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991.
Taizo Wada MD Yasuko Ishimoto MSc Mayumi Hirosaki MA Akiko Konno BSc Yoriko Kasahara MPH Yumi Kimura MPH Hiroaki Nakatsuka MD Ryota Sakamoto MD Masayuki Ishine MD Kiyohito Okumiya MD Michiko Fujisawa MD Kuniaki Otsuka MD Kozo Matsubayashi MD 《Journal of the American Geriatrics Society》2009,57(12):2369-2371
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Yoshio Katamura Hiroshi Aikata Yuki Kimura Tomokazu Kawaoka Shintaro Takaki Koji Waki Akira Hiramatsu Yoshiiku Kawakami Shoichi Takahashi Masaki Ishikawa Masashi Hieda Hideaki Kakizawa Kazuaki Chayama 《Journal of gastroenterology and hepatology》2010,25(6):1117-1122
Background and Aims: We investigated the efficacy of intra‐arterial 5‐fluorouracil (5‐FU) and systemic interferon (IFN)‐α (5‐FU‐IFN) in the treatment of hepatocellular carcinoma (HCC) with portal vein tumor thrombosis in the first branch or trunk (Vp3/4) and extrahepatic metastases. Methods: We examined 17 HCC patients with Vp3/4 and extrahepatic metastases (meta group) and 31 HCC patients with Vp3/4 (non‐meta group). Baseline intrahepatic tumor factors and the hepatic reserve were similar between groups. The extrahepatic metastases of the meta group were not considered prognostic factors. Following the administration of 5‐FU/IFN to all patients, we compared the survival rates, response, time to progression (TTP), and safety between groups. Results: For intrahepatic HCC, complete response, partial response, stable disease, progressive disease, and drop out were observed in no (0%), one (6%), seven (41%), nine (53%), and no (0%) patients of the meta group, and in five (16%), seven (23%), 13 (42%), five (16%) and one (3%) patient of the non‐meta group, respectively. The response rate was significantly lower in the meta group (6% vs 39%, P = 0.018). The median TTP of intrahepatic HCC and the median survival time were significantly shorter in the meta group than in the non‐meta group (1.6 vs 6.3 months, P = 0.0001, and 3.9 months vs 10.5 months, P < 0.0001, respectively). The multivariate analysis showed that the absence of extrahepatic metastases was a significant and independent determinant of both TTP of intrahepatic HCC (P < 0.001) and overall survival (P < 0.001). No patient died of extrahepatic HCC‐related disease. Conclusions: The efficacy of 5‐FU/IFN for advanced HCC with Vp3/4 and extrahepatic metastases was markedly limited. 相似文献
994.
Naka Saito MT Shingo Kato MD Noritaka Saito MT Tatsuya Nakachi MD Kazuki Fukui MD Tae Iwasawa MD Masami Kosuge MD Kazuo Kimura MD 《Echocardiography (Mount Kisco, N.Y.)》2017,34(8):1257-1259
A case of double aortic arch that was well visualized using transthoracic echocardiography is reported. A 38‐year‐old man underwent transthoracic echocardiography for the evaluation of dyspnea. A suprasternal view of transthoracic echocardiography showed the ascending aorta bifurcate to left and right aortic arches, with blood flow from the ascending aorta to bilateral aortic arches. The diagnosis of right side–dominant double aortic arch was made, and the patient's symptom was conceivably related to compression of the trachea due to a vascular ring. This report indicates the potential usefulness of transthoracic echocardiography for noninvasive detection of double aortic arch in adults. 相似文献
995.
Yoshinobu Okabe Kotaro Kuwaki Hiroshi Kawano Ryohei Kaji Gen Sugiyama Yusuke Ishida Makiko Yasumoto Yoshiki Naito Atsushi Toyonaga Osamu Tsuruta Michio Sata 《Digestive endoscopy》2010,22(4):319-321
A 75‐year‐old man who underwent choledochojejunostomy for gallstones 30 years ago was hospitalized for general malaise. Abdominal computed tomography revealed marked dilation of the intrahepatic bile duct in the right lobe and an image of a hypervascular tumor. Endoscopic retrograde cholangiography using double‐balloon enteroscopy (DBE) showed a filling defect that was localized to the right hepatic bile duct. Furthermore, the scope was able to readily pass through the anastomosed site of the choledochojejunostomy and, therefore, we observed the interior of the bile duct using the same scope. We obtained an image showing a whitish, papillary‐like tumor, and a biopsy of the tumor rendered the pathology of intraductal papillary mucinous carcinoma. Direct cholangioscopy using DBE is a useful diagnostic tool, particularly in patients with a past history of choledochojejunostomy. 相似文献
996.
Levels, temporal trends, and tissue distribution of perfluorinated surfactants in freshwater fish from Asian countries 总被引:1,自引:0,他引:1
Murakami M Adachi N Saha M Morita C Takada H 《Archives of environmental contamination and toxicology》2011,61(4):631-641
Perfluorinated surfactants (PFSs) in Asian freshwater fish species were analyzed to investigate tissue distribution, temporal trends, extent of pollution, and level of PFS exposure through food intake. Freshwater fish species, namely carp, snakehead, and catfish, were collected in Japan, Vietnam, India, Malaysia, and Thailand, and 10?PFSs, including perfluorooctanesulfonate (PFOS) and perfluorooctanoate, were analyzed by liquid chromatography?Ctandem mass spectrometry. PFSs in carp in Tokyo were more concentrated in kidneys (??10 PFSs?=?257?±?95?ng/g wet weight [ww]) and livers (119?±?36?ng/g?ww) than in ovaries (43?±?2?ng/g?ww) and muscles (24?±?17?ng/g?ww). Concentrations of PFOS and its precursor, perfluorooctane sulfonamide, in livers of carp and in waters in Tokyo showed a dramatic decrease during the last decade, probably because of 3?M??s phasing-out of the manufacture of perfluorooctanesulfonyl-fluoride-based products in 2000. In contrast, continuing contamination by long-chain perfluorocarboxylates (PFCAs) with????9 fluorinated carbons was seen in multiple media, suggesting that these compounds continue to be emitted. PFS concentrations in freshwater fish species in tropical Asian countries were generally lower than those in developed countries, such as Japan, e.g., for PFOS in muscle, Vietnam?<?0.05?C0.3?ng/g?ww; India?<?0.05?C0.2?ng/g?ww; Malaysia?<?0.05?C0.2?ng/g?ww; Thailand?<?0.05?ng/g?ww; and Japan (Tokyo)?=?5.1?C22?ng/g?ww. Daily intake of short-chain PFCAs with????8 fluorinated carbons from freshwater fish species in Japan was approximately one order of magnitude lower than that from drinking water, whereas daily intake of PFOS and long-chain PFCAs with????9 fluorinated carbons from freshwater fish species was comparable with or greater than that from drinking water. Because the risk posed by exposure to these compounds through intake of fish species is a matter of concern, we recommend the continued monitoring of PFS levels in Asian developing countries. 相似文献
997.
Familial Cervical Paragangliomas with Lymph Node Metastasis Expressing Somatostatin Receptor Type 2A
We report a case of familial, bilateral cervical paragangliomas (PGs) with lymph node metastasis. Patient I-1 is a 56-year-old
man with a right carotid body tumor and a left vagal PG. Patient II-1 is a 29-year-old woman and the daughter of Patient I-1;
she had a left carotid body tumor with regional lymph node metastasis. Histology of all the tumors showed the typical pattern
of PGs, i.e., a zellballen pattern composed of chief cells positive for chromogranin A, and sustentacular cells positive for
S100 protein. The Ki-67 labeling index was 1% to 3% in these PGs in both the primary and the metastatic tumors. Immunohistochemical
analysis showed expression of somatostatin receptor (sstr) type 2A, but was negative for sstr type 5. Genomic mutation in
succinate dehydrogenase type D was confirmed in both patients. Here, we present a case of familial PGs, and discuss the cases
with special reference to pathologic diagnosis, genetics, and treatment. 相似文献
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