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991.
Rodrigo Abarca-Del-Rio Jean-Francois CrÉtaux Muriel Berge-Nguyen Philippe Maisongrande 《Remote sensing letters.》2013,4(8):707-714
Complementary analysis of satellite mission data (altimetry, Moderate Resolution Imaging Spectroradiometers (MODIS)) and climate fields over 2000–2009 was conducted to investigate the variability of the water cover surfaces and the geographical source of water inflowing into the Lake Poopó system. The results suggest that over the time span of 2000–2009 a great part of the variability of the Poopó system originates from geographic sources other than Lake Titicaca. Possible alternative causes include climate change inducing increased temperatures and greater evaporation rates along the Altiplano; increased glacier and snow melting over the Andes Cordillera; and a potential increased anthropogenic water use (such as irrigation, minery, etc.) throughout the path of the Desaguadero River (which connects lakes Titicaca and Poopó). This change in the hydrology of this region could lead to a collapse of water supplies and endanger the already fragile Poopó system as well as the regional socioeconomic system, which closely depends upon it. 相似文献
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To date, the general assumption was that most mutations interested protein-coding genes only. Thus, only few illustrations have mentioned here that mutations may occur in non-protein coding genes such as microRNAs (miRNAs). We thus report progress in delineating their contribution as phenotypic modulators, genetic switches and fine-tuners of gene expression. We reasoned that browsing their contribution to genetic disease may provide a framework for understanding the proper requirements to devise miRNA-based therapy strategies, in particular the relief of an appropriate dosage. Gain and loss of function of miRNA enforce the need to respectively antagonize or supply the miRNAs. We further categorized human disease according to the different ways in which the miRNA was altered arising either de novo, or inherited whether as a mendelian or as an epistatic trait, uncovering its role in epigenetics. We discuss how improving our knowledge on the contribution of miRNAs to genetic disease may be beneficial to devise appropriate gene therapy strategies. 相似文献
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996.
Thibaud Lefebvre Muriel Coupaye Marina Esposito-Farse Nathalie Gault Neila Talbi Caroline Quintin Caroline Schmitt Soumeya Bekri Andr Bado Herv Puy Simon Msika Carole Brasse-Lagnel Zoubida Karim 《Nutrients》2021,13(8)
Iron deficiency with or without anemia, needing continuous iron supplementation, is very common in obese patients, particularly those requiring bariatric surgery. The aim of this study was to address the impact of weight loss on the rescue of iron balance in patients who underwent sleeve gastrectomy (SG), a procedure that preserves the duodenum, the main site of iron absorption. The cohort included 88 obese women; sampling of blood and duodenal biopsies of 35 patients were performed before and one year after SG. An analysis of the 35 patients consisted in evaluating iron homeostasis including hepcidin, markers of erythroid iron deficiency (soluble transferrin receptor (sTfR) and erythrocyte protoporphyrin (PPIX)), expression of duodenal iron transporters (DMT1 and ferroportin) and inflammatory markers. After surgery, sTfR and PPIX were decreased. Serum hepcidin levels were increased despite the significant reduction in inflammation. DMT1 abundance was negatively correlated with higher level of serum hepcidin. Ferroportin abundance was not modified. This study shed a new light in effective iron recovery pathways after SG involving suppression of inflammation, improvement of iron absorption, iron supply and efficiency of erythropoiesis, and finally beneficial control of iron homeostasis by hepcidin. Thus, recommendations for iron supplementation of patients after SG should take into account these new parameters of iron status assessment. 相似文献
997.
998.
Pouny I Etiévant C Marcourt L Huc-Dumas I Batut M Girard F Wright M Massiot G 《Planta medica》2011,77(5):461-466
Six protoflavonoids, including two new compounds, were isolated during a large scale screening of fern extracts for original interaction with mitosis. The new compounds isolated from PHEGOPTERIS decursive-pinnata and EQUISETUM fluviatile were 2',3'-dihydroprotogenkwanone (1) and 2',3'-dihydro-2'-hydroxyprotoapigenone (2). Known compounds were: protoapigenone, protogenkwanone, protoapigenin, and 4'- O- β-D-glucopyranosyl protoapigenin. They showed a cytotoxic activity against HeLa cells at a micromolar level. IC?? values were 2 μM for compound 1 > 10 μM for compound 2, and respectively 2.4, 0.6, > 10 μM for the known compounds. Their cytotoxic effects were associated with phenotypic changes never observed before and characterized by the loss of centrosomal γ-tubulin labelling in both mitotic and interphasic cells. 相似文献
999.
Sergi G. Costafreda Cynthia H.Y. Fu Marco Picchioni Fergus Kane Colm McDonald Diana P. Prata Sridevi Kalidindi Muriel Walshe Vivienne Curtis Elvira Bramon Eugenia Kravariti Nicolette Marshall Timothea Toulopoulou Gareth J. Barker Anthony S. David Michael J. Brammer Robin M. Murray Philip K. McGuire 《Human brain mapping》2009,30(10):3287-3298
During verbal‐fluency tasks, impairments in performance and functional abnormalities in the inferior frontal cortex have been observed in both schizophrenia patients and their unaffected relatives. We sought to examine whether such functional abnormalities are a specific marker of genetic vulnerability to schizophrenia. We studied a sample of 132 subjects, comprising 39 patients with schizophrenia, 10 unaffected monozygotic (MZ) cotwins of schizophrenia probands, 28 patients with bipolar disorder, 7 unaffected MZ cotwins of bipolar disorder probands and 48 healthy controls. Blood oxygen level‐dependent response was measured using functional magnetic resonance imaging during the performance of an overt verbal‐fluency task with two levels of task difficulty, in a cytoarchitectonic region of interest encompassing Brodmann areas 44 and 45 bilaterally. Patients with schizophrenia and the unaffected MZ cotwins of schizophrenia probands showed increased activation in the inferior frontal cortex relative to healthy controls and bipolar patients. Increased engagement of the inferior frontal cortex during verbal‐fluency may thus be a marker of genetic vulnerability to schizophrenia. Hum Brain Mapp, 2009. © 2009 Wiley‐Liss, Inc. 相似文献
1000.
Deruelle P Denervaud M Hachulla E Ducloy-Bouthors AS Valat AS Puech F Trillot N Hatron PY Subtil D 《European journal of obstetrics, gynecology, and reproductive biology》2006,127(1):73-78
BACKGROUND: During the first trimester of pregnancy, unfractionated heparin is the standard anticoagulant treatment for pregnant women at high risk of thrombosis. OBJECTIVE: To observe maternal and fetal tolerance for low-molecular-weight heparin begun in the first trimester of pregnancy. METHODS: Observational study conducted from 1 January 1997 to 31 May 2001. All patients began treatment before the 15th week of pregnancy. The outcome measures were the incidence and causality of adverse events in mother and fetus. RESULTS: The study included 97 patients (and 111 pregnancies) at very high risk for thrombosis. Seven fetal losses (6.3%) were observed: three early spontaneous abortions, three late spontaneous abortions and one medically indicated abortion. Twenty-five (22.5%) bleeding events occurred during pregnancy, seven (6.3%) of which required medical intervention: five curettages for first trimester spontaneous abortions, one late abortion at 21 weeks and one placental abruption at 25 weeks. Of nine (8.1%) primary postpartum hemorrhages involving a blood loss > or = 500 mL, three involved losses of 1000 mL or more and one required embolization of the uterine arteries. Five patients had thrombocytopenia, but none was treatment-related. Local cutaneous reactions occurred in 33 (29.7%) patients. Six (5.4%) maternal thromboembolic complications occurred during pregnancy or postpartum. At birth, two children had non-chromosomal congenital malformations (pyelectasia, cleft lip and palate). No fetal or neonatal complication was attributed to the treatment. CONCLUSION: The use of low-molecular-weight heparin (LMWH) for patients requiring anticoagulant treatment from the first trimester appears safe for mother and fetus. 相似文献