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51.
应用CD3AK细胞预防肝癌术后复发的初步观察 总被引:4,自引:0,他引:4
目的 观察CD3AK细胞治疗对肝癌术后复发的影响。方法 62例肝癌切除术按序列单双数的原则分为两组,研究组32例术后1周开始应用CD3AK细胞治疗,每隔2~3个月施行一疗程,共2~6个疗程;对照组30例术后不用CD3AK细胞治疗,仅作一般护治疗。结果 ①研究组术后1年复发率6.3%(2/32)明显低于对照组26.7%(8/30)(P〈0.05);②研究组和对照组术后4周免疫功能有明显差异(P〈0. 相似文献
52.
1993年7月~1998年1月为103例(106只眼)难治性青光眼患者施行国产房水引流物(HAD)置入术。术后平均随访328月。术后1年时平均眼压22±1.4kPa。术后1~5年的手术成功率分别为838%,804%,771%,710%及643%。术中联合应用丝裂霉素C的病例,其术后1年时的成功率为895%。术后常见的并发症有持续性浅前房,局限性脉络膜脱离及眼压升高等。认为HAD可用于治疗难治性青光眼。 相似文献
53.
Cotrutz CE Medrihan M Bălţătescu M Morariu C Petreuş T Moşoiu C Ionescu CR Nevinglovschi R Cotrutz C 《Revista medico-chirurgical?? a Societ????ii de Medici ??i Naturali??ti din Ia??i》1999,103(3-4):78-82
Exist a statistically significant association between a diagnosis of coronary heart disease and certain oral health parameters. These parameters are independent and more strongly associated with coronary heart disease than were recognized risk factors, such as serum cholesterol levels, body mass index, diabetes and smoking status. The correlation between serum and salivary cholesterol concentration and the role of salivary lipids in oral health have been poorly characterized. Lipids in saliva are mostly glandular in origin, through some may diffuse diffuse directly from the serum. The surface of the enamel (in case of dietary fat which have an cariostatic effect) is protected against demineralization by a mixture of salivary lipids and proteins. Salivary lipids may have anucleating role in the early mineralization of the dental plaque. The prevalence of periodontal disease may be increased in patients with atherosclerosis, and dental and periodontal infections have been shown to be associated with occurrence of acute and chronic coronary heart disease. Among the known risk factors of atherosclerosis, high serum lipid levels, especially cholesterol may be important with regard to periodontal health. 相似文献
54.
用10只犬复制失血性休克模型,观察休克前、休克30min及回输血后30min时,血浆中心肌相关酶—肌酸激酶(CK)、谷草转氨酶(GOT)、α-羟丁酸脱氢酶(HBD)活性值的变化。结果发现:失血性休克30min时,CK、GOT较休克前显著下降(P<0.05,P<0.01);HBD值也下降,但无统计学意义(P>0.05)。输血后30min时,CK、GOT、HBD值回升,与休克30min时比显著升高(P<0.05),与休克前比无显著性差别(P>0.05)。提示:失血性休克早期心肌细胞可能存在有一种保护性反应,心肌细胞没有发生明显损伤。 相似文献
55.
在我国中等发达及上农村地区,大病统筹合作医疗或医疗保险以其可缓解农村居民的就医经济风险而受到欢迎,但是在方案的拟订过程中尚存在一些明显的技术缺陷,比如,“大病”的技术定义、农村居民就医经济风险分析、风险临界线界定、保险经付比测算和保险费率厘定等,这些技术的缺乏,已严重影响农村合作医疗或医疗保险的推广和实施效果。 相似文献
56.
目的观察小分割分次立体定向放射治疗(fractionated stereotatic radiation therapy,FSRT)脑转移瘤的近期疗效.方法15例病人单纯全脑外照射(WBRT组),中间平面剂量20~40Gy/10~20次/2~4周.17例病人接受FSRT(FSRT组),每次分次剂量为2.5~3.0Gy.其中11病人行单纯FSRT,中心总剂量为30~60Gy/1 0~20次/2~4周;6例病人先行WBRT,然后行FSRT,中心总剂量为46~60Gy/5~6周.结果KSP评分增加10分以上者,WBRT组为5 3.3%,FSRT组为82.4%.(P<0.05).WBRT组有效率(CR PR)为50.0%;FSRT组有效率(CR PR)为80.0%.中位生存率:WBRT组为3.5月,FSRT组为10.0月.结论FSRT能有效地控制脑转移瘤,减轻神经系统症状,提高生存质量,延长病人生存期,而没有增加副作用,值得临床推广应用. 相似文献
57.
妊娠合并肺动脉高压23例分析 总被引:5,自引:0,他引:5
目的 探讨合并肺动脉高压(PH)妇女能否妊娠及妊娠的适宜时间。方法 回顾性分析1997~2002年在我院诊治的23例合并有PH的孕妇,分析PH的分类,妊娠结局。结果 3例合并原发性肺动脉高压(PPH)孕妇,2例在剖宫产术中死亡,1例在孕早期终止妊娠后存活。14例因合并风湿性心脏病(风心病)致PH的孕妇,妊娠至足月行剖宫产者10例,1例早产,3例引产,无一例孕妇死亡。6例因合并先天性心脏病(先心痛)致PH的孕妇,轻度PH孕妇3例,均妊娠至足月;重度PH孕妇3例,2例死亡,1例存活。结论 PPH患者应避免妊娠。风心病致PH的孕妇,依心功能、PH高低及血氧饱和度决定是否终止妊娠。对先心病致PH者,最好在手术或药物治疗后妊娠;患Eisenrnenger’s综合征妇女禁止妊娠。 相似文献
58.
Vázquez Rueda F Moñiz Mora MV Salas Molina J Pizarro de Celis FJ Ocaña Losa JM 《Actas urologicas espa?olas》2000,24(3):260-261
We report a new case of spermatic cord lymphangioma in a infant 2 years old. The initial diagnosis was funicular hydrocele. The treatment was the local excision of tumor and the diagnostic was histological. Postoperative course was excellent. Must be explored the transillumination of the mass which would have led us to think other the diagnosis different from that of the cord hydrocele before the operation since it would have given negative. During the operation, must the assured that the cystic anomaly is limited to spermatic cord, to evite recurrences in the postoperative course. 相似文献
59.
Véronique Diéras Pierre Fumoleau Gilles Romieu Michèle Tubiana-Hulin Mo?se Namer Louis Mauriac Jean-Paul Guastalla Eric Pujade-Lauraine Pierre Kerbrat Philippe Maillart Frédérique Pénault-Llorca Marc Buyse Pierre Pouillart 《Journal of clinical oncology》2004,22(24):4958-4965
PURPOSE: This randomized, noncomparative, parallel-group study was designed to evaluate the pathologic complete response (pCR) rate of combined doxorubicin plus paclitaxel (AP) and doxorubicin plus cyclophosphamide (AC) as neoadjuvant chemotherapy in patients with previously untreated breast cancer who were unsuitable for conservative surgery. PATIENTS AND METHODS: A total of 200 patients with T2-3, N0-1, M0 disease were randomly assigned in a 2:1 ratio to receive preoperative chemotherapy with either doxorubicin 60 mg/m(2) plus paclitaxel 200 mg/m(2) as a 3-hour infusion (AP) or doxorubicin 60 mg/m(2) plus cyclophosphamide 600 mg/m(2) (AC) every 3 weeks for 4 courses followed by surgery. RESULTS: A pCR (eradication of invasive carcinoma in tumor and in axillary lymph nodes) was found in 16% and 10% of patients in the AP and AC arms, respectively, by study center pathologists, and in 8% and 6% of patients, respectively, by independent pathologists. Patients with pCRs tended to have unifocal disease, tumors with negative hormonal receptor status, and less differentiation (Scarff, Bloom, and Richardson scale grade 3). Breast-conserving surgery was performed in 58% and 45% of patients in the AP and AC arms, respectively. An objective clinical response was achieved in 89% of patients in the AP arm and 70% in the AC arm. At a median follow-up of 31 months, disease-free survival (DFS) was higher in patients who reached pCR versus those without pCR (91% v 70%). CONCLUSION: The encouraging pathologic and clinical responses of patients with breast cancer after neoadjuvant chemotherapy with doxorubicin plus paclitaxel warrant additional investigation of paclitaxel in the neoadjuvant setting of breast cancer management. 相似文献
60.
Anthony T C Chan Brigette B Y Ma Y M Dennis Lo S F Leung W H Kwan Edwin P Hui Tony S K Mok Michael Kam Lisa S Chan Samuel K W Chiu K H Yu K Y Cheung Karen Lai Maria Lai Frankie Mo Winnie Yeo Ann King Philip J Johnson Peter M L Teo Benny Zee 《Journal of clinical oncology》2004,22(15):3053-3060
PURPOSE: To assess the efficacy of neoadjuvant paclitaxel and carboplatin (TC) followed by concurrent cisplatin and radiotherapy (RT) in patients with locoregionally advanced nasopharyngeal carcinoma (NPC) and to monitor treatment response with plasma Epstein-Barr virus (EBV) DNA. PATIENTS AND METHODS: Thirty-one patients with International Union Against Cancer stages III and IV undifferentiated NPC had two cycles of paclitaxel (70 mg/m2 on days 1, 8, and 15) and carboplatin (area under the curve 6 mg/mL/min on day 1) on a 3-weekly cycle, followed by 6 to 8 weeks of cisplatin (40 mg/m2 weekly) and RT at 66 Gy in 2-Gy fractions. Plasma EBV DNA was measured serially using the real-time quantitative polymerase chain reaction method. Results All patients completed planned treatment. Response to neoadjuvant TC was as follows: 12 patients (39%) achieved partial response (PR) and 18 achieved (58%) complete response (CR) in regional nodes; five patients (16%) achieved PR and no patients achieved CR in nasopharynx. At 6 weeks after RT, one patient (3%) achieved PR and 30 patients (97%) achieved CR in regional nodes, and 31 patients (100%) achieved CR in nasopharynx; 29 patients (93%) had EBV DNA level of less than 500 copies/mL. Neoadjuvant TC was well tolerated, and the most common acute toxicity of cisplatin plus RT was grade 3 mucositis (55%). At median follow-up of 33.7 months (range, 7 to 39.3 months), six distant and three locoregional failures occurred. Plasma EBV DNA level increased significantly in eight of nine patients who experienced treatment failure but did not increase in those who did not. The 2-year overall and progression-free survival rates were 91.8% and 78.5%, respectively. CONCLUSION This strategy was feasible and resulted in excellent local tumor control. Serial plasma EBV DNA provides a noninvasive method of monitoring response in NPC. 相似文献