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排序方式: 共有9714条查询结果,搜索用时 15 毫秒
81.
Tomomi Nakagawa Kazuyoshi Shigehara Yuki Kato Shohei Kawaguchi Hiroki Nakata Taito Nakano Kouji Izumi Yoshifumi Kadono Atsushi Mizokami 《Journal of medical virology》2023,95(1):e28110
Although urine and bladder washing samples are commonly used for the cytological evaluation of the bladder mucosa, it has been unknown whether these samples are likely suitable to investigate human papillomavirus (HPV) prevalence in the urinary bladder. The present study aimed to elucidate the appropriateness of spontaneously voided urine or bladder washing in screening HPV infection in the urinary bladder. Urine and bladder washing samples were obtained from 201 patients who underwent transurethral bladder tumor resection. After extracting DNA from both samples, HPV-DNA was examined using a nested polymerase chain reaction with GP5+/6+ and MY09/11 primers. HPV genotyping was performed in the HPV-positive samples. In situ hybridization (ISH) was performed to observe the HPV-DNA localization in urothelial cells among cytological samples and paraffin-embedded tumor tissues in HPV-positive washing samples. HPV prevalence in urine and washing samples were 9.5% and 7.0%, respectively. High-risk HPV prevalence in urine and washing samples was 7.5% and 4.0%, respectively. The most common HPV type was HPV 16, followed by HPV 52 and HPV 18 in both samples. HPV type distribution in both samples was not in agreement (κ = −0.431). The ISH analysis revealed that HPV-DNA signal was observed in urothelial cells of five (55.7%) of nine detectable HPV-positive cytological samples. Six (66.7%) of nine HPV-positive cases had HPV-DNA signals in tumor tissue. The use of washing samples was likely applicable for investigating HPV prevalence in the urinary bladder. HPV-DNA detected in washing samples might be frequently derived from the urinary bladder. 相似文献
82.
Iwabuchi Satoru Handa Masashi Usuda Katsuo Sato Masami Kondo Takashi Tanita Tatsuo Fujimura Shigefumi 《Surgery today》1994,24(11):1014-1018
A 52-year-old Japanese man with a slow-growing chondroma originating from the sternal bone was referred to our hospital. A subtotal resection of the sternum was performed, hereafter termed the sandwich method, and an originally designed prosthesis made from ultra-high-molecular-weight polyethylene and Marlex mesh was used for reconstruction. The postoperative course was uneventful without any symptoms due to paradoxical movement of the chest or regional abscess, and no disturbance in the movement of the upper limbs, such as a surgical sequelae, was observed. 相似文献
83.
Takafumi Ichida Masashi Kato Akihito Hayakawa Shinichi Ito Shigeki Mori Tomomi Sato Souichi Sugitani Hiroshi Sato Masashi Watanabe Hitoshi Asakura 《Cancer chemotherapy and pharmacology》1994,33(Z1):S74-S78
Prior injection of an anticancer agent and Lipiodol mixture is a key point for the treatment of hepatocellular carcinoma (HCC). We therefore prepared a new, improved emulsion of Lipiodol containing a high dose ofcis-diamminedichloroplatinum (CDDP) and epirubicin by replacing the ionic contrast medium (Urografin 67) with a nonionic contrast medium (Iopamidol; Iopamiron 300) and adding phosphatidyl choline. This CDDP-epirubicin-Lipiodol emulsion (CELE) was examined pharmacologically and chemically with the following results. The size of these particles is less than 10 m (diameter) for up to 24 h; the release of 28%–34% of the CDDP and 80%–90% of the epirubicin was estimated in the dissolution test, and 85% of the CDDP and 35% of the epirubicin was retained in the organs in the moment calculation. CELE was injected into 58 HCC patients via a celiac angiographic catheter. In 36 of these patients, the CELE injection was followed by transcatheter arterial embolization (TAE) therapy. Following the administration of CELE as one-shot injection therapy for stage IV HCC, the 1-year survival rate was 59% and the 2-year survival rate was 27%. Moreover, in patients (stage II, 12; stage III, 8; stage IV, 16) who received CELE and subsequently underwent TAE therapy, the 1-year survival rate was 90% and the 2-year survival rate was 67%. The nonionic contrast medium with Lipiodol forms finer emulsified particles, and these particles are more capable of penetrating into the tumor. In addition, the greater pharmacological stability of these particles provides a slow-release effect and prolonged stability of their shape. Finally, theoretically, the use of two major anticancer agents such as CDDP and epirubicin showed a greater clinical effect in the treatment of HCC than either our earlier suspension or a single anticancer agent.Work presented at the Third International Symposium on Treatment of Liver Cancer, Seoul, Korea, 12–13 February 1993 相似文献
84.
Androgen receptor and Ki-67 were immunohistochemically investigated in biopsy specimens taken from 50 cases of prostatic carcinoma and the correlation between histologic grade and AR and Ki-67 was examined using a computer-assisted image analysis system. When the immunoreactive intensity of AR of tumor cells was the same or stronger than that of stromal cells in the same section, the tumor cells were defined AR-positive. An immunohistochemical study revealed that AR positive cases-were significantly higher in well differentiated type (86%) and moderately differentiated type (85%) than in poorly (38%) differentiated type. The expression of Ki-67 was significantly higher in poorly and moderately differentiated types than in well, differentiated type. There was a significant correlation between the histologic grade, and AR and Ki-67; however, there was no correlation between the clinical stage and AR or Ki-67. 相似文献
85.
Shiomi H Hase T Matsuno S Izumi M Tatsuta T Ito F Kishida A Tani T Kodama M 《Surgery today》1999,29(12):1280-1284
An 18-year-old male was admitted to our Emergency Department with a traumatic abdominal wall hernia (TAWH) of the left lower
quadrant (LLQ) after suffering hypogastric blunt injury and urogenital lacerations in a motorcycle accident. Upright chest
X-ray showed a small amount of right infradiaphragmatic free air, and a computed tomographic (CT) scan demonstrated an abdominal
wall hernia. At surgery, no impairment was found in the digestive tract, and an abdominal herniorrhaphy was performed. It
is suggested that the free air had passed through a connection between the scrotal laceration and the contralateral abdominal
defect via the subcutaneous space and was palpated as emphysema. This is a new type of TAWH, which suggests that blunt abdominal
trauma may result in negative pressure in the subcutaneous and peritoneal cavity, and this could reflect the pathophysiology
of TAWH. 相似文献
86.
Sakakibara H Zhu SK Furuta M Kondo T Miyao M Yamada S Hideaki T 《Environmental health and preventive medicine》1996,1(3):114-118
Factors associated with knee pain were investigated using 871 self-administered questionnaires (405 men and 466 women) from
residents aged over 30 years in a rural area of Japan. The prevalence of knee pain increased with age, particularly in women
over 50. It was significantly higher in women than in men. Body mass index (BMI) was significantly related to knee pain in
women, though not in men. With reference to occupational factors, frequent heavy lifting on the job was significantly associated
with knee pain in both men and women, whereas job-related standing and walking showed no such relationship. As for living
conditions, residence on rather steep mountain slopes and the habit of sitting on Japanese tatami mats were significant factors
related to knee pain in men, but not in women. There was no association of knee pain with the style of toilet (Japanese or
Western). After controlling for all significant factors by multiple logistic regression analysis, age, heavy lifting, and
residence on steep slopes were found to be independent factors related to knee pain in men; and age, BMI, and heavy lifting
were the factors in women. 相似文献
87.
Masashi Takamatsu Mitsuru Ohata Kazuhiko Sakamoto Yasuyuki Searashi Kunihiko Takeda Hideaki Suzuki Hisato Nakajima Masayoshi Yamauchi Ken Hokkyo Gotaro Toda Noritoshi Shinkai 《Nihon Arukōru Yakubutsu Igakkai zasshi》2003,38(6):492-497
A case of female alcoholic who developed liver cirrhosis with small amounts of alcohol by the common use of contraceptive agent was reported. A case was a 33-year-old female who had complained of systemic edema and jaundice. She had been drinking alcohol, while she had been taking the contraceptive agent from 20-year-old. On admission, she had a large amount of ascites with jaundice. She was diagnosed as liver cirrhosis and hepatic failure by CT scanning of abdomen and laboratory data. Her condition was temporarily improved by the abstinence and the treatment. Since she drank under hospitalization, she had to change the hospital and died after 2 months. She had been drinking for only 10 years. Her cumulative alcohol intake was also very small. She may have developed alcoholic cirrhosis with small amount of alcohol because of common use of contraceptive agent with drinking. 相似文献
88.
89.
Keiichi Ichimura Masashi Sugasawa Ken-ichi Nibu Esao Takasago Kenji Hasezawa 《Auris, nasus, larynx》1997,24(4):391-397
We sometimes experience patients with persistent or progressive arytenoid edema, among which residual or recurrent cancer is often accompanied. Because it is difficult to distinguish tumour rest or recurrence from normal tissue sequelae in the early period after irradiation, it is important to know both the contributing factors for arytenoid edema, and the incidence of residual or recurrent tumours in patients with postirradiation laryngeal edema. We therefore reviewed the charts of 67 patients with early laryngeal carcinoma who had received a curative dose of irradiation in the last 5 years. Fourteen patients (20.9%) had moderate or severe laryngeal edema persisting for or developing at more than 3 months after completion of a course of definitive radiotherapy. The incidence was highest in supraglottic T2 disease, followed by glottic T2 tumour. Of the 14 patients with edema, six (42.9%) had persistent or recurrent disease. The primary disease was uncontrolled in 18 patients, 17 of whom received successful salvage surgery. In patients without residual tumours, the edema was usually moderate and resolved within a year, although four patients had chronic edema lasting more than a year after treatment. All four had supraglottic T2 lesions and received 70 Gy of X-ray. We also reviewed, for sake of comparison, the records of 38 patients treated with radiotherapy at doses of more than 40 Gy between l975 and 1980, when endoscopic microsurgery for laryngeal cancer was introduced as a primary part of treatment. The incidence of persistent or late developed edema over the period, though not significant, was 36.8%: nearly twice that of the last 5 years. Microscopic endolaryngeal surgical procedures seem to have been a causal factor for edema in this period. 相似文献
90.
Fujio Kakuya Masashi Takase Noriyuki Ishii Mayumi Kajino Tokitsugi Hayashi Kazutoshi Miyamoto Senichi Muraki Jun Iwamoto Akimasa Okuno 《Pediatrics international》1998,40(2):155-158
Abstract The delivery of nitric oxide (NO) via a nasopharyngeal tube is an alternative to endotracheal intubation. A male infant with end-stage pulmonary hypertension (PH) due to a severe hypoplastic lung developed a PH crisis on day 145 and received NO inhalation via a nasopharyngeal tube. Clinical improvement was maintained for 7 days with18–22ppm NO inhalation. The patient remained in close physical contact with his parents without the use of sedation. Blood methemoglobin levels remained below 1%. The environmental NO levels were less than 0.06 ppm and NO2 less than 0.3 ppm throughout the treatment, well within the safety margin. On day 152, the patient succumbed to hypoxemia and heart failure. The use of a nasopharyngeal NO delivery system without sedation, as an alternative to endotracheal intubation with sedation, was a practical method in treating a patient with PH while maintaining a certain quality of life for the patient and the family. 相似文献