全文获取类型
收费全文 | 3788篇 |
免费 | 152篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 51篇 |
儿科学 | 46篇 |
妇产科学 | 52篇 |
基础医学 | 422篇 |
口腔科学 | 69篇 |
临床医学 | 230篇 |
内科学 | 1242篇 |
皮肤病学 | 60篇 |
神经病学 | 259篇 |
特种医学 | 64篇 |
外科学 | 479篇 |
综合类 | 8篇 |
一般理论 | 1篇 |
预防医学 | 72篇 |
眼科学 | 20篇 |
药学 | 399篇 |
中国医学 | 14篇 |
肿瘤学 | 467篇 |
出版年
2023年 | 16篇 |
2022年 | 26篇 |
2021年 | 64篇 |
2020年 | 39篇 |
2019年 | 43篇 |
2018年 | 35篇 |
2017年 | 41篇 |
2016年 | 55篇 |
2015年 | 60篇 |
2014年 | 88篇 |
2013年 | 97篇 |
2012年 | 155篇 |
2011年 | 204篇 |
2010年 | 104篇 |
2009年 | 98篇 |
2008年 | 162篇 |
2007年 | 187篇 |
2006年 | 201篇 |
2005年 | 181篇 |
2004年 | 192篇 |
2003年 | 167篇 |
2002年 | 190篇 |
2001年 | 107篇 |
2000年 | 140篇 |
1999年 | 153篇 |
1998年 | 41篇 |
1997年 | 31篇 |
1996年 | 38篇 |
1995年 | 28篇 |
1994年 | 25篇 |
1993年 | 36篇 |
1992年 | 98篇 |
1991年 | 66篇 |
1990年 | 68篇 |
1989年 | 79篇 |
1988年 | 74篇 |
1987年 | 71篇 |
1986年 | 39篇 |
1985年 | 60篇 |
1984年 | 46篇 |
1983年 | 44篇 |
1982年 | 21篇 |
1981年 | 18篇 |
1979年 | 44篇 |
1978年 | 16篇 |
1975年 | 20篇 |
1973年 | 18篇 |
1972年 | 18篇 |
1969年 | 17篇 |
1968年 | 21篇 |
排序方式: 共有3955条查询结果,搜索用时 31 毫秒
71.
72.
73.
Ken Fukunaga Yoshio Ohda Nobuyuki Hida Masaki Iimuro Yoko Yokoyama Koji Kamikozuru Kazuko Nagase Shiro Nakamura Hiroto Miwa Takayuki Matsumoto 《Journal of gastroenterology and hepatology》2012,27(12):1808-1815
Background and Aim: Topical mesalamine or corticosteroid has shown efficacy in patients with ulcerative proctitis, but patients often become refractory to these interventions. Xilei San is a herbal preparation with evidence of anti‐inflammatory effects. We evaluated the efficacy of topical Xilei San in ulcerative proctitis patients. Methods: In a double blind setting, 30 patients with intractable ulcerative proctitis despite ≥ 4 weeks of topical mesalamine or corticosteroid were randomly assigned to True (n = 15) and placebo (n = 15). Patients in True received suppository Xilei San (0.1 g/dose per day of Xilei San), the other 15 received placebo suppository. The initial efficacy was evaluated on day 14. Primary endpoint of the trial was avoiding relapse during 180 days, relapse meant recurrence of active disease. Riley's index was applied for endoscopic and histological evaluations, while patients' quality of life was evaluated by an inflammatory bowel disease questionnaire. Results: On day 14, the number of patients who achieved remission, clinical activity index ≤ 4 in True was significantly higher versus placebo (P < 0.04). Likewise, at day 180, an 81.8% of patients in True were without relapse versus 16.7% in placebo (P < 0.001). Further, significant endoscopic (P < 0.01), histological (P < 0.02) and inflammatory bowel disease questionnaire (P < 0.04) improvements were observed in True, but not in placebo. Conclusions: This is the first controlled investigation showing significant clinical and endoscopic efficacy for Xilei San in patients with intractable ulcerative proctitis. Topical Xilei San was well tolerated, and was without safety concerns. 相似文献
74.
Environmental stress is a major factor that affects courtship behavior and evolutionary fitness. Although mature virgin females of Drosophila melanogaster usually accept a courting male to mate, they may not mate under stressful conditions. Above the temperature optimal for mating (20–25?°C), copulation success of D. melanogaster declines with increasing temperature although we observed vigorous courtship attempts by males, and no copulation takes place at temperatures over 36?°C. We attempted to identify the sensory pathway for detecting heat threat that drives a female to escape rather than to engage in mating that detects hot temperature and suppresses courtship behavior. We found that the artificial activation of warmth-sensitive neurons (‘hot cells’) in the antennal arista of females completely abrogates female copulation success even at permissive temperatures below 32?°C. Moreover, mutational loss of the GR28b.d thermoreceptor protein caused females to copulate even at 36?°C. These results indicate that antennal hot cells provide the input channel for detecting the high ambient temperature in the control of virgin female mating under stressful conditions. 相似文献
75.
76.
77.
Akiko Danjo Kanako Yamaguchi Kazuma Fujimoto Toshihito Saitoh Masahiko Inamori Takashi Ando Tomohiko Shimatani Kyoichi Adachi Fukunori Kinjo Shiko Kuribayashi Shoji Mitsufuji Yasuhiro Fujiwara Shigeki Koyama Junichi Akiyama Atsushi Takagi Noriaki Manabe Hiroto Miwa Yasuyuki Shimoyama Motoyasu Kusano 《Journal of gastroenterology and hepatology》2009,24(4):633-638
Background and Aim: We compared endoscopic findings of the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG), a written questionnaire developed in Japan, to that for the questionnaire for the diagnosis of reflux esophagitis (QUEST) for the diagnosis of reflux esophagitis. Methods: We registered 475 patients with untreated symptoms of upper abdominal pain (male/female: 252/223, average age 52.4 ± 17.8 years). Subjects were assessed first with the FSSG and QUEST questionnaires, then by endoscopy, before allocation to a gastric ulcer (GU), duodenal ulcer (DU), gastroesophageal reflux disease (GERD) or functional dyspepsia (FD) group. Results: On the basis of the endoscopic findings the diagnoses for the 475 subjects were as follows: FD 52.2%, DU 7.6%, GU 7.8%, and GERD 32.4% (Grade M 10.1%, Grade A + B 20.2%, Grade C + D 2.3%). There was no difference between the FSSG and QUEST in sensitivity, specificity or accuracy for any condition. The FSSG score rose with increasing endoscopic severity of GERD, but there was no correlation between the QUEST score and endoscopic severity. The FSSG total score was inferior to QUEST in terms of distinguishing GERD from other conditions, but when only the questions relating to reflux symptoms were used, the FSSG was able to distinguish GERD from other conditions as well as QUEST. Conclusions: The FSSG score reflects the severity of the endoscopic findings of GERD. 相似文献
78.
79.
80.
Three cases of hereditary nonspherocytic hemolytic anemia associated with red blood cell glutathione deficiency 总被引:1,自引:2,他引:1
Hirono A; Iyori H; Sekine I; Ueyama J; Chiba H; Kanno H; Fujii H; Miwa S 《Blood》1996,87(5):2071-2074
Three unrelated Japanese patients with chronic nonspherocytic hemolytic anemia wer found to have marked deficiency of red blood cell (RBC) reduced glutathoine (GSH) (4.4%, 13.1%, and 6.9% of normal, respectively). A panel of RBC enzyme assays showed that one patient had decreased glutathione synthetase activity and the other two were moderately deficient in gamma-glutamylcystine synthetase. Some family members of each patient showed mild deficiency of the respective enzymes. RBCs of these patients also showed a decreased level of glutathione-S-transferase as in previously described GSH-deficient cases. Hemolytic anemia was their only manifestation, and neither 5- oxoprolinemia nor 5-oxoprolinuria, which are usually associated with to generalized type of glutathione synthetase deficiency, was noted in our patients. 相似文献