An analysis of biological hard tissues using the tomographic reconstruction error formula

A variety of teeth and bone specimens have been scanned using the constant statistics tomographic scanner developed at the London Hospital Medical College. Each data set has been reconstructed with several Hamming filters, and for a geometric resolution ranging from 20 to 50 micrometers. The reconstructions have been studied using the approximate error formula for the convolution backprojection algorithm. Some inferences are made on the relative structure of the cross sections.     

Management Strategies for Relapsed Multiple Myeloma

Multiple myeloma is the second most common hematologic malignancy after non-Hodgkin lymphoma. Numerous treatments for this disease are available, but despite high overall response rates, relapse occurs in almost all patients, and survival has typically been no more than 5 years. Treatment options for relapsed patients include pulsed dexamethasone; cyclophosphamide-based therapy; doxorubicin-based regimens; melphalan and prednisone; thalidomide with or without dexamethasone; bortezomib; and high-dose chemotherapy supported by autologous or allogeneic stem cell transplantation. Relapsed disease is more difficult to treat, and patients characteristically become resistant to therapy. As a result of the numerous potential complications of multiple myeloma, including fatigue, bone pain, renal dysfunction, increased susceptibility to infection, and spinal cord compression, quality of life has a significant role in the choice of therapy. New strategies in the treatment of relapsed disease are focusing on therapy that is targeted to various cell-signaling pathways and microenvironmental interactions involved in the pathogenesis of multiple myeloma. As they become available, these strategies are showing promise in the treatment of both relapsed and refractory disease, the most recent being the potent thalidomide analog lenalidomide. Research efforts are also concentrated on improving front-line therapy to reduce the rate of relapse so that, ultimately, survival may be extended and patient outcome improved.     

Juvenile hyaline fibromatosis: a case report

Juvenile hyalinefibromatosis (JHF) is a rare autosomal recessive (4q21) genodermatosis characterized by a triad of cephalic fibrous outgrowths, gingival hypertrophy and flexion contractures. This paper presents a case report of juvenile hyaline fibromatosis.     

有症状门诊病人深静脉血栓形成的诊断,临床评价和D-二聚体分析可能减少对影像学诊断的需要

深静脉血栓形成(DVT)的年发病率为48-182／10万,一般估计为1／1000。DVT病死率为1%-5%,发病率和病死率与年龄密切相关。慢性疼痛、肿胀、偶尔腿部皮肤溃疡等血栓后综合征见于1／3发生过DVT的患者。血栓后综合征可出现较早,也可迟至10年才出现,总的发病率为2年23%,5年28%。患者如使用弹力加压袜至少2年以上,腿部病变的发生率可