高校教师主观幸福感实证研究

目的探讨影响高校教师主观幸福感的原因,为高校教师的心理健康教育工作提供依据。方法运用主观幸福感问卷,整体随机抽样,对800名大学教师进行问卷调查。结果高校教师的主观幸福感得分显著高于全国常模;男教师81.75±11.07高于女教师79.73±13.04,差异有统计学意义(P<0.05);工龄在5年以下79.34±13.64、6~10年80.21±12.23、11~15年81.17±12.16、15年以上80.41±15.34相比,差异有统计学意义(P<0.01);学历为专科81.04±11.17、本科81.74±12.13、硕士80.87±11.02、博士79.41±12.21相比,差异有统计学意义(P<0.01);职称为助教78.03±12.31、讲师81.72±11.81、副教授79.53±11.62、教授80.11±12.43相比,差异有统计学意义(P<0.01)。结论高校教师的主观幸福感处于较高水平,性别、年龄、职称、专业对高校教师的主观幸福感有显著影响。     

阿魏酸钠对大鼠角膜新生血管的抑制作用研究

目的 探讨阿魏酸钠(SF)对角膜新生血管(CNV)的抑制作用及其机制.方法 将不同质量浓度的SF用于缝线诱导的大鼠CNV模型,观察其抑制CNV形成的效果,采用免疫组织化学法和RT-PCR法检测血管内皮生长因子(VEGF)蛋白和mRNA在角膜组织中的表达水平.结果 0.025%和0.1%SF治疗组CNV面积均小于阴性对照组,以后者更明显,差异均有统计学意义(P＜0.05),0.1%SF治疗组与阳性对照组间差异无统计学意义(P＞0.05);免疫组织化学显示VEGF在正常角膜不表达或在上皮基底细胞有弱表达,阴性对照组染色明显增强,0.1%SF治疗组表达明显减弱;VEGFmRNA和蛋白水平表达有一致性.结论 SF滴眼液能有效地抑制CNV的生长,其抑制VEGF的表达可能是SF抑制CNV生成的一个重要机制.     

嘉兴市秀洲区学校传染病暴发疫情分析

[目的]了解中小学校造成传染病暴发的原因和流行病种，为制定决策和采取相应的预防控制措施提供科学依据。[方法]根据《全国传染病统一诊断标准》，传染病暴发疫情判断标准以某种传染病在学校（群体）中连续发生≥3例或在21 d内≥5例印视为暴发。进行描述性分析。[结果]2004和2005年中小学校以呼吸道传染病暴发为主，时间分布于秋冬或冬春季节多见，传染病暴发起次小学〉中学。中小学生传染病发病率分别为1．65％和9．43％,小学生〉中学生。而男女生传染病发病率分别为6．93％和7．01％，男女生对各种暴发传染病同样易感。[结论]学校应把健康教育和晨检制度列入教育议事日程，加强学生体育锻炼，提高身体素质及采取综合性预防和控制措施阻止学校中传染病的暴发和流行。     

烧伤患者静脉留置针检出金黄色葡萄球菌及耐药性分析

目的分析烧伤患者静脉留置针金黄色葡萄球菌检出率及耐药谱,为临床治疗及合理使用抗菌药物提供参考。方法收集175例烧伤患者静脉留置针标本,经培养分离后,采用法国生物梅里埃公司的细菌鉴定、药敏条进行鉴定及药敏分析。结果烧伤患者静脉留置针致病菌以金黄色葡萄球菌为主,占60.3%;所有菌株均为耐甲氧西林金黄色葡萄球菌(MRSA),对青霉素、苯唑西林、庆大霉素的耐药率为100.0%,对克林霉素、四环素、利福平等的耐药率均>50.0%,对米诺环素、替考拉宁耐药率为2.3%,未发现万古霉素、夫西地酸、喹奴普汀/达福普汀耐药株。结论金黄色葡萄球菌为烧伤患者静脉留置针感染的主要致病菌,且耐药性严重,及时对烧伤患者静脉留置针进行细菌培养及药敏检测,对于临床合理应用抗菌药物、减少耐药菌株产生有重要意义。     

贵州4个民族群体3对遗传性状的基因频率

目的：了解贵州布依族、苗族、水族和白裤瑶眼部遗传性状基因频率分布特征。方法：采用群体遗传学公认的方法，对贵州布依族、苗族、水族和白裤瑶眼色、眼裂开度和眼裂方向3对遗传性状进行调查，并计算出各遗传性状的基因频率。被调查者年龄18—55岁，三代均为同一民族。结果：贵州布依族、苗族、水族和白裤瑶眼色的显性基因频率分别为0．0376、0．0493、0．0488和0．0110，眼裂开度的显性基因频率分别为0．6763、0．7048、0．8139和0．6769，眼裂方向的显性基因频率分别为0．0816、0．1441、0．1969和0．0575。结论：眼裂方向性状的民族间差异较大，眼色、眼裂开度则较小。     

大剂量131Ⅰ治疗分化型甲状腺癌的临床观察

目的 分化型甲状腺癌的功能性转移灶具有吸收和浓聚^131 I的能力，利用^131 I的β射线有效破坏转移性癌灶，达到治疗目的．方法 和外科合作，采用先行手术，术后恢复后口服大剂量^131I，治疗后采用甲状腺激素替代疗法的综合治疗方案。按照病理类型、服碘次数、转移情况、毒副反应、显像情况等进行分类统计。结果 ^131I治疗甲状腺癌与患者一般情况、病理、转移、术式及病灶吸碘情况有关。结论 ^131 I内照射治疗具有一定靶向性，利用^131 Iβ射线有效破坏转移癌灶，疗效肯定，但需根据患者的不同情况调整治疗方案。     

Prognostic role of detection method and its relationship with tumor biomarkers in breast cancer: the university of Texas M.D. Anderson Cancer Center experience.

PURPOSE: To assess the effect of tumor detection method (screening versus symptom-based diagnosis) in predicting breast cancer survival and investigate how biological features of breast cancer are related to the tumor detection method. PATIENTS AND METHODS: The study population consisted of 5,481 women diagnosed with primary invasive breast cancer between 1997 and 2005 and received their treatment at The University of Texas M. D. Anderson Cancer Center. RESULTS: Patients with symptom-detected tumors had an increased risk of recurrence or death [relative risk (RR), 1.34; P = 0.006] and breast cancer-specific death (RR, 1.31; P = 0.117) than patients with screen-detected tumors after adjusting for tumor characteristics and treatments received. This relationship was especially evident among estrogen receptor (ER)-negative tumors (RR, 1.60 for breast cancer recurrence for ER-negative tumors; RR, 1.18 for ER-positive tumors). ER status and Ki-67 expression were statistically significantly associated with symptom detection rate after adjusting for patients' age, tumor stage, tumor size, and nuclear grade [odds ratio (OR) of ER negative versus ER positive, 1.35; P < 0.001; OR of Ki-67 10-30% versus <10%, 1.40; P = 0.005; OR of Ki-67 >30% versus <10%, 2.11; P < 0.001]. CONCLUSION: The method of detection was a statistically significant independent predictor of breast cancer recurrence. Information on the method of tumor detection should be collected to improve the prediction of prognosis of breast cancer patients.     

Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer

Background  

Our previous study revealed that Vav3 oncogene is overexpressed in human prostate cancer, activates androgen receptor, and stimulates growth in prostate cancer cells. The current study is to determine a potential role of Vav3 oncogene in human breast cancer and impact on estrogen receptor a (ERα)-mediated signaling axis.     

Principal component analysis for the comparison of metabolic profiles from human rectal cancer biopsies and colorectal xenografts using high-resolution magic angle spinning <Superscript>1</Superscript>H magnetic resonance spectroscopy

Background  

This study was conducted in order to elucidate metabolic differences between human rectal cancer biopsies and colorectal HT29, HCT116 and SW620 xenografts by using high-resolution magnetic angle spinning (MAS) magnetic resonance spectroscopy (MRS) and for determination of the most appropriate human rectal xenograft model for preclinical MR spectroscopy studies. A further aim was to investigate metabolic changes following irradiation of HT29 xenografts.     

Introduction to HUA Xue-gui＇s Experience in Acupuncture Treatment of Tinnitus and Deafness

Doctor HUA Xue-gui, an associate chief physician in Shanghai Research Institute of Acupuncture and Meridian, has been engaged in clinical practice and scientific research of acupuncture for over 30 years. She has created a set of unique and complete acupuncture modalities for neurotic tinnitus and deafness. The authors are honored to have studied with Doctor HUA and have achieved a lot. Now, Doctor HUA＇s experience is summarized as follows.