全文获取类型
收费全文 | 8648篇 |
免费 | 500篇 |
国内免费 | 71篇 |
专业分类
耳鼻咽喉 | 42篇 |
儿科学 | 178篇 |
妇产科学 | 86篇 |
基础医学 | 897篇 |
口腔科学 | 117篇 |
临床医学 | 956篇 |
内科学 | 2136篇 |
皮肤病学 | 149篇 |
神经病学 | 457篇 |
特种医学 | 218篇 |
外国民族医学 | 1篇 |
外科学 | 1658篇 |
综合类 | 220篇 |
现状与发展 | 1篇 |
一般理论 | 5篇 |
预防医学 | 538篇 |
眼科学 | 153篇 |
药学 | 790篇 |
中国医学 | 156篇 |
肿瘤学 | 461篇 |
出版年
2024年 | 16篇 |
2023年 | 174篇 |
2022年 | 532篇 |
2021年 | 663篇 |
2020年 | 394篇 |
2019年 | 479篇 |
2018年 | 472篇 |
2017年 | 286篇 |
2016年 | 314篇 |
2015年 | 353篇 |
2014年 | 418篇 |
2013年 | 492篇 |
2012年 | 762篇 |
2011年 | 691篇 |
2010年 | 325篇 |
2009年 | 306篇 |
2008年 | 452篇 |
2007年 | 427篇 |
2006年 | 359篇 |
2005年 | 341篇 |
2004年 | 258篇 |
2003年 | 252篇 |
2002年 | 119篇 |
2001年 | 63篇 |
2000年 | 44篇 |
1999年 | 34篇 |
1998年 | 22篇 |
1997年 | 14篇 |
1996年 | 15篇 |
1995年 | 8篇 |
1994年 | 7篇 |
1993年 | 10篇 |
1992年 | 8篇 |
1991年 | 8篇 |
1990年 | 7篇 |
1989年 | 8篇 |
1988年 | 9篇 |
1987年 | 3篇 |
1986年 | 3篇 |
1985年 | 7篇 |
1984年 | 9篇 |
1983年 | 4篇 |
1982年 | 8篇 |
1981年 | 13篇 |
1980年 | 4篇 |
1979年 | 3篇 |
1978年 | 5篇 |
1977年 | 3篇 |
1976年 | 5篇 |
1972年 | 3篇 |
排序方式: 共有9219条查询结果,搜索用时 15 毫秒
21.
Muhammad Novrizal Abdi Sahid Takeshi Kiyoi 《Journal of immunoassay & immunochemistry》2020,41(4):778-816
ABSTRACT Mast cells (MCs) are well known for their role in allergic conditions. This cell can be activated by various types of secretagogues, ranging from a small chemical to a huge protein. Mast cell activation by secretagogues triggers the increase in intracellular calcium (iCa2+) concentration, granule trafficking, and exocytosis. Activated mast cells release their intra-granular pre-stored mediator or the newly synthesized mediator in the exocytosis process, in the form of degranulation or secretion. There are at least three types of exocytosis in mast cells, which are suggested to contribute to the release of different mediators, i.e.,, piecemeal, kiss-and-run, and compound exocytosis. The status of mast cells, i.e., activated or resting, is often determined by measuring the concentration of the released mediator such as histamine or β-hexosaminidase. This review summarizes several mast cell components that have been and are generally used as mast cell activation indicator, from the classical histamine and β-hexosaminidase measurement, to eicosanoid and granule trafficking observation. Basic principle of the component determination is also explained with their specified research application and purpose. The information will help to predict the experiment results with a certain study design. 相似文献
22.
Ito Y Tanaka N Fujimoto Y Yasunaga Y Ishida O Agung M Ochi M 《Journal of biomedical materials research. Part A》2004,69(3):454-461
The clinical use of cultured marrow stromal stem cells (MSCs) has recently attracted attention in the field of tissue engineering. For the clinical use of the MSCs, a prominent scaffold is needed. A scaffold hybridized with MSCs is transformed into a "bioactive bone substitute," and this provides good osteoconduction. In this study, a novel calcium hydroxyapatite ceramic with an interconnected porous structure (IP-CHA) was used as a scaffold. MSCs were harvested from Green rats containing Green Fluorescent Protein (GFP), and then these hybrids were implanted into the tibias of Sprague-Dawley rats. The purposes of this study were to examine the osteogenic ability of these hybrids without coculture, and to evaluate whether the resulting bone formation originated from the grafted MSCs or the recipient's cells. The hybridized group showed excellent bone formation compared with the IP-CHA-only implant group. Observation of the implanted MSCs revealed that they survived 8 weeks after surgery, and differentiated into osteoblast-like cells, thus providing bone formation. This implantation of the MSCs/IP-CHA composite provides excellent osteoconduction, and is expected to have extensive clinical applications. 相似文献
23.
24.
Wajid M Abbasi AA Ansar M Pham TL Yan K Haque S Ahmad W Leal SM 《European journal of human genetics : EJHG》2003,11(10):812-815
This article describes the identification of a novel locus (DFNB39) responsible for an autosomal recessive form of hearing loss segregating in a Pakistani consanguineous family. The hearing impaired members of this family present with profound prelingual sensorineural hearing impairment and use sign language for communications. Linkage was established to microsatellite markers located on chromosome 7q with a maximum multipoint lod score of 3.8. The region of homozygosity spans a 19 cM region that is bounded by markers D7S3046 and D7S644. 相似文献
25.
26.
27.
Elias N. Nasr Muhammad A. K. Bhatti Errol Warner 《Journal of the National Medical Association》1981,73(6):525-529
Five cases of duodenal injuries were treated in our hospital between January 1, 1975 and June 18, 1979. They belonged to the Class II and early Class III of duodenal injuries. They were treated with simple closure of the perforation in a single or double layer with external drainage. Only in one case were gastrojejunostomy and bilateral vagotomy added because the patient had a history of ulcer disease. The delay in operative treatment ranged between five and 48 hours. All responded well to the surgical treatment. In the instance of the longest operative delay, a purulent drainage occurred and it responded promptly to a selective antibiotic therapy. The average hospitalization stay was nine days for the patients operated upon early, whereas it was 15 days for the two delayed cases. No mortality was recorded. 相似文献
28.
Idrees M Gandhi C Betchen S Strauchen J King W Wolfe D 《Archives of pathology & laboratory medicine》2005,129(1):e11-e15
Peripheral primitive neuroectodermal tumors (pPNETs) are aggressive, poorly differentiated neoplasms that occur in children and young adults. These tumors are associated with a peak incidence in the second decade and a slight male preponderance. Recently, Ewing sarcoma and pPNET tumors have been proven to carry identical translocations, the most common being t(11;22)(q24;q12). Intracranial Ewing sarcoma/pPNETs have rarely been described in the literature. We studied a case of intracranial pPNET arising in the right cavernous sinus of a 46-year-old man. On imaging, the tumor had both sellar and suprasellar components and was centered within the right parasellar region. Histologically, the tumor was composed of intermediate to large cells with round to oval hyperchromatic nuclei with distinct nucleoli. The cells contained a moderate amount of slightly basophilic cytoplasm. The tumor was markedly fibrotic and had collagen bands surrounding both individual and groups of cells. A large immunohistochemical panel was positive only for CD99 and vimentin. Fluorescence in situ hybridization did not show translocations associated with Ewing sarcoma/pPNET. However, a small percentage of these tumors can be negative for this translocation. In these cases, histology and immunohistochemical techniques in the absence of an alternative diagnosis are the only tools available to establish the diagnosis. 相似文献
29.
Magnié MN Bermon S Martin F Madany-Lounis M Suisse G Muhammad W Dolisi C 《Psychophysiology》2000,37(3):369-377
Electrophysiological effects of aerobic fitness and maximal aerobic exercise were investigated by comparing P300 and N400 before and after a maximal cycling test. Event-related potentials (ERPs) were obtained from 20 students divided into two matched groups defined by their aerobic fitness level (cyclists vs. sedentary subjects). The session of postexercise ERPs was performed immediately after body temperature and heart rate returned to preexercise values. At rest, no significant differences were observed in ERP parameters between cyclists and sedentary subjects. This finding argued against the hypothesis that ERP modifications may be directly assumed by aerobic fitness level. The postexercise session of ERPs showed a significant P300 amplitude increase and a significant P300 latency decrease in all subjects. Similarly, N400 effect increased significantly after the maximal exercise in all subjects. ERP changes were of the same magnitude in the two groups. The present study argues for a general arousing effect of maximal aerobic exercise, independently of the aerobic fitness level. 相似文献
30.
Lyme disease spirochete,Borrelia burgdorferi endemic at epicenter in Rondeau Provincial Park,Ontario
The Lyme disease spirochete, Borrelia burgdorferi Johnson, Schmidt, Hyde, Steigerwalt, and Brenner was discovered in blacklegged ticks, Ixodes scapularis Say at Rondeau Provincial Park, Ontario, Canada During this 2-yr study, spirochetes were found in B. burgdorferi-positive I. scapularis larvae attached to B. burgdorferi-infected white-footed mice, Peromyscus leucopus Rafinesque. Isolates of B. burgdorferi were cultured from blacklegged tick adults, and confirmed positive with polymerase chain reaction by targeting OspA and rrf (5S)-rrl (23S) genes. These findings show an endemic area for B. burgdorferi within an established population of L. scapularis at Rondeau Provincial Park. 相似文献