Yishen huanshuai recipe retard progression of chronic renal failure

ObjectiveTo investigate the effect of Yishen Huanshuai recipe (YSHSR) on the progression of chronic renal failure (CRF). MethodsForty-six patients with CRF were divided into two groups group A (self-controlled group, n=18), whose treatment plan was subdivided into two phases. During the first phase, the patients treated with low protein diet and controlling blood pressure, while in the second phase, YSHSR was given. Group B (n=28), whose treatment plan was similar with that of group A in the second phase. The rate of progression of CRF was estimated by slope of the creatinine reciprocal (dl/mg) with time (month). Results Mean slope of the creatinine reciprocal with time from the group A during the first phase was -0.0104±0.0021, while during the second phase, it was -0.0034±0.0018. There was significant difference between them (P<0.05). Mean slope from the group B was -0.0047±0.0020. There was also significant difference between that from the group B and that from the group A during the first phase (P<0.05). Conclusion Low protein diet and controlling blood pressure combined with YSHSR therapy could markedly retard the rate of progression of CRF.     

普通额镜下鼻内激光泪囊鼻腔造孔术治疗慢性泪囊炎

报告在普通额镜下以YAG激光经鼻腔行泪囊鼻腔造孔术，治疗慢性泪囊炎患者37例（45眼），经3～24个月的随访观察，泪道阻塞均解除，有效率为95．6％，治愈率为88．9％。本手术具有损伤小，操作简便，快捷，术后反应轻，并发症少等优点。并对手术方法及影响疗效的因素进行了探讨。     

正常与病态下嗓音的客观指标的评价

对158例正常人和136例各种喉疾病患者连续元音[i]发声时的平均气流率、声强、频率、频率微扰商和发声效率同步进行了测定.并对各测定指标间的相互关系进行了探讨.频率微扰商是表示连续元音发声时声带振动相邻周期间的微细变动量;发声效率反映平均气流率与声能的有效转换率.在低、中和高强度发声时.随发声强度的提高,平均气流率.频率和发声效率随之提高而频率微扰商则变小.中等声强发声时.平均气流率与声强,声强与频率均呈正相关;而平均气流率与发声效率.声强(男性)和频率(女性)与频率微扰商均呈负相关.多数喉疾病患者显示出较正常人高的平均气流率和频率微扰商,发声效率则降低.当声强和频率作为参考指标时,平均气流率,频率微扰商和发声效率可作为评价喉发声功能的客观、定量指标.     

Recombinant human relaxin as a cervical ripening agent

Objective The aim of this study was to investigate the efficacy and safety of recombinant human relaxin (rhRIx) as a cervical ripening agent in women with an unfavourable cervix before induction of labour at term.
Design A multi-centre, double-blind, placebo-controlled trial performed in Edinburgh, Glasgow and Oxford. Women were treated with 0, 1, 2 or 4 mg of rhRIx in a gel vehicle administered intravaginally. Analysis of variance tests were performed on all continuous variables, and Cochran Mantel-Haenszel tests employed for all discrete variables.
Participants Ninety-six women at 37 to 42 weeks of gestation with a singleton pregnancy and a modified Bishop score of 4 were recruited.
Results There was no significant difference in the change in modified Bishop score between the four treatment groups. The lengths of the first and second stages of labour were similar in all 4 groups. PGE₂ and oxytocin requirements were similar in all groups, as was the mode of delivery. There was no evidence that relaxin was absorbed systemically when given in this way.
Conclusion Recombinant human relaxin 1 to 4 mg, administered as an intravaginal gel, has no effect as a cervical ripening agent before induction of labour at term.     

Primary Endodermal Sinus Tumor of the Vulva: A Case Report and Review of the Literature

Background.Extragonadal endodermal sinus tumors arising in the external genitalia represent an exceedingly rare malignancy in women. Six cases of endodermal sinus tumors of the vulva have been reported to date, with three cases failing to respond to conservative surgery and vincristine-based chemotherapy. We report a seventh case of vulvar endodermal sinus tumor that was treated with radical surgery and platinum-based chemotherapy.Case.RT is an 18-year-old female who presented with a vulvar mass that was diagnosed as endodermal sinus tumor at the time of biopsy. She was subsequently treated with modified radical vulvectomy and ipsilateral groin lymphadenectomy, followed by bleomycin, etoposide, and cisplatin chemotherapeutic regimen. She has since remained free of disease for 18 months as evidenced by serum α-fetoprotein and physical exam at 18 months.Conclusions.Vulvar endodermal sinus tumors represent a very small number of germ cell tumors in women. Based on the previous accounts, this disease appears to be more fatal than endodermal sinus tumor arising at other sites. These tumors also have a predilection for local metastasis. Due to the previous accounts, we chose to treat this patient with radical surgery and platinum-based chemotherapy. This treatment regimen has resulted in a disease-free state for 18 months.     

骨质疏松患者的脊柱畸形及其与腰背痛的关系

为分析骨质疏松患者的脊柱畸形与腰前疼痛症状的关系。本文统计了２２１名老年性骨质疏松症患者的脊柱外观化、请柬菜程度、椎体骨折类型及其与腰背痛程度的关系。结果：腰背痛的程度和频率有程度有关。椎体呈楔状变形的患者其痛痛程度更为严重其差异具有显著统计学意义（Ｐ〈０．０５）。结论：骨质疏松患者的脊柱畸莆主要表现为脊柱的局部后凸尤其是胸段脊柱后凸角的增大，其中又以凹圆背畸形最为多见。柱畸形明显者其腰背疼前也更     

浅探溃疡病胃镜征象与中医辨证关系

通过观察１１６例溃疡病人内镜下病变部位的粘膜相，根据四诊资料进行辨证分型，试图从微观角度探讨中医病因、病机、诊断；分析了内镜诊断，胃粘膜相与中医舌象、传统辨证的关系，认为胃粘膜相与舌象改变基本一致。对有血瘀症状而无舌脉改变者，胃镜亦能提示瘀阻胃络的粘膜改变，故可作为中医望诊的延伸运用于临床。将宏观辨证与微观辨证有机结合，可补充传统辨证的不足，有利于对中医证型本质的探讨，为中医辨证论治开辟新的前景。     

乳腺癌术后胸壁及区域淋巴结复发的治疗

本文对我科1985年6月至1988年6月收治的52例乳腺癌术后复发病例进行了分析。全部病例均完成了放射治疗，其中39例与化疗联合。全组病例局部控制率为59．6％，1年及2年生存率分别为80．8％和51.9%，本文结果提示，单纯胸壁复发的病例，预后明显好于胸壁及区域淋巴结同时复发的病例（P＜0．05)，与化疗联合对局部控制率无影响，但能显著提高长期生存率（P＜O．01）。     

Sequential production and activation of matrix-metalloproteinase-9 (MMP-9) with breast cancer progression

The degradation of the basement membrane by matrix-metalloproteinase(MMP) and serine protease is a critical pointin tumor invasion and metastasis. We measured theactivity of MMP-9 from 28 normal, 12 benignand 126 breast cancer tissues using gelatin zymographywith an image analysis system. ProMMP-9 was expressedin 17.5% of the cancer patients compared to2.5% in 40 non-cancerous tissues (p=0.014).The mature form of MMP-9 (82 kD) wasexpressed only in T2–T4 stages. During the earlyphase of breast cancer (DCIS and T1 stage)progression, only production of proMMP-9 increased. However, asthe cancer grew or invaded skin (T2–T4), orwith lymphovascular permeation, both production and activation ofMMP-9 increased. In conclusion, proMMP-9 production was themain cause of increased MMP-9 activity during theearly phase, while both production and activation increasedin the late phase of breast cancer.     

百合更年安冲剂主要药效学研究Ⅰ

百合更年安部皮１．５、３．０、６．０ｇ／ｋｇ给小鼠灌胃，中、大剂量组均能显著抑制活动，减少被动活动能对抗去水吗啡引起动物的运动增加；与戊巴比妥钠有协同作用；有一定的镇痛效果。对交感神经兴奋有对抗作用。