDA) as a lipid peroxidation product, and antioxidants (superoxide dismutase (SOD), glutathione peroxidase and catalase) were measured. The concentration of linoleic acid was lower, and that of docosahexaenoic acid, which has more double bonds than linoleic acid, was increased in hypoxic hearts. SOD activity decreased in hypoxia, whereas MDA was unchanged, but significantly increased in "Hypoxia"+O2. LCAR reduced the increase in MDA, and had no effect on SOD activity or fatty acid composition. The administration of LCAR caused an increase in the ventricular levels of acetylcarnitine. CONCLUSIONS: These results suggest that chronic hypoxia changes the cardiac fatty acid composition of juvenile rats to fatty acids that contain more double-bonds and reduce SOD activity, and that lipid peroxidation was augmented by exposure to oxygen. 相似文献
78.
Mongan NP Jääskeläinen J Green K Schwabe JW Shimura N Dattani M Hughes IA 《The Journal of clinical endocrinology and metabolism》2002,87(3):1057-1061
The androgen insensitivity syndrome (AIS) is the most common cause of male undermasculinization and is typically caused by mutations in the AR gene. Affected individuals may exhibit either complete external feminization (complete AIS) or a partial phenotype (partial AIS). Here we describe monozygotic twins diagnosed with complete AIS who each possess two substitutions (C-->G at position 2930 and T-->C at position 2955, both in exon 7), leading to Phe(856)Leu and Ser(865)Pro mutations, respectively. Neither parent was found to be a carrier for these mutations, indicating that the double mutation arose de novo. Both mutations were recreated by site-directed mutagenesis and compared functionally with the wild-type receptor. The Phe(856)Leu mutation did not affect androgen binding when expressed in COS-1 cells, nor did this mutation decrease androgen-dependent trans-activation in transfected HeLa cells. However, the Ser(865)Pro mutation completely ablated androgen binding and trans-activation. In this study we demonstrate that the replacement of serine by proline at position 865 is sufficient in itself to cause complete AIS in these twins. Analyses of nuclear receptor structures suggest that this mutation is likely to perturb the conformation of helix 10/11, which plays a role in ligand binding, dimerization, and receptor activation. To our knowledge this is the first confirmed instance of AIS (complete or partial) due to an AR mutation occurring in twins. Furthermore, the phenotype was associated with two mutations that were both novel in nature. 相似文献
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