全文获取类型
收费全文 | 335篇 |
免费 | 25篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 11篇 |
妇产科学 | 5篇 |
基础医学 | 63篇 |
临床医学 | 18篇 |
内科学 | 85篇 |
皮肤病学 | 9篇 |
神经病学 | 54篇 |
特种医学 | 10篇 |
外科学 | 15篇 |
综合类 | 3篇 |
预防医学 | 18篇 |
眼科学 | 3篇 |
药学 | 46篇 |
中国医学 | 3篇 |
肿瘤学 | 20篇 |
出版年
2023年 | 2篇 |
2022年 | 9篇 |
2021年 | 8篇 |
2020年 | 5篇 |
2019年 | 9篇 |
2018年 | 8篇 |
2017年 | 4篇 |
2016年 | 8篇 |
2015年 | 14篇 |
2014年 | 18篇 |
2013年 | 21篇 |
2012年 | 22篇 |
2011年 | 35篇 |
2010年 | 17篇 |
2009年 | 14篇 |
2008年 | 22篇 |
2007年 | 26篇 |
2006年 | 26篇 |
2005年 | 29篇 |
2004年 | 21篇 |
2003年 | 11篇 |
2002年 | 11篇 |
2001年 | 1篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1991年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1982年 | 2篇 |
1979年 | 1篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1972年 | 1篇 |
1969年 | 1篇 |
1966年 | 2篇 |
1964年 | 1篇 |
排序方式: 共有364条查询结果,搜索用时 15 毫秒
31.
Irena Papadopoulos Steve Wright Christina Koulouglioti Sheila Ali Runa Lazzarino Ángel Martín-García Cristina Oter-Quintana Christiana Kouta Elena Rousou Katalin Papp Radka Krepinska Valerie Tothova Maria Malliarou Paraskevi Apostolara Małgorzata Lesińska-Sawicka Małgorzata Nagorska Miroslava Liskova Line Nortvedt Lise-Merete Alpers Sylvia Biglete-Pangilinan Ma. Florinda Oconer-Rubiano Wireeporn Chaisetsampun Nutchanath Wichit Akhtar-Ebrahimi Ghassemi Ezzat Jafarjalal Akile Zorba Andrea Kuckert-Wöstheinrich Rabin Malla Tomiko Toda Özlem Akman Candan Öztürk Teresa Puvimanasinghe Tahereh Ziaian Orit Eldar-Regev Sara Nissim 《Japan Journal of Nursing Science》2023,20(2):e12523
Aim
This study explored the views of an international sample of registered nurses and midwives working in health and social care concerning socially assistive robots (SARs), and the relationship between dimensions of culture and rejection of the idea that SARs had benefits in these settings.Methods
An online survey was used to obtain rankings of (among other topics) the extent to which SARs have benefits for health and social care. It also asked for free text responses regarding any concerns about SARs.Results
Most respondents were overwhelmingly positive about SARs' benefits. A small minority strongly rejected this idea, and qualitative analysis of the objections raised by them revealed three major themes: things might go wrong, depersonalization, and patient-related concerns. However, many participants who were highly accepting of the benefits of SARs expressed similar objections. Cultural dimensions of long-term orientation and uncertainty avoidance feature prominently in technology acceptance research. Therefore, the relationship between the proportion of respondents from each country who felt that SARs had no benefits and each country's ratings on long-term orientation and uncertainty avoidance were also examined. A significant positive correlation was found for long-term orientation, but not for uncertainty avoidance.Conclusion
Most respondents were positive about the benefits of SARs, and similar concerns about their use were expressed both by those who strongly accepted the idea that they had benefits and those who did not. Some evidence was found to suggest that cultural factors were related to rejecting the idea that SARs had benefits. 相似文献32.
Bohuslav Melichar Miroslava Tou kov Josef Dvo k Pavel Jandí k Otakar Kopecký 《Immunopharmacology and immunotoxicology》2001,23(2):163-173
Presence of functional immune system is critical for any attempt aimed at improving survival of breast cancer patients by strategies based on immune system manipulation. We evaluated by flow cytometry the phenotype of peripheral blood leukocyte of 43 breast cancer patients. In 11 patients, the phenotype was evaluated before and during the chemotherapy by combination of doxorubicin and paclitaxel (AT). Compared with controls breast cancer patients had significantly higher relative and absolute numbers of CD3-HLADR+, CD3-CD69+ and CD14+CD16-, and significantly lower percentages of CD3- and CD8-CD28+ cells. After one cycle of AT, the absolute numbers of CD3+, CD3-CD4-, CD3+CD8+ and CD8-CD28+ cells increased significantly. Present data show a presence of T-cell activation in breast cancer patients. Administration of AT may lead to an increase in functional T-cells in peripheral blood, indicating a potential for combining chemotherapy with immunotherapy in the treatment of breast cancer patients. 相似文献
33.
Jana Maslankova Ivana Vecurkovska Miroslava Rabajdova Jana Katuchova Milos Kicka Michala Gayova Vladimir Katuch 《World journal of gastroenterology : WJG》2022,28(33):4744-4761
According to data from 2020, Slovakia has long been among the top five countries with the highest incidence rate of colorectal cancer (CRC) worldwide, and the rate is continuing to rise every year. In approximately 80% of CRC cases, allelic loss (loss of heterozygosity, LOH) occurs in the long arm of chromosome 18q. The most important genes that can be silenced by 18q LOH or mutations are small mothers against decapentaplegic homolog (SMAD) 2 and SMAD4, which are intracellular mediators of transforming growth factor (TGF)-β superfamily signals. TGF-β plays an important role in the pro-oncogenic processes, including such properties as invasion, epithelial-mesenchymal transition (commonly known as EMT), promotion of angiogenesis, and immunomodulatory effects. Several recent studies have reported that activation of TGF-β signaling is related to drug resistance in CRC. Because the mechanisms of drug resistance are different between patients in different stages of CRC, personalized treatment is more effective. Therefore, knowledge of the activation and inhibition of factors that affect the TGF-β signaling pathway is very important. 相似文献
34.
Seasonal variation of water characteristics, predominantly temperature, is considered to strongly affect fish physiology and
immunology. In nature, this variation directly influences the life cycle especially in fish parasites, but the infection of
parasites is also altered by the host immune response. This study is aimed to analyze the seasonal changes in selected physiological
and immunological parameters, the latter a potential measure of fish immunocompetence. Moreover, the seasonal changes in metazoan
parasite infection were investigated, and the potential associations between fish physiology, immunocompetence, and parasitism
were estimated. No differences in gender were recognized for immunological parameters. The significant differences in the
spleen–somatic index were found among fish samples of different seasons indicating higher investment in spleen size in April
(after winterizing) and August (post-breeding with low gonado-somatic index [GSI]). The significant seasonal differences in
erythrocyte and leukocyte cell counts, as well as in phagocyte count affecting respiratory burst, were recorded. The general
trend of leukocyte composition was similar in all seasons investigated; however, the changes in proportion of different neutrophilic
cells were reported. The parasite diversity and the infection parameters in parasite communities were highest in spring and
early summer. When comparing parasite abundance in infracommunities among seasons, the statistically highest values were observed
in April and June for Monogenea, in April and November for Acanthocephala, and in April for Cestoda. The positive correlations
between GSI and the parasite abundance of groups with higher infection parameters were found in males. Moreover, the positive
association between Monogenea as the dominant parasite group and respiratory burst was observed. The higher investment in
condition and the seasonal variation in GSI were associated with a decrease immune function measured by spleen size or leukocyte
cell count especially for males suggesting the seasonal energy allocation between immune function and somatic or reproductive
investment. 相似文献
35.
Peter Kubisz Ján Stasko Miroslava Dobrotová Jela Ivanková Dusan Mesko 《Clinical and applied thrombosis/hemostasis》2005,11(3):331-334
Patients with hemophilia demonstrate quite variable clinical phenotype even in cases with the same level of deficient factor or the same molecular abnormality. Different interacting factors including congenital and acquired alterations of coagulation inhibitors can modulate both clinical expression and severity of hemophilia. In this study, plasma levels of factor VIII (FVIII), factor IX (FIX) as well as protein C (PC), protein S (PS), and antithrombin (AT) plasma levels were measured in 80 patients with severe hemophilia A and B. Patients were divided into two groups according to the risk of bleeding: the first group (n = 32) with mild bleeding (< 2 bleeds/year), and the second group (n = 48) with severe bleeding (> or = 2 bleeds/year). Both hemophilia groups showed significantly decreased PC plasma levels compared to levels in healthy control subjects (the first group: p < 0.0001 and second group: p < 0.01). The difference in PC plasma levels between the first and second hemophilia group was significant (p < 0.05). Moreover, there was positive correlation between age and the functional PC in both hemophilia groups. Our results suggest that decreased PC plasma levels can testify to a slightly protective effect of the PC pathway on the severity and frequency of bleeding in patients with severe hemophilia A and B. 相似文献
36.
Detection of muscle wasting in patients with chronic heart failure using C‐terminal agrin fragment: results from the Studies Investigating Co‐morbidities Aggravating Heart Failure (SICA‐HF) 下载免费PDF全文
37.
Begonja AJ Gambaryan S Geiger J Aktas B Pozgajova M Nieswandt B Walter U 《Blood》2005,106(8):2757-2760
Platelets play a crucial role in the physiology of primary hemostasis and pathophysiologic processes such as arterial thrombosis. Accumulating evidence suggests a role of reactive oxygen species (ROSs) in platelet activation. Here we show that platelets activated with different agonists produced intracellular ROSs, which were reduced by reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) oxidase inhibitors and superoxide scavengers. In addition, we demonstrate that ROSs produced in platelets significantly affected alphaIIbbeta3 integrin activation but not alpha and dense granule secretion and platelet shape change. Thrombin-induced integrin alphaIIbbeta3 activation was significantly decreased after pretreatment of platelets with NAD(P)H oxidase inhibitors (diphenylene iodonium [DPI] [45% +/- 9%] and apocynin [43% +/- 11%]) and superoxide scavengers (tiron [60% +/- 9%] and Mn(III)tetrakis (1-methyl-4-pyridyl)porphyrin [MnTMPyP] [70% +/- 6%]). These inhibitors also reduced platelet aggregation and thrombus formation on collagen under high shear and achieved their effects independent of the nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway. 相似文献
38.
39.
Valero MA Perez-Crespo I Khoubbane M Artigas P Panova M Ortiz P Maco V Espinoza JR Mas-Coma S 《Infection, genetics and evolution》2012,12(2):403-410
Fascioliasis is a zoonotic parasitic disease caused by Fasciola hepatica and Fasciola gigantica. Of both species, F. hepatica is the only one described in the Americas, mainly transmitted by lymnaeid snail vectors of the Galba/Fossaria group. Human fascioliasis endemic areas are mainly located in high altitude areas of Andean countries. Given the necessity to characterize F. hepatica populations involved, the phenotypic features of fasciolid adults infecting sheep present in human fascioliasis endemic areas were analysed in the Cajamarca Valley and Mantaro Valley (valley transmission patterns) and the northern Bolivian Altiplano (altiplanic transmission pattern). A computer image analysis system (CIAS) was applied on the basis of standardized measurements. The aforementioned highland populations were compared to standard lowland natural and experimental populations of European origin. Liver fluke size was studied by multivariate analyses. Two phenotypic patterns could be distinguished in F. hepatica adult size: the valley pattern (Cajamarca and Mantaro, Peru) and the altiplanic pattern (northern Altiplano, Bolivia). Results showed that the Andean valley population and European standard populations presented a phenotypic homogeneity. The Altiplano population showed a large size range with a pronouncedly lower minimum size indicating that uterus gravidity is reached at a smaller size than in valley populations. The results of this study demonstrate that there is no apparent relationship between the shape of fasciolid adults with regard to altitudinal difference or geographical origin and that allometry-free shape appears as a more stable trait than size in fasciolid species. Results are analysed in terms of intensity/crowding effect aspects and permanent/seasonal transmission characteristics. 相似文献
40.