全文获取类型
收费全文 | 1615篇 |
免费 | 104篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 65篇 |
儿科学 | 48篇 |
妇产科学 | 14篇 |
基础医学 | 163篇 |
口腔科学 | 36篇 |
临床医学 | 118篇 |
内科学 | 259篇 |
皮肤病学 | 31篇 |
神经病学 | 93篇 |
特种医学 | 33篇 |
外科学 | 460篇 |
综合类 | 33篇 |
预防医学 | 77篇 |
眼科学 | 46篇 |
药学 | 126篇 |
中国医学 | 5篇 |
肿瘤学 | 116篇 |
出版年
2023年 | 8篇 |
2022年 | 21篇 |
2021年 | 61篇 |
2020年 | 25篇 |
2019年 | 49篇 |
2018年 | 59篇 |
2017年 | 41篇 |
2016年 | 34篇 |
2015年 | 37篇 |
2014年 | 52篇 |
2013年 | 56篇 |
2012年 | 107篇 |
2011年 | 129篇 |
2010年 | 66篇 |
2009年 | 61篇 |
2008年 | 94篇 |
2007年 | 91篇 |
2006年 | 121篇 |
2005年 | 92篇 |
2004年 | 79篇 |
2003年 | 68篇 |
2002年 | 79篇 |
2001年 | 40篇 |
2000年 | 51篇 |
1999年 | 30篇 |
1998年 | 21篇 |
1997年 | 12篇 |
1996年 | 9篇 |
1995年 | 7篇 |
1994年 | 7篇 |
1993年 | 4篇 |
1992年 | 11篇 |
1991年 | 12篇 |
1990年 | 14篇 |
1989年 | 12篇 |
1988年 | 7篇 |
1987年 | 4篇 |
1986年 | 2篇 |
1985年 | 5篇 |
1984年 | 5篇 |
1983年 | 5篇 |
1982年 | 2篇 |
1981年 | 7篇 |
1979年 | 4篇 |
1978年 | 3篇 |
1973年 | 2篇 |
1966年 | 2篇 |
1957年 | 2篇 |
1933年 | 1篇 |
1929年 | 1篇 |
排序方式: 共有1723条查询结果,搜索用时 93 毫秒
51.
52.
53.
Sameena Shah Rabab Zehra Jafri Khalil Mobin Rabeea Mirza Kashmira Nanji Fatima Jahangir Sufian Jawed Patel Muzamil Shabana Ejaz Iman Qaiser Hira Iftikhar Komal Aziz Wajiha Khan Humza S. Maqbool Hassaan Ahmed 《BMC family practice》2018,19(1):198
Background
Nocturnal enuresis (NE) is a common symptom in children worldwide. International Children’s Continence Society (ICCS) defines enuresis as either mono-symptomatic, NE with lower urinary tract symptoms and NE with co-morbid conditions. The objectives of this study were to determine the frequencies and types of NE and associated symptoms and conditions in children aged 5 to 16?years based on ICCS criteria.Methods
A multi-center cross sectional study was conducted between November 2012 and December 2013 in the primary care clinics of four hospitals in Karachi. Children aged five to fifteen years were included through consecutive sampling. Informed consent was obtained from the parents and a pre-coded semi-structured questionnaire was used to obtain the information. Data was entered on SPSS version 20.0 and multivariable logistic regression analysis was used for data analysis.Results
Out of 429 children aged between five and sixteen years, 243(56.9%) were boys and the remaining 186(43.1%) were girls. One hundred and eighty three children (43%) had nocturnal enuresis (NE). Forty four (10.3%), had mono-symptomatic NE, 57(31.1%) had associated lower urinary tract symptoms (NE-LUTS), whereas 30 (16.3%) had NE with a co-morbid condition. Fifty two (28.4%) NE’s had at least one of both LUTS and a co-morbid condition. Out of the 246(57%) non-enuretic’s, 31(12.6%) had a LUTS, 95(38.6%) had a co-morbid condition and 57(23.2%) had at least one of both LUTS and a co-morbid condition. The remaining 63 (25.6%) were symptom free. Increased voiding frequency, urgency, dysuria, suprapubic pain and daytime incontinence were the LUTS significantly associated with NE. Co-morbid conditions significantly associated with NE included constipation, congenital defects, developmental delay, and learning and sleep problems.Conclusion
Although NE can be an only symptom, it is often associated with lower urinary tract symptoms like dysuria, urgency, suprapubic pain, and daytime incontinence. Children presenting with NE often have co-morbid conditions like constipation, urinary tract infection, sleep disorders, and developmental delay. Many children presenting with these conditions as the primary complaint may also have NE. It should be addressed as unrecognized and untreated NE can cause additional morbidity and distress.54.
Didier Roulin Catherine Blanc Mirza Muradbegovic Dieter Hahnloser Nicolas Demartines Martin Hübner 《World journal of surgery》2014,38(8):2153-2159
Background
Enhanced recovery protocols have been proven to decrease complications and hospital stay following elective colorectal surgery. However, these principles have not yet been reported for urgent surgery procedures. We aimed to assess our initial experience with urgent colectomies performed within an established enhanced recovery pathway.Methods
In a prospective cohort study, all patients undergoing colonic resection between April 2012 and March 2013 were treated according to a standardized enhanced recovery protocol. Urgent surgeries were compared with the elective procedures with regards to baseline characteristics, compliance with enhanced recovery items, and clinical outcome.Results
Patients (N = 28) requiring urgent colonic resection were included and compared with patients undergoing elective colectomy (N = 63). Overall compliance with the protocol was 57 % for the urgent compared with 77 % for the elective procedures (p = 0.006). The pre-operative compliance was 64 versus 96 % (p < 0.001), the intra-operative compliance was 77 versus 86 % (p = 0.145), and the post-operative compliance was 49 versus 67 % (p = 0.015), for the urgent and elective resections, respectively. Overall, 18 urgent patients (64 %) and 32 elective patients (51 %) developed postoperative complications (p = 0.261). Median postoperative length of stay was 8 days in the urgent setting compared with 5 days in the elective setting (p = 0.006).Conclusions
Many of the intra-operative and post-operative enhanced recovery items can also be applied to urgent colectomy, entailing outcomes that approach the results achieved in the elective setting. 相似文献55.
56.
Ronith Elk Robert Andres Andrew Helfgott Howard Rhoades Lorna Mangus Iman Mirza Ramona Burroughs John Grabowski 《The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions》1996,5(4):292-300
The authors investigated AIDS-related knowledge, high-risk behaviors, and relationships between AIDS-related knowledge, high-risk behaviors, and sociodemographic characteristics of 41 pregnant women entering treatment who were dependent on cocaine or opiates. At entry, patients completed self-report questionnaires on AIDS-related knowledge and sexual and drug use practices. There was a high rate of understanding of risk associated with drug use and perinatal transmission of HIV. Knowledge of high-risk sexual behavior varied, and knowledge of the medical consequences of HIV was modest. Engagement in several high-risk behaviors was identified: lack of condom use, intravenous drug use, sharing of needles, sex with an injecting drug user, and exchanging sex for money or drugs. AIDS-related knowledge and engagement in high-risk behaviors were not significantly correlated. Authors discussed implications of these findings for developing effective HIV prevention strategies in this population. (American Journal on Addictions 1996; 5:292–300) 相似文献
57.
Islam MZ Itoh M Mirza R Ahmed I Ekram AR Sarder AH Shamsuzzaman SM Hashiguchi Y Kimura E 《The American journal of tropical medicine and hygiene》2004,70(1):78-82
A new direct agglutination test (DAT) for use with urine samples for the diagnosis of visceral leishmaniasis (VL) has been developed and compared with the conventional DAT with serum samples and our previously reported enzyme-linked immunosorbent assay (ELISA) with urine samples (urine ELISA). The new DAT, in which anti-human IgG was used as enhancing antibody, was tested with urine samples from 75 VL patients and 225 non-VL patients and healthy people. The sensitivity of the new DAT (90.7%), was almost the same as that of the conventional DAT (91.0%) and the urine ELISA (93.3%). The specificity of the new DAT (96.4%) was nearly identical with that of the urine ELISA (97.3%). A urine-based DAT has several advantages over the conventional DAT: sample collection is non-invasive and it can process larger numbers of samples with smaller amounts of antigen. 相似文献
58.
59.
Rita E. Mirza Milie M. Fang Eileen M. Weinheimer-Haus William J. Ennis Timothy J. Koh 《Diabetes》2014,63(3):1103-1114
The hypothesis of this study was that sustained activity of the Nod-like receptor protein (NLRP)-3 inflammasome in wounds of diabetic humans and mice contributes to the persistent inflammatory response and impaired healing characteristic of these wounds. Macrophages (Mp) isolated from wounds on diabetic humans and db/db mice exhibited sustained inflammasome activity associated with low level of expression of endogenous inflammasome inhibitors. Soluble factors in the biochemical milieu of these wounds are sufficient to activate the inflammasome, as wound-conditioned medium activates caspase-1 and induces release of interleukin (IL)-1β and IL-18 in cultured Mp via a reactive oxygen species–mediated pathway. Importantly, inhibiting inflammasome activity in wounds of db/db mice using topical application of pharmacological inhibitors improved healing of these wounds, induced a switch from proinflammatory to healing-associated Mp phenotypes, and increased levels of prohealing growth factors. Furthermore, data generated from bone marrow–transfer experiments from NLRP-3 or caspase-1 knockout to db/db mice indicated that blocking inflammasome activity in bone marrow cells is sufficient to improve healing. Our findings indicate that sustained inflammasome activity in wound Mp contributes to impaired early healing responses of diabetic wounds and that the inflammasome may represent a new therapeutic target for improving healing in diabetic individuals. 相似文献
60.
Maren H. Harms Quisette P. Janssen Rene Adam Christophe Duvoux Darius Mirza Ernest Hidalgo Christopher Watson Stephen J. Wigmore Massimo Pinzani Helena Isoniemi Johann Pratschke Krzysztof Zieniewicz Jurgen L. Klempnauer William Bennet Vincent Karam Henk R. van Buuren Bettina E. Hansen Herold J. Metselaar 《Alimentary pharmacology & therapeutics》2019,49(3):285-295