全文获取类型
收费全文 | 4071篇 |
免费 | 228篇 |
国内免费 | 50篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 112篇 |
妇产科学 | 27篇 |
基础医学 | 583篇 |
口腔科学 | 87篇 |
临床医学 | 261篇 |
内科学 | 1165篇 |
皮肤病学 | 22篇 |
神经病学 | 252篇 |
特种医学 | 180篇 |
外科学 | 749篇 |
综合类 | 19篇 |
预防医学 | 80篇 |
眼科学 | 23篇 |
药学 | 221篇 |
中国医学 | 6篇 |
肿瘤学 | 554篇 |
出版年
2023年 | 37篇 |
2022年 | 68篇 |
2021年 | 135篇 |
2020年 | 65篇 |
2019年 | 76篇 |
2018年 | 142篇 |
2017年 | 88篇 |
2016年 | 115篇 |
2015年 | 129篇 |
2014年 | 164篇 |
2013年 | 183篇 |
2012年 | 351篇 |
2011年 | 352篇 |
2010年 | 174篇 |
2009年 | 158篇 |
2008年 | 256篇 |
2007年 | 289篇 |
2006年 | 268篇 |
2005年 | 215篇 |
2004年 | 225篇 |
2003年 | 237篇 |
2002年 | 194篇 |
2001年 | 35篇 |
2000年 | 34篇 |
1999年 | 42篇 |
1998年 | 52篇 |
1997年 | 35篇 |
1996年 | 34篇 |
1995年 | 31篇 |
1994年 | 19篇 |
1993年 | 26篇 |
1992年 | 31篇 |
1991年 | 11篇 |
1990年 | 13篇 |
1989年 | 8篇 |
1988年 | 11篇 |
1987年 | 14篇 |
1986年 | 3篇 |
1985年 | 5篇 |
1984年 | 6篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1977年 | 2篇 |
1975年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1970年 | 2篇 |
1967年 | 1篇 |
排序方式: 共有4349条查询结果,搜索用时 265 毫秒
41.
(Received for publication on Dec. 8, 1997; accepted on July 7, 1998) 相似文献
42.
Delivery of a normal newborn after intensive medical treatment for an acute exacerbation of ulcerative colitis during pregnancy: A case report 总被引:1,自引:0,他引:1
(Received for publication on Sept. 21, 1998; accepted on May 27, 1999) 相似文献
43.
Taro Semba Yasuhiro Funahashi Naoto Ono Yuji Yamamoto Naoko Hata Sugi Makoto Asada Kentaro Yoshimatsu Toshiaki Wakabayashi 《Clinical cancer research》2004,10(4):1430-1438
We reported previously that an angiogenesis inhibitor, E7820, inhibits in vitro tube formation of human umbilical vein endothelial cell through the suppression of integrin alpha2 expression. Here we describe the antiangiogenic and antitumor effects of E7820 in mice and discuss the feasibility of using platelet integrin alpha2 expression on platelets as a biological marker of the efficacy of E7820. Oral administration of E7820 significantly inhibited basic fibroblast growth factor-induced angiogenesis in Matrigel implants and human colon WiDr tumor-induced angiogenesis in a dorsal air sac model. Twice-daily treatment with E7820 clearly inhibited the s.c. tumor growth of seven tumor cell lines derived from human colon, breast, pancreas, and kidney, and completely suppressed the growth of human pancreatic KP-1 and human colon LoVo cell lines. Moreover, E7820 significantly inhibited the growth of KP-1 and human colon tumor Colo320DM cells orthotopically implanted in the pancreas and cecum, respectively. The efficacy of E7820 was comparable in the s.c. and orthotopic transplantation models. Immunohistochemical analyses using anti-CD31 antibody showed that E7820 significantly reduced microvessel density in orthotopically implanted KP-1 tumor. E7820 reduced integrin alpha2 expression on a megakaryocytic cell line, Dami cells, induced by phorbol 12-myristate 13-acetate treatment. It also decreased the expression level of integrin alpha2 on platelets withdrawn from mice bearing s.c. KP-1 tumor at a dosage close to that affording antitumor activity. These data demonstrate that E7820 showed a broad-spectrum antitumor effect in mice through inhibition of angiogenesis and indicate that the decrease of integrin alpha2 on platelets might serve as a biological marker for the antitumor efficacy of E7820. 相似文献
44.
Tsukasa Ohnishi Kiyoshi Mori Sei Ohta Kohei Yokoi Naoto Miyazawa Keigo Tominaga Mitsuru Adachi 《International journal of clinical oncology / Japan Society of Clinical Oncology》1997,2(4):235-237
Tumor lysis syndrome is a rare complication of nonhematologic malignancies that results from massive necrosis of neoplastic
cells after chemotherapy. This syndrome consists of life-threatening metabolic derangements, including severe hyperphosphatemia,
hyperkalemia, hyperuricemia, and hypocalcemia, and may result in renal failure and death if not recognized early and treated
appropriately. We report a case of tumor lysis syndrome after induction chemotherapy in a patient with widely metastatic smallcell
lung cancer. This case emphasizes the importance of awareness and early treatment of this syndrome. 相似文献
45.
Hironori Kikkawa Daisei Miyamoto Hidetoshi Imafuku Chieko Koike Yasuo Suzuki Shoji Okada Hideo Tsukada Tatsuro Irimura Naoto Oku 《Cancer science》1998,89(12):1296-1305
To elucidate the early events of blood-borne metastasis under actual blood flow, real-time trafficking of RAW117 large cell lymphoma cells, namely parental RAW117-P and liver-metastatic RAW117-H10 cells, was investigated using positron emission tomography (PET). Both types of cells accumulated in the liver immediately after injection via the portal vein, and were eliminated from the liver time-dependently. The elimination rate of RAW117-H10 cells, however, was slower than that of RAW117-P cells, suggesting that RAW117-H10 cells interact more strongly with hepatic sinusoidal endothelium than the parental cells. This result correlated with the metastatic potential of these cells: RAW117-H10 cells metastasized in the liver to a greater extent than RAW117-P cells after injection via this route. To investigate the role of sialylglycoconjugates in the interaction of RAW117-H10 cells with the hepatic endothelium after injection via the portal vein, the trafficking of RAW117-H10 cells was examined after the cells had been treated with sialidase. The elimination rate of RAW117-H10 cells from liver was observed to be greatly accelerated by sialidase treatment. To elucidate what kind of sialylglycoconjugates is related to this phenomenon, we analyzed the distribution of sialyl Lewis A and sialyl Lewis X antigens of both sublines of RAW117 by using flow cytometry. RAW117-H10 cells were found to express a much higher level of sialyl Lewis A than RAW117-P cells, whereas the amount of sialyl Lewis X did not differ significantly. These findings suggest that some sialylglycoconjugates, perhaps sialyl Lewis A in particular, play an important role in the initial interaction of RAW117-H10 cells with the hepatic endothelium, leading to metastasis. 相似文献
46.
47.
Mutsumi Nozue Naoto Koike Tohru Kawamoto Kisako Toko Takashi Sindou Kazuo Orii Tadashi Kondou Yumi Mun Manabu Nithou Takeshi Todoroki Katashi Fukao 《Journal of surgical oncology》1993,52(2):115-118
The thymidylate synthase (TS) inhibition rate was measured after tegafur (FT) administration (1.5 g/day, at least 10 days) in 7 sigmoid colon cancer patients. The TS inhibition rate decreased as the interval between the time of the last administration and the time of the tumor resection increased longer. This study provides basic data for considering methods of drug administration and assessment of modification, for example, by leucovorin. © 1993 Wiley-Liss, Inc. 相似文献
48.
Antitumor effect of novel anti‐podoplanin antibody NZ‐12 against malignant pleural mesothelioma in an orthotopic xenograft model 下载免费PDF全文
Shinji Abe Mika Kato Kaneko Yuki Tsuchihashi Toshihiro Izumi Satoshi Ogasawara Naoto Okada Chiemi Sato Makoto Tobiume Kenji Otsuka Licht Miyamoto Koichiro Tsuchiya Kazuyoshi Kawazoe Yukinari Kato Yasuhiko Nishioka 《Cancer science》2016,107(9):1198-1205
Podoplanin (aggrus) is highly expressed in several types of cancers, including malignant pleural mesothelioma (MPM). Previously, we developed a rat anti‐human podoplanin mAb, NZ‐1, and a rat–human chimeric anti‐human podoplanin antibody, NZ‐8, derived from NZ‐1, which induced antibody‐dependent cellular cytotoxicity (ADCC) and complement‐dependent cytotoxicity against podoplanin‐positive MPM cell lines. In this study, we showed the antitumor effect of NZ‐1, NZ‐8, and NZ‐12, a novel rat–human chimeric anti‐human podoplanin antibody derived from NZ‐1, in an MPM orthotopic xenograft SCID mouse model. Treatment with NZ‐1 and rat NK (CD161a+) cells inhibited the growth of tumors and the production of pleural effusion in NCI‐H290/PDPN or NCI‐H226 orthotopic xenograft mouse models. NZ‐8 and human natural killer (NK) (CD56+) cells also inhibited tumor growth and pleural effusion in MPM orthotopic xenograft mice. Furthermore, NZ‐12 induced potent ADCC mediated by human MNC, compared with either NZ‐1 or NZ‐8. Antitumor effects were observed following treatment with NZ‐12 and human NK (CD56+) cells in MPM orthotopic xenograft mice. In addition, combined immunotherapy using the ADCC activity of NZ‐12 mediated by human NK (CD56+) cells with pemetrexed, led to enhanced antitumor effects in MPM orthotopic xenograft mice. These results strongly suggest that combination therapy with podoplanin‐targeting immunotherapy using both NZ‐12 and pemetrexed might provide an efficacious therapeutic strategy for the treatment of MPM. 相似文献
49.
50.
Izuru Maekawa Hitoshi Satoh Naoto Aoki Yasuyuki Morishita Norifumi Tsukamoto Masamitsu Karasawa Yasunobu Nonaka Mami Shiota Yoshihisa Nojima Shigeo Mori 《Japanese journal of cancer research》2002,93(1):61-69
T cell lymphoma carrying Epstein Barr virus (EBV(+) TL) is very rare among Western countries while it is much more common among Japanese. Here we report an EBV(+) TL which has been maintained for years by the use of mice with severe combined immune deficiency (SCID) mice. Lymphoma was obtained from a 55-year-old male suffering from oculomotor nerve palsy and lymphadenopathy. A small piece of biopsied tumor was transplanted into SCID mice and the lymphoma has been maintained for over 3 years with passages every 2 - 3 weeks. The maintained lymphoma, termed as TMS24, and the original lymphoma cells showed identical phenotype and genotype, including diffuse medium-sized cell morphology lacking granules, suppressor / cytotoxic immunophenotype and identical T cell receptor beta-chain gene rearrangement mode. Further, both were shown to carry an identical EBV clone in terms of the number of terminal repeats and the latency II-type restricted gene expression profile. Cytogenetically, TMS24 retained two characteristic chromosomal translocations of t(1;18)(q32;q21) and t(6;12)(p21;q24). Since only one cell line with such characters has been reported previously, TMS24 should be useful for detailed analysis of EBV(+) TL. 相似文献