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71.
Matsuura K Tanaka Y Takagi K Hiramatsu K Kani S Gotoh T Wakimoto Y Joh T Mizokami M 《Rinsho byori. The Japanese journal of clinical pathology》2007,55(11):983-988
The Abbott Real Time HCV assay (lower limit of detection 12 IU/ml) was developed as a highly sensitive HCV RNA quantitative assay using real-time detection PCR(RTD-PCR). We assessed whether the new assay more effectively predicts sustained virological response (SVR) than conventional PCR (PCR) in 38 chronic hepatitis patients infected with HCV genotype 1b and treated with pegylated interferon alpha2b plus ribavirin. Sixteen patients reached SVR, 10 patients relapsed, 9 patients did not respond, 3 patients discontinued treatment. Positive predictive value (PPV) for SVR of undetectable HCV RNA at W4, 8, 12 by RTD-PCR and PCR was (100% vs. 100% at W4), (100% vs. 100% at W8), (83.3% vs. 72.7% at W12). HCV RNA undetectable at W12 had a higher PPV for SVR when measured by RTD-PCR than by conventional PCR. 相似文献
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Daisuke Gotoh MD PhD Nobutaka Shimizu MD PhD Naoki Wada MD PhD Katsumi Kadekawa MD PhD Tetsuichi Saito MD Shinsuke Mizoguchi MD PhD Yosuke Morizawa MD PhD Shunta Hori MD PhD Makito Miyake MD PhD Kazumasa Torimoto MD PhD William C. de Groat PhD Kiyohide Fujimoto MD PhD Naoki Yoshimura MD PhD 《Neurourology and urodynamics》2020,39(8):2120-2127
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Osamu Uemura Takuhito Nagai Kenji Ishikura Shuichi Ito Hiroshi Hataya Yoshimitsu Gotoh Naoya Fujita Yuko Akioka Tetsuji Kaneko Masataka Honda 《Clinical and experimental nephrology》2014,18(5):718-725
Background
Renal inulin clearance is the gold standard for evaluation of kidney function, but is compromised by problems of collecting urine samples in children, especially those <6 years or with a bladder dysfunction. Therefore, we should utilize the serum cystatin C (cysC)-based estimated glomerular filtration rate (eGFR) for measuring serum cysC. The purpose of the present study is to determine the applicability of the new serum cysC-based eGFR in Japanese children and adolescents, including infants with chronic kidney disease (CKD), for evaluation of renal function.Methods
Inulin clearance and standardized serum cysC level determined by the colloidal gold immunoassay were measured in 135 pediatric CKD patients between the ages of 1 month and 18 years with no underlying disease that affects renal function except CKD, to determine serum cysC-based eGFR in Japanese children and adolescents.Results
We showed the inulin clearance by expression of 1/serum cysC in pediatric CKD patients, which resulted in the equation: inulin GFR (mL/min/1.73 m2) = 104.1 × 1/serum cysC (mg/L) ? 7.80. We also validated the cysC-based eGFR formula for Japanese adults. eGFR values obtained with the adult formula significantly underestimated GFR by approximately 8 % in children with CKD.Conclusion
We determined the new cysC-based eGFR formula is useful for clinical screening of renal function in Japanese children and adolescents, including infants. 相似文献80.